scholarly journals Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor

2020 ◽  
Vol 154 (1) ◽  
pp. 15-22
Author(s):  
Everton Freitas de Morais ◽  
Hélder Domiciano Dantas Martins ◽  
Katianne Soares Rodrigues ◽  
Glória Maria de França ◽  
Éricka Janine Dantas da Silveira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Therapeutic Modality ◽  
Biological Behavior ◽  
Clinicopathologic Characteristics ◽  
Long Term Follow Up ◽  
Mean Size ◽  
Fibrous Tumor

Abstract Objectives The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior. Methods We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Results Seventy-three published articles were included in our systematic review, corresponding to a total of 154 cases. SFT showed a slight female predilection (53.2%), and the cheek mucosa/cheek, tongue, and palate were the most affected anatomical sites. The mean size of SFT in the oral cavity and maxillofacial region at diagnosis was 1.4 cm. Histologic features of malignancy by morphologic analysis (P < .001) were significantly associated with a larger tumor size. Surgical excision was the most frequent therapeutic modality. Recurrence and metastasis were uncommon findings in our sample. Conclusions Histologic features of malignancy can be important parameters of tumor behavior. Adequate surgical treatment and long-term follow-up are required for these cases.

scholarly journals An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Everton Freitas de Morais ◽  
Deborah Gondim Lambert Moreira ◽  
Viviane Alves De Oliveira ◽  
Rodrigo Rodrigues Rodrigues ◽  
Adriano Rocha Germano ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Normal Morphology ◽  
S 100 ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

scholarly journals Solitary fibrous tumor of the scrotum: a case report and review of the literature

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tsung-Hsin Chang ◽  
Marcelo Chen ◽  
Chih-Chiao Lee
Keyword(s):  
Solitary Fibrous Tumor ◽  
Soft Tissue Tumor ◽  
English Literature ◽  
Surgical Excision ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
English Medical Literature ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a rare soft tissue tumor originally reported in the pleura. Although it has been reported in various extra-pleural sites, the occurrence of SFT in the scrotum is extremely rare. Herein, we present a 48-year-old man who had scrotal SFT. There are very few reported cases of genitourinary SFTs, this is only the fifth report of SFT of the scrotum in the English medical literature. Case presentation In this study, we report on a 48-year-old man who presented with a 5 × 8 cm scrotal mass between his testes. Physical examination revealed a 4.7 × 8.5 cm lobulated tumor mass located between his testicles. Surgical excision of the tumor with scrotal approach was done and pathology reported a SFT. The patient was alive without tumor recurrence or distant metastasis during ongoing follow-up for 9 months post-operatively.. Conclusion Scrotal SFTs are very rare and only five cases have been reported in English literature to date. Treatment often involves surgical resection, and a definite diagnosis is made with the help of immunohistochemistry. The current general consensus for the management of SFTs is long-term follow-up after surgical excision of the tumor.

Intracranial Solitary Fibrous Tumor of the Skull Base: 2 Cases and Systematic Review of the Literature

2021 ◽  
Vol 149 ◽  
pp. e345-e359
Author(s):  
Sricharan Gopakumar ◽  
Visish M. Srinivasan ◽  
Caroline C. Hadley ◽  
Adrish Anand ◽  
Marc Daou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Skull Base ◽  
Solitary Fibrous Tumor ◽  
Review Of The Literature ◽  
Fibrous Tumor

scholarly journals Malignant Solitary Fibrous Tumor of the Right Cerebellum: A Case Report

2021 ◽  
Vol 13 (1) ◽  
pp. 259-266
Author(s):  
Ye-Tao Zhu ◽  
Yang Liu ◽  
Li-Gang Chen ◽  
Da-Ping Song
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Solitary Fibrous Tumor ◽  
Immunohistochemical Staining ◽  
Biological Behavior ◽  
Resonance Imaging ◽  
Solitary Fibrous Tumors ◽  
The Central Nervous System ◽  
Fibrous Tumor ◽  
The Right

Solitary fibrous tumor is a very rare mesenchymal tumor that occurs mostly in the pleura, and there are few reported cases of a presence in the central nervous system, particularly in the cerebellum. In 2016, the WHO classified solitary fibrous tumors into grade I. In this article, we present a case of malignant solitary fibrous tumor recurring 8 years after surgery in a 63-year-old male. Magnetic resonance imaging showed low to intermediate mixed signal intensity on T1W1. Immunohistochemical staining positivity for Vimentin, CD99, CD34 and Bcl-2, it is consistent with the immunohistochemical characteristics of solitary fibrous tumor. We resected the patient’s tumor, and the patient was followed up for 3 months with no signs of recurrence. Solitary fibrous tumors are very rare in the central nervous system. Immunohistochemical staining positivity for CD34 and Bcl-2 is strongly expressed in most solitary fibrous tumor. Surgical resection is the preferred treatment. Due to the small number of cases, the biological behavior and prognosis of this tumor need to be further explored.

