scholarly journals Optimal Solubility of Diclofenacβ-Cyclodextrin in Combination with Local Anaesthetics for Mesotherapy Applications

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Giuseppe Tringali ◽  
Pierluigi Navarra
Keyword(s):  
Normal Saline ◽  
Local Anaesthetic ◽  
Visual Analysis ◽  
Local Anaesthetics ◽  
Sterile Water ◽  
Injection Volume ◽  
Ideal Candidate ◽  
Final Injection

Because of low injection volume, the recently marketed injectable solution of diclofenac in complex withβ-cyclodextrin (Akis®, IBSA Farmaceutici Italia) is an ideal candidate for mesotherapy applications. In this study, we investigated the solubility of Akis, 25 and 50 mg/kg, in combination with various local anaesthetics (lidocaine, mepivacaine, bupivacaine, levobupivacaine, and ropivacaine) at different concentrations in aqueous vehicles (normal saline, sterile water, or bicarbonate). Final injection mixtures were classified as limpid, turbid, or milky at visual analysis under standardized conditions. We found that (i) the use of sterile water for injections or normal saline as vehicles to dilute Akis in combination with whatever local anaesthetic normally results in milky solutions and therefore is not recommended; (ii) using bicarbonate, optimal solubility was obtained combining Akis with lidocaine, both 1 and 2%, or mepivacaine, both 1 and 2%, whereas solutions were turbid in combination with bupivacaine, levobupivacaine, or ropivacaine. Thus, we recommend that Akis is used in combination with lidocaine or mepivacaine in a bicarbonate vehicle.

scholarly journals The effect of butacaine on adenine nucleotide binding and translocation in rat liver mitochondria

1975 ◽  
Vol 148 (3) ◽  
pp. 527-531 ◽  
Author(s):  
D R Fayle ◽  
G J Barritt ◽  
F L Bygrave
Keyword(s):  
Rat Liver ◽  
Local Anaesthetic ◽  
Binding Sites ◽  
Adenine Nucleotide ◽  
Adenine Nucleotides ◽  
Nucleotide Binding ◽  
Local Anaesthetics ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Mitochondrial Inner Membrane

The effect of the local anaesthetic, butacaine, on adenine nucleotide binding and translocation in rat liver mitochondria partially depleted of their adenine nucleotide content was investigated. The range of butacaine concentrations that inhibit adenine nucleotide translocation and the extent of the inhibition are similar to the values obtained for native mitochondria. Butacaine does not alter either the total number of atractyloside-sensitive binding sites of depleted mitochondria, or the affinity of these sites for ADP or ATP under conditions where a partial inhibition of the rate of adenine nucleotide translocation is observed. The data are consistent with an effect of butacaine on the process by which adenine nucleotides are transported across the mitochondrial inner membrane rather than on the binding of adenine nucleotides to sites on the adenine nucleotide carrier. The results are briefly discussed in relation to the use of local anaesthetics in investigations of the mechanism of adenine nucleotide translocation.

Local anaesthetics: Theoretical aspects

2021 ◽  
pp. 175573802110351
Author(s):  
Gareth Allen ◽  
Rebecca Butler
Keyword(s):  
Primary Care ◽  
Adverse Effects ◽  
Surgical Procedures ◽  
Local Anaesthetic ◽  
Secondary Care ◽  
Local Anaesthetics ◽  
Clinical Use ◽  
Minor Surgical Procedures ◽  
Nervous Conduction

Local anaesthetics are frequently used in both primary and secondary care. These agents transiently reduce the nervous conduction of nociceptive signals, reducing sensations of pain. In primary care, local anaesthetics are often used for minor surgical procedures. However, there are other uses for these agents. It is important to understand the issues encountered when using local anaesthetics in primary care. This review will cover clinical use, relevant pharmacology and adverse effects of the different local anaesthetic preparations.

