Long-Term Follow-Up of the Fellow Eye in Patients Undergoing Surgery on One Eye for Treating Myopic Traction Maculopathy

Objective. To observe the fellow eye in patients undergoing surgery on one eye for treating myopic traction maculopathy.Methods. 99 fellow eyes of consecutive patients who underwent unilateral surgery to treat MTM were retrospectively evaluated. All patients underwent thorough ophthalmologic examinations, including age, gender, duration of follow-up, refraction, axial length, intraocular pressure, lens status, presence/absence of a staphyloma, and best-corrected visual acuity (BCVA). Fundus photographs and SD-OCT images were obtained. When feasible, MP-1 microperimetry was performed to evaluate macular sensitivity and fixation stability.Results. At an average follow-up time of 24.7 months, 7% fellow eyes exhibited partial or complete MTM resolution, 68% stabilized, and 25% exhibited progression of MTM. Of the 38 eyes with “normal” macular structure on initial examination, 11% exhibited disease progression. The difference in progression rates in Groups 2, 3, and 4 was statistically significant. Refraction, axial length, the frequency of a posterior staphyloma, chorioretinal atrophy, initial BCVA, final BCVA, and retinal sensitivity all differed significantly among Groups 1–4.Conclusions. Long axial length, chorioretinal atrophy, a posterior staphyloma, and anterior traction contribute to MTM development. Patients with high myopia and unilateral MTM require regular OCT monitoring of the fellow eye to assess progression to myopic pre-MTM. For cases exhibiting one or more potential risk factors, early surgical intervention may maximize the visual outcomes.

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Effects of Orthokeratology Lens On Axial Length Elongation in Myopia With Anisometropia Children

10.21203/rs.3.rs-741927/v1 ◽

2021 ◽

Author(s):

Ziyang Chen ◽

Kai-Ming Chen ◽

Ying Shi ◽

Zhao-Da Ye ◽

Sheng Chen ◽

...

Keyword(s):

Retrospective Study ◽

Axial Length ◽

Statistical Significance ◽

Spherical Equivalent ◽

Significant Difference ◽

The Mean ◽

The Difference ◽

Better Than ◽

Group 1

Abstract AimTo investigate the effect of orthokeratology (OK) lens on axial length (AL) elongation in myopia with anisometropia children.MethodsThirty-seven unilateral myopia (group 1) and fifty-nine bilateral myopia with anisometropia children were involved in this 1-year retrospective study. And bilateral myopia with anisometropia children were divided into group 2A (diopter of the lower SER eye under − 2.00D) and group 2B(diopter of the lower SER eye is equal or greater than − 2.00D). The change in AL were observed.The datas were analysed using SPSS 21.0.Results(1) In group 1, the mean baseline AL of the H eyes and L eye were 24.70 ± 0.89 mm and 23.55 ± 0.69 mm, respectively. In group 2A, the mean baseline AL of the H eyes and L eyes were 24.61 ± 0.84 mm and 24.00 ± 0.70 mm respectively. In group 2B, the mean baseline AL of the H eyes and L eyes were 25.28 ± 0.72 mm and 24.70 ± 0.74 mm. After 1 year, the change in AL of the L eyes was faster than the H eyes in group 1 and group 2A (all P<0.001).While the AL of the H eyes and L eyes had the same increased rate in group 2B. (2) The effect of controlling AL elongation of H eyes is consistent in three groups (P = 0.559).The effect of controlling AL elongation of L eyes in group 2B was better than that in group 1 and group 2A (P < 0.001). And the difference between group 1 and group 2A has no statistical significance. (3) The AL difference in H eyes and L eyes decreased from baseline 1.16 ± 0.55mm to 0.88 ± 0.68mm after 1 year in group 1.And in group 2A, the AL difference in H eyes and L eyes decreased from baseline 0.61 ± 0.34mm to 0.48 ± 0.28mm. There was statistically significant difference (all P<0.001). In group 2B, the baseline AL difference in H eyes and L eyes has no significant difference from that after 1 year (P = 0.069).ConclusionsMonocular OK lens is effective on suppression AL growth of the myopic eyes and reduce anisometropia value in unilateral myopic children. Binocular OK lenses only reduce anisometropia with the diopter of the low eye under − 2.00D. Binocular OK lenses cannot reduce anisometropia with the diopter of the low eye equal or greater than − 2.00D. Whether OK lens can reduce refractive anisometropia value is related to the spherical equivalent refractive of low refractive eye in bilateral myopia with anisometropia children after 1-year follow-up.

