Expression of Maspin and Ezrin Proteins in Periocular Basal Cell Carcinoma

Background.The aim of this study was to investigate maspin and ezrin expression in different subtypes of periocular basal cell carcinoma (BCC).Methods.Tissue samples from 43 patients with periocular BCC. Our cases were comprised of 10 morpheaform, 25 nodular, and 8 adenoid type BCCs. Immunohistochemical staining for maspin and ezrin was performed by Envision detection system.Results.There was no difference between different subtypes of BCC in maspin expression regarding positivity, intensity, and pattern of expression. Ezrin was expressed in all subtypes of BCC but the intensity was significantly higher in morpheaform BCC compared to nodular and adenoid types (P<0.001andP=0.012, resp.); ninety percent of morpheaform samples showed strong ezrin intensity, while this strong intensity was only present in 25% and 12% of adenoid and nodular subtypes, respectively. There was no correlation between age, sex, or tumor margin involvement and expression of neither maspin nor ezrin. There was no correlation between maspin and ezrin expression except in nodular type, in which an inverse correlation was found(P=0.004).Conclusion.Ezrin is expressed intensely in morpheaform BCC of periocular region. Further studies are needed to show the significance of this finding in prognosis of morpheaform BCC.

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Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes

Journal of Clinical Medicine ◽

10.3390/jcm9030612 ◽

2020 ◽

Vol 9 (3) ◽

pp. 612

Author(s):

Paola Pasquali ◽

Gonzalo Segurado-Miravalles ◽

Mar Castillo ◽

Ángeles Fortuño ◽

Susana Puig ◽

...

Keyword(s):

Retrospective Study ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Inverse Correlation ◽

Basal Cells ◽

White Population ◽

First Line ◽

Common Skin ◽

Cytological Features

Background: Basal cell carcinoma (BCC) is the most common skin cancer in the white population. Nonsurgical treatments are first-line alternatives in superficial BCC (sBCC); therefore, differentiating between sBCC and non-sBCC is of major relevance for the clinician. Scraping cytology possesses several advantages, such as an earlier diagnosis and scarring absence, in comparison to a biopsy. Nevertheless, previous studies reported difficulties in differentiating the different BCC subtypes. The objective of this study was to determine the capability and accuracy of scraping cytology to differentiate between sBCC and non-sBCC. Methods: In this retrospective study, cytological samples of histologically confirmed BCC were examined. Select cytological features were correlated to BCC subtypes (sBCC or non-sBCC). Results: A total of 84 BCC samples were included (29 sBCC; 55 non-sBCC). An inverse correlation between the diagnosis of sBCC and the presence of mucin, dehiscence, and grade of atypia in the basal cells was observed. The presence of medium and large basal cell clusters correlated directly to a sBCC diagnosis. The presence of clear cells is strongly associated with sBCC. Therefore, Conclusion: Scraping cytology is reliable in differentiating sBCC from other BCC subtypes.

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Linear Basal Cell Carcinoma: A Distinct Clinical Entity in the Periocular Region

Ophthalmology ◽

10.1016/j.ophtha.2005.04.035 ◽

2006 ◽

Vol 113 (2) ◽

pp. 338-342 ◽

Cited By ~ 15

Author(s):

I MAVRIKAKIS ◽

R MALHOTRA ◽

R BARLOW ◽

S HUILGOL ◽

D SELVA

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Clinical Entity ◽

Distinct Clinical Entity ◽

Periocular Region

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Margin involvement and clinical pattern of basal cell carcinoma with mixed histology

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/j.1468-3083.2011.04104.x ◽

2011 ◽

Vol 26 (4) ◽

pp. 483-487 ◽

Cited By ~ 12

Author(s):

R. Betti ◽

G. Radaelli ◽

C. Crosti ◽

S. Ghiozzi ◽

L. Moneghini ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Clinical Pattern ◽

Margin Involvement ◽

Mixed Histology

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Periocular basal cell carcinoma - clinical perspectives

Oncology Reviews ◽

10.4081/oncol.2020.420 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Alena Furdova ◽

Karolina Kapitanova ◽

Alexandra Kollarova ◽

Juraj Sekac

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Treatment Options ◽

Surgical Excision ◽

Cancer Type ◽

Non Melanoma Skin Cancer ◽

Periocular Region ◽

Age Over 60 ◽

Orbital Invasion

Basal cell carcinoma (BCC) as a non-melanoma skin cancer type is the most common malignant tumor throughout the world. The incidence is higher in age over 60. The intense of exposure to ultraviolet radiation is one of the known risk factors. Over 50% of BCC of the periocular region initially occur on the lower lid and inner angle. Literature review of treatment options for basal cell carcinoma, which consist of surgery, or combined techniques plus vismodegib, radiotherapy and imiquimod. The first consideration for treatment of periocular BCC is radical surgical excision using Mohs micrographic technique. Functional and esthetic outcome in patients are important after clear excisions and reconstruction should be carefully considered. Radical exenteration is considered in the case of orbital invasion of high-risk aggressive BCC.

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Ultrastructure of Mouse Basal Cell Carcinoma Exhibiting Sebaceous Differentiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600003214 ◽

1980 ◽

Vol 38 ◽

pp. 738-739

Author(s):

Victoria L. Wade ◽

Winslow G. Sheldon ◽

James W. Townsend ◽

William Allaben

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Topical Application ◽

Basal Cell ◽

Sebaceous Gland ◽

Rats And Mice ◽

Mixed Tumors

Sebaceous gland tumors and other tumors exhibiting sebaceous differentiation have been described in humans (1,2,3). Tumors of the sebaceous gland can be induced in rats and mice following topical application of carcinogens (4), but spontaneous mixed tumors of basal cell origin rarely occur in mice.

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