scholarly journals Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Hampar Akkaya ◽  
Havva Serap Toru ◽  
Ebru Sebnem Ayva ◽  
Zulfikar Karabulut ◽  
Cicek Durusoy
Keyword(s):  
Soft Tissue ◽  
Clinical Features ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Histopathological Diagnosis ◽  
Diagnostic Challenge ◽  
True Nature ◽  
Incomplete Removal

Granular cell tumor (GCT) is a Schwann cell related benign neoplasm of soft tissue. GCT is an uncommon entity that occurs in a wide variety of body sites, but it is generally presented in the skin, oral cavity, superficial soft tissue, and respiratory and digestive tracts. Most of the GCTs are benign but clinically and radiologically these may mimic malignancy. Histopathological diagnosis is gold standard for establishing the true nature of the lesion. GCT is most commonly solitary but in about 10% of cases can be multifocal, usually involving various skin and soft tissue sites versus involving various internal sites. Therefore, these can involve skin and soft tissue or submucosa and viscera. GCT is usually benign; however, local recurrence is common due to incomplete removal. Malignant cases are rarely reported in 1-2% of cases. In this study, we report clinical and histopathological findings of a 36-year-old woman with metachronous GCT in breast and scalp. The clinical features raise the question of whether these are metachronous benign GCTs or whether this is establishment of malignant behavior. The aim of this report is to present the histopathological and clinical features of GCT and the diagnostic challenge of differentiating benign from malignant GCT.

scholarly journals Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge

Rare Tumors ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Meyyappa Devan Rajagopal ◽  
Debasis Gochhait ◽  
Dasarathan Shanmugan ◽  
Adarsh Wamanrao Barwad
Keyword(s):  
Granular Cell Tumor ◽  
Subcutaneous Tissue ◽  
Case Reports ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Cell Of Origin ◽  
Diagnostic Challenge ◽  
Diagnostic Difficulties ◽  
Colon And Rectum

Granular cell tumor (GCT) also known as Abrikossoff's tumor is a benign neoplasm that is usually seen in the fourth to sixth decades of life with slight female preponderance. It is most frequently seen in the oral cavity, skin, and subcutaneous tissue. Gastrointestinal tract involvement is uncommon, in which esophagus is the most commonly affected site. There are case reports of GCT in stomach, appendix, colon and rectum. In this article, we report a case of GCT involving cecum. The cell of origin in GCT is controversial. There are various pools of thoughts regarding its histogenesis, the details of which are reviewed in this article with emphasis on the diagnostic difficulties encountered in this tumor.

scholarly journals Cutaneous granular cell tumor: A case report

2019 ◽  
Vol 9 (1) ◽  
pp. 1511-1513
Author(s):  
Deliya Paudel ◽  
Ram Chandra Adhikari
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Histopathological Examination ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Soft Tissue Tumors ◽  
Cell Tumor ◽  
Internal Organs ◽  
History Of ◽  
Biliary Ducts

Granular cell tumor is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. Granular cell tumor can affect both sexes and in any age, although it is most common in females. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as soft tissue, bronchus, stomach, rectum, anus, biliary ducts. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a Granular cell tumor at histopathological examination.

scholarly journals Granular cell tumor of the breast: correlations between imaging and pathology findings

2020 ◽  
Vol 53 (2) ◽  
pp. 105-111
Author(s):  
Natacha Abreu ◽  
Juliana Filipe ◽  
Saudade André ◽  
José Carlos Marques
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Granular Cell Tumor ◽  
Kinetic Curve ◽  
Granular Cell ◽  
Cell Tumor ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Diagnostic Challenge ◽  
Picture Archiving And Communication

Abstract Objective: To review the imaging features of granular cell tumors of the breast (on mammography, ultrasound, and magnetic resonance imaging), establishing a pathological correlation, in order to familiarize radiologists with this entity and make them aware of the differential diagnoses, other than malignancy, of lesions with spiculated margins. Materials and Methods: We reviewed the medical records (from a clinical-pathology database and picture archiving and communication system) of five patients with a pathologically confirmed diagnosis of granular cell tumor of the breast, treated at the Portuguese Oncology Institute of Lisbon, in the city of Lisbon, Portugal, between January 2012 and December 2018. Results: All five tumors exhibited imaging features highly suggestive of malignancy (BI-RADS 5 lesions), namely spiculated margins, significant depth, and posterior acoustic shadowing (on ultrasound). One tumor showed a kinetic curve indicative of washout on magnetic resonance imaging, two were adherent to the pectoralis muscle, and one was accompanied by skin retraction. Pathology provided the definitive diagnosis in all cases. Conclusion: Granular cell tumors of the breast pose a diagnostic challenge because they can present with clinical and imaging features mimicking malignancy, and the diagnosis is therefore provided by pathology. Radiologists should be familiarized with this entity, so they can be aware of the fact that breast lesions with spiculated margins can be indicative of diagnoses other than malignancy.

