scholarly journals Omental Solitary Fibrous Tumor: A Rare Tumor at Rare Site

2021 ◽  
Author(s):  
Abhijeet Ingle ◽  
Surender Reddy ◽  
Vamshi Krishna Reddy
Keyword(s):  
Adjuvant Treatment ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Risk Category ◽  
Rare Tumor ◽  
Rare Site ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor ◽  
Risk Categorization

AbstractExtrapleural solitary fibrous tumor-hemangiopericytoma is a rare tumor. We present a case of this tumor arising in omentum, which is an extremely rare site. The diagnosis was confirmed by diffuse expression of STAT6 on immunohistochemistry. The tumor was assigned a low-risk category according to recent risk categorization models. The patient was advised close follow-up as the tumor was excised completely. These tumors have the potential for recurrence and metastasis even after surgical excision. However, there are no definitive guidelines for adjuvant treatment due to lack of data.

Extrapleural Solitary Fibrous Tumor of the Foot

2015 ◽  
Vol 105 (6) ◽  
pp. 557-559
Author(s):  
Charles A. Kean ◽  
Bridget R. Moore ◽  
Ashley M. Nettles ◽  
Richard P. Bui
Keyword(s):  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Solitary Fibrous Tumors ◽  
Mesenchymal Neoplasms ◽  
Complete Surgical Excision ◽  
Rare Manifestation ◽  
Painless Mass ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor ◽  
Male Veteran

Solitary fibrous tumors are uncommon mesenchymal neoplasms that were initially described as pleural tumors, but in recent years, numerous extrapleural sites have been reported. A solitary fibrous tumor is characterized as a circumscribed, painless mass with a patternless growth pattern, positive CD34 spindle-shaped cells, bcl-2, and dense keloidal collagen with areas of hypercellularity and hypocellularity. This case report describes a 55-year-old male veteran who presented with a rare manifestation of an extrapleural solitary fibrous tumor of the medial right hallux. Microscopic and immunohistochemical findings were consistent with the previously documented characteristics of solitary fibrous tumors. Complete surgical excision of the tumor is the treatment of choice.

scholarly journals An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Everton Freitas de Morais ◽  
Deborah Gondim Lambert Moreira ◽  
Viviane Alves De Oliveira ◽  
Rodrigo Rodrigues Rodrigues ◽  
Adriano Rocha Germano ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Normal Morphology ◽  
S 100 ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

scholarly journals Solitary Fibrous Tumor of the Chest Wall in an Infant- A Rare Case Report

2015 ◽  
Vol 4 (1) ◽  
pp. 28-31
Author(s):  
SM Sabbir Enayet ◽  
Kaniz Hasina
Keyword(s):  
Chest Wall ◽  
Solitary Fibrous Tumor ◽  
Malignant Tumors ◽  
Therapeutic Option ◽  
Surgical Excision ◽  
Mesenchymal Neoplasm ◽  
Accurate Preoperative Diagnosis ◽  
Rare Case Report ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor

Solitary fibrous tumor is an uncommon mesenchymal neoplasm that very rarely appears in extra serosal soft tissue. Though pleural solitary fibrous tumor is more common, up to one third of the reported cases were at extra pleural sites. Although pleural and extrapleural solitary fibrous tumors are regarded as indolent tumors, there is some evidence that extrapleural subgroup could be a subset of more aggressive malignant tumors. Accurate preoperative diagnosis of extrapleural solitary fibrous tumor is very difficult and usually is a diagnosis of exclusion. Surgical excision is mandatory and is the best therapeutic option. In this article we report a case of solitary fibrous tumor of the chest wall in a 2 months old boy.J. Paediatr. Surg. Bangladesh 4(1): 28-31, 2013 (January)

scholarly journals Solitary fibrous tumor of the scrotum: a case report and review of the literature

BMC Urology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tsung-Hsin Chang ◽  
Marcelo Chen ◽  
Chih-Chiao Lee
Keyword(s):  
Solitary Fibrous Tumor ◽  
Soft Tissue Tumor ◽  
English Literature ◽  
Surgical Excision ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
English Medical Literature ◽  
Fibrous Tumor

Abstract Background Solitary fibrous tumor (SFT) is a rare soft tissue tumor originally reported in the pleura. Although it has been reported in various extra-pleural sites, the occurrence of SFT in the scrotum is extremely rare. Herein, we present a 48-year-old man who had scrotal SFT. There are very few reported cases of genitourinary SFTs, this is only the fifth report of SFT of the scrotum in the English medical literature. Case presentation In this study, we report on a 48-year-old man who presented with a 5 × 8 cm scrotal mass between his testes. Physical examination revealed a 4.7 × 8.5 cm lobulated tumor mass located between his testicles. Surgical excision of the tumor with scrotal approach was done and pathology reported a SFT. The patient was alive without tumor recurrence or distant metastasis during ongoing follow-up for 9 months post-operatively.. Conclusion Scrotal SFTs are very rare and only five cases have been reported in English literature to date. Treatment often involves surgical resection, and a definite diagnosis is made with the help of immunohistochemistry. The current general consensus for the management of SFTs is long-term follow-up after surgical excision of the tumor.

