Evaluation of Clinical Effectiveness and Subjective Satisfaction of a New Toothbrush for Postsurgical Hygiene Care: A Randomized Split-Mouth Double-Blind Clinical Trial

The aim of this RCT was to evaluate plaque control and gingival health promotion effectiveness of a new toothbrush with extra-soft filaments in postsurgical sets. Ten consecutive patients with at least two scheduled symmetrical periodontal surgeries were selected. Following the first periodontal surgery, a test (TB1) or control (TB2) toothbrush was randomly assigned. After the second surgery, the remaining toothbrush was given. Patients were asked to gently wipe the surgical area from days 3 to 7 postoperatively and to gently brush using a roll technique from day 7 till the end of the study. Baseline evaluation took place on the day of surgery and follow-ups were performed at days 7, 14, and 30 postoperatively. A more evident PI reduction was recorded for test toothbrush where a regular decrease was observed till day 14; then, this parameter tended to stabilize, remaining however lower than that recorded for the control toothbrush. There were no statistical differences in the GI between test and control toothbrushes. All patients introduced the test toothbrush at surgical site at third day; the control toothbrush was introduced within a mean of 9 days. The introduction of the test toothbrush 3 days after periodontal surgery may be recommended.

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Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?

Dermatology Research and Practice ◽

10.1155/2018/6974045 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Mina Mirnezami ◽

Hoda Rahimi

Keyword(s):

Side Effects ◽

Adverse Effects ◽

Acne Vulgaris ◽

Control Group ◽

Case Group ◽

Omega 3 ◽

Double Blind ◽

Severe Acne ◽

Double Blind Clinical Trial ◽

And Control

Background. Acne vulgaris is an inflammatory disease of pilosebaceous units which may cause permanent dyspigmentation and/or scars if not treated. Isotretinoin is recommended in the treatment of recalcitrant or severe acne, but it is associated with common adverse effects that frequently result in patients incompliance and discontinuation of the drug. The present study was designed to assess the efficacy of oral omega-3 in decreasing the adverse effects of isotretinoin. Materials and Methods. In this randomized double-blind clinical trial, a total of 118 patients with moderate or severe acne were randomly divided into two (case and control) groups. The control group was treated with isotretinoin 0.5 mg/kg, and the case group was treated with the same dose of isotretinoin combined with oral omega-3 (1 g/day). The treatment was lasted for 16 weeks and mucocutaneous side effects of isotretinoin were recorded and compared between the two groups in weeks 4, 8, 12, and 16. Results. Cheilitis (at weeks 4, 8, and 12), xerosis, dryness of nose at all weeks, and dryness of eyes (at week 4) were less frequent in the group that received isotretinoin combined with oral omega-3 compared to the group that received isotretinoin alone. Conclusion. Administration of oral omega-3 in acne patients who are receiving isotretinoin decreases the mucocutaneous side effects of isotretinoin. This trial is registered with IRCT201306238241N2.

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Use of platelet-rich plasma in periodontal surgery—a prospective randomised double blind clinical trial

Clinical Oral Investigations ◽

10.1007/s00784-008-0223-7 ◽

2008 ◽

Vol 13 (2) ◽

pp. 179-187 ◽

Cited By ~ 30

Author(s):

L. Harnack ◽

R. H. Boedeker ◽

I. Kurtulus ◽

S. Boehm ◽

J. Gonzales ◽

...

Keyword(s):

Clinical Trial ◽

Platelet Rich Plasma ◽

Periodontal Surgery ◽

Double Blind ◽

Double Blind Clinical Trial

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Effect of Nebulized Eucalyptus for Preventing Ventilator-Associated Pneumonia in Patients under Mechanical Ventilation: A Randomized Double Blind Clinical Trial

10.21203/rs.1.15/v1 ◽

2018 ◽

Author(s):

HasanAli Karimpour ◽

Behzad Hematpour ◽

Saeed Mohammadi ◽

Javad Aminisaman ◽

Maryam Mirzaei ◽

...

