scholarly journals Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Nooshin Ghodsian ◽  
Patimah Ismail ◽  
Salma Ahmadloo ◽  
Farzad Heidari ◽  
Polin Haghvirdizadeh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Essential Hypertension ◽  
Density Lipoprotein ◽  
Enzymic Activity ◽  
Nucleotide Polymorphisms ◽  
Dominant Form

With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension. Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms ofWNK4gene and essential hypertension (EHT). The aim of this study was to determine the association of Ala589Ser polymorphism ofWNK4gene with essential hypertensive patients in Malaysia.WNK4gene polymorphism was specified utilizing mutagenically separated polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method in 320 subjects including 163 cases and 157 controls. Close relation betweenAla589Serpolymorphism and elevated systolic and diastolic blood pressure (SBP and DBP) was recognized. Sociodemographic factors including body mass index (BMI), age, the level of fasting blood sugar (FBS), low density lipoprotein (LDL), and triglyceride (TG) in the cases and healthy subjects exhibited strong differences (p<0.05). The distribution of allele frequency and genotype ofWNK4geneAla589Serpolymorphism showed significant differences (p<0.05) between EHT subjects with or without type 2 diabetes mellitus (T2DM) and normotensive subjects, statistically. TheWNK4gene variation influences significantly blood pressure increase.Ala589Serprobably has effects on the enzymic activity leading to enhanced predisposition to the disorder.

scholarly journals Association Between Pulse Index and Metabolic syndrome in Individuals with Type 2 Diabetes Mellitus: Outcome of a Twelve-Weeks Therapeutic Exercise

2009 ◽  
pp. 10-15
Author(s):  
Ade Fatai Adeniyi ◽  
Arinola O Sanya ◽  
A A Fasanmade ◽  
B Tijjani ◽  
A E Uloko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cardiovascular Fitness ◽  
Therapeutic Exercises

Background and Objective: Metabolic syndrome (MS) is an entity with clustering of cardiovascular risk factors and is associated with Type 2 Diabetes Mellitus (T2DM). Low level cardiovascular fitness is also associated with risk of T2DM. An association between Pulse Index (PI) and MS requires further description. This study sought to determine the association between PI and components of MS. Methods: Seventy-seven participants/subjects aged 48.6±6.52 years with T2DM were enrolled into the study at Aminu-Kano Teaching Hospital, Kano, Nigeria. PI and components of MS including Fasting Blood Glucose (FBG), Glycosylated Haemoglobin (HBAlc), High-Density Lipoprotein (HDL-CHOL), Triglycerides (TRIG.), Blood Pressure (BP) and obesity were assessed before and after twelve-week therapeutic exercises. Results: Inverse correlations were obtained for PI and each ofFBG (r=-0.45), HBAlc (r=-0.52), TRIG (r=-0.26), BP(r=-0.43/-0.32), Waist Circumference (r=-0.53), BMI (r=-0.79), blood pressure (r=-0.43/-0.32) except HDL-CHOL (r= 0.67), (P< 0.05 for all the subjects/participants). Conclusions: Low-levels of PI were associated with poor glycaemia, hypertension, obesity and dyslipidaemia. Therapeutic exercises aimed at improving cardiovascular fitness may have significant improvement on MS. which in turn aids the prevention of both T2DM and cardiovascular diseases. Keywords: Type 2 Diabetes Mellitus, Cardiovascular fitness, aerobic exercises, Pulse Index'

scholarly journals ESSENTIAL HYPERTENSION

2007 ◽  
Vol 14 (04) ◽  
pp. 627-633
Author(s):  
IMRAN ASHRAF ◽  
Imran Khan ◽  
NOOR KAMIL ◽  
Abdul Mannan ◽  
Muhammad Shamaun Razi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Essential Hypertension ◽  
Blood Glucose ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Once Daily

