scholarly journals Matrix Metalloproteinase-9 Is a Predictive Factor for Systematic Hypertension and Heart Dysfunction in Patients with Obstructive Sleep Apnea Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Shuhui Wang ◽  
Shisheng Li ◽  
Bin Wang ◽  
Jiajia Liu ◽  
Qinglai Tang
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Cardiovascular Diseases ◽  
Matrix Metalloproteinase ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Metalloproteinase 9

Patients with obstructive sleep apnea syndrome (OSAS) showed higher prevalence in cardiovascular diseases due to aberrant hypoxia and oxidative stress. However, not all OSAS patients end up with cardiovascular disorders, and identification of novel biomarker will be invaluable for differentiating patients at risk. Here we tested the serum matrix metalloproteinase-9 (MMP-9) levels in 47 untreated OSAS patients and found that the MMP-9 level was positively correlated with severity of OSAS, which was consistent with hypoxia degree and duration. Besides, the MMP-9 level was higher in patients complicated with systematic hypertension (P < 0.001). Furthermore, we selected those OSAS patients without any cardiovascular dysfunction (n=35) and followed up for up to five years. By the end of follow-up, 12 patients had hypertension onset and 3 patients had left ventricular hypertrophy. By analyzing the clinical outcomes with MMP-9 expression, we demonstrated that high serum MMP-9 in OSAS patients was a risk factor for occurrence of cardiovascular diseases. In addition, we cultured the vascular endothelial cells (VEC) from rat aorta in hypoxia condition to investigate whether MMP-9 was elevated due to hypoxia in OSAS patients. Cellular results revealed that the expression, secretion, and activity of MMP-9 were all upregulated by hypoxia and can cleave the beta2-adrenergic receptor (β2AR) on VEC surface. Our results not only determined MMP-9 as a risk factor for cardiovascular diseases in OSAS patients, but also showed the possible involvement of hypoxia-MMP-9-β2AR signaling axis.

scholarly journals Obstructive sleep apnea syndrome is a risk factor for arterial hypertension

2003 ◽  
Vol 9 (2) ◽  
pp. 37-41
Author(s):  
A. L. Kalinkin
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Cardiovascular Diseases ◽  
Arterial Hypertension ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Experimental Studies ◽  
Obstructive Sleep ◽  
Apnea Syndrome

The obstructive sleep apnea syndrome (OSAS) is a risk factor for cardiovascular diseases The results of epidemiological, observational, and experimental studies support the fact that OSAS is of considerable importance in the development of arterial hypertension via chronic sympathetic activation and sleep-induced neurohumoral changes OSAS is of prime importance in the development of refractory AH CPAP therapy not only eliminates sleep-induced obstructive respiratory impairments, but frequently lowers blood pressure in hypertensive patients, and improves the prognosis of cardiovascular diseases

Is obstructive sleep apnea syndrome a risk factor for auditory pathway?

2011 ◽  
Vol 16 (2) ◽  
pp. 413-417 ◽  
Author(s):  
Manuele Casale ◽  
Emanuela Vesperini ◽  
Massimiliano Potena ◽  
Marco Pappacena ◽  
Federica Bressi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Auditory Pathway ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Obstructive sleep apnea syndrome

2009 ◽  
Vol 6 (1) ◽  
pp. 32-41
Author(s):  
Aleksandr Yur'evich Litvin ◽  
Irina Evgen'evna Chazova ◽  
A Y Litvin ◽  
I E Chazova
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiovascular Diseases ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Present Stage ◽  
Obstructive Sleep ◽  
Major Treatment ◽  
Apnea Syndrome ◽  
Multiple References

The paper describes the major mechanisms of occurrence of obstructive sleep apnea syndrome (OSAS). Large populationbased randomized studies in this area show the importance and prevalence of obstructive sleep respiratory disorders and provide evidence for their clinical significance in the practice of a therapist and cardiologist. Multiple references demonstrate the specific features of an association of OSAS with cardiovascular diseases, as well as major treatment approaches and methods at the present stage are given. Key words: obstructive sleep apnea syndrome, pathogenesis, epidemiology, diagnosis, clinical picture, treatment, cardiovascular diseases

scholarly journals Comparison of the Effects of the Somatotype on the Physical Activity, Kinesiophobia, and Fatigue Levels of Obstructive Sleep Apnea Syndrome Patients and Healthy Individuals

2021 ◽  
Author(s):  
Şeyma Toy ◽  
Rukiye Çiftçi ◽  
Deniz Şenol ◽  
Fatma Kizilay ◽  
Hilal Ermiş
Keyword(s):  
Physical Activity ◽  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Activity Level ◽  
Healthy Individuals ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: We aimed to compare the physical activity, kinesiophobia, and fatigue levels of obstructive sleep apnea syndrome (OSAS) patients and healthy individuals in terms their somatotypes. Methods: A total of 165 individuals were enrolled referred to the Department of Chest Diseases Sleep Disorders Center Outpatient Clinic of Inonu University, Malatya, Turkey in 2018. The somatotype analysis was conducted using the Heath-Carter method, the fatigue level was assessed using the Functional Assessment of Chronic Illness Therapy (FACIT) fatigue scale, the kinesiophobia level was assessed using the Tampa Scale for Kinesiophobia (TSK), and the physical activity level was assessed using the International Physical Activity Questionnaire (IPAQ). Results: The results of the somatotype analysis revealed 3 different somatotypes in the healthy individuals and the OSAS patients’ mesomorph endomorph, endomorphic mesomorph, and mesomorphic endomorph. When comparing the somatotypes of the healthy individuals and the OSAS patients, statistically significant differences were found in the FACIT scores of the mesomorph endomorphs, the IPAQ and FACIT scores of the endomorphic mesomorphs, and the TSK and FACIT scores of the mesomorphic endomorphs (P<0.05). Conclusion: In all three somatotypes of the OSAS patients, the fatigue index scores were higher when compared to those of the healthy individuals. Moreover, when compared with the healthy individuals, the physical activity levels of the endomorphic mesomorphs with OSAS were low, while the kinesiophobia scores of the mesomorphic endomorphs with OSAS were high. Based on the results of this study, in OSAS patients, the endomorphic mesomorph somatotype could be a risk factor for reduced physical activity, while the mesomorphic endomorph somatotype could be a risk factor for increased kinesiophobia.

EVALUATION OF OBSTRUCTIVE SLEEP APNEA SYNDROME AS A RISK FACTOR FOR DIABETIC MACULAR EDEMA IN PATIENTS WITH TYPE II DIABETES

Retina ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 274-280 ◽  
Author(s):  
Anne-Laure Vié ◽  
Laurent Kodjikian ◽  
Emilie Agard ◽  
Nicolas Voirin ◽  
Hussam El Chehab ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Macular Edema ◽  
Obstructive Sleep Apnea Syndrome ◽  
Type Ii Diabetes ◽  
Sleep Apnea Syndrome ◽  
Type Ii ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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