scholarly journals Metabolomic Study on the Preventive Effect ofPatrinia scabiosaefoliaFisch on Multipathogen Induced Pelvic Inflammatory Disease in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wei Zou ◽  
Xiaoke Wen ◽  
Yi Zheng ◽  
Zuoqi Xiao ◽  
Jieying Luo ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Sugar Metabolism ◽  
Tca Cycle ◽  
Inflammatory Cells ◽  
Preventive Effect ◽  
Elevated Expression ◽  
Patrinia Scabiosaefolia ◽  
Metabolomic Study

Patrinia scabiosaefoliaFisch (PSF), a well-known traditional Chinese medicine (TCM), has been used as a “heat-clearing and detoxifying” agent. The present study was to illustrate the preventive effect of PSF on pelvic inflammatory disease (PID) in rats. The PID model was constructed by multipathogen infection of the upper genital tract with reference to the method previously reported. Urine metabolomic analysis was conducted with a GC-MS coupled with derivatization method. In this study, PID rats showed obvious infiltration of inflammatory cells and elevated expression of cytokines (IL-1βand IL-6) in upper genital tract, compared with control rats. Sixteen differentiating metabolites contributed to the alteration of metabolic profile in PID rats, including two amino acids, three fat acids, nine organic acids, and two types of sugars. The rats, infected by multipathogen and administered with PSF, showed decreased infiltration of inflammatory cells and lowered expression of cytokines in upper genital tract, compared with PID rats. Meanwhile, PSF intervened in the PID-associated alterations in TCA cycle, sugar metabolism, amino acid metabolism, and other uncertain metabolic pathways. These results indicate that PSF has preventive effect on multipathogen induced PID and holistic interventional effect on disease-associated metabolomic change.

scholarly journals Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNK/NF-κB Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Yao Li ◽  
Yang Liu ◽  
Qian Yang ◽  
Zhihui Shi ◽  
Yanhua Xie ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Nuclear Translocation ◽  
Immunohistochemical Analysis ◽  
Dependent Manner ◽  
Preventive Effect ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Inflammatory Effect

Objectives. In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model. Methods. To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days. The histological examination, immunohistochemical analysis, and ELISA were carried out. Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF-κB p65, and IκB-α in uterus. Results. As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL-1β, IL-6, CXCL-1, and TNF-α were also reduced in a dose-dependent manner. We also found that FYCWYC inhibited apoptosis induced by infection. Furthermore, FYCWYC could block the infection-induced nuclear translocation of NF-κB. We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38. Additional, the effects of SP600125, an inhibitor of phospho-JNK, were similar to the results of FYCWYC. Conclusions. Taken together, our results demonstrated that FYCWYC had anti-inflammatory effect in pathogen-induced PID model, and the mechanism might be through inhibiting NF-κB nuclear translocation which is mediated by JNK.

Pelvic inflammatory disease

2020 ◽  
pp. 1622-1625
Author(s):  
Jonathan D.C. Ross
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Pelvic Pain ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Infectious Complication ◽  
Anaerobic Bacteria ◽  
Clinical Manifestations ◽  
Pelvic Abscess ◽  
Tubal Infertility ◽  
Severe Peritonitis

Pelvic inflammatory disease (PID) is an infection of the endometrium, fallopian tubes, and adnexae caused by a wide variety of bacteria, including Chlamydia trachomatis, Neisseria gonorrhoeae, and genital tract bacteria, most notably anaerobes. PID is often asymptomatic but clinical manifestations can range from mild pelvic pain and tenderness to severe peritonitis. Pelvic abscess formation is a serious infectious complication. However, only about 5% of patients with PID have a fever or severe infectious manifestations. An accurate clinical diagnosis of PID is difficult and it is commonly confused with other pelvic conditions, including ectopic pregnancy, appendicitis, and rupture or torsion of an ovarian cyst. Antibiotic therapy is aimed primarily at C. trachomatis, N. gonorrhoeae, and anaerobic bacteria, with prompt identification and treatment of PID recommended in an attempt to reduce the 15% rate of tubal infertility and 40% risk of chronic pelvic pain following this infection.