Topical Anaesthesia to Reduce Pain Associated with Carpal Tunnel Surgery

2002 ◽  
Vol 27 (5) ◽  
pp. 462-464 ◽  
Author(s):  
T. M. LAWRENCE ◽  
V. V. DESAI
Keyword(s):  
Carpal Tunnel ◽  
Local Anaesthetic ◽  
Carpal Tunnel Release ◽  
Statistical Significance ◽  
Eutectic Mixture ◽  
Local Anaesthetics ◽  
Needle Insertion ◽  
Visual Analogue Pain ◽  
Pain Scores ◽  
Carpal Tunnel Surgery

This randomized, double-blinded study assessed the effectiveness of a topical anaesthetic, eutectic mixture of local anaesthetics (EMLA), in reducing pain associated with carpal tunnel release performed under local anaesthetic. Fifty-six patients undergoing carpal tunnel release under local anaesthetic were randomized into either EMLA ( n=29) or placebo ( n=27) groups. Visual analogue pain scores were obtained for needle insertion, injection of anaesthetic and surgery itself. Pain scores were significantly less for needle insertion ( P=0.001) and injection of anaesthetic ( P=0.0005). Scores related to surgery were also lower in the EMLA group, but this did not reach statistical significance.

scholarly journals Additional Analgesia for Central Venous Catheter Insertion: A Placebo Controlled Randomized Trial of Dexmedetomidine and Fentanyl

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Aloka Samantaray ◽  
Mangu Hanumantha Rao ◽  
Chitta Ranjan Sahu
Keyword(s):  
Central Venous Catheter ◽  
Normal Saline ◽  
Local Anaesthetic ◽  
Venous Catheter ◽  
Catheter Insertion ◽  
Double Blind Study ◽  
Central Venous Catheter Insertion ◽  
Central Venous ◽  
Anaesthetic Injection ◽  
Local Anaesthetic Injection

We aimed to show that a single preprocedural dose of either dexmedetomidine or fentanyl reduces procedural pain and discomfort and provides clinically acceptable sedation. In this prospective, double-blind study, sixty patients scheduled for elective surgery and requiring planned central venous catheter insertion were randomized to receive dexmedetomidine (1 μg/kg), fentanyl (1 μg/kg), or 0.9% normal saline intravenously over ten minutes followed by local anesthetic field infiltration before attempting central venous catheterization. The primary outcome measures are assessment and analysis of pain, discomfort, and sedation level before, during, and after the central venous catheter insertion at five time points. The median (IQR) pain score is worst for normal saline group at local anaesthetic injection [6 (4–6.7)] which was significantly attenuated by addition of fentanyl [3 (2–4)] and dexmedetomidine [4 (3–5)] in the immediate postprocedural period (P=0.001). However, the procedure related discomfort was significantly lower in dexmedetomidine group compared to fentanyl group in the first 10 min of procedure after local anaesthetic Injection (P=0.001). Fentanyl is more analgesically efficient for central venous catheter insertion along with local anaesthetic injection. However, dexmedetomidine has the potential to be superior to fentanyl and placebo in terms of providing comfort to the patients during the procedure.

Oral Acupuncture

1995 ◽  
Vol 13 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Jochen Gleditsch
Keyword(s):  
Effective Treatment ◽  
Oral Mucosa ◽  
Normal Saline ◽  
Local Anaesthetic ◽  
The Body ◽  
Internal Organs

The oral mucosa offers non traditional acupoints, forming an acupuncture microsystem that may be used for treatment of disease throughout the body. Through palpation of tender spots this system can be an aid to diagnosis, or by injection of tiny volumes of normal saline or local anaesthetic it can be used as an effective treatment. Oral acupuncture has been clinically tested over a period of 25 years and has proved effective for a variety of diseases. Additionally, relationships with internal organs and body acupoints have been demonstrated.

scholarly journals Effect of local anaesthetics on mitochondrial membrane potential in living cells

