scholarly journals Imaging-Cytology Correlation of Thyroid Nodules with Initially Benign Cytology

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shin Hye Hwang ◽  
Ji Min Sung ◽  
Eun-Kyung Kim ◽  
Hee Jung Moon ◽  
Jin Young Kwak

Objective. To determine the role of imaging-cytology correlation in reducing false negative results of fine-needle aspiration (FNA) at thyroid nodules.Methods. This retrospective study included 667 nodules 1 cm or larger in 649 patients diagnosed as benign at initial cytologic evaluation and that underwent follow-up ultrasound (US) or FNA following a radiologist’s opinion on concordance between imaging and cytologic results. We compared the risk of malignancy of nodules classified into subgroups according to the initial US features and imaging-cytology correlation.Results. Among included nodules, 11 nodules were proven to be malignant (1.6%) in follow-up FNA or surgery. The malignancy rate was higher in nodules with suspicious US features (11.4%) than in nodules without suspicious US features (0.5%,P<0.001). When a thyroid nodule had discordant US findings on image review after having benign FNA results, malignancy rate increased to 23.3%, significantly higher than that of nodules with suspicious US features (P<0.001). However, no significant difference was found in the risk of malignancy between the nodules without suspicious US features (0.5%) and imaging-cytology concordant nodules (0.6%,P=0.438).Conclusions. Repeat FNA can be effectively limited to patients with cytologically benign thyroid nodules showing discordance in imaging-cytology correlation after initial biopsy, which reduces unnecessary repeat aspirations.

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Dorota Słowińska-Klencka ◽  
Ewa Woźniak-Oseła ◽  
Bożena Popowicz ◽  
Stanisław Sporny ◽  
Mariusz Klencki

Purpose. The aim of the study was to compare the risk of thyroid malignancy and efficacy of repeat FNA in patients with thyroid nodules diagnosed cytologically as benign lesion (BL) with features of chronic thyroiditis (BL-CT) and BL without CT features (BL-nCT).Methods. The analysis included 917 patients with BL-CT and 7046 with BL-nCT in the first FNA. Repeat biopsy was carried out in 787 patients of BL-CT and 5147 of BL-nCT; 218 patients of BL-CT and 2462 of BL-nCT were operated; in 88 cases of BL-CT and 563 of BL-nCT both ways of follow-up were available.Results. Outcome of repeat cytology implied surgery more frequently in patients with BL-CT than with BL-nCT—3.2% versus 1.9%,P< 0.05. Incidence of cancer (including incidentalomas) was higher in patients with BL-CT operated after one benign cytology than in patients with two benign FNA outcomes: 10.8% versus 1.6%,P< 0.05. In patients with BL-nCT that difference was not significant: 3.2% versus 2.6%.Conclusions. Patients with thyroid nodules diagnosed as BL with CT features have higher risk of malignancy than patients with BL without CT features. Repeat biopsy significantly lowers percentage of FN results in patients with BL-CT in the first FNA.


2020 ◽  
Vol 13 (1) ◽  
pp. 413-414 ◽  
Author(s):  
Mohamed Farouk Allam

Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple, could be calculated in a few minutes, and incorporates the main possible data/findings of any patient.


2020 ◽  
Vol 41 (11) ◽  
pp. 1342-1346
Author(s):  
Kimberly K. Broughton ◽  
Caroline Williams ◽  
Christopher P. Miller ◽  
Kristen Stupay ◽  
John Y. Kwon

Background: In the setting of apparently isolated distal fibula fractures, the gravity stress view (GSV) is a validated method to determine mortise stability. There is currently no published data evaluating whether dynamic muscle activation can reduce an unstable mortise. If patients with instability can overcome gravity, resultant images could yield false-negative results. The goal of this investigation was to determine if patient effort can influence medial clear space (MCS) measurements in proven unstable bimalleolar-equivalent ankle fractures. Methods: Patients presenting with Weber B fibula fractures were assessed for mortise stability using the GSV. If the GSV demonstrated instability based on MCS widening >4 mm, 3 additional views were performed: GSV with an assistant maintaining the ankle in a neutral position; GSV with the patient actively dorsiflexing to neutral; and GSV with the patient actively dorsiflexing and supinating the foot. Twenty-four consecutive patients met inclusion criteria, with a mean age of 48.7 (range, 22-85) years. Fifteen patients (62.5%) were female and 9 (37.5%) were male. The laterality was evenly divided. Results: The mean MCS was 5.8 ± 2.0 6.0 ± 2.6, and 6.2 ± 2.7 mm for the manual assist, active dorsiflexion, and active supination radiograph measurement groups, respectively ( P = .434). Only 5 of 24 subjects had any measurable decrease in their MCS with active supination, with a maximum change of 1.2 mm. The remainder of the patients had an increase in MCS ranging from 0.1 to 4.0 mm. Conclusion: There was no significant difference between measurement states indicating that muscle activation is unlikely to yield a false-negative result on GSV. Mortise instability, secondary to deep deltoid injury in the presence of gravity stress, is unlikely to be actively overcome by dynamic stabilizers, supporting the validity and specificity of the GSV. Level of Evidence: Level III, prospective study.