Background: Hypertension and type 2 diabetes mellitus also tend to coexist.The goal of antihypertensive therapy should consist of reducing cardiovascular morbidity and mortality associated withhypertension by a strategy focused on lowering blood pressure while minimizing the impact on other associatedcardiovascular risk factors like diabetes mellitus. Objectives: To observe and compare any change in serum glucosein patients with newly diagnosed essential hypertension with Atenolol and Amlodipine. Setting: Department ofPharmacology and Therapeutics, Basic Medical Science Institute (BMSI), Jinnah Post Graduate Medical Centre(JPMC), Karachi. Period: 12 weeks (90 days) Methods: Patients with newly diagnosed essential hypertension (N=70)were enrolled in this study and were divided into two groups, each comprised of 35 patients and were given tabletAtenolol 50/100mg once daily and tablet Amlodipine 5/10 mg once daily respectively for 90 days. Fasting Blood glucosewas measured on day of inclusion i.e. day 0, day 45 and day 90. At each fortnightly visit, blood pressure was recorded.Results: Atenolol raised mean blood glucose levels from baseline levels of 91.82±1.34 mg/dl to 99.73±1.33 mg/dl onday 90 (P<0.001) while Amlodipine had no significant effect on blood glucose level (P= N.S). Conclusion: Atenololmay not be a good choice for essential hypertensive patient with type 2 diabetes mellitus as it is found to impair the normal glucose metabolism. Long term clinical trials in diabetic patients are needed to confirm the observation of thepresent study.

scholarly journals The role of natural supplement of apple vinegar and syrup in the management of type 2 diabetes mellitus

2014 ◽  
Vol 4 (3) ◽  
pp. 176-180 ◽  
Author(s):  
Bećir Heljić ◽  
Zelija Velija-Ašimi ◽  
Azra Bureković ◽  
Vanja Karlović ◽  
Azra Avdagić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Waist Circumference ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein

Introduction: The increased risk of coronary artery disease in diabetics could be explained by the lipoprotein irregularities associated with diabetes mellitus. The primary aim of this study is to examine the role of apple vinegar and syrup in the management of type 2 diabetes mellitus.Methods: The interventional study included 500 participants (195 men and 305 women) with dyslipidemia and prediabetes or type 2 diabetes mellitus, aged 50-70 years, living in Sarajevo area. Patients were recruited from 5 outpatient diabetes counselling departments and treated with natural apple vinegar and syrup supplementation over a period of five weeks. The patients have been evaluated before treatment and 5 weeks after the treatment. During the study, dosage of drugs for diabetes or prediabetes was not changed.Results: After 5 weeks of supplementation with apple vinegar and syrup waist circumference (p=0.016), total cholesterol (p=0.01), low density lipoprotein (LDL) cholesterol (p=0.008) and triglycerides (p=0.019) were significantly reduced, as well as blood pressure (-14%). Study results show decrease of mean fasting blood levels of glucose, but statistically not significant (p=0.058). The body mass index also decreased insignificantly (p=0.089). The high density lipoprotein cholesterol level was not increased significantly after supplementation (p=0.26).Conclusion: According to our results, apple vinegar has important role in reduction of total cholesterol levels, triglycerides, LDL cholesterol and waist circumference in patients with type 2 diabetes. Also, it has positive effect on blood pressure.

scholarly journals The Niemann–Pick C1-like 1 rs2073547 polymorphism is associated with type 2 diabetes mellitus in a Chinese population

2019 ◽  
Vol 47 (9) ◽  
pp. 4260-4271
Author(s):  
Zhenxing Huang ◽  
Ruyin Tan ◽  
Liheng Meng ◽  
Haiyan Yang ◽  
Xinghuan Liang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Population ◽  
Density Lipoprotein ◽  
Genotype Distribution ◽  
Nucleotide Polymorphisms ◽  
Gamma Glutamyl Transpeptidase ◽  
Niemann Pick

