Comparison of Diagnostic Performance of Three-Dimensional Positron Emission Mammography versus Whole Body Positron Emission Tomography in Breast Cancer

Objective. To compare the diagnostic performance of three-dimensional (3D) positron emission mammography (PEM) versus whole body positron emission tomography (WBPET) for breast cancer.Methods. A total of 410 women with normal breast or benign or highly suspicious malignant tumors were randomized at 1 : 1 ratio to undergo 3D-PEM followed by WBPET or WBPET followed by 3D-PEM. Lumpectomy or mastectomy was performed on eligible participants after the scanning.Results. The sensitivity and specificity of 3D-PEM were 92.8% and 54.5%, respectively. WBPET showed a sensitivity of 95.7% and specificity of 56.8%. After exclusion of the patients with lesions beyond the detecting range of the 3D-PEM instrument, 3D-PEM showed higher sensitivity than WBPET (97.0% versus 95.5%,P= 0.913), particularly for small lesions (<1 cm) (72.0% versus 60.0%,P= 0.685).Conclusions. The 3D-PEM appears more sensitive to small lesions than WBPET but may fail to detect lesions that are beyond the detecting range. This study was approved by the Ethics Committee (E2012052) at the Tianjin Medical University Cancer Institute and Hospital (Tianjin, China). The instrument positron emission mammography (PEMi) was approved by China State Food and Drug Administration under the registration number 20153331166.

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Pretreatment CLR 124 Positron Emission Tomography Accurately Predicts CLR 131 Three-Dimensional Dosimetry in a Triple-Negative Breast Cancer Patient

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/cbr.2018.2568 ◽

2019 ◽

Vol 34 (1) ◽

pp. 13-23

Author(s):

Abigail E. Besemer ◽

Joseph J. Grudzinski ◽

Jamey P. Weichert ◽

Lance T. Hall ◽

Bryan P. Bednarz

Keyword(s):

Breast Cancer ◽

Positron Emission Tomography ◽

Cancer Patient ◽

Breast Cancer Patient ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Three Dimensional ◽

Emission Tomography ◽

Positron Emission

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Texture Analysis in the Diagnosis of Primary Breast Cancer: Comparison of High-Resolution Dedicated Breast Positron Emission Tomography (dbPET) and Whole-Body PET/CT

Frontiers in Medicine ◽

10.3389/fmed.2020.603303 ◽

2020 ◽

Vol 7 ◽

Author(s):

Yoko Satoh ◽

Kenji Hirata ◽

Daiki Tamada ◽

Satoshi Funayama ◽

Hiroshi Onishi

Keyword(s):

Breast Cancer ◽

Positron Emission Tomography ◽

High Resolution ◽

Texture Analysis ◽

Texture Features ◽

Emission Tomography ◽

Whole Body ◽

Tumor Characteristics ◽

Positron Emission ◽

Pet Ct

Objective: This retrospective study aimed to compare the ability to classify tumor characteristics of breast cancer (BC) of positron emission tomography (PET)-derived texture features between dedicated breast PET (dbPET) and whole-body PET/computed tomography (CT).Methods: Forty-four BCs scanned by both high-resolution ring-shaped dbPET and whole-body PET/CT were analyzed. The primary BC was extracted with a standardized uptake value (SUV) threshold segmentation method. On both dbPET and PET/CT images, 38 texture features were computed; their ability to classify tumor characteristics such as tumor (T)-category, lymph node (N)-category, molecular subtype, and Ki67 levels was compared. The texture features were evaluated using univariate and multivariate analyses following principal component analysis (PCA). AUC values were used to evaluate the diagnostic power of the computed texture features to classify BC characteristics.Results: Some texture features of dbPET and PET/CT were different between Tis-1 and T2-4 and between Luminal A and other groups, respectively. No association with texture features was found in the N-category or Ki67 level. In contrast, receiver-operating characteristic analysis using texture features' principal components showed that the AUC for classification of any BC characteristics were equally good for both dbPET and whole-body PET/CT.Conclusions: PET-based texture analysis of dbPET and whole-body PET/CT may have equally good classification power for BC.

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