Keyword(s):

Clinical Trial ◽

Intensive Care Unit ◽

Intensive Care ◽

Intervention Group ◽

Control Group ◽

Pulmonary Infections ◽

Double Blind ◽

Double Blind Clinical Trial ◽

And Control ◽

And Staphylococcus Aureus

Abstract Background: Pneumonia caused by the ventilator is the most common acquired infection in the intensive care unit, which increases the morbidity and mortality of the patients. Eucalyptus plant has antiseptic properties. Therefore, the present study investigates the effect of eucalyptus incense on prevention of pneumonia in patients with endotracheal tube in the intensive care unit. Methods: This clinical trial study was performed on 100 patients under ventilation in two intervention and control groups in Imam Reza Hospital, Kermanshah, Iran in 2018. The patients in the intervention group, Eucalyptus solution 2% and in the control group received 10 cc distilled water as an inhaler three times a day. The results of the two groups were compared to the incidence of pulmonary infections based on CPIS criteria and compared with SPSS version 19 software. Results: The incidence of late pneumonia was significantly lower in the intervention group (P=0.02). The onset of pneumonia significantly later in the intervention group than the control group (P=0.01). The prevalence of Klebsiella, Candida albicans, and Staphylococcus aureus was significantly decreased in the intervention group (P=0.02) (P=0.04) (P=0.01). Conclusion: The results of this study showed that eucalyptus inhalation is effective in reducing the incidence of pulmonary infection in patients under ventilation. It is recommended that these products be used to prevent pulmonary infections in these patients.

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Addition of Neostigmine and Tramadol to 1.5 % Lidocaine for paracervical block to reduce post-operative pain in colporrhaphy

European Journal of Translational Myology ◽

10.4081/ejtm.2018.7351 ◽

2018 ◽

Vol 28 (2) ◽

Author(s):

Alireza Kamali ◽

Maryam Shokrpour ◽

Bijan Yazdi ◽

Atefeh Khalilpour

Keyword(s):

Clinical Trial ◽

Human Perception ◽

Narcotic Drug ◽

Double Blind ◽

Post Operative Pain ◽

Double Blind Clinical Trial ◽

And Control ◽

Paracervical Block ◽

Surgery Duration

Pain is a complex and multi-faceted human perception and several factors could dampen the pain. Therefore, we aimed to comparison of addition of neostigmine and tramadol to 1.5 % lidocaine with paracervical block in reduce of post-operative pain in colporrhaphy. This study was a randomized and double-blind clinical trial for 108 patients’ as candidate for colporrhaphy. Patients were randomly divided in three groups (Neostigmine, tramadol and control).We recorded pain in 2 and 6 and 12 hours after surgery, duration of analgesia and mean of use narcotic drug in 24 hours after surgery for all patients. Mean of narcotic drug used in 24 hours after surgery in neostigmine group was more than tramadol group(p=0/01).Pain in 2 and 6 and 12 hours after surgery in neostigmine group was more than tramadol group (p=0/01). Duration of analgesia in tramadol group was over neostigmine group and also, it was in neostigmine group was more than placebo (p=0/01).Taken together, tramadol could reduce pain in 2 and 6 and 12 hours after surgery and mean of narcotic drug used in 24 hours after surgery and increase duration of analgesia.

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The effects of pulsatile flushing on phlebitis and peripheral intravenous catheters patency

Journal of Birjand University of Medical Sciences ◽

10.32592/jbirjandunivmedsci.2020.27.3.102 ◽

2020 ◽

pp. 16-25

Keyword(s):

Clinical Setting ◽

Intervention Group ◽

Practical Method ◽

Control Group ◽

Control Groups ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Significant Difference ◽