scholarly journals A rare mediastinal tumor-fat-forming solitary fibrous tumor

2018 ◽  
Vol 5 (4) ◽  
pp. 1069
Author(s):  
Deependra Kr. Rai ◽  
Somesh Thakur ◽  
Abhisheka Kr. ◽  
Sanjay Pandey
Keyword(s):  
Solitary Fibrous Tumor ◽  
Mediastinal Tumor ◽  
Spindle Cell ◽  
Surgical Excision ◽  
Intermediate Type ◽  
Radiological Features ◽  
Pleural Surface ◽  
Male Patients ◽  
Fibrous Tumor

Solitary fibrous tumor is uncommon spindle cell mediastinal tumor arising mainly from pleural surface. Authors discuss a clinic-radiological features of Fat forming SFT which is rare variant of SFT in 70yrs old male patients. Initially we kept differential of Liposarcoma, Lymphoma on clinico-radiologically features but later after histopathology and Immunohistochemistery turns out to be Solitary fibrous tumor. Here accurate classification is important as SFT classified as intermediate type (rarely malignant), require wide surgical excision with close follow-up.

scholarly journals Giant Solitary Fibrous Tumor of the Parotid Gland

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Octavian Chis ◽  
Silviu Albu
Keyword(s):  
Parotid Gland ◽  
Clinical Presentation ◽  
Surgical Excision ◽  
Rare Tumor ◽  
Imaging Procedures ◽  
Solitary Fibrous Tumors ◽  
Complete Surgical Excision ◽  
Fibrous Tumor ◽  
Slow Growing

Solitary fibrous tumors (SFTs) are rare tumors that are mostly found arising from the pleura. SFT of the parotid gland is a rare tumor; only a few cases have been described in the literature. SFTs are benign in most cases. Clinically, SFTs usually manifest as well circumscribed, slow-growing, smooth, and painless masses. CT-Scan and MRI are the most sensitive imaging procedures used. The treatment of choice is complete surgical excision of the lesion. Since recurrence and metastasis can take place after several years, a lifelong clinical and imaging regular follow-up is compulsory. In this paper, we describe the diagnostic and therapeutic challenges of the up-to-now biggest parotid SFT. The clinical presentation, surgical management, and pathological and immunohistochemistry findings are described.

Pazopanib-associated secondary adrenal insufficiency in a patient with malignant solitary fibrous tumor

2021 ◽  
pp. 107815522110160
Author(s):  
Muhammed Muhiddin Er ◽  
Murat Araz ◽  
Meryem Karabacak ◽  
Muzaffer Uğraklı ◽  
Melek Karakurt Eryılmaz ◽  
...  
Keyword(s):  
Adrenal Insufficiency ◽  
Solitary Fibrous Tumor ◽  
Single Case ◽  
Soft Tissue Sarcomas ◽  
Pituitary Hormones ◽  
Secondary Adrenal Insufficiency ◽  
Primary Adrenal Insufficiency ◽  
Hypoglycemic Attack ◽  
Fibrous Tumor

Introduction Pazopanib is an agent that is being successfully used in soft tissue sarcomas. Some endocrine side effects may develop during pazopanib treatment. Here, we presented a case diagnosed with secondary adrenal insufficiency while being investigated for etiology of hypoglycemia which developed after pazopanib. Case report A 69-year-old male patient was operated in June 2019 due to a lung mass 26 × 18 × 10 cm in size. Pathological diagnosis revealed a solitary fibrous tumor with malignant behavior. The patient received three lines of chemotherapy. After pazopanib treatment, a hypoglycemic attack was reported. Management and outcome: Blood cortisol and ACTH (Adrenocorticotropic hormone) levels were not increased at the time of the hypoglycemic attack, and levels of other pituitary hormones were found to be normal. Electrolyte levels were in normal range. Since the counteracting hormone did not reach a sufficient level, it was considered secondary adrenal insufficiency. Hypoglycemic attacks did not occur during follow-up while taking steroid therapy and pazopanib. Discussion A single case of primary adrenal insufficiency has been reported in the literature. We here present a case who developed hypoglycemia after pazopanib and was diagnosed with drug-associated secondary adrenal insufficiency. When hypoglycemia develops during pazopanib treatment, we must be aware of adrenal insufficiency.