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Changes in Visual Acuity and Refraction in the Exfoliation Syndrome. A Five-Year Follow-up Study

European Journal of Ophthalmology ◽

10.1177/112067210101100306 ◽

2001 ◽

Vol 11 (3) ◽

pp. 245-251 ◽

Cited By ~ 2

Author(s):

P.M. Puska ◽

A.H.A. Tarkkanen

Keyword(s):

Visual Acuity ◽

Main Type ◽

Exfoliation Syndrome ◽

Follow Up Study ◽

Exfoliative Glaucoma ◽

The Difference ◽

Term Management ◽

Fellow Eyes

Purpose To examine changes in visual acuity (VA) and refraction in non-glaucomatous patients with unilateral exfoliation syndrome (EXS). Methods The best corrected values for VA (Snellen acuity cards) subjectively adjusted for refraction, and IOP were measured, and the development of lens opacities was examined in 46 non-glaucomatous patients with unilateral EXS. Results After five years the rate of conversion to bilateral exfoliation was 22% and to exfoliative glaucoma 30%. There was a significant decrease in VA in the exfoliative (E) eyes (median; QI, QIII, range: 1; 0.8, 1, 0.4-1.3 vs. 0.55; 0.4, 1, 0.05-1.4, p<0.0001) and the fellow, initially non-exfoliative (NE), eyes (1; 0.9, 1, 0.3–1.3 vs. 0.7; 0.5, 0.9, 0.1–1.4, p<0.0001) and a significant myopic change in refraction in the E eyes (+1.02 ± 2.48 vs. +0.11 ± 3.06, p=0.0001) and the NE eyes (+0.99 ± 2.25 vs. +0.43 ± 2.55 D, p<0.01). At study entry the difference in refraction between the fellow eyes (refraction in the NE eye – refraction in the E eye) was −0.27 ± 1.00D. After five years it was +0.32 ± 1.44 (p 0.016), reflecting greater myopic changes in the E eyes. The main type of lens opacification was nuclear sclerosis. Conclusions In five years, significant decreases in VA and myopic shifts in refraction occurred in the E and fellow eyes. The E eyes showed significantly greater myopic changes than the fellow eyes; the cause was clearly nuclear sclerosis, which must be taken into account in the long-term management of patients with EXS.

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Changes in Spinal Instability After Combined Therapy of Conventional Radiotherapy and Bone Modifying Agents for Painful Vertebral Bone Metastases

10.21203/rs.3.rs-258203/v1 ◽

2021 ◽

Author(s):

Eiji Nakata ◽

Shinsuke Sugihara ◽

Yoshifumi Sugawara ◽

Ryuichi Nakahara ◽

Shouta Takihira ◽

...

Keyword(s):