FDG PET-CT Evaluation of Granular Cell Tumor of the Soft Tissue

2010 ◽  
Vol 35 (3) ◽  
pp. 192-193 ◽  
Author(s):  
Kenichiro Hamada ◽  
Tetsuho Fujimoto ◽  
Shinsuke Omori ◽  
Makoto Emori ◽  
Susumu Joyama ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Fdg Pet ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Pet Ct ◽  
Ct Evaluation ◽  
Fdg Pet Ct

scholarly journals A case report of metastatic malignant granular cell tumor of femoral soft tissue origin.

1989 ◽  
Vol 28 (6) ◽  
pp. 970-975 ◽  
Author(s):  
Akira ISAKA ◽  
Takanori WATANABE ◽  
Kastuji OOMORI ◽  
Hando HAKOZAKI ◽  
Fumiko OOTSUKI ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Malignant Granular Cell Tumor ◽  
Tissue Origin

scholarly journals Granular Cell Tumor of the Tongue: A Rare Case Presentation of a 14 Years Old Girl

2021 ◽  
pp. 1-2
Author(s):  
Mansour Nacouzi ◽  
Keyword(s):  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Lateral Border ◽  
Case Presentation ◽  
Granular Cytoplasm ◽  
The Right ◽  
Sixth Decade ◽  
Mobile Tongue

Granular cell tumor or Abrikossoff ’s tumor is an infrequent tumor that can arise in most organs, and especially in the ENT area. It is a usually benign neoplasm, that can lead to a misdiagnose of malignancy. It affects both sex, between the fourth and the sixth decade. We present in this report a case of a 14 years old girl with a slowly growing lesion on the right lateral border of the mobile tongue. The biopsy showed a proliferation of large cells with a granular cytoplasm that expressed two immunohistochemistry markers: CD68 and S100 antibodies. Surgical resection was completed with a one centimeter margin.The rare issue about this case is the age of presentation: the age of the patient is 14, whereas this tumor usually affects adult patients.

Abriks's tumor in a teenager's tongue - a case report

2018 ◽  
Vol 7 (4) ◽  
pp. 1-5
Author(s):  
Przemysław Krawczyk ◽  
Daniel Majszyk ◽  
Antoni Bruzgielewicz ◽  
Kazimierz Niemczyk
Keyword(s):  
Case Report ◽  
Children And Adolescents ◽  
Malignant Transformation ◽  
Surgical Resection ◽  
Granular Cell Tumor ◽  
Benign Neoplasm ◽  
Granular Cell ◽  
Cell Tumor ◽  
Upper Airways

Granular cell tumor is benign neoplasm rarely diagnosed among young children and adolescents. The tumor developed commonly within mucous membrane of upper airways, but precise etiology is not known. Treatment is based on surgical resection of tumor and intense follow up due to risk of recurrence and malignant transformation.

scholarly journals Granular Cell Tumor over the Mons Pubis: An Uncommon Tumor

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
M. Patabendige ◽  
D. J. Wickramasooriya ◽  
L. Dasanayake
Keyword(s):  
Soft Tissue ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
The Body ◽  
Complete Surgical Excision ◽  
Neural Origin ◽  
Labium Majus ◽  
Uncommon Tumor

Granular cell tumors are uncommon, usually benign, soft tissue neoplasms of neural origin. They occur throughout the body; vulval involvement is uncommon and labium majus is the commonest site in vulva. Complete surgical excision is the preferred treatment of choice to prevent recurrence. Here, we present a benign granular cell tumor over the mons pubis of vulva in a 27-year-old woman.

scholarly journals A Malignant Granular Cell Tumor Excised with Mohs Micrographic Surgery

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
David Crowe ◽  
Elias E. Ayli ◽  
Hugh M. Gloster
Keyword(s):  
Metastatic Disease ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
Diagnostic Challenge ◽  
Early Presentation ◽  
Malignant Granular Cell Tumor

Malignant granular cell tumors are extremely rare, aggressive neoplasms displaying rapid growth and frequent associated metastatic disease. Excision and evaluation for metastatic disease are mandatory. We present a 54-year-old patient with a malignant granular cell tumor, treated with Mohs micrographic surgery. Cutaneous granular cell tumors are uncommon neoplasms, likely of perineural origin. Most follow a benign and uneventful course, with wide local excision being the treatment of choice (Enzinger, 1988). The malignant granular cell tumor is an extremely rare, aggressive variant, which provides a diagnostic challenge and management dilemma, especially with early presentation when it may be mistaken for other entities. There is also controversy regarding surgical management and follow-up of both benign and malignant granular cell tumors.

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