scholarly journals Solitary Fibrous Tumors of the Chest: An Analysis of Fifty Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
Jingwen Zhang ◽  
Jumin Liu ◽  
Zhihao Zhang ◽  
Beizong Tian
Keyword(s):  
Solitary Fibrous Tumor ◽  
Chest Tightness ◽  
Ki 67 ◽  
Imaging Characteristics ◽  
Enhanced Ct ◽  
The Common ◽  
The Difference ◽  
Low Incidence ◽  
Fibrous Tumor

BackgroundA solitary fibrous tumor of the chest (SFTC) is a subtype of solitary fibrous tumor (SFT) with a low incidence rate. The purpose of this study is to analyze the diagnosis and treatment of SFTC and the difference between benign and malignant solitary fibrous tumor of the pleura (SFTP) to improve the understanding of this rare disease.MethodsA retrospective analysis of fifty patients with SFTC (33 cases in the pleura and 17 in the lung) was performed. Clinical and imaging characteristics, pathological features, and treatment follow-up outcomes were analyzed.ResultsThe common symptoms of the 50 patients included a cough, expectoration, chest tightness, fever, and chest pain. Space occupying lesions were found via plain computed tomography (CT) and enhanced CT was used for enhancement of the tumors. It was also found that 18 cases had necrosis, and 5 cases had calcification. The histopathology results showed that frequent nuclear division, obvious morphological variation, necrosis, and the high expression of Ki-67 cells are markers of malignant SFTC. There were significant differences in age, chest tightness, necrotic foci in CT, and expression of Ki-67 between the benign and malignant SFTP cases. All the patients who received treatment were given an excellent prognosis.ConclusionA combination of enhanced CT, histopathology, and immunohistochemistry can be used for the accurate diagnosis of SFTC. Advanced age, chest tightness, necrotic foci in CT, and a high Ki-67 index were more likely to be malignant SFTP. Operation and radiofrequency ablation can provide favorable outcomes for both benign and malignant SFTC.

scholarly journals Extrapleural Solitary Fibrous Tumor (SFT) at Dorsum Foot - A Rare Case Report

2016 ◽  
Vol 2 (5) ◽  
Author(s):  
Singh Harpal ◽  
Ramandeep Kaur ◽  
Ramandeep Kaur ◽  
Sunita Bhagat ◽  
Ramanpreet Kaur ◽  
...  
Keyword(s):  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Rare Case ◽  
Rare Case Report ◽  
Fibrous Tumor ◽  
Extrapleural Solitary Fibrous Tumor

scholarly journals Clinical presentation, natural history and therapeutic approach in patients with solitary fibrous tumor: A retrospective analysis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e22522-e22522
Author(s):  
Patrick Schoffski ◽  
Iris Timmermans ◽  
Daphne Hompes ◽  
Marguerite Stas ◽  
Veerle Boecxstaens ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Metastatic Disease ◽  
Solitary Fibrous Tumor ◽  
Systemic Therapy ◽  
Single Agent ◽  
Disease Free Survival ◽  
Metachronous Metastasis ◽  
Palliative Intent ◽  
Fibrous Tumor

e22522 Background: Solitary fibrous tumor (SFT), a rare variant of soft tissue sarcoma (STS), is characterized by the presence of a NAB2-STAT6 fusion. Given the orphan character of SFT we performed a retrospective analysis. Methods: We retrospectively reviewed all patients (pts) with SFT treated in our institution between 12/1990 - 09/2017. Results: We identified 94 SFT pts (incl. hemangiopericytoma) with a med. follow-up for 4.7 yrs. Common anatomic sites were chest (33%), abdomen (21.3%), brain (12.8%) and extremities (9.6%). The symptomatology at diagnosis was variable. Only 6.4% presented with synchronous metastasis. Hypoglycemia (Doege-Potter syndrome) was seen in 2.1% of cases. A resection of the primary SFT was done in 86 pts (91.5%), their disease-free survival was 35.5 mo and 43% stayed SFT-free during follow-up. Local recurrence occurred in 26.7% of cases, associated with a med. overall survival (OS) of 45.1 mo. Metachronous metastasis was seen in 30.2% of pts, occurring after a med. follow-up of 36 mo. Med. OS after diagnosis of metastasis was 19.0 mo. Systemic therapy was given to 92.9% of pts with inoperable/metastatic disease. The most common 1st line therapy was doxorubicin single agent (57.7% of pts), achieving responses in 13.3% of pts. 2nd line therapies included ifosfamide and pazopanib (31.3% of pts each), 3rd line treatment was very heterogeneous. Conclusions: SFT is an orphan malignancy with a variable clinical course, low incidence of distant spread at first diagnosis but considerable risk of local failure and metachronous metastasis. Surgery is the only curative option at diagnosis, time of relapse and in case of resectable metastasis. Palliative systemic therapy is considered in pts with inoperable/metastatic disease but achieves low response rates. The natural course and survival outcomes of SFT cases treated with palliative intent tend to be better than in non-selected STS pts.

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