scholarly journals Cholecystectomy in Patients with Liver Cirrhosis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jonas Strömberg ◽  
Folke Hammarqvist ◽  
Omid Sadr-Azodi ◽  
Gabriel Sandblom
Keyword(s):  
Liver Cirrhosis ◽  
Postoperative Complications ◽  
Open Cholecystectomy ◽  
Population Based ◽  
Decompensated Cirrhosis ◽  
Population Based Study ◽  
National Patient Registry ◽  
Postoperative Blood Transfusion ◽  
National Patient ◽  
To Receive

Background. The aim of this population-based study was to describe characteristics of patients with liver cirrhosis undergoing cholecystectomy and evaluate the risk for perioperative and postoperative complications during the 30-day postoperative period.Method. All laparoscopic and open cholecystectomy procedures registered between 2006 and 2011 in the Swedish Registry for Gallstone Surgery and ERCP (GallRiks) were included. Patients with liver cirrhosis were identified by linking data to the Swedish National Patient Registry (NPR).Results. Of 62,488 patients undergoing cholecystectomy, 77 (0.12%) had cirrhosis, of which 29 patients (37.7%) had decompensated cirrhosis. Patients with cirrhosis were older and had more often gallstone complications at the time for surgery. Postoperative complications were registered in 13 (16.9%) patients with liver cirrhosis and in 5,738 (9.2%) patients in the noncirrhotic group(P<0.05). Univariable analysis showed that patients with liver cirrhosis are more likely to receive postoperative blood transfusion (OR = 4.4, CI 1.08–18.0,P<0.05) and antibiotic treatment >1 day (OR = 2.3, CI 1.11–4.84,P<0.05) than noncirrhotic patients.Conclusion. Patients with cirrhosis undergoing cholecystectomy have a higher incidence of postoperative complications than patients without cirrhosis. However, cholecystectomy is safe and if presented with adequate indication, surgery should not be delayed due to fears of surgical complications.

scholarly journals Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark

2019 ◽  
pp. oemed-2018-105469 ◽  
Author(s):  
Aisha S Dickerson ◽  
Johnni Hansen ◽  
Aaron J Specht ◽  
Ole Gredal ◽  
Marc G Weisskopf
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Population Based Study ◽  
Employment History ◽  
National Patient Registry ◽  
Increased Risk ◽  
National Patient ◽  
Pb Exposure ◽  
Lateral Sclerosis

ObjectivesPrevious research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.MethodsALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.ResultsFor men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.ConclusionsOur study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.

scholarly journals Sex-specific risks of death in patients hospitalized for hyponatremia: a population-based study

Endocrine ◽  
2019 ◽  
Vol 66 (3) ◽  
pp. 660-665 ◽  
Author(s):  
Buster Mannheimer ◽  
Jakob Skov ◽  
Henrik Falhammar ◽  
Jan Calissendorff ◽  
Jonatan D. Lindh ◽  
...  
Keyword(s):  
Total Population ◽  
Cox Regression ◽  
Underlying Disease ◽  
Population Based ◽  
Concomitant Disease ◽  
Population Based Study ◽  
National Patient Registry ◽  
Drug Register ◽  
Hazard Ratios ◽  
National Patient

Abstract Purpose Several studies have reported an association between hyponatremia and lethality. However, it remains elusive whether hyponatremia independently contributes to lethality. The aim of the study was to investigate associations between hyponatremia and lethality and differences in lethality between men and women hospitalized due to hyponatremia. Methods Four registries were utilized in this population-based retrospective study: The National Patient Registry, the Cause of Death Register, the Swedish Prescribed Drug Register and the Total Population Register (NPR) from which the controls were sampled. All hospitalized patients with a first-ever principal ICD10 diagnosis of hyponatremia or syndrome of inappropriate ADH secretion in the NPR between 1 October 2005 and 31 December 2014 were defined as cases. Cox regression with adjustment for potential confounders was used. Results 14,359 individuals with a principal diagnosis of hyponatremia, and 57,382 matched controls were identified. Median age was 76 years and the majority were women (72%). Median age for women and men was 79 and 68 years, respectively. Adjusted hazard ratios (and 95% CI) for lethality in those with hyponatremia compared with controls were for the entire population 5.5 (4.4–7.0) and in the subgroup free from previously known underlying disease 6.7 (3.3–13.3). Lethality in women with hyponatremia was lower compared with men: HR: 0.56 (0.49–0.64). In the healthier group the lethality remained lower for women: HR: 0.49 (0.34–0.71). Conclusions Patients hospitalized due to hyponatremia faced an increased subsequent lethality that was independent of concomitant disease. This increase was nearly twice as large among men compared with women.

