scholarly journals Vasogenic Cerebral Edema following CT Myelogram with Nonionic Omnipaque 300

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Sara Khodor ◽  
Scott Blumenthal
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Cerebral Edema ◽  
Complication Rates ◽  
Safe Procedure ◽  
Ionic Contrast ◽  
Nonionic Contrast Agent

Computed Tomography (CT) with myelogram is a relatively safe procedure. It requires the use of nonionic contrast agents which, unlike ionic contrast agents, have been associated with low complication rates. We report a case of a 69-year-old female who developed diffuse bilateral cerebral edema following a lumber myelogram with the use of intrathecal nonionic contrast agent Omnipaque (Iohexol) 300. We were able to find one other reported case of cerebral edema following the use of intrathecal nonionic contrast agent in the literature.

scholarly journals Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Petri Paakkari ◽  
Satu I. Inkinen ◽  
Miitu K. M. Honkanen ◽  
Mithilesh Prakash ◽  
Rubina Shaikh ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Articular Cartilage ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Photon Counting ◽  
Spectral Imaging ◽  
Ct Scanning ◽  
Photon Counting Detector ◽  
Tissue Contrast ◽  
Reference Parameters

AbstractPhoton-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.

Comparison of the Nonionic Contrast Agent Iopamidol and an Ionic Contrast Agent in Aortofemoral and Peripheral Arteriography

1984 ◽  
Vol 19 (Supplement) ◽  
pp. S210-S211 ◽  
Author(s):  
STEVEN R. MILLS ◽  
ARL V. MOORE ◽  
DENNIS K. HEASTON ◽  
SUSAN ALLEN ◽  
MILTON BATES ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Ionic Contrast ◽  
Nonionic Contrast Agent

The place of computed tomography as a guidance modality in percutaneous nephrostomy: analysis of a 10-year single-center experience

2007 ◽  
Vol 48 (7) ◽  
pp. 806-813 ◽  
Author(s):  
H. Egilmez ◽  
I. Oztoprak ◽  
M. Atalar ◽  
A. Cetin ◽  
C. Gumus ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Percutaneous Nephrostomy ◽  
Complication Rates ◽  
Safe Procedure ◽  
Single Center ◽  
Macroscopic Hematuria ◽  
Ct Guided ◽  
Single Center Experience ◽  
Major Complications ◽  
Inpatient Settings

Background: Percutaneous nephrostomy (PCN) has been established as an effective technique for urinary decompression or diversion. This procedure may be performed with the guidance of fluoroscopy, ultrasonography, a combination of fluoroscopy and ultrasonography, computed tomography (CT), or magnetic resonance imaging. Purpose: To retrospectively review experience with CT-guided PCN over a 10-year period in a single center. Material and Methods: All CT-guided PCN procedures performed in adults at our institution between 1995 and 2005 were evaluated. In 882 patients, 1113 nephrostomy catheters were inserted. Interventional radiologists or radiology residents under direct attending supervision inserted all catheters. During the PCN procedure, bleeding, sepsis, and injuries to adjacent organs were regarded as major complications. Clinical events requiring nominal therapy with no sequelae were regarded as minor complications. Results: PCN procedures were performed via 1–3 punctures in patients with grades 0–1 and 2 hydronephrosis, and via 1–2 punctures in patients with grade 3 hydronephrosis. They were carried out with a procedure time ranging from 9 to 26 min. All PCNs were considered as technically successful, and no major complications were observed. There were minor complications including transient macroscopic hematuria (28.6%, 19.9%, and 4.9% in patients with hydronephrosis grades 0–1, 2, and 3, respectively) and perirenal hematomas in a total of eight patients. No patient required additional intervention secondary to complications of the PCN procedure. Conclusion: CT-guided PCN is an efficient and safe procedure with major and minor complication rates below the accepted thresholds. It can be used for the management of patients requiring nephrostomy insertion in inpatient settings, and might be a preferable procedure in patients with minimal or no dilatation of the renal pelvis.