2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0014
Author(s):  
Kimberly K. Broughton ◽  
Christopher P. Miller ◽  
Caroline Williams ◽  
Kristen L. Stupay ◽  
John Y. Kwon

Category: Ankle; Trauma Introduction/Purpose: In the setting of apparently isolated distal fibula fractures, the radiographic gravity stress view (GSV) has been validated as a reliable method to determine mortise stability. Based on previous studies demonstrating that plantarflexion can increase the measured medial clear space (MCS), patients are often asked to actively hold their ankle in a neutral position. However, it has not been studied whether dynamic muscle activation in the form of attempted dorsiflexion and/or supination can reduce and realign an unstable mortise. If these efforts can overcome gravity, resultant images could lead to a false negative result and missed diagnosis of instability. The goal of the present investigation is to determine if active effort by the patient can influence MCS measurements in proven unstable bimalleolar-equivalent ankle fractures. Methods: Eighteen consecutive patients with apparently isolated distal fibula fractures (Weber-B type) identified on initial nonweightbearing radiographs were assessed for mortise stability with a standard, unassisted GSV. If the radiograph demonstrated MCS widening > 4 mm, 3 additional views were performed: GSV with an assistant manually maintaining the ankle in a neutral position; GSV with the patient actively dorsiflexing the ankle to the same neutral position; and GSV with the patient actively dorsiflexing and supinating the foot to the same neutral position. All radiographs were digitally obtained and measured using a DICOM measurement tool. The MCS was measured by the senior author (JYK) who was blinded to the nature of the ankle position. Statistical analysis of the data was then conducted. Results: Of the eighteen patients who met inclusion criteria, the mean age was 48.9 years (range: 22-85, SD=18.9). Twelve patients (66%) were female and six (33%) were male. The laterality was evenly split with nine patients presenting with a right ankle injury and nine left ankles. The data was non-parametric; therefore, a Friedman’s test was utilized for analysis between the different MCS measurements per patient. There was no statistically significant difference in the measured MCS in any of the three tested scenarios, χ2(2)=4.261, p=0.119. Only 5 of 18 subjects had any measurable decrease in their MCS when asked to supinate their foot. Of these 5, the maximum reduction was 1.21mm. The remainder of patients had an increase in MCS ranging from 0.1 to 4.0mm. Conclusion: This investigation supports the notion that the gravity stress test is unlikely to yield false negative results when patients attempt to actively maintain a neutral ankle position during imaging. There was a non-significant inverse trend indicating that dynamic effort may in fact further displace the mortise as indicated by an increased MCS in several study participants, rather than reduce it. Thus, one can conclude that despite voluntary effort, patients with bimalleolar-equivalent ankle fractures are unlikely able to overcome the effect of gravity on the unstable mortise.


2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
O Jones ◽  
V Blackabey ◽  
N Bhat

Abstract Introduction Fine needle aspiration (FNA) is the gold standard for the diagnostic assessment of thyroid nodules, with cytology stratified using the Thy classification (Thy 1-5). The management of cases where cytology is indeterminate (Thy-3) is challenging and subject to controversy. The current British Thyroid Association guidelines subclassify Thy-3 lesions into Thy-3a (atypia) and Thy-3f (follicular). Repeat FNA is generally recommended for Thy-3a specimens, whilst Thy-3f lesions should proceed to diagnostic hemithyroidectomy. The aim of this study was to determine the risk of malignancy in Thy-3a and Thy-3f lesions. Method This was a retrospective study of all patients who underwent FNA of a thyroid nodule from 01/01/2018 – 31/12/19. Those with Thy-3 cytology were identified and results correlated with final surgical histology. Results In total, there were 179 patients with Thy-3 cytology: 37 Thy-3a and 142 Thy-3f. The rate of malignancy was 21.6% (n = 8) for Thy-3a lesions and 20.4% (n = 29) for Thy-3f. When excluding microcarcinoma, the rates fell to 20.4% (n = 7) and 12.7% (n = 18) respectively. There was no statistically significant difference in malignant conversion between the two groups (p = 0.20). Conclusions This study does not demonstrate any statistically significant difference in the risk of malignancy between the Thy-3a and Thy-3f groups, suggesting that this subclassification does not add any additional utility to clinical decision making. Consideration should be given to the use of local malignant conversion rates to guide further management and pre-operative patient counselling in the Thy3 group.


Author(s):  
Suzanne Lisbeth Ekelund

This paper describes the problems with false covid-19 test results, both false positive and false negative results. The problems are related to the quality of tests, test sampling and the currently limited follow-up procedures. A test and follow-up strategy that could decrease the potential problems is suggested.


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