1990 ◽  
Vol 271 (1) ◽  
pp. 269-272 ◽  
Author(s):  
M Grouselle ◽  
O Tueux ◽  
P Dabadie ◽  
D Georgescaud ◽  
J P Mazat
Keyword(s):  
Cell Culture ◽  
Membrane Potential ◽  
Local Anaesthetic ◽  
Mitochondrial Membrane ◽  
Transmembrane Potential ◽  
Local Anaesthetics ◽  
Living Cells ◽  
Lipid Solubility ◽  
Laser Dye ◽  
Lipophilic Anion

Using the laser dye rhodamine 123, we demonstrated that local anaesthetics can reach mitochondria in cell culture and reversibly decrease, or even collapse, their transmembrane potential. This effect is highly dependent on the lipid-solubility of the local anaesthetic and can be facilitated by the presence of a lipophilic anion.

Comparison of cocaine and lignocaine as intranasal local anaesthetics

1988 ◽  
Vol 102 (7) ◽  
pp. 628-629 ◽  
Author(s):  
D. A. Jonathan ◽  
N. S. Violaris
Keyword(s):  
Nasal Cavity ◽  
Local Anaesthetic ◽  
Local Anaesthetics ◽  
The Other ◽  
Relative Efficacy ◽  
Anaesthetic Agents

AbstractThe relative efficacy of Cocaine and Lignocaine as local anaesthetic agents in the nose were compared. Twenty-five patients undergoing bilateral intra-nasal antroscopy under local anaesthetic were used as their own controls when one nasal cavity was anaesthetised with Cocaine and the other with Lignocaine. On 56 per cent of occasions the patients experienced no difference in the level of discomfort. However, on 36 per cent of occasions Cocaine was noted to give better subjective anaesthesia as compared with 8 per cent of occasions when Lignocaine was superior.

scholarly journals Efficacy of local anaesthetic and steroid combination in prevention of post-herpetic neuralgia: A meta-analysis

2022 ◽  
Vol 38 (3) ◽  
Author(s):  
Xiaolu Zhang ◽  
Zhiwei Wang ◽  
Yiyuan Xian
Keyword(s):  
Nerve Block ◽  
Local Anaesthetic ◽  
Meta Analysis ◽  
Local Anaesthetics ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Post Herpetic Neuralgia ◽  
Steroid Injections ◽  
Creative Commons ◽  
Neuralgic Pain

Objective: The objective was to provide synthesized evidence on the efficacy of local anaesthetics and steroid injections for prevention and management of PHN, compared to the standard treatment using anti-viral and analgesic medications. The primary outcomes of interest were incidence of PHN and duration of neuralgic pain. Methods: Comprehensive searches were done systematically through PubMed, Scopus, Cochrane Central Register of Controlled Trials and Google scholar databases. Randomized controlled trials that compared the efficacy of local anaesthetics and steroid injections for preventing and managing PHN were included for this meta-analysis. A comprehensive search was done for papers published until 15th July 2021. Results: A total of 10 RCTs were included in the meta-analysis. In the overall pooled analyses, compared to standard care/placebo, those receiving a combination of local anaesthetic and steroid injection had 55% lower risk of PHN at 3 months from onset of rash (RR 0.45; 95% CI, 0.29; 0.70). Out of the different modes of intervention delivery i.e., intravenous, subcutaneous and nerve block, maximum beneficial effect in reducing the incidence of PHN was noted in nerve block (RR 0.55; 95% CI, 0.34, 0.89). Conclusions: The meta-analysis provides some evidence to support the use of combined local anaesthetic and steroids in reducing risk of post-herpetic neuralgia and duration of neuralgic pain in patients with herpes zoster rash. doi: https://doi.org/10.12669/pjms.38.3.5140 How to cite this:Zhang X, Wang Z, Xian Y. Efficacy of local anaesthetic and steroid combination in prevention of post-herpetic neuralgia: A meta-analysis. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5140 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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