Combined Therapy ◽

Spinal Metastases ◽

Spinal Instability ◽

Vertebral Metastases ◽

Conventional Radiotherapy ◽

Potential Risk Factors ◽

The Difference ◽

Over Time ◽

Selection Of

Abstract Precise assessment of spinal instability is critical at the beginning and after radiotherapy for selection of the treatment and evaluating the effectiveness of radiotherapy. We investigated changes of spinal instability after radiotherapy and examined potential risk factors for the difference of the outcome of spinal instability for painful spinal metastases. We evaluated 81 patients who received radiotherapy for painful vertebral metastases in our institution between 2012 and 2016. The pain at the vertebrae was assessed. Radiological responses of irradiated vertebrae were assessed by computed tomography. Spinal instability was assessed by Spinal Instability Neoplastic Score (SINS). Follow-up assessments were done at the start of radiotherapy and at 1, 2, 3, 4, and 6 months after radiotherapy. At each of one to six months, pain disappeared in 62%, 84%, 93%, 98%, and 100% of patients. The median SINS were 8, 7, 6, 5, 5, and 4 at the beginning of radiotherapy and after 1, 2, 3, 4, and 6 months, respectively, which significantly decreased over time (P < 0.001). Multivariate analysis revealed that PLISE was the only risk factor for spinal instability at one month. In conclusion, spinal instability significantly improved over time after radiotherapy. Clinicians should take attention to PLISE in the radiotherapy of vertebral metastases.

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Rates of rehospitalisation in the first 2 years among preterm infants discharged from the NICU of a tertiary children hospital in Vietnam: a follow-up study

BMJ Open ◽

10.1136/bmjopen-2019-036484 ◽

2020 ◽

Vol 10 (10) ◽

pp. e036484

Author(s):

Chuong Huu Thieu Do ◽

Malene Landbo Børresen ◽

Freddy Karup Pedersen ◽

Ronald Bertus Geskus ◽

Alexandra Yasmin Kruse

Keyword(s):

Preterm Infants ◽

Low Income ◽

Neonatal Intensive Care ◽

Respiratory Diseases ◽

Scale Up ◽

Middle Income ◽

Middle Income Countries ◽

Potential Risk Factors ◽

The Difference

ObjectivesTo describe the characteristics of rehospitalisation in Vietnamese preterm infants and to examine the time-to-first-readmission between two gestational age (GA) groups (extremely/very preterm (EVP) vs moderate/late preterm (MLP)); and further to compare rehospitalisation rates according to GA and corrected age (CA), and to examine the association between potential risk factors and rehospitalisation rates.Design and settingA cohort study to follow up preterm infants discharged from a neonatal intensive care unit (NICU) of a tertiary children’s hospital in Vietnam.ParticipantsAll preterm newborns admitted to the NICU from July 2013 to September 2014.Main outcomesRates, durations and causes of hospital admission during the first 2 years.ResultsOf 294 preterm infants admitted to NICU (all outborn, GA ranged from 26 to 36 weeks), 255 were discharged alive, and 211 (83%) NICU graduates were followed up at least once during the first 2 years CA, of whom 56% were hospital readmitted. The median (IQR) of hospital stay was 7 (6–10) days. Respiratory diseases were the major cause (70%). Compared with MLP infants, EVP infants had a higher risk of first rehospitalisation within the first 6 months of age (p=0.01). However, the difference in risk declined thereafter and was similar from 20 months of age. There was an interaction in rehospitalisation rates between GA and CA. Longer duration of neonatal respiratory support and having older siblings were associated with higher rehospitalisation rates. Lower rates of rehospitalisation were seen in infants with higher cognitive and motor scores (not statistically significant in cognitive scores).ConclusionsHospital readmission of Vietnamese preterm infants discharged from NICU was frequent during their first 2 years, mainly due to respiratory diseases. Scale-up of follow-up programmes for preterm infants is needed in low-income and middle-income countries and attempts to prevent respiratory diseases should be considered.

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Optical Biometry and Influence of Media Opacity Due to Cataract on Development of Axial Length in Pediatric Eyes

10.21203/rs.3.rs-147299/v1 ◽

2021 ◽

Author(s):

Harsha Bhattacharjee ◽

Suklengmung Buragohain ◽

Henal Javeri ◽

Saurabh Deshmukh

Keyword(s):

