scholarly journals Lack of Association betweenJAK3Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Mercedes García-Bermúdez ◽  
Raquel López-Mejías ◽  
Fernanda Genre ◽  
Santos Castañeda ◽  
Alfonso Corrales ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Potential Role ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Ultrasonography ◽  
Promising Target ◽  
Atherosclerotic Process ◽  
Cv Disease

Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms inJAK3gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role ofJAK3polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752JAK3gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association betweenJAK3polymorphisms and CV disease in RA.

scholarly journals Lack of Association betweenABO,PPAP2B,ADAMST7,PIK3CG, andEDNRAand Carotid Intima-Media Thickness, Carotid Plaques, and Cardiovascular Disease in Patients with Rheumatoid Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Raquel López-Mejías ◽  
Fernanda Genre ◽  
Mercedes García-Bermúdez ◽  
Begoña Ubilla ◽  
Santos Castañeda ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Variants ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Ultrasonography ◽  
Carotid Plaques ◽  
Media Thickness ◽  
Artery Disease ◽  
Cv Disease

Introduction. Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. Recent studies have identified theABOrs579459,PPAP2Brs17114036, andADAMTS7rs3825807 polymorphisms as genetic variants associated with coronary artery disease and thePIK3CGrs17398575 andEDNRArs1878406 polymorphisms as the most significant signals related to the presence of carotid plaque in nonrheumatic Caucasian individuals. Accordingly, we evaluated the potential relationship between these 5 polymorphisms and subclinical atherosclerosis (assessed by carotid intima-media thickness (cIMT) and presence/absence of carotid plaques) and CV disease in RA.Material and Methods. 2140 Spanish RA patients were genotyped for the 5 polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 620 of these patients by carotid ultrasonography technology.Results. No statistically significant differences were found when each polymorphism was assessed according to cIMT values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV disease after adjusting for potential confounders.Conclusion. Our results do not confirm association betweenABOrs579459,PPAP2Brs17114036,ADAMTS7rs3825807,PIK3CGrs17398575, andEDNRArs1878406 and subclinical atherosclerosis and CV disease in RA.

Common Carotid Intima-media Thickness in Patients with Late Rheumatoid Arthritis; What Is the Role of Gender?

2011 ◽  
Vol 14 (16) ◽  
pp. 812-816 ◽  
Author(s):  
Abolhassan Shakeri ◽  
Mohammad Babaei Bazzaz ◽  
Alireza Khabbazi ◽  
Rohollah Fadaei Fouladi
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Double role of mannose-binding lectin in relation to carotid intima–media thickness in patients with rheumatoid arthritis

2010 ◽  
Vol 47 (4) ◽  
pp. 713-718 ◽  
Author(s):  
Lone N. Troelsen ◽  
Peter Garred ◽  
Buris Christiansen ◽  
Christian Torp-Pedersen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Genetic Markers of Cardiovascular Disease in Rheumatoid Arthritis

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Luis Rodríguez-Rodríguez ◽  
Raquel López-Mejías ◽  
Mercedes García-Bermúdez ◽  
Carlos González-Juanatey ◽  
Miguel A. González-Gay ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Genetic Basis ◽  
Strong Association ◽  
Premature Mortality ◽  
Base Pairs ◽  
Increased Risk ◽  
Atherosclerotic Process ◽  
Cv Disease ◽  
Polygenic Diseases

Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studies have confirmed the role of genetic factors in the development of the atherogenesis observed in RA. In this regard, besides a strong association between theHLA-DRB1*04shared epitope alleles and both endothelial dysfunction, an early step in the atherosclerotic process, and clinically evident CV disease, other polymorphisms belonging to genes implicated in inflammatory and metabolic pathways, located inside and outside the HLA region, such as the 308 variant (G>A, rs1800629) of theTNFAlocus, the rs1801131 polymorphism (A>C; position + 1298) of theMTHFRlocus, or a deletion of 32 base pairs on theCCR5gene, seem to be associated with the risk of CV disease in patients with RA. Despite considerable effort to decipher the genetic basis of CV disease in RA, further studies are required to better establish the genetic influence in the increased risk of CV events observed in patients with RA.

scholarly journals Postprandial Apolipoprotein B48 is Associated with Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis

2020 ◽  
Vol 9 (8) ◽  
pp. 2483
Author(s):  
Natalia Mena-Vázquez ◽  
Marta Rojas-Gimenez ◽  
Francisco Gabriel Jimenez Nuñez ◽  
Sara Manrique-Arija ◽  
José Rioja ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity Score ◽  
Plasma Lipids ◽  
Subclinical Atherosclerosis ◽  
Postprandial Lipemia ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Joint Disease ◽  
Negative Effect ◽  
Apolipoprotein B48

