Infrarenal Aorta Thrombosis Associated with H1N1 Influenza A Virus Infection

Influenza viruses are members of the Orthomyxoviridae family, of which influenza A, B, and C viruses constitute three separate genera. Arterial thrombosis associated with H1N1 influenza A virus infection has rarely been reported. A Turkish man aged 28 years was admitted to our emergency department with dyspnea, bilateral lower extremity insensitivity, and cold. He reported symptoms of fever, myalgia, and cough, which he had had for fifteen days before being admitted to our hospital. The patient was tested for pandemic influenza A (H1N1) virus using polymerase chain reaction (PCR) tests, which were positive. Abdominal computerized tomography with contrast revealed a large occlusive thrombus within the infrarenal aorta.

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The origin of the recent swine influenza A(H1N1) virus infecting humans

Eurosurveillance ◽

10.2807/ese.14.17.19193-en ◽

2009 ◽

Vol 14 (17) ◽

Cited By ~ 2

Author(s):

V Trifonov ◽

H Khiabanian ◽

B Greenbaum ◽

R Rabadan

Keyword(s):

Influenza A Virus ◽

Preliminary Analysis ◽

Influenza A ◽

H1n1 Virus ◽

Swine Influenza ◽

H1n1 Influenza ◽

Influenza Viruses ◽

Influenza A H1n1

Preliminary analysis of the genome of the new H1N1 influenza A virus responsible for the current pandemic indicates that all genetic segments are related closest to those of common swine influenza viruses.

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Next Generation of Computationally Optimized Broadly Reactive HA Vaccines Elicited Cross-Reactive Immune Responses and Provided Protection against H1N1 Virus Infection

Vaccines ◽

10.3390/vaccines9070793 ◽

2021 ◽

Vol 9 (7) ◽

pp. 793

Author(s):

Ying Huang ◽

Monique S. França ◽

James D. Allen ◽

Hua Shi ◽

Ted M. Ross

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Immune Responses ◽

H1n1 Virus ◽

Influenza Virus Infection ◽

H1n1 Influenza ◽

Influenza Viruses ◽

Next Generation ◽

Wild Type ◽

Influenza A H1n1

Vaccination is the best way to prevent influenza virus infections, but the diversity of antigenically distinct isolates is a persistent challenge for vaccine development. In order to conquer the antigenic variability and improve influenza virus vaccine efficacy, our research group has developed computationally optimized broadly reactive antigens (COBRAs) in the form of recombinant hemagglutinins (rHAs) to elicit broader immune responses. However, previous COBRA H1N1 vaccines do not elicit immune responses that neutralize H1N1 virus strains in circulation during the recent years. In order to update our COBRA vaccine, two new candidate COBRA HA vaccines, Y2 and Y4, were generated using a new seasonal-based COBRA methodology derived from H1N1 isolates that circulated during 2013–2019. In this study, the effectiveness of COBRA Y2 and Y4 vaccines were evaluated in mice, and the elicited immune responses were compared to those generated by historical H1 COBRA HA and wild-type H1N1 HA vaccines. Mice vaccinated with the next generation COBRA HA vaccines effectively protected against morbidity and mortality after infection with H1N1 influenza viruses. The antibodies elicited by the COBRA HA vaccines were highly cross-reactive with influenza A (H1N1) pdm09-like viruses isolated from 2009 to 2021, especially with the most recent circulating viruses from 2019 to 2021. Furthermore, viral loads in lungs of mice vaccinated with Y2 and Y4 were dramatically reduced to low or undetectable levels, resulting in minimal lung injury compared to wild-type HA vaccines following H1N1 influenza virus infection.

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A Functional Variation in CD55 Increases the Severity of 2009 Pandemic H1N1 Influenza A Virus Infection

The Journal of Infectious Diseases ◽

10.1093/infdis/jis378 ◽

2012 ◽

Vol 206 (4) ◽

pp. 495-503 ◽

Cited By ~ 52

Author(s):

Jie Zhou ◽

Kelvin Kai-Wang To ◽

Hui Dong ◽

Zhong-Shan Cheng ◽

Candy Choi-Yi Lau ◽

...