1000 THE CLINICAL COURSE OF ALCOHOLIC LIVER CIRRHOSIS: A DANISH POPULATION-BASED STUDY

2009 ◽  
Vol 50 ◽  
pp. S362-S363
Author(s):  
P. Jepsen ◽  
H. Vilstrup ◽  
P.K. Andersen ◽  
P. Ott ◽  
H.T. Sørensen
Keyword(s):  
Liver Cirrhosis ◽  
Clinical Course ◽  
Population Based ◽  
Alcoholic Liver Cirrhosis ◽  
Danish Population ◽  
Population Based Study

Sa1022 EPIDEMIOLOGY OF DEPRESSIVE DISORDERS IN PATIENTS WITH LIVER CIRRHOSIS: A POPULATION-BASED STUDY IN THE UNITED STATES.

2020 ◽  
Vol 158 (6) ◽  
pp. S-245-S-246
Author(s):  
Mohammad Abureesh ◽  
Motasem Alkhayyat ◽  
Rawan Badran ◽  
George Khoudari ◽  
Liliane S. Deeb
Keyword(s):  
United States ◽  
Liver Cirrhosis ◽  
Depressive Disorders ◽  
The United States ◽  
Population Based ◽  
Population Based Study

scholarly journals Amiodarone and risk of liver cirrhosis: a nationwide, population-based study

2019 ◽  
Vol Volume 15 ◽  
pp. 103-112 ◽  
Author(s):  
Ching-Hui Huang ◽  
Ya-Yun Lai ◽  
Yu-Jui Kuo ◽  
Su-Ching Yang ◽  
Yu-Jun Chang ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Population Based ◽  
Population Based Study

scholarly journals Impact of combination MMRV vaccine on first-dose coverage for measles and varicella: a population-based study

2020 ◽  
Author(s):  
Shannon E. MacDonald ◽  
Suzanne Tough ◽  
Xiaoyan Guo ◽  
James D. Kellner
Keyword(s):  
Vaccine Coverage ◽  
Varicella Vaccine ◽  
Population Based ◽  
Combination Vaccine ◽  
Population Based Study ◽  
Vaccine Introduction ◽  
Opt Out ◽  
Combination Vaccines ◽  
Before And After ◽  
To Receive

Abstract Aim Combination vaccines decrease the number of needles required, addressing a common concern of parents. However, some parents are hesitant about combination vaccines and/or want to opt out of certain vaccine components. This study assessed whether introduction of the combination MMRV vaccine influenced coverage levels for measles- and varicella-containing vaccines. Study and methods This was a population-based study of children born in Alberta, Canada between 2006 and 2012. We utilized administrative health data to evaluate coverage for the first dose of measles- and varicella-containing vaccines at the age of 24 months (i.e. between 2008 and 2014) before and after introduction of the combination MMRV vaccine in 2010. Among those who were vaccinated, we assessed whether any children continued to receive separate vaccines after the combination vaccine was introduced. Results Of 308,212 children, 272,345 (88.36%) were vaccinated with measles- and/or varicella-containing vaccines at the age of 24 months. Although coverage for measles-containing vaccines did not change overall between 2008 and 2014, coverage for varicella vaccine increased in the years following the introduction of MMRV. After the combination vaccine introduction, 96.55% of vaccinated children (n = 121,131) received MMRV vaccine. Conclusion Vaccine coverage for varicella increased after the introduction of the combination MMRV vaccine, and there was a narrowing in the gap between MMR and varicella coverage. Very few children received separate vaccines after the introduction of the combination MMRV vaccine. These findings suggest that combination vaccines are acceptable to most parents and increase coverage for varicella in our setting.