Objective: To describe postprandial lipemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis measured as carotid intima-media thickness (cIMT). Methods: We performed an observational study of 40 patients with RA and 40 sex and age-matched controls. Patients with dyslipidemia were excluded. Pathologically increased cIMT was defined as a carotid thickness greater than the 90th percentile (>p90) for age and sex. Fasting and postprandial plasma lipids, cholesterol, triglycerides, apolipoprotein B48 (ApoB48), and total ApoB were evaluated. The other variables included were clinical and laboratory values, Framingham score, and the 28-joint Disease Activity Score (DAS28). Two multivariate models were constructed to identify factors associated with pathologic cIMT in patients with RA. Results: Fasting lipid values were similar in patients with RA and controls, although those of postprandial ApoB48 were higher (median (IQR), 14.4 (10.8–12.1) vs. 12.1 (2.3–9,8); p = 0.042). Pathologic cIMT was recorded in 10 patients with RA (25%) and nine controls (22.5%). In patients with RA, pathologic cIMT was associated with postprandial ApoB48 (OR (95% CI), 1.15 (1.0–1.3)) and total ApoB (OR [95% CI], 1.12 [1.1–1.2]). The second model revealed a mean increase of 0.256 mm for cIMT in patients with elevated anticitrullinated protein antibodies (ACPAs). Conclusion: Postprandial ApoB48 levels in patients with RA are higher than in controls. Postprandial ApoB48 and total ApoB levels and markers of severity, such as ACPAs, are associated with pathologic cIMT in patients with RA. Our findings could indicate that these atherogenic particles have a negative effect on the endothelium.

scholarly journals Gender Differences in Cardiovascular Risk Profile in Rheumatoid Arthritis Patients with Low Disease Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Bożena Targońska-Stępniak ◽  
Małgorzata Biskup ◽  
Wojciech Biskup ◽  
Maria Majdan
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Hdl Cholesterol ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Risk Profile ◽  
Atherogenic Index ◽  
Low Disease Activity ◽  
Amino Terminal ◽  
Cv Disease

Objective. Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular (CV) disease (CVD). The objective of the study was to compare CV risk profile in female and male RA patients with low disease activity. Materials and Methods. The study group consisted of 70 RA patients with continuous low disease activity and no CVD (54 women, 16 men) and 33 healthy controls of comparable age. The groups were assessed for blood pressure, serum amino-terminal pro-brain natriuretic peptide (NT-proBNP), carotid intima media thickness (cIMT), electrocardiography, ejection fraction (EF), and diastolic dysfunction (DD). Results. Significantly higher burden of atherosclerosis, as revealed by higher cIMT, was found in males [0.93 (0.2) mm] vs females [0.80 (0.2) mm]. The risk of 10-year CVD was significantly higher in men than in women with RA. High/very high risk of fatal CVD was found in 62.5% of male patients. Males were significantly more often current/ex-smokers and had lower HDL-cholesterol and higher atherogenic index. There were no significant differences in NT-proBNP, QTc duration, and parameters of EF and DD. Conclusions. In RA patients with continued low disease activity, a higher burden of atherosclerosis was found in males than in females. The data suggest a significant impact of traditional CV risk factors.

scholarly journals Carotid intima-media thickness and coronary artery Disease

2018 ◽  
Vol 15 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Murari Prasad Barakoti
Keyword(s):  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Ultrasound Measurement ◽  
Media Thickness ◽  
Atherosclerotic Burden ◽  
Future Events ◽  
Artery Disease ◽  
Atherosclerotic Process ◽  
A Site

It is known from the post-mortem studies of accidental death that atherosclerotic process begins in childhood and gradually progresses over decades. Only when the process leads to flow limiting stenosis as a gradual narrowing or when a thrombus forms at a site of plaque due to rupture or erosion, then the clinical cardiovascular event is manifested. Although only a certain percentage of people with underlying atherosclerosis become manifest, the greater degree of subclinical atherosclerosis is associated with greater chance of future events. The event could be sudden cardiac death at its extreme. The ultrasound measurement of carotid intima-media thickness (CIMT) has withstood test of time as an important technique of measuring atherosclerotic burden. It has been more than three decades to know the value of CIMT in the risk prediction.NepaleseHeart Journal 2018; 15(1): 9-15

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