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Influenza A ◽

H1n1 Influenza ◽

Pandemic H1n1 ◽

Functional Variation ◽

Pandemic H1n1 Influenza ◽

Influenza A Virus Infection

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Severe Thrombocytopenia in the Third Trimester of Pregnancy Subsequent to Seasonal Non-H1N1 Influenza A Virus Infection

Infectious Diseases in Clinical Practice ◽

10.1097/ipc.0000000000000368 ◽

2016 ◽

Vol 24 (5) ◽

pp. 289-290

Author(s):

Samantha Curtis ◽

Stephen Carlan ◽

John Busowski ◽

Mary Busowski ◽

Faisal Musa

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Influenza A ◽

H1n1 Influenza ◽

Severe Thrombocytopenia ◽

Third Trimester ◽

The Third ◽

Influenza A Virus Infection

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Acute myocarditits in H1N1 influenza a virus infection

Revista da Associação Médica Brasileira ◽

10.1590/s0104-42302010000400008 ◽

2010 ◽

Vol 56 (4) ◽

pp. 394-394 ◽

Cited By ~ 3

Author(s):

Daniela Calderaro ◽

Sigrid de Souza dos Santos ◽

Adriana Coracini Tonacio ◽

Danielle Menosi Gualandro ◽

Paulo Cury Rezende ◽

...

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Influenza A ◽

H1n1 Influenza ◽

Influenza A Virus Infection

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Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection

Cellular Immunology ◽

10.1016/j.cellimm.2019.103949 ◽

2019 ◽

Vol 344 ◽

pp. 103949 ◽

Cited By ~ 3

Author(s):

Kohei Tatsumi ◽

Clare M. Schmedes ◽

E. Reaves Houston ◽

Emily Butler ◽

Nigel Mackman ◽

...

Keyword(s):

Virus Infection ◽

Influenza A Virus ◽

Influenza A ◽

H1n1 Influenza ◽

Coxsackievirus B3 ◽

Influenza A Virus Infection

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Contemporary Seasonal Influenza A (H1N1) Virus Infection Primes for a More Robust Response To Split Inactivated Pandemic Influenza A (H1N1) Virus Vaccination in Ferrets

Clinical and Vaccine Immunology ◽

10.1128/cvi.00247-10 ◽

2010 ◽

Vol 17 (12) ◽

pp. 1998-2006 ◽

Cited By ~ 11

Author(s):

Ali H. Ellebedy ◽

Thomas P. Fabrizio ◽

Ghazi Kayali ◽

Thomas H. Oguin ◽

Scott A. Brown ◽

...

Keyword(s):

Influenza Virus ◽

Pandemic Influenza ◽

Influenza A ◽

Seasonal Influenza ◽

H1n1 Virus ◽

H1n1 Influenza ◽

Influenza Viruses ◽

Inactivated Vaccine ◽

H1n1 Influenza Virus ◽

Influenza A H1n1

ABSTRACT Human influenza pandemics occur when influenza viruses to which the population has little or no immunity emerge and acquire the ability to achieve human-to-human transmission. In April 2009, cases of a novel H1N1 influenza virus in children in the southwestern United States were reported. It was retrospectively shown that these cases represented the spread of this virus from an ongoing outbreak in Mexico. The emergence of the pandemic led to a number of national vaccination programs. Surprisingly, early human clinical trial data have shown that a single dose of nonadjuvanted pandemic influenza A (H1N1) 2009 monovalent inactivated vaccine (pMIV) has led to a seroprotective response in a majority of individuals, despite earlier studies showing a lack of cross-reactivity between seasonal and pandemic H1N1 viruses. Here we show that previous exposure to a contemporary seasonal H1N1 influenza virus and to a lesser degree a seasonal influenza virus trivalent inactivated vaccine is able to prime for a higher antibody response after a subsequent dose of pMIV in ferrets. The more protective response was partially dependent on the presence of CD8+ cells. Two doses of pMIV were also able to induce a detectable antibody response that provided protection from subsequent challenge. These data show that previous infection with seasonal H1N1 influenza viruses likely explains the requirement for only a single dose of pMIV in adults and that vaccination campaigns with the current pandemic influenza vaccines should reduce viral burden and disease severity in humans.

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