scholarly journals Insufficient social distancing may be related to a future COVID-19 outbreak in Ijuí-Brazil: Predictions of further social interventions

2020 ◽  
Author(s):  
Thiago Gomes Heck ◽  
Matias Nunes Frizzo ◽  
Carlos Henrique Ramires François ◽  
Mirna Stela Ludwig ◽  
Marilia Arndt Mesenburg ◽  
...  
Keyword(s):  
Population Based ◽  
Population Increase ◽  
Daily Routine ◽  
Population Based Study ◽  
Social Distancing ◽  
Social Interventions ◽  
The Social ◽  
Community Transmission ◽  
To Receive ◽  
Community Infection

AbstractThe coronavirus disease that initiates in 2019 (COVID-19) has proven to be highly contagious since it became pandemic quickly and nowadays presents higher transmission rates worldwide, including small Brazilian cities, as Ijuí. Located in the northwestern of the State of Rio Grande do Sul (RS) with 83,475 inhabitants, Ijuí was selected to receive a population-based survey divided into four steps separated by 15 days each that involved 1,750 subjects. Subjects were tested for the presence of antibodies against coronavirus (SARS CoV-2) and answered questions about social distance adherence, daily routine, comorbidities, and sociodemographic characteristics. In parallel, the local government registered the official COVID-19 cases in Ijuí. In this study, we demonstrated the levels of social distancing adherence and the beginning of COVID-19 community transmission in Ijuí and showed some predictions for cases, hospitalization, and deaths. We concluded that the insufficient social distancing registered in the population-based study might be related to the rapid increase of COVID-19 cases in Ijuí. Our study predicts a closer outbreak of community infection of COVID-19, which could be avoided or attenuated if the levels of the social distancing in the population increase in the next weeks.

scholarly journals Sex differences and temporal trends in aortic dissection: a population-based study of incidence, treatment strategies, and outcome in Swedish patients during 15 years

2020 ◽  
Vol 41 (26) ◽  
pp. 2430-2438 ◽  
Author(s):  
Christian Smedberg ◽  
Johnny Steuer ◽  
Karin Leander ◽  
Rebecka Hultgren
Keyword(s):  
Sex Differences ◽  
Aortic Dissection ◽  
Large Population ◽  
Temporal Trends ◽  
Treatment Strategies ◽  
Population Based ◽  
Favourable Outcome ◽  
Hospitalized Patients ◽  
Population Based Study ◽  
National Patient

Abstract Aims As large population-based studies of aortic dissection are lacking, the incidence numbers and knowledge about time-trends and sex differences are uncertain. The objective was to describe incidence, temporal trends and outcome of aortic dissection with particular emphasis on sex differences. Methods and results During the study period 2002–2016, 8057 patients in Sweden were diagnosed with aortic dissection, identified from the National Patient Register and the Cause of Death Register. A total of 5757 (71%) patients were hospitalized, whereas 2300 (29%) patients were deceased without concurrent hospital stay. The annual incidence was 7.2 per 100 000 (9.1 in men and 5.4 in women), decreasing over time in men (P = 0.005). Mean age in the hospitalized patients was 68 years (SD 13), 2080 (36%) were women. Within the first 14 days after onset, 1807 patients (32%) underwent surgical repair. The proportion of surgically treated increased from the 5-year period 2002–2006 to 2012–2016 [27% vs. 35%, odds ratio (OR) 1.61, 95% confidence interval (CI) 1.39–1.86; P &lt; 0.001]. In hospitalized patients, 30-day mortality decreased between the same periods (26% vs. 21%, OR 0.68, 95% CI 0.59–0.80; P &lt; 0.001). Long-term mortality decreased as well (hazard ratio 0.74, 95% CI 0.67–0.82; P &lt; 0.001). Women had higher 30-day mortality than men after acute repair, a sex difference that remained after age adjustment (17% vs. 12%, OR 1.38, 95% CI 1.04–1.82; P = 0.006). Conclusion This population-based study detected a higher incidence of aortic dissection than prior reports, but a decreasing incidence in men. Surgical therapy was increasingly used and with more favourable outcome but was less frequently offered to elderly patients. The sustained sex differences regarding both incidence and outcome require further attention.

Sign in / Sign up

Export Citation Format

Share Document