scholarly journals Reduced Risk of Parkinson’s Disease in Users of Calcium Channel Blockers: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Kapil Gudala ◽  
Raju Kanukula ◽  
Dipika Bansal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Calcium Channel ◽  
Random Effects ◽  
Calcium Channel Blockers ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Channel Blockers ◽  
Random Effects Model

Aim. To pool the data currently available to determine the association between calcium channel blockers (CCBs) and risk of Parkinson’s disease (PD).Methods. Literature search in PubMed, EBSCO, and Cochrane library was undertaken through March 2014, looking for observational studies evaluating the association between CCBs use and PD. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model. Subgroup analyses, sensitivity Analysis, and cumulative meta-analysis were also performed.Results. Six studies were included in our meta-analysis according to the selection criteria, including three cohort studies and three case-control studies involving 27,67,990 subjects including 11,941 PD cases. We found CCBs use was associated with significant decreased risk of PD, compared with not using CCBs (random effects model pooled RR, 0.81 (95% CI, 0.69–0.95)); a significant heterogeneity was found between studies (P=0.031;I254.6%). Both the classes of CCB, that is, dihydropyridine calcium channel blockers (DiCCB) (0.80 (95% CI, 0.65–0.98)P=0.032) and non-DiCCB (0.70 (95% CI, 0.53–0.92)P=0.013), were found to be reducing the risk of PD.Conclusion. In our analysis, we found that CCBs use was associated with a Significantly decreased risk of PD compared with non-CCB use.

scholarly journals Calcium channel blockers and β-blockers in relation to Parkinson's disease

2007 ◽  
Vol 13 (3) ◽  
pp. 165-169 ◽  
Author(s):  
Thanh G.N. Ton ◽  
Susan R. Heckbert ◽  
W.T. Longstreth ◽  
Mary Anne Rossing ◽  
Walter A. Kukull ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Β Blockers

scholarly journals Risk of Parkinson’s Disease in the Users of Antihypertensive Agents: An Evidence from the Meta-Analysis of Observational Studies

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Amarnath Mullapudi ◽  
Kapil Gudala ◽  
Chandra Sekhar Boya ◽  
Dipika Bansal
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Publication Bias ◽  
Observational Studies ◽  
Meta Analysis ◽  
Antihypertensive Agents ◽  
Protective Role ◽  
Large Sample Size ◽  
Significant Heterogeneity ◽  
Channel Blockers

Background. Antihypertensive agents have been shown to inhibit oxidative stress and inflammatory response and thus neuroprotection in Parkinson’s disease (PD). Epidemiological evidence suggests inconsistency between use of antihypertensives and risk of PD. This study is aimed to examine the association between antihypertensive use and risk of PD. Methods. Literature search in PubMed, EMBASE, and PsycINFO database was undertaken through February 2012 looking for observational studies evaluating the association between antihypertensive drug use and risk of PD. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model (DerSimonian and Laird method). Subgroup analyses and sensitivity analysis were also performed. Results. Seven relevant studies including a total of 28,32,991 subjects were included. Pooled RR of overall use of antihypertensive agents was found to be 0.95 (95% CI 0.84–1.05). A significant reduction in the risk of PD was observed among users of calcium channel blockers (RR 0.82, 95% CI 0.71–0.93). Significant heterogeneity (I2 = 76.2%) but no publication bias was observed. Conclusions. Overall use of antihypertensive agents showed no significant association with the risk of PD. CCBs provided significant protective role. However, studies with large sample size and dose relationships are required to strengthen our hypothesis.

scholarly journals L-type calcium channel blockers and Parkinson's disease in Denmark

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Beate Ritz ◽  
Shannon L. Rhodes ◽  
Lei Qian ◽  
Eva Schernhammer ◽  
Jorgen Olsen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

scholarly journals Burden and Determinants of Chronic Kidney Disease Among Diabetic Patients in Ethiopia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 42 ◽  
Author(s):  
Tadesse Tolossa ◽  
Getahun Fetensa ◽  
Bikila Regassa ◽  
Mekdes Tigistu Yilma ◽  
Merga Besho ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Random Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Special Focus ◽  
Significant Heterogeneity ◽  
Random Effects Model ◽  
Patients With Diabetes

Background: Chronic kidney disease (CKD) among diabetic patients is becoming a global health burden with a high economic cost to health systems. The incidence of CKD is higher in low-income countries such as Ethiopia. In Ethiopia, there is no national representative evidence on the burden and determinants of CKD among patients with diabetes. Therefore, this review aimed to estimates the pooled burden and determinants of CKD among patients with diabetes.Methods: Published articles from various electronic databases such as Pub Med, Google Scholar, CINAHL, Scopes, Cochrane library, the Web of Science, and African Journals Online were accessed. Also, unpublished studies from Addis Ababa digital library were identified. We included all observational studies (cross-sectional, case-control, and cohort) in the review. Data were extracted on the Microsoft Excel spreadsheet and analyzed using STATA 14.1 version. A random-effects model was used to estimate the pooled estimate with a 95% confidence interval (CI). Forest plots were used to visualize the presence of heterogeneity and estimate the pooled burden and determinants of chronic kidney disease among diabetic patients. The presence of publication bias was assessed by funnel plots and Egger’s statistical tests.Results: Published (297) and unpublished (2) literature were identified from several databases and digital libraries, of which twelve articles were selected for final meta-analysis. Significant heterogeneity was observed across studies (I2 = 85.2%), which suggests a random-effects model to estimate pooled burden. The analysis found that the pooled burden of CKD among patients with diabetes was 18.22% (95% CI: 15.07–21.38). Factors such as hypertension (OR = 2.65, 95%, CI: 1.38, 5.09), type of DM (OR = 0.33, 95%, CI: 0.14–0.76), and duration of DM (OR = 0.51, 95%, CI: 0.34–0.77) were found to have significant association with CKD.Conclusion: The current review revealed a higher burden of CKD among patients with diabetes in Ethiopia. The presence of hypertension, type II diabetes, and duration of diabetes for a longer duration were found to be independent determinants of CKD among patients with diabetes. For better control of chronic kidney disease, integrated management of hypertension and DM should be designed with a special focus on chronic diabetic patients.