Objective To explore the association between Niemann–Pick C1-like 1 gene ( NPC1L1) single nucleotide polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods Using propensity score matching, 490 T2DM patients and 490 matched controls were recruited from 13 communities in Guangxi, China. NPC1L1 rs217386 and rs2073547 genotyping was performed using a MassARRAY system. Results The rs2073547 genotype distribution differed significantly among patient groups. Low-density lipoprotein cholesterol levels were similar among different rs2073547 genotypes and alleles. The rs2073547 AG genotype was significantly more prevalent in patients with T2DM. After adjusting for risk or protective factors for diabetes, AG and GG+AG genotypes of rs2073547 were associated with significantly increased risks of T2DM. Compared with the AA genotype, the AG genotype was associated with a significantly higher risk of T2DM in participants with gamma-glutamyl transpeptidase (GGT) <45 U/L, systolic blood pressure (SBP) ≥140 mmHg, or triglyceride <1.70 mmol/L. In participants with GGT <45 U/L or SBP ≥140 mmHg, the GG+AG genotype was associated with a significantly higher T2DM risk versus the AA genotype. Conclusions The rs2073547 polymorphism of NPC1L1 may be related to T2DM susceptibility in the Chinese population.

scholarly journals Prevalence of Microalbuminuria and Associated Factors Among Type 2 Diabetes Mellitus Patients in Jigjiga Town Public Hospitals, Somali Regional State, Ethiopia, 2020

2021 ◽  
Author(s):  
Abdilahi Ibrahim Muse ◽  
Mohamed Omar Osman ◽  
Girma Tadesse Wedajo ◽  
Kalkidan Hassen Abate ◽  
Ahmed Mohammed Ibrahim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Associated Factors ◽  
Density Lipoprotein ◽  
Public Hospitals ◽  
P Value ◽  
Adult Type

Abstract Background and AimUnder normal circumstances, a urine albumin excretion of 5-10 mg/L is considered to be normal. Micro-albuminuria is, however, defined as a level of albumin in the urine that is between 20 mcg/min, and 200 mcg/min (30-300mg/24h) with normal urine flow of 1 ml/min.The aim of this study is to assess the prevalence of micro-albuminuria and associated factors among adult type two diabetes mellitus clients in public hospitals of Jigjiga town, Somali region, Ethiopia, from April 1 to July15, 2020Methods: Institutional based cross-sectional study design was used from April 1 to July 15, 2020. A pre-tested structured questionnaire was used to collect a data from 204 Type 2 diabetes mellitus patients visiting at Karamara general and Jigjiga University referral hospitals for follow up. Descriptive statistics was computed. Logistic regression model was used to identify covariates using SPSS version 20. The direction and strength of statistical association was measured by odds ratio with 95 % CI and a P-value < 0.05 was considered as statistically significant.Results: The prevalence of micro-albuminuria was 48.0% with [95% CI (41.2, 54.9)] Duration of DM between 11-20 years [AOR=3.71; 95% CI (1.45, 9.49)] Family history of hypertension [AOR=2.24; 95% CI: (1.02, 4.70)] Systolic blood pressure [AOR=3.36; 95% CI:(1.39, 8.13)], Low density lipoprotein [AOR=5.60; 95%CI: (2.22,14.11)] High density lipoprotein [AOR=5.210;95%CI:(2.067,13.131)] and Glycated hemoglobin [AOR = 3.246; 95% CI (1.356, 7.78)] were significantly associated with micro-albuminuriaConclusion: There is a significant level of micro-albuminuria among type 2 diabetes mellitus patients. Effective secondary prevention program directed on blood glucose and lipid with steps to improve blood pressure are critical in undertaking in the setting and regular screening of micro-albuminuria is needed so that an early preventive and treatment measures against its burden are put in place.

scholarly journals Metabolic, Anthropometric, and Type 2 Diabetes Mellitus Related Risk Factors in Normal and Pre-Diabetic Adults

