Natural Rubber Latex: Study of a Novel Carrier for Casearia sylvestris Swartz Delivery

ISRN Polymer Science ◽

10.1155/2014/241297 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 11

Author(s):

Felipe Azevedo Borges ◽

Luis Felipe Cesar Bolognesi ◽

Alberto Trecco ◽

Bruno de Camargo Drago ◽

Larisa Baldo de Arruda ◽

...

Keyword(s):

Wound Healing ◽

Natural Rubber ◽

Drug Delivery Systems ◽

Natural Rubber Latex ◽

Prolonged Release ◽

Tissue Formation ◽

Cell Adherence ◽

Rubber Latex ◽

The Matrix ◽

Casearia Sylvestris

Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, sensors and prosthesis and for drug delivery systems (for drugs, plant extracts, and nanoparticles). To enhance its wound healing properties was incorporated Casearia sylvestris Swartz extract, whose pharmacological activity includes anti-inflammatory, analgesic, antiseptic, antiulcer, and antitumor due to its casearins and phenols. Results showed the prolonged release of its compounds (35 days) and the mechanism of release is super case II (n>1) by Korsmeyer-Peppas model. Although SEM shows different sizes of clusters at the surface, the release is homogeneous through the biomembrane. FTIR shows no interaction between the matrix and the extract, with computation of the presence of some casearins.

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Propranolol Hydrochloride Extended-Release Matrix Tablets Using Natural Rubber Latex as Binder

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.747.91 ◽

2013 ◽

Vol 747 ◽

pp. 91-94 ◽

Cited By ~ 1

Author(s):

Kamon Panrat ◽

Prapaporn Boonme ◽

Wirach Taweepreda ◽

Wiwat Pichayakorn

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Natural Rubber ◽

Release Rate ◽

Drug Delivery Systems ◽

Natural Rubber Latex ◽

Delivery Systems ◽

Matrix Tablets ◽

Propranolol Hydrochloride ◽

Rubber Latex

Matrix is one of the most interesting drug delivery systems to control drug release in pharmaceutical dosage forms. Natural rubber latex (NRL) from Hevea brasiliensis consists of cis-1,4-polyisoprene as the major polymer. It presents interesting physical properties such as easy to manipulate, low cost, high mechanical resistance, and insoluble in water. The aim of this study was to use the NRL as binder in matrix tablets for controlling the release rate of drug. NRL, sodium carboxymethylcellulose, olive oil, Tween 80, and lactose were used as polymer, adsorbent, plasticizer, surfactant, and diluent, respectively. Propranolol hydrochloride was used as a model drug. Propranolol hydrochloride matrix tablets were prepared by conventional heat-melting method. The in vitro release of drug from matrix tablets was determined by UV-Vis method according to dissolution test under Propranolol Hydrochloride Tablets USP30-NF25 monograph. Morphology of propranolol hydrochloride matrix tablet before and after released study was observed by scanning electron microscopy (SEM). It was found that NRL matrix tablets could control the drug release up to 12 hours. The release profiles were best fitted with Higuchi model. NRL amounts affected the properties of the propranolol hydrochloride matrix tablets. Increasing the NRL quantity in the matrices provided the decrease of release rate of drug. SEM photographs showed the number, size, and distribution of pore in propranolol hydrochloride matrix tablets that depended on amount of NRL addition. These results confirmed that NRL was possible to use as binder for matrix tablets in oral drug delivery systems.

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RECYCLING WASTE NATURAL RUBBER LATEX BY BLENDING WITH POLYSTYRENE – CHARACTERIZATION OF MECHANICAL PROPERTIES

International Journal of Modern Physics Conference Series ◽

10.1142/s2010194512003492 ◽

2012 ◽

Vol 06 ◽

pp. 391-396 ◽

Cited By ~ 1

Author(s):

O. BOONDAMNOEN ◽

M. OHSHIMA ◽

A. R. AZURA ◽

S. CHUAYJULJIT ◽

A. ARIFFIN

Keyword(s):

Natural Rubber ◽

Natural Rubber Latex ◽

Crosslinking Density ◽

Tensile Fracture ◽

Rubber Latex ◽

Tensile Fracture Surface ◽

The Matrix ◽

Lower Elongation ◽

Internal Mixer

Waste natural rubber latex was blended with polystyrene (WNRL/PS) for recycling. A mixture with a 50/50 ratio of rubber to PS was blended by an internal mixer (Haake) at 140 °C and 60 rpm. The PS became the matrix, and the WNRL was dispersed within the matrix. Dynamically vulcanized natural rubber/PS (NRv/PS) blends and natural rubber/PS (NR/PS) blends without vulcanization were also prepared in the same way for comparison. The tensile properties and morphologies of all blends were investigated. The crosslinking density was determined by using the Flory-Rehner equation. The experiments showed that the WNRL/PS blend exhibited a higher tensile strength, Young's modulus and crosslinking density, but a lower elongation at break, than the NRv/PS and NR/PS blends. SEM observations of the tensile fracture surface and TEM observations of the blend morphology indicated that the WNRL/PS blend needed a higher energy to break than the NRv/PS and NR/PS blends.

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