Axial Length ◽

Systemic Disease ◽

Bilateral Cataract ◽

Optical Biometry ◽

Paediatric Outpatient ◽

Group A ◽

The Difference ◽

Group B ◽

Unilateral Cataract ◽

Fellow Eyes

Abstract Aim: To study the influence of media opacity due to cataract on the development of axial length in paediatric eyes with the help of optical biometry.Method: In this prospective, observational study, all patients attending the paediatric outpatient department (OPD) of the institute underwent a comprehensive ocular and systemic evaluation. Patients suffering from any other ocular disease and systemic disease were excluded. Optical biometry was performed to measure the axial length in all the eyes. In each eye, five biometric measurements were acquired and average of these five readings were considered for the study. Patients were divided into three groups after proper age matching – 1. Group A (Bilateral cataract) 2. Group B (Unilateral cataract) 3. Group C (Bilateral normal). The axial length of the various groups were then compared. Results: A total of 540 eyes of 270 patients were involved in the study. 120 cases (n = 240 eyes) in Group A (bilateral cataract), 30 cases (n = 60 eyes) in Group B (unilateral cataract) and 120 (n = 240 eyes) in Group C (no cataracts). The mean age of the patients in all the groups was 9.38 ± 3.67 years (range: 1-17 years). In Group B, the difference in the AL between the cataractous eyes (22.44±1.48 mm; n = 30) and the fellow eyes (22.09±0.93 mm; n = 30) was not statistically significant (P = 0.277). The difference in the AL between the cataractous right eyes of Group A (22.9±3.51 mm, n = 120) and the non-cataractous right eye of Group C fellow eyes (22.57±0.71 mm, n = 120) was not statistically significant (P = 0.316). The difference in the AL between the cataractous left eyes of Group A (23.06±2.33 mm, n = 120) and the non-cataractous left eyes of Group C fellow eyes (22.56±0.78, n = 120) was statistically significant (P = 0.028). Conclusion: The results of our study and reported literature to date, seem to indicate a more significant role of genetic factors in comparison to media opacity, in the proportionate development of the AL.

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Differences in Axial Length and IOLs Power Basing on Alternative A-Scan or Fellow-Eye Biometry in Macular-Off Rhegmatogenous Retinal Detachment Eyes

10.21203/rs.3.rs-252317/v1 ◽

2021 ◽

Author(s):

Rui Liu ◽

Hongrong Li ◽

Qingchen Li

Keyword(s):

Retinal Detachment ◽

Axial Length ◽

Rhegmatogenous Retinal Detachment ◽

Silicone Oil ◽

Power Prediction ◽

Fellow Eye ◽

Lens Extraction ◽

Silicone Oil Tamponade ◽

The Mean ◽

The Difference

Abstract We observe the potential refractive error basing on alternative A-scan ultrasound and fellow-eye biometry for phacovitrectomy in phakic macula-off rhegmatogenous retinal detachment (RRD) eyes, when IOLMaster fails to obtain data. Vitrectomy without lens extraction was performed for RRD repair. Preoperative axial length was measured using alternative A-scan ultrasound (AL-US). Postoperative axial length in eyes with silicone oil tamponade (AL-SO) and fellow-eye biometry (AL-FE) were obtained using IOLMaster. AL-US, AL-FE and AL-SO were 25.39 ± 2.14 mm, 25.85 ± 2.16 mm and 26.08 ± 2.53 mm, respectively. The Bland-Altman agreements among AL-US, AL-FE and AL-SO were well (95.5%, 21/22 of cases were in LoA). The mean IOLs power calculated using AL-US (Power-US) was 16.81 ± 7.19 D, using AL-FE (Power-FE) was 14.74 ± 6.95 D, and using AL-SO (Power-SO) was 13.54 ± 8.32 D. The difference between AL-US and AL-SO was significant (P < 0.05), while that between AL-FE and AL-SO was not (P > 0.05). The difference between Power-US and Power-SO was significant (P < 0.05), while that between Power-FE and Power-SO was not (P > 0.05). It showed that the alternative A-scan ultrasound leads to significant differences in axial length and IOLs power prediction, while fellow-eye biometry provided similar measurements compared with those of silicone oil-filled eyes after RRD repair.

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Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05188-y ◽

2021 ◽

Author(s):

Fidan A. Aghayeva ◽

Panagiotis Chronopoulos ◽

Alexander K. Schuster ◽

Norbert Pfeiffer ◽

Esther M. Hoffmann

Keyword(s):

Intraocular Pressure ◽

Retrospective Chart Review ◽

Glaucoma Surgery ◽

Pressure Change ◽

Fellow Eye ◽

Lowering Effect ◽

Potential Risk Factors ◽

Iop Elevation ◽

Clinically Significant ◽

Fellow Eyes

Abstract Purpose This study assesses short-term intraocular pressure (IOP) change in the fellow eye of glaucoma patients after mitomycin C–augmented trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation in the treated eye. Materials and methods Retrospective chart review of 235 glaucoma patients (235 eyes) was performed. Patients underwent initial trabeculectomy (187 patients), filtering canaloplasty (25 patients), or PreserFlo™ microshunt implantation (23 patients) in one eye, while the fellow eye was naïve to any previous glaucoma surgery. IOP was evaluated before and on the 1st and 2nd days and at 1 week after surgery. Main outcome measure was IOP change in the fellow eye. Secondary outcomes were proportion of clinically significant IOP elevation in the fellow eye and evaluation of potential risk factors associated with postoperative IOP fluctuation. Results IOP in the fellow eye at 1 week after trabeculectomy was statistically significantly lower than preoperatively (p < 0.0001), while the IOP did not change significantly in the fellow eyes in filtering canaloplasty or PreserFlo groups. The higher the preoperative IOP was in the fellow eye, the larger was the intraocular pressure-lowering effect at 1 week after trabeculectomy (p < 0.0001). A clinically significant IOP elevation was noted in 14.2%, 9.5%, and 5% of fellow eyes after trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation, respectively. Conclusions This study shows an IOP-lowering effect in the fellow eye of glaucoma patients after trabeculectomy. Significant IOP rise might occur in the fellow eye of some glaucoma patients after different types of glaucoma surgery.

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Canine Keratomycosis in 11 Dogs: A Case Series (2000–2011)

Journal of the American Animal Hospital Association ◽

10.5326/jaaha-ms-6012 ◽

2014 ◽

Vol 50 (2) ◽

pp. 112-118 ◽

Cited By ~ 22

Author(s):

Erin M. Scott ◽

Renee T. Carter

Keyword(s):

Case Series ◽

Diagnostic Techniques ◽

Fungal Keratitis ◽

Predisposing Factors ◽

Initial Examination ◽

Corneal Disease ◽

Fungal Organisms ◽

Potential Risk Factors ◽

Penicillium Spp

Keratomycosis is rarely reported in dogs. The purpose of this study was to review the signalment, clinical characteristics, predisposing factors, and outcome of 11 cases of canine keratomycosis. Medical records of included dogs were reviewed and follow-up information was obtained by re-examination of patients following their initial diagnosis. All 11 patients possessed predisposing factors for fungal keratitis, including an underlying endocrinopathy, pre-existing corneal disease, intraocular surgery, and/or prolonged use of either topical antibiotics or corticosteroids at the time of initial examination. Diagnostic techniques included corneal cytology demonstrating yeast or hyphae in 6 of 11 eyes, and fungal cultures with positive results in 7 of 11 eyes. Fungal organisms isolated included Cladosporium spp. (n = 1), Chrysosporium spp. (n = 1), Curvularia spp. (n = 2), Aspergillus spp. (n = 1), Penicillium spp. (n = 1), and Phialemonium spp. (n = 1). Of the 11 patients, 6 responded to medical management alone. Two resolved after a superficial keratectomy, and three were enucleated due to either endophthalmitis or progression of corneal disease. This study identified potential risk factors for developing fungal keratitis.

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Differences in Axial Length and IOLs Power Basing on Alternative A-Scan or Fellow-Eye Biometry in Macular-off Rhegmatogenous Retinal Detachment Eyes

10.21203/rs.3.rs-115392/v1 ◽

2020 ◽

Author(s):

Rui Liu ◽

Hongrong Li ◽

Qingchen Li

Keyword(s):

Retinal Detachment ◽

Axial Length ◽

Prediction Error ◽

Rhegmatogenous Retinal Detachment ◽

Silicone Oil ◽

Fellow Eye ◽

Lens Extraction ◽

Significant Difference ◽

Silicone Oil Tamponade ◽

The Difference

Abstract Background: To observe the potential refractive prediction error basing on alternative A-scan ultrasound and fellow-eye biometry for phacovitrectomy in macula-off rhegmatogenous retinal detachment (RRD) eyes, when the optic biometry IOLMaster fails to obtain data.Methods: Phakic macula-off RRD eyes without axial length (AL) measured using IOLMaster were included. Vitrectomy with silicone oil tamponade but not lens extraction was performed. Preoperative AL was measured using A-scan ultrasound, and postoperative AL, as well as fellow-eye biometry, was obtained using IOLMaster. The IOLs power was calculated according to preoperative A-scan, postoperative IOLMaster and fellow-eye AL.Results: AL measured by alternative A-scan (AL-US) was 25.39±2.14 mm, and AL of fellow-eyes (AL-FE) was 25.85±2.16 mm, and AL in eyes with silicone oil tamponade (AL-SO) was 26.08±2.53 mm. The Bland-Altman agreements among AL-US, AL-FE and AL-SO were well (95.5%, 21/22 of cases were in LoA). The mean IOLs power calculated using AL-US (Power-US) was 16.81±7.19 D, using AL-FE (Power-FE) was 14.74±6.95 D, and using AL-SO (Power-SO) was 13.54±8.32 D. The difference between AL-US and AL-SO was significant (P<0.05), while that between AL-FE and AL-SO was not (P>0.05). The difference between Power-US and Power-SO was significant (P<0.05), while that between Power-FE and Power-SO was not (P>0.05).Conclusion: The alternative A-scan ultrasound leads to a significant difference in AL and prediction error in IOLs power, while fellow-eye biometry provided similar results compared with those of silicone oil-filled eyes after RRD repair.

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Distribution of phthisis bulbi and status of fellow eyes at a tertiary eye-care centre in Nigeria: a ten-year review

African Health Sciences ◽

10.4314/ahs.v21i1.54 ◽

2021 ◽

Vol 21 (1) ◽

pp. 437-44

Author(s):

Bolajoko A Adewara ◽

Sarat A Badmus ◽

Olukemi T Olugbade ◽

Edak Ezeanosike ◽

Bernice O Adegbehingbe

Keyword(s):

Clinic Visit ◽

University Teaching ◽

Teaching Hospitals ◽

Fellow Eye ◽

Phthisis Bulbi ◽

The Status ◽

The Mean ◽

University Teaching Hospitals ◽

Fellow Eyes

Background: Phthisis bulbi is an irreversible cause of visual loss with insufficient evidence about its aetiology and status of patients’ fellow eyes. Objectives: To identify the distribution of patients with phthisis bulbi and determine the status of their fellow eyes at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Methods: We analysed data retrospectively retrieved from medical records of patients diagnosed with phthisis bulbi at in- itial clinic visit from January 2008 to December 2017. Information abstracted included biodata, laterality of phthisical eye, duration and aetiology of phthisis bulbi, visual acuity, and morbidities present in fellow eyes. Results: Seventy-nine patients presented with unilateral phthisis bulbi. The mean age was 51±21.2 years and forty (50.6%) were males. The commonest aetiologies of phthisis bulbi were trauma 37 (46.8%), infection 17 (21.5%) and uveitis/inflam- mation 11 (13.9%). Seventy (88.6%) patients had morbidities in their fellow eye such as glaucoma 26 (32.9%), refractive errors 23 (29.1%) and cataract 22 (27.9%). Forty (50.6%) patients were either visually impaired or blind in their fellow eye (p=0.001). Conclusion: The commonest cause of phthisis bulbi was trauma. Approximately nine out of ten patients had ocular mor- bidities in their fellow eye. A thorough follow-up of patients with phthisis bulbi is recommended. Keywords: Fellow eye; Nigeria; ocular trauma; distribution; phthisis bulbi.

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