scholarly journals Use of Calcium Channel Blockers and Parkinson’s Disease

2012 ◽  
Vol 175 (7) ◽  
pp. 627-635 ◽  
Author(s):  
Björn Pasternak ◽  
Henrik Svanström ◽  
Nete M. Nielsen ◽  
Lars Fugger ◽  
Mads Melbye ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

scholarly journals Burden and determinants of chronic kidney disease among diabetic patients in Ethiopia: A systematic Review and Meta-analysis, 2020

2020 ◽  
Author(s):  
Tadesse Tolossa ◽  
Getahun Fetensa ◽  
Bikila Regassa ◽  
Mekdes Tigistu ◽  
Ginenus Fekadu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Random Effects ◽  
Digital Library ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
Special Focus ◽  
Significant Heterogeneity ◽  
Random Effects Model

Abstract Background Chronic kidney disease (CKD) among diabetic patients is becoming a global health burden with a high economic cost to health systems. Its incidence is increased at higher rate in low income countries including Ethiopia. In Ethiopia, there is no national representative evidence on burden and determinants of chronic kidney disease among diabetic patients. Therefore, this review aimed to estimates the pooled burden and determinants of chronic kidney disease among diabetic patients. Methods Published articles from various electronic databases such as Pub Med, Google scholar, CINAHL, Scopes, Cochrane library, the Web of Science and African Journals Online were accessed. Also, unpublished studies from Addis Ababa digital library were identified. All observational studies that were conducted on the burden and determinants of chronic kidney disease among diabetic patients were included. Data were extracted on the Microsoft excel spreadsheet and analyzed using STATA 14.1 version. A random-effects model was used to estimate the pooled estimate with a 95% confidence interval (CI). Forest plots were used to visualize the presence of heterogeneity and estimate the pooled burden and determinants of chronic kidney disease among diabetic patients. The presence of publication bias was assessed by funnel plots and Egger’s statistical tests. Results Published (163) and unpublished (2) literature were identified from several databases and digital library, of which ten articles were selected for final meta-analysis. Significant heterogeneity was observed across studies (I 2 = 84.6%), which suggests random-effects model to estimate pooled burden. The analysis found that the pooled burden of chronic kidney disease among diabetic patients was 17.55% (95%CI: 14.23–20.88). Being hypertensive patient, type II DM and staying with DM for greater than 10 years had positive significant association with chronic kidney disease. Conclusion The current review revealed a higher burden of chronic kidney diseases among diabetic patients in Ethiopia. Presence of hypertension, type of diabetes mellitus and staying with diabetes for longer duration were found to be independent determinants of chronic kidney disease among diabetic patients. For better control of chronic kidney disease, integrated management of hypertension and DM should be designed with special focus on chronic diabetic patients.

scholarly journals The influence of levodopa on respiratory function in Parkinson's disease patients: a systematic review and meta-analysis

2021 ◽  
Vol 10 (14) ◽  
pp. e457101422262
Author(s):  
Francisco José Silva Ferreira ◽  
Paulo Eduardo Gonçalves ◽  
Alice Santos Lima ◽  
Diogo Costa Garção
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lung Function ◽  
Respiratory Function ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Random Effects Model ◽  
Exclusion Criteria

There is no consensus in the literature about the influence of levodopa on respiratory disorders, which are the main cause of death in Parkinson’s disease patients. Thus, the aim of this study was to conduct a systematic review and meta-analysis to assess the influence of levodopa on lung function in patients with Parkinson’s disease. A systematic search was performed in the MEDLINE-PubMed, Lilacs, IEEE Xplore Digital Library and Cochrane Library databases, until July 2020. Eligibility, screening, data extraction and quality assessment of the studies found were conducted independently by a minimum of two reviewers. The meta-analysis was made using RevMan 5, using standardized difference of means (SDM) with the random effects model and 95% confidence interval. The presence of heterogeneity was evaluated through the percentage of i². In total, 78 studies were identified; of these,7 were included in the review and meta-analysis after considering the inclusion and exclusion criteria. By comparing the 'on' and 'off' levodopa states, in the outcomes of interest found in the included studies, the following results were obtained in the meta-analysis: FVC (SMD of 0.12, p = 0.41); FEV1 (SMD of 0.10, p = 0.47); PEF (SMD of -0.00, p = 0.99); FEV1/FVC (SMD 0.04, p = 0.76). The conducted study suggested that there was no influence of levodopa treatment on any of the pulmonary variables assessed in patients with Parkinson’s disease.    

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