The relationship of genital tract actinomycetes and the development of pelvic inflammatory disease

1982 ◽  
Vol 143 (5) ◽  
pp. 585-589 ◽  
Author(s):  
Ronald Burkman ◽  
Sarah Schlesselman ◽  
Lee McCaffrey ◽  
Prabodh K. Gupta ◽  
Michael Spence
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Relationship Of ◽  
The Relationship

scholarly journals Unveiling New Molecular Factors Useful for Detection of Pelvic Inflammatory Disease due to Chlamydia trachomatis Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
Carmen Rodriguez-Cerdeira ◽  
Elena Sanchez-Blanco ◽  
Alberto Molares-Vila ◽  
Alfonso Alba
Keyword(s):  
Chlamydia Trachomatis ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Nucleic Acid Amplification ◽  
Chlamydia Trachomatis Infection ◽  
Diagnosis And Prognosis ◽  
Pubmed Database ◽  
Genital Tract Infections ◽  
Tract Infections

Background. Untreated Chlamydia trachomatis infections in women can result in disease sequelae such as pelvic inflammatory disease (PID), ultimately culminating in tubal occlusion and infertility. While nucleic acid amplification tests can effectively diagnose uncomplicated lower genital tract infections, they are not suitable for diagnosing upper genital tract pathological sequelae. Objective. The purpose of this paper was to provide a comprehensive review of new molecular factors associated with the diagnosis and prognosis of PID. Material and Methods. The literature was searched using the key words “Chlamydia trachomatis infections,” “pelvic inflammatory disease,” and “molecular factors” in the PubMed database. Relevant articles published between 1996 and 2012 were evaluated. Conclusions. The use of new molecular factors could potentially facilitate earlier diagnosis and prognosis in women with PID due to C. trachomatis infection.

scholarly journals Dynamic laparascopy as a stage of hospital rehabilitation in patients with tubal pregnancy

2005 ◽  
Vol 54 (5S) ◽  
pp. 33-34
Author(s):  
Е. V. Shipitsyna ◽  
А. V. Novikov ◽  
К. V. Shalepo ◽  
V. F. Bezhenar ◽  
А. М. Savicheva
Keyword(s):  
Chlamydia Trachomatis ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Tubal Pregnancy ◽  
Tubal Infertility ◽  
Chlamydia Trachomatis Infection ◽  
Hospital Rehabilitation

Objectives: Chlamydia trachomatis infection of the upper genital tract often results in pelvic inflammatory disease (PID), and its sequels include ectopic pregnancy (EP), miscarriage and tubal infertility. This study was aimed to evaluate the rate of C. trachomatis detection as well as anti-C trachomatis antibodies in women with EP.

scholarly journals Unilateral Pyosalpinx in an Adult Female presenting with Features of Acute Abdomen: A Case Report

2021 ◽  
Vol 23 (3) ◽  
pp. 272-274
Author(s):  
Shankar Poudel ◽  
U. Sangroula ◽  
A. Rajak
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Acute Abdomen ◽  
Inflammatory Disease ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Great Role ◽  
Inflammatory Changes ◽  
Ovarian Abscess ◽  
Late Manifestation ◽  
Female Genital

Pyosalpinx is defined as collection of pus in the fallopian tube and is a late manifestation of pelvic inflammatory disease. Pelvic inflammatory disease refers to a spectrum of inflammatory changes of the female genital tract. It comprises of endometritis, salpingitis, cervicitis, pyosalpinx, tubo-ovarian abscess and peritonitis. Pyosalpinx may progress to tubo-ovarian abscess which may rupture leading to peritonitis. In addition, pelvic inflammatory disease commonly affects both side of the tube. Thus, early diagnosis and proper intervention plays a great role in the management of pyosalpinx. We report a case of unilateral left sided pyosalpinx which presented with features of acute abdomen.

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