scholarly journals Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

2016 ◽  
Vol 19 (1) ◽  
pp. 113
Author(s):  
Antonione Santos Bezerra Pinto ◽  
Vera Cavalcanti De Araújo ◽  
Fabrício Passador Santos ◽  
José Ferreira de Menezes Filho ◽  
Viviane Siqueira ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Hard Palate ◽  
Salivary Gland Tumor ◽  
Immunohistochemical Analysis ◽  
Soft Tissue Tumors ◽  
Rare Entity ◽  
Gland Tumor ◽  
Clinical Imaging ◽  
Fibrous Tumor

<p align="justify"><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US">A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least </span></span></span></span><span style="font-family: Arial, serif;"><span><span lang="en-US">2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. </span></span></span><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US">Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. </span></span></span></span></p><p lang="en-US" align="justify"> </p><p align="justify"><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US"><strong><span>Keywords</span></strong></span></span></span></span></p><p align="justify"><span style="font-family: Arial, serif;"><span><span lang="en-US">Solitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.</span></span></span></p><p lang="en-US" align="justify"> </p>

Recurrent Solitary Fibrous Tumor of the Pleura With Malignant Transformation

2004 ◽  
Vol 128 (4) ◽  
pp. 460-462
Author(s):  
Rani Kanthan ◽  
Bahman Torkian
Keyword(s):  
Malignant Transformation ◽  
Solitary Fibrous Tumor ◽  
Immunohistochemical Staining ◽  
White Woman ◽  
Accurate Diagnosis ◽  
Malignant Progression ◽  
Biological Behavior ◽  
Fibrous Tumor

Abstract Recurrent solitary fibrous tumor of the pleura with malignant progression occurs rarely. We report a case of solitary fibrous tumor of the pleura in an 85-year-old white woman that recurred 4 times during a span of 10 years and subsequently underwent malignant transformation. The accurate diagnosis of solitary fibrous tumor is aided by ancillary techniques, such as immunohistochemical staining; however, with malignant transformation, such tools may be of limited value. Long-term clinical follow-up is recommended for all patients with solitary fibrous tumor because of the potential adverse biological behavior of this tumor, which may lead to repeated recurrences and/or malignant transformation.

Solitary fibrous tumor of the oral cavity: the need for an extensive sampling for a correct diagnosis

2007 ◽  
Vol 36 (9) ◽  
pp. 538-542 ◽  
Author(s):  
Lorenzo Lo Muzio ◽  
Massimo Mascolo ◽  
Saverio Capodiferro ◽  
Gianfranco Favia ◽  
Eugenio Maiorano
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Correct Diagnosis ◽  
Fibrous Tumor

scholarly journals A Case Report of a Solitary Fibrous Tumor of the Maxillary Sinus

Reports ◽  
2021 ◽  
Vol 4 (4) ◽  
pp. 33
Author(s):  
Mattia Di Bartolomeo ◽  
Sara Negrello ◽  
Arrigo Pellacani ◽  
Anna Maria Cesinaro ◽  
Stefano Vallone ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Maxillary Sinus ◽  
Solitary Fibrous Tumor ◽  
Malignant Neoplasm ◽  
Neck Region ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Purulent Discharge ◽  
Fibrous Tumor

A solitary fibrous tumor (SFT) is a benign neoplasm, firstly described as a mesenchymal tumor of the pleura. Its incidence range in the head and neck region is about 5–27%, but only rarely does it affect paranasal sinuses. The differential diagnosis is challenging, owing to its erosive growth pattern and immuno-histochemical features. SFTs have an aggressive behavior and an important recurrence potential. Therefore, a radical surgical excision is the gold standard therapeutic procedure. A rare SFT originating from the right maxillary sinus is reported here. The 37-year-old patient presented to the outpatient clinic with a painful expansive lesion in the whole right maxillary region. The overlying skin was inflamed and the patient had no epistaxis episodes. The 1.5 dentary element tested negative for vitality; however, a puncture of the lesion led to a hematic spill and no purulent discharge. An endoscopic-guided biopsy was suggestive either of SFT or hemangioperictoma, excluding a malignant neoplasm. A multi-equipe surgical team was activated. The lesion was embolized in order to achieve a good hemostatic control and, after 48 h, the neoplasm was radically excised with a combined open and endoscopic approach. The patient was disease-free at 12-month radiological and clinical follow-up. Given the rarity of this lesion and the delicacy required in addressing head and neck neoplasms, we believe that the present case report might be of help in further understanding how to approach cranio-facial SFTs.

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