scholarly journals The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Huikang Tao ◽  
Pei Xie ◽  
Yuhang Cao ◽  
Liqi Shu ◽  
Liping Li ◽  
...  

Background. DNA demethylation, the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), plays important roles in diverse biological processes and multiple diseases by regulating gene expression. Methods. In this study, utilizing DNA dot blot, immunofluorescence staining, and qRT-PCR, we studied the expression pattern of Tets, the enzymes governing DNA demethylation, and the levels of 5hmC, 5fC, and 5caC during the postnatal neuronal development of mice. Results. It was found that 5hmC, 5fC, and 5caC were highly enriched in multiple brain regions and aNSCs and displayed temporal and spatial patterns during postnatal neuronal development and the differentiation of aNSCs. Consistently, the expression of Tets also exhibited temporal and spatial patterns. Conclusion. DNA demethylation displayed dynamic features during postnatal neuronal development and the differentiation of aNSCs of mice, which could contribute to appropriate gene expression.

1995 ◽  
Vol 171 (2) ◽  
pp. 374-385 ◽  
Author(s):  
Keiji Inohaya ◽  
Shigeki Yasumasu ◽  
Mika Ishimaru ◽  
Akihiro Ohyama ◽  
Ichiro Iuchi ◽  
...  

2009 ◽  
Vol 180 (1) ◽  
pp. 151-160 ◽  
Author(s):  
Christophe M. R. LeMoine ◽  
Paul M. Craig ◽  
Kalindi Dhekney ◽  
Julie J. Kim ◽  
Grant B. McClelland

2018 ◽  
Vol 8 (2) ◽  
pp. 334-336
Author(s):  
A. V. Matsyura

Here we presented the preliminary results of hawk kite usage against the feral pigeons in some grain processing factory. We studied the temporal and spatial patterns of repellent effect and bird behavior. We suggested the feral pigeons gradually increase the level of tolerance towards the hawk kite if no additional repellent measures were undertaken. Moreover, even initially the feral pigeons demonstrate higher tolerance towards the hawk kite compared to the Rooks or Hooded Crows.


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