2016 ◽  
Vol 9 (1) ◽  
pp. 224 ◽  
Author(s):  
Mohamed H. Al-Thani ◽  
Heba S. Nasser ◽  
Suzan Sayegh ◽  
Alexandra Haddad ◽  
Eman Sadoun
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Fat Free Mass ◽  
Categorical Variables

Type 2 diabetes mellitus (T2DM) is a major global health problem. The present study examines the relationship between the metabolic, anthropometric and Finnish risk score (FINDRISC) among normal and pre-diabetic adults. Subjects (n = 1319, aged above 18 years) from the Qatari population were classified into two groups based on their hemoglobin A1c (HbA1c) measurements (non-diabetic A1c<5.6% and pre-diabetic 5.6% ≤ A1c ≤ 6.4%) were examined for their anthropometric (height, weight and waist circumference), metabolic [fat, fat free mass (FFM), muscle mass (MM), total body water (TBW), bone mass, degree of obesity, basal metabolic rate (BMR), body mass index (BMI), metabolic age, visceral fat rating, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (Total-C), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting / random plasma glucose (FPG / RPG), HbA1c and vitamin D (VitD)] and FINDRISC. Means and frequencies were determined in aggregate and by subgroups for all variables and correlations between categorical variables were tested to estimate the association between the anthropometric and metabolic risk factors with the FINDRISC. A percentage of 74.8% (n = 987) of the study population aged below 45 years old and their overall BMI was 28.8±5.2kg/m2 (overweight). Pre-diabetic subgroup have shown a statistically higher FINDRISC compared to their non-diabetic counterparts (11.2±4.1 vs. 9.8±4, p<0.001). The FINDRISC was significantly and directly correlated with the BMI, HbA1c and FPG. However, HbA1c was correlated directly with BMI, SBP, DBP, FPG / RPG and indirectly with the levels of HDL. This study demonstrates an apparent relationship between the HbA1c and FINDRISC score. Pursuing further research on this association may permit using HbA1c with the FINDRISC in predicting the risk of T2DM to be a better tool rather than using the current FPG/RPG, OGTT methods.

scholarly journals Metabolically Abnormal But Normal-Weight Individuals Had a Higher Risk of Type 2 Diabetes Mellitus in a Cohort Study of a Chinese Population

2021 ◽  
Vol 12 ◽  
Author(s):  
Qiannan Chen ◽  
Yaohan Zhou ◽  
Chen Dai ◽  
Gang Zhao ◽  
Yimin Zhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Family History Of Diabetes ◽  
Antidiabetic Treatment ◽  
Elevated Systolic Blood Pressure

AimsObesity is a heterogeneous disease in terms of body mass index (BMI) and metabolic status. The purpose of this study was to investigate the risk of type 2 diabetes mellitus (T2DM) in subjects with metabolically abnormal but normal weight (MANW) in China.Materials and MethodsA prospective cohort with a total of 17,238 participants of the Zhejiang metabolic syndrome cohort was recruited. According to the standard of the Working Group on Obesity in China, general obesity is defined. Metabolic abnormality was defined as two or more abnormal components (elevated triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C), elevated systolic blood pressure (SBP) or diastolic blood pressure (DBP) or use of antihypertensive therapy, and elevated fasting plasma glucose or antidiabetic treatment). The hazard ratio (HR) and its 95% CI were calculated using a multiple regression model, adjusted for the potential confounding factors.ResultsCompared with metabolically normal and normal weight (MNNW) subjects, the metabolically abnormal and obesity/overweight (MAO) subjects had the highest risk of T2DM disease, with an HR of 4.67 (95% CI: 3.23–6.76), followed by MANW subjects (HR = 2.61, 95% CI: 1.74–3.92) and metabolically normal but obesity/overweight (MNO) subjects (HR = 2.09, 95% CI: 1.29–3.38) after adjusting for age, sex, smoking, drinking, physical activity, and family history of diabetes. Compared with that in the MNNW subjects, the HR in MANW subjects was significantly higher than that in MNO subjects. In normal-weight subjects, the HR of T2DM was significantly positively correlated with the number of components with metabolic abnormalities.ConclusionsMANW subjects had a higher risk of T2DM. MANW subjects should be given more attention in the prevention and control of common chronic diseases.