And Control ◽

Intravenous Catheters

Background and Aim: Thrombophlebitis is considered as a major cause of peripheral intravenous catheters (PICs) failure. The flushing technique in the laboratory has been effective in clearing the catheter duct, but its effectiveness in the clinical setting is unknown, therefore, the aim of this study was to determine the effect of pulsatile flushing on phlebitis, type, and duration of PICs patency in patients. Materials and Methods: In this double-blind clinical trial, 71 patients admitted to the inpatient and surgical wards of Imam Khomeini Esfarayen Hospital were randomly assigned to the intervention and control groups after sampling by available methods. In the intervention group, the flushing technique was performed by injecting 1 ml of the normal saline solution for one second, then interrupting less than one second and repeating the injection and interrupting until the end of 5 ml of the solution. The Consequences of this study were phlebitis, duration, and type of PICs patency, which were evaluated every 12 hours by using Jackson's phlebitis instrument and direct observation of the catheter. Results: The incidence of phlebitis in the intervention group was lower than the control group (P<0.001). In addition, two groups had a statistically significant difference in the type of PICs (P<0.001). The median duration of PICs patency in the intervention group was significantly higher than the control group (P<0.001). Conclusion: Pulsatile flushing is an effective technique to increase longevity of PICs and recommended as a practical method in clinical setting.

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Healing With Bach® Flower Essences: Testing a Complementary Therapy

Complementary health practice review ◽

10.1177/1533210107300705 ◽

2007 ◽

Vol 12 (1) ◽

pp. 3-14 ◽

Cited By ~ 8

Author(s):

Robert Halberstein ◽

Lydia DeSantis ◽

Alicia Sirkin ◽

Vivian Padron-Fajardo ◽

Maria Ojeda-Vaz

Keyword(s):

Complementary Therapy ◽

Double Blind ◽

Standard Dosage ◽

Double Blind Clinical Trial ◽

Significant Difference ◽

Situational Stress ◽

Situational Anxiety ◽

Before And After ◽

Anxiety Treatment ◽

And Control

Bach®Original Flower Essence (BFE) Rescue®Remedy, a modality used since 1930 but not yet thoroughly investigated scientifically, was evaluated for the reduction of acute situational stress. A double-blind clinical trial comparing a standard dosage of BFE Rescue Remedy against a placebo of identical appearance was conducted in a sample of 111 individuals aged 18 to 49, randomized into treatment ( n = 53) and control ( n = 58) groups. The Spielberger State-Trait Anxiety Inventory (STAI) was administered before and after the use of Rescue Remedy or placebo. Downward trends in anxiety level measurements were discovered in both the treatment (Rescue Remedy) and control (placebo) groups. Statistical analyses indicated that only the high-state anxiety treatment subgroup demonstrated a statistically significant difference between pretest and posttest scores. The results suggest that BFE Rescue Remedy may be effective in reducing high levels of situational anxiety.

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The effect of Lactobacillus casei and Bifidobacterium breve on antibiotic-associated diarrhea treatment: randomized double-blind clinical trial

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86822012000100021 ◽

2012 ◽

Vol 45 (1) ◽

pp. 112-116 ◽

Cited By ~ 12

Author(s):

Daniela Nogueira Prado de Souza ◽

Miguel Tanús Jorge

Keyword(s):

Lactobacillus Casei ◽

Specific Class ◽

Double Blind ◽

Bifidobacterium Breve ◽

Double Blind Clinical Trial ◽

Antibiotic Associated Diarrhea ◽

And Control ◽

To Receive ◽

Higher Doses ◽

Relapse Rates

INTRODUCTION: Antibiotic-associated diarrhea (AAD) is an important side effect of this specific class of drugs. The objective of this study was to investigate the effect of the use of probiotics in the treatment of AAD. METHODS: A group of hospitalized patients, who contracted diarrhea during or after 7 days of suspension of antimicrobial medication, was blindly randomized to receive a standardized diet associated with the use of the probiotics (Lactobacillus casei and Bifidobacterium breve) or its corresponding placebo, three times a day. RESULTS: Seventy patients were studied. For the experimental (n=35) and control (n=35) groups, respectively, the average time of treatment was 5.06±2.18 and 5.49±3.17 days (p=0.95), and the average duration of diarrhea, among those who were healed, was 4.87±2.13 and 4.52±2.55 days (p=0.36). Four (11.4%) patients who received probiotics and ten (28.6%) who received the placebo were not cured (p=0.13), and relapse rates were similar between both groups. Seven patients from each group, in addition to diarrhea, presented cases of bloating and/or abdominal cramps and/or vomiting (p=1.00). CONCLUSIONS: In this light, it is concluded that L. casei associated with B. breve, in the administered dosage and frequency, has no effect on the antibiotic-associated diarrhea. Similar studies need to be conducted with higher doses of these or other probiotics.