PEGylated Gd(OH)3 nanorods as metabolizable contrast agents for computed tomography imaging

2015 ◽  
Vol 39 (11) ◽  
pp. 8999-9005 ◽  
Author(s):  
Yingda Du ◽  
Ming Xing ◽  
Zhiman Li ◽  
Wei Guo
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Computed Tomography Imaging ◽  
Hydrothermal Route ◽  
Tomography Imaging

PEGylated Gd(OH)3 nanorods have been efficiently prepared via a facile and green hydrothermal route and used as a metabolizable computed tomography contrast agent for in vivo imaging.

scholarly journals Perbandingan Penyangatan Senyawa Pengontras Nano Partikel Emas Dendrimer Poly (Amidoamine) Konsentrasi dan Delay Time Berbeda pada Hepar Tikus dengan Pemeriksaan Computed Tomography

2016 ◽  
Vol 1 (3) ◽  
pp. 131-137
Author(s):  
Indrarini Listyowati ◽  
Rista D Soetikno ◽  
Leni Santiana
Keyword(s):  
Computed Tomography ◽  
Statistical Analysis ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ct Scan ◽  
Rat Liver ◽  
Delay Time ◽  
P Value ◽  
Average Value ◽  
Targeted Contrast Agents

Background: Computed tomography (CT) is one of the diagnostic imaging tool that is most commonly available in hospitals today. But unlike Magnetic Resonance Imaging (MRI) and nuclear medicine imaging modalities, CT has not been considered as a molecular imaging modality because it does not have a specifc-targeted contrast agents. Diagnostic quality of CT scans can be improved by using specifc-targeted contrast agents. Gold nanoparticles (AuNPs) can be used as X-ray contrast agents that can overcome some of the limitations of the iodine-based contrast agents. Higher atomic numbers than iodine and its ability to be able to bind to the dendrimer support that AuNPS could be developed as a specifc-targeted contrast agents.Objectives: The purpose of this study was to determine the enhancement relationship of AuNPs-Poly(amido)amine in the rat liver with di?erent concentration and delay time on CT scans.Materials and Methods: This research is an experimental study with a statistical analysis to determine enhancement di?erences on rat liver given AuNPs-PAMAM with di?erent concentration and delay time. The samples were divided into 4 groups, each consisting of 6 rats. The independent variables in this study were the delay time and the concentration of AuNPs-PAMAM, the dependent variables was the enhancement on rat liver.Results: The results obtained showed that the average value enhancement of AuNPs-PAMAM is highest in 10 minutes delay time at a concentration of 1 mg/dL. Statistical analysis showed that there were signifcant di?erences between AuNPs-PAMAM contrast enhancement in the rat liver with di?erent concentration and delay time on CT scan with p-value less than alpha (0.000 <0.05).Conclusions: Concentration and delay time contribute to the average value enhancement of AuNPs-PAMAM contrast agent on CT scan. This new type of contrast agent can be further developed as a more specifc-targeted contrast agent for CT scan examination.

scholarly journals Facile Fabrication of BiF3: Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jun Xie ◽  
Zonglang Zhou ◽  
Sihan Ma ◽  
Xian Luo ◽  
Jiajing Liu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Oral Administration ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ct Imaging ◽  
Average Particle ◽  
Gi Tract ◽  
X Ray ◽  
Ct Value ◽  
Ct Contrast

AbstractX-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number (Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm2 kg−1 at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF3: Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF3: Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF3: Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF3: Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF3: Ln@PVP NPs. Finally, the BiF3: Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF3: Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging.

scholarly journals Malignant Cerebral Edema following CT Myelogram Using Isovue-M 300 Intrathecal Nonionic Water-Soluble Contrast: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-6
Author(s):  
Brian C. Kelley ◽  
Simon Roh ◽  
Philip L. Johnson ◽  
Paul M. Arnold
Keyword(s):  
Case Report ◽  
Contrast Medium ◽  
Current Literature ◽  
Cerebral Edema ◽  
Intrathecal Injection ◽  
Water Soluble ◽  
Complication Rates ◽  
Nonionic Contrast Medium ◽  
Ionic Contrast ◽  
Water Soluble Contrast

Lumbar myelogram utilizing nonionic contrast is a commonly performed procedure to identify spinal pathology. Complication rates are low. Cerebral edema has been shown to occur following intrathecal injection of ionic contrast; however, no current literature has documented this complication relating to the ubiquitously used nonionic contrast medium. We report a case of a patient who developed malignant cerebral edema following a lumbar myelogram with Isovue-M 300 nonionic water-soluble intrathecal contrast. We believe this is the first reported case of cerebral edema resulting from the use of a nonionic contrast.

scholarly journals Immediate adverse reactions to intravenous iodinated contrast media in computed tomography

2007 ◽  
Vol 15 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Beatriz Cavalcanti Juchem ◽  
Clarice Maria Dall'Agnol
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agent ◽  
Quantitative Research ◽  
Adverse Reactions ◽  
Care Delivery ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Ionic Contrast ◽  
South Of Brazil

This exploratory-descriptive, non-experimental quantitative research aimed to learn about immediate adverse reactions to intravenous iodinated contrast media in hