scholarly journals Cervical Carcinoma Manifesting as Progressive Bilateral Visual Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-2
Author(s):  
O’Sam Shibeeb ◽  
Paul Athanasiov ◽  
Sumu Simon ◽  
Jagjit Gilhotra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retinal Detachment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Visual Loss ◽  
Serous Retinal Detachment ◽  
Cervical Squamous Cell Carcinoma ◽  
Fundus Examination ◽  
Choroidal Metastasis ◽  
Work Up

We report a patient with bilateral choroidal metastasis from disseminated cervical squamous cell carcinoma. A 52-year-old woman presented with progressive bilateral visual loss due to choroidal masses in both eyes. The fundus examination revealed posterior serous retinal detachment in both eyes associated with creamy choroidal lesions. A thorough systemic work-up revealed choroidal metastasis from a squamous cell carcinoma of the cervix. This case highlights the importance of a thorough systemic evaluation in patients with choroidal tumours.

Invasive conjunctival squamous cell carcinoma presenting with serous retinal detachment

2013 ◽  
Vol 48 (6) ◽  
pp. e158-e159 ◽  
Author(s):  
Shaheen C. Kavoussi ◽  
Debra J. Shetlar ◽  
Andrew J. Barkmeier ◽  
Petros E. Carvounis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retinal Detachment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Serous Retinal Detachment ◽  
Conjunctival Squamous Cell Carcinoma

scholarly journals Bilateral Diffuse Uveal Melanocytic Proliferation in a Woman with Metastatic Scalp Squamous Cell Carcinoma Treated with Cemiplimab

2021 ◽  
pp. 961-966
Author(s):  
Etti Katzburg ◽  
Dinah Zur ◽  
Orit Gutfeld ◽  
Ilya Kirgner ◽  
Zohar Habot-Wilner
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Visual Loss ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Fundus Examination ◽  
First Case ◽  
Appropriate Treatment ◽  
Underlying Malignancy

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular syndrome that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. The IgG factor – cultured melanocyte elongation and proliferation – was found in the IgG fraction of the serum of BDUMP patients. It has been shown to be involved in melanocytic proliferation. In this case report, we describe the first case of BDUMP related to metastatic cutaneous squamous cell carcinoma (cSCC) of the scalp. A 61-year-old woman complained of decreased vision in both of her eyes, while being treated with cemiplimab (an anti-PD-1 therapy) for metastatic cSCC. Fundus examination showed hypopigmented lesions in a leopard pattern and pigmentary clumps in both eyes. Further imaging confirmed the diagnosis of BDUMP. The patient was successfully treated with plasmapheresis. During follow-up, cataract progressed in both eyes, and she underwent cataract surgery with visual acuity improvement to 20/20. BDUMP is a challenging diagnosis especially in patients treated with anti-PD-1 immunotherapy as it can be confused with drug-related effects. It is crucial to distinguish between the cases in order to allow the appropriate treatment which includes continuation of systemic anti-PD-1 for the underlying malignancy and plasmapheresis therapy for BDUMP.

scholarly journals Significance of miR-141 and miR-340 in cervical squamous cell carcinoma

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 864-872
Author(s):  
Wenting Li ◽  
Bo Yang ◽  
Yiqun Li ◽  
Cuicui Wang ◽  
Xinzhi Fang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Target Gene ◽  
Squamous Epithelium ◽  
Figo Stage ◽  
Cervical Squamous Cell Carcinoma ◽  
Squamous Intraepithelial Lesion ◽  
Nerve Invasion ◽  
Intraepithelial Lesion

Abstract Background We investigated the expression and clinical significance of miR-141 and miR-340 in cervical squamous cell carcinoma (CSCC). Methods Expression of miR-141 and miR-340 in CSCC, high-grade squamous intraepithelial lesion (HSIL), and normal cervical squamous epithelium were detected by qRT-PCR. PTEN was assessed by immunohistochemistry. Their relationship with clinicopathological features was analyzed. Results The changes of miR-141 and miR-340 were different in CSCC, HSIL, and normal squamous epithelium (P = 0.030). miR-141 expression was statistically significant in gross type, differentiation, uterine corpus invasion, nerve invasion, vagina invasion, and FIGO stage in CSCC (P < 0.05). miR-340 expression was related to tumor size, differentiation, nerve invasion, lymph node metastasis, and FIGO stage in CSCC (P < 0.05). miR-141 and miR-340 expressions were statistically significant in different ages (P < 0.05) in HSIL. The AUC of miR-141 in CSCC diagnosis and that of miR-340 in HSIL diagnosis were 0.893 and 0.764, respectively. The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively. miR-141 and miR-340 expressions are associated with PTEN expression (P = 0.002 and P < 0.001). Conclusion miR-141 and miR-340 may be associated with their target gene PTEN and involved in the carcinogenesis of cervical squamous epithelium.

Pathologic Determination of Multifocality in pT1a1 Squamous Cell Carcinoma of the Cervix: A Retrospective Analysis

2021 ◽  
pp. 106689692199072
Author(s):  
Jingjing Hu ◽  
Kojo R. Rawish ◽  
Mariah Leivo ◽  
Dennis Adams ◽  
Somaye Y. Zare ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Residual Disease ◽  
Cervical Squamous Cell Carcinoma ◽  
Tnm Staging ◽  
Stromal Invasion ◽  
Lateral Extent ◽  
Clinicopathologic Parameters

When more than one focus of stromal invasion is present in a superficially invasive cervical squamous cell carcinoma (SCC), determination of the tumoral lateral extent/horizontal extension, and hence tumor-nodes-metastases (TNM) staging, can be problematic. In recent years, a diagnostic approach to distinguish multifocal pT1a1 from pT1b cases has gained increased attention. These criteria call for classifying SCC as multifocal when invasive foci are separated by blocks of uninvolved cervical tissues, and/or are located on separated cervical lips in a tumor that is discontinuous, and/or are situated far apart (≥2 mm) from each other. In this study, we assess our experience with multifocal stage pT1a1 cervical SCC that was retrospectively classified as such using these criteria. Slides from the loop electrosurgical excision or conization specimens, comprising 212 pT1a1, 173 pT1a2, and 206 pT1b cases, were reviewed. Twenty-four (11%) of the 212 pT1a1 cases were classified as multifocal after review. The 24 multifocal pT1a1 cases were compared with the 188 unifocal pT1a1 cases regarding a variety of clinicopathologic parameters. Notably, these 2 groups showed no significant differences regarding all parameters that were evaluated, including patient age, recurrence rate, primary tumoral features in the primary excision specimen (rate of positive margins, median depth of stromal invasion, frequency of lymphovascular invasion), and frequency of residual disease in additional excisions. In summary, we demonstrate comparably favorable patient outcomes in both unifocal and multifocal cases of pT1a1 SCC of the cervix, and, accordingly, we conclusively affirm the validity of the aforementioned criteria for establishing multifocality.

NUCKS1 overexpression is a novel biomarker for recurrence-free survival in cervical squamous cell carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 35 (8) ◽  
pp. 7831-7836 ◽  
Author(s):  
Lina Gu ◽  
Bairong Xia ◽  
Lili Zhong ◽  
Yuan Ma ◽  
Lei Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Recurrence Free Survival ◽  
Free Survival

Recurrence during pregnancy of a conservatively treated early-stage cervical squamous cell carcinoma

2011 ◽  
Vol 95 (1) ◽  
pp. 290.e13-290.e16 ◽  
Author(s):  
Pascale Jadoul ◽  
Denis Querleu ◽  
Jean-Luc Squifflet ◽  
Jacques Donnez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Cervical Squamous Cell Carcinoma
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