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Effect of Neem containing Toothpaste on Plaque and Gingivitis—A Randomized Double Blind Clinical Trial

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1776 ◽

2015 ◽

Vol 16 (11) ◽

pp. 880-883 ◽

Cited By ~ 5

Author(s):

S Supreetha ◽

KN Abhishek ◽

S Nubesh Khan ◽

KH Chaithanya ◽

Nishad Abdul

Keyword(s):

Clinical Trial ◽

Oral Hygiene ◽

Dental Students ◽

T Test ◽

Control Group ◽

First Year ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Significant Difference ◽

And Control

ABSTRACT Aim The present study was designed to assess the effect of toothpaste containing neem on plaque and gingivitis. Materials and methods Randomized, double blind clinical trial was designed. Thirty first year dental students volunteered to participate in the study. Neem containing tooth paste was used as an intervention. Clinical examination was carried out using Silness and Loe plaque index (PI) and Loe and Silness gingival index (GI). Independent t-test and paired t-test was used for the intergroup and the intragroup comparison. Results Out of 30 participants, 22 (73.3%) were females and eight (26.7%) were males. A statistically significant difference was found between the test and control group after intervention with respect to the PI and GI. Conclusion Neem containing toothpaste can be used as an adjunct for maintenance of oral hygiene. Clinical significance Regular brushing with neem toothpaste might act as an adjunct to maintenance of good oral hygiene, and thus improve oral health. How to cite this article Abhishek KN, Supreetha S, Sam G, Khan SN, Chaithanya KH, Abdul N. Effect of Neem containing Toothpaste on Plaque and Gingivitis—A Randomized Double Blind Clinical Trial. J Contemp Dent Pract 2015;16(11):880-883.

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A tailored tooth brushing program to control plaque accumulation and gingivitis among orphan children: A randomized trial

Journal of Global Oral Health ◽

10.25259/jgoh_39_2020 ◽

2020 ◽

Vol 3 ◽

pp. 118-122

Author(s):

Rajitharan Vijayasekaram ◽

Osheda Senerath ◽

Nivethika Thevarasah ◽

Mohammed Habibulla Baig ◽

S. S. Raj

Keyword(s):

Tooth Brushing ◽

Control Group ◽

Controlled Clinical Trial ◽

Gingival Inflammation ◽

Double Blind ◽

Socially Disadvantaged ◽

Gingival Health ◽

Supragingival Plaque ◽

Plaque Control ◽

Chennai City

Objectives: Poor oral hygiene among children is major cause of gingivitis, caries, and especially orphans constitute socially disadvantaged group. The objective of the study was to assess the efficacy of a tailored tooth brushing program to improve supragingival plaque control and gingival health among 13–17-year-old orphan children in Chennai city over a period of 21 days. Materials and Methods: A double-blind parallel, controlled clinical trial was conducted among 60 orphan children (28 males and 32 females) with mean age of 15.24 years. Dental plaque was assessed using the Turesky modification of Quigley-Hein index; gingival inflammation was assessed using gingival index at initial visit and after 14 and 21 days. Subjects were randomly allocated into one of two groups (study – audiovisual and individual demonstration of brushing technique with reinforcement at 14 days follow-up/control – only individual demonstration) and instructed to brush twice daily using modified bass technique with the toothbrush and paste provided throughout the trial. Results: The children who had audiovisual, individual demonstrations of brushing technique exhibited significantly superior total oral plaque control and significant reduction in the gingival inflammation at the end of 21 days trial (P < 0.05). The study group participants reported improved compliance and motivation to practice modified bass technique because of the reinforcement. Conclusion: The children who had both audiovisual and individual demonstration exhibited superior total plaque control and gingival health compared to control group and continued to demonstrate modified bass technique without any reinforcement at the end of 21 days trial.

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