scholarly journals Gray Matter Volumes in Patients with Chronic Fatigue Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Le-wei Tang ◽  
Hui Zheng ◽  
Liang Chen ◽  
Si-yuan Zhou ◽  
Wen-jing Huang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Central Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Gray Matter ◽  
Chronic Fatigue ◽  
Brain Regions ◽  
Complex Disorder ◽  
Fatigue Syndrome ◽  
The Central Nervous System ◽  
Gray Matter Volumes

Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue with uncertain pathologic mechanism. Neuroimage may be an important key to unveil the central nervous system (CNS) mechanism in CFS. Although most of the studies found gray matter (GM) volumes reduced in some brain regions in CFS, there are many factors that could affect GM volumes in CFS, including chronic pain, stress, psychiatric disorder, physical activity, and insomnia, which may bias the results. In this paper, through reviewing recent literatures, we discussed these interferential factors, which overlap with the symptoms of CFS.

Treatment of fibromyalgia (chronic widespread pain) and chronic fatigue syndrome

2020 ◽  
pp. 1330-1341
Author(s):  
Jonathan Price
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Chronic Widespread Pain ◽  
Widespread Pain ◽  
Fatigue Syndrome ◽  
System P ◽  
The Central Nervous System ◽  
Key Aspects

Fibromyalgia (FM), one of the chronic widespread pain syndromes, and chronic fatigue syndrome (CFS) are important and common conditions. They are considered together here because they are commonly comorbid and because of their similarities—they are long-term conditions with a relatively poor prognosis; central nervous system mechanisms and deconditioning play an important role in aetiology; graded exercise and psychological treatments have an important role in management; and comorbid mental disorders are common and have an adverse impact on important outcomes, including disability and chronicity. The prevalence of FM is rising, while that of CFS is declining. There is increased acceptance of the pivotal role of central nervous system factors in FM, while in CFS, the positions of different aetiological ‘movements’ appear bitterly entrenched. The main focus of this chapter is on FM and, in particular, key aspects of aetiology and treatment, especially those relating to the central nervous system.

Chronic Fatigue Syndrome and the Central Nervous System

2008 ◽  
Vol 36 (5) ◽  
pp. 867-874 ◽  
Author(s):  
R Chen ◽  
FX Liang ◽  
J Moriya ◽  
J Yamakawa ◽  
H Sumino ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Fatigue Syndrome ◽  
Neurotrophic Factors ◽  
Focal Point ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
The Central Nervous System ◽  
The Brain

An increasing amount of neuroimaging evidence supports the hypothesis that chronic fatigue syndrome patients have structural or functional abnormalities within the brain. Moreover, some neurotrophic factors, neurotransmitters and cytokines have also been evaluated in order to elucidate the mechanism of abnormal neuropsychic findings in chronic fatigue syndrome. In this review, we suggest that the focal point of chronic fatigue syndrome research should be transferred to the central nervous system.

Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity

2001 ◽  
Vol 31 (1) ◽  
pp. 107-114 ◽  
Author(s):  
E. BAZELMANS ◽  
G. BLEIJENBERG ◽  
J. W. M. VAN DER MEER ◽  
H. FOLGERING
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Chronic Fatigue Syndrome ◽  
Physical Fitness ◽  
Maximal Exercise ◽  
Negative Relationship ◽  
Chronic Fatigue ◽  
Controlled Study ◽  
Fatigue Syndrome ◽  
Physical Deconditioning

Background. Chronic fatigue syndrome (CFS) patients often complain that physical exertion produces an increase of complaints, leading to a greater need for rest and more time spent in bed. It has been suggested that this is due to a bad physical fitness and that physical deconditioning is a perpetuating factor in CFS. Until now, studies on physical deconditioning in CFS have shown inconsistent results.Methods. Twenty CFS patients and 20 matched neighbourhood controls performed a maximal exercise test with incremental load. Heart rate, blood pressure, respiratory tidal volume, O2 saturation, O2 consumption, CO2 production, and blood-gas values of arterialized capillary blood were measured. Physical fitness was quantified as the difference between the actual and predicted ratios of maximal workload versus increase of heart rate. Fatigue, impairment and physical activity were assessed to study its relationship with physical fitness.Results. There were no statistically significant differences in physical fitness between CFS patients and their controls. Nine CFS patients had a better fitness than their control. A negative relationship between physical fitness and fatigue was found in both groups. For CFS patients a negative correlation between fitness and impairment and a positive correlation between fitness and physical activity was found as well. Finally, it was found that more CFS patients than controls did not achieve a physiological limitation at maximal exercise.Conclusions. Physical deconditioning does not seem a perpetuating factor in CFS.

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