scholarly journals The single nucleotide polymorphisms rs11761556 and rs12706832 of the leptin gene are associated with type 2 diabetes mellitus in the iraqi population

2021 ◽  
pp. 5-5
Author(s):  
Karar Musafer ◽  
Fahrul Huyop ◽  
Mufeed Ewadh ◽  
Eko Supriyanto ◽  
Tahreer Al-Thuwaini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Single Strand Conformation Polymorphism ◽  
Model Assessment ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

This study was conducted to assess the potential association between leptin (LEP) gene polymorphisms and type 2 diabetes mellitus (T2DM) in Iraqi patients. Genomic DNA was extracted from 120 diabetic subjects and 100 controls. Three specific PCR fragments were designed to flank three highly frequent single nucleotide polymorphism (SNP)s within LEP, rs11761556, rs12706832 and rs2167270. The amplified loci were genotyped by PCR-single-strand conformation polymorphism (SSCP) followed by Sanger sequencing for representative genotypes. Logistic regression analysis was performed to detect the association between the targeted genetic variants and T2DM. PCR-SSCP genotyping showed three banding patterns for all three targeted SNPs. Individuals with the AA genotype in both rs11761556 and rs12706832 SNPs showed significantly higher (P<0.05) body mass index (BMI), waist circumference (WC), fasting blood glucose (FBG), hemoglobin A1c (HbA1c), homeostatic model assessment for insulin resistance (HOMA-IR), insulin, low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) values than those with other genotypes. Association analysis revealed that individuals with the A allele exhibited a greater risk of T2DM. Data of the present investigation indicated that both rs11761556 and rs12706832 SNPs exerted a noticeable association with T2DM. The study suggests implementing both rs11761556 and rs12706832 SNPs in the early detection of T2DM.

scholarly journals Association of polymorphisms in CYP2C8 and CYP2C9 with susceptibility to type 2 diabetes mellitus in a Chinese population

2020 ◽  
Author(s):  
Li Jin ◽  
Yan Huang ◽  
Yangyang Li ◽  
Bo Xu ◽  
Cheng Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Population ◽  
Density Lipoprotein ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Beneficial Effects ◽  
Study Population

Abstract Background: CYP2C8 and CYP2C9 are cytochrome P450 epoxygenases that metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs). EETs are important lipid mediators with many beneficial effects in type 2 diabetes mellitus. In this study, we aimed to investigate the association of CYP2C8 and CYP2C9 variants with type 2 diabetes in a Chinese population. Methods: We genotyped 9 tag single nucleotide polymorphisms (SNPs) in CYP2C8 and 10 tag SNPs in CYP2C9 based on HapMap Chinese and Japanese data. Then, we genotyped the SNPs in a Chinese population that included 3410 type 2 diabetes patients and 3401 normal controls. The association between the SNPs and type 2 diabetes was analysed. Results: In the study population, we found that rs1819173 in the CYP2C9 gene region was associated with type 2 diabetes and the A allele was protective against type 2 diabetes (odds ratio: 0.840, 95% confidence interval (CI): 0.780-0.904, P=3.04×10-6). Haplotypes GT and AT (rs2071426-rs6583967) in CYP2C8 were associated with type 2 diabetes (P=0.049 and 0.038, respectively). On the other hand, an interaction effect between rs1819173 in CYP2C9 and rs12766752 in CYP2C8 on type 2 diabetes was found (P=0.003). What’s more, rs1819173 showed significant association with HDL-C (high-density lipoprotein cholesterol).Conclusions: Our results suggested that common SNPs in the CYP2C8 and CYP2C9 regions were associated with T2DM in a Chinese Han population.

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