scholarly journals Genetic Analysis of the Atrial Natriuretic Peptide Gene Polymorphisms among Essential Hypertensive Patients in Malaysia

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Nooshin Ghodsian ◽  
Patimah Ismail ◽  
Salma Ahmadloo ◽  
Narges Eskandarian ◽  
Ali Etemad
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Gene Polymorphisms ◽  
Small Sample Size ◽  
Sociodemographic Factors ◽  
Small Sample ◽  
Sequence Variations ◽  
Peptide Gene ◽  
Atrial Natriuretic

Background. Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis. Several of the studies have utilized anonymous genetic polymorphic markers and made inconsequent claims about theANPrelevant disorders. Thus, we screened Insertion/Deletion (ID) and G191A polymorphisms ofANPto discover sequence variations with potential functional significance and to specify the linkage disequilibrium pattern between polymorphisms. The relationships of detected polymorphisms with EH with or without Type 2 Diabetes Mellitus (T2DM) status were tested subsequently.Method.ANPgene polymorphisms (I/DandA191G) were specified utilizing mutagenically separated Polymerase Chain Reaction (PCR) in 320 subjects including 163 EH case subjects and 157 controls.Result. This case-control study discovered a significant association betweenI/Dpolymorphisms ofANPgene in EH patient without T2DM. However, the study determined no association between G191A polymorphisms ofANPin EH with or without T2DM. In addition, sociodemographic factors in the case and healthy subjects exhibited strong differences (P<0.05).Conclusion. As a risk factor,ANPgene polymorphisms may affect hypertension. Despite the small sample size in this study, it is the first research assessing theANPgene polymorphisms in both EH and T2DM patients among Malaysian population.

scholarly journals Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes

2012 ◽  
Vol 25 (5) ◽  
pp. 524-527 ◽  
Author(s):  
Laurent Larifla ◽  
Suriya Maimaitiming ◽  
Fritz-Line Velayoudom-Cephise ◽  
Severine Ferdinand ◽  
Anne Blanchet-Deverly ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Artery Disease ◽  
Peptide Gene ◽  
Atrial Natriuretic

scholarly journals Atrial Natriuretic Peptide Gene Polymorphisms and Risk of Ischemic Stroke in Humans

Stroke ◽  
2004 ◽  
Vol 35 (4) ◽  
pp. 814-818 ◽  
Author(s):  
Speranza Rubattu ◽  
Rosita Stanzione ◽  
Emanuele Di Angelantonio ◽  
Bastianina Zanda ◽  
Anna Evangelista ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Gene Polymorphisms ◽  
Peptide Gene ◽  
Atrial Natriuretic

Alteration of Atrial Natriuretic Peptide and Brain Natriuretic Peptide Gene Expression Associated with Progression and Regression of Cardiac Hypertrophy in Renovascular Hypertensive Rats

1996 ◽  
Vol 90 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Hideo Kawakami ◽  
Hideki Okayama ◽  
Mareomi Hamada ◽  
Kunio Hiwada
Keyword(s):  
Gene Expression ◽  
Atrial Natriuretic Peptide ◽  
Cardiac Hypertrophy ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Mrna Levels ◽  
Hypertensive Rats ◽  
Regression Of Cardiac Hypertrophy ◽  
Peptide Gene ◽  
Atrial Natriuretic

1. We assessed the changes of atrial natriuretic peptide and brain natriuretic peptide gene expression associated with progression and regression of cardiac hypertrophy in renovascular hypertensive rats (RHR). 2. Two-kidney, one-clip hypertensive rats (6-week-old male Wistar) were made and studied 6 (RHR-1) and 10 weeks (RHR-2) after the procedure. Regression of cardiac hypertrophy was induced by nephrectomy at 6 weeks after constriction, and the nephrectomized rats were maintained further for 4 weeks (nephrectomized rat: NEP). Sham operation was performed, and the rats were studied after 6 (Sham-1) and 10 weeks (Sham-2). Atrial natriuretic peptide and brain natriuretic peptide gene expression in the left ventricle was analysed by Northern blotting. 3. Plasma atrial natriuretic peptide and brain natriuretic peptide were significantly higher in RHR-1 and RHR-2 than in Sham-1, Sham-2 and NEP. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels in RHR-1 were approximately 7.2-fold and 1.8-fold higher than those in Sham-1, respectively, and the corresponding levels in RHR-2 were 13.0-fold and 2.4-fold higher than those in Sham-2, respectively. Atrial natriuretic peptide and brain natriuretic peptide mRNA levels of NEP were normalized. Levels of atrial natriuretic peptide and brain natriuretic peptide mRNA were well correlated positively with left ventricular weight/body weight ratios. There was a significant positive correlation between the levels of atrial natriuretic peptide and brain natriuretic peptide mRNA (r = 0.86, P<0.01). 4. We conclude that the expression of atrial natriuretic peptide and brain natriuretic peptide genes is regulated in accordance with the degree of myocardial hypertrophy and that the augmented expression of these two natriuretic peptides may play an important role in the maintenance of cardiovascular haemodynamics in renovascular hypertension.

Atrial Natriuretic Peptide Gene Expression within Invertebrate Hearts

1995 ◽  
Vol 100 (1) ◽  
pp. 61-68 ◽  
Author(s):  
John E. Poulos ◽  
William R. Gower ◽  
Frank E. Friedl ◽  
David L. Vesely
Keyword(s):  
Gene Expression ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Peptide Gene ◽  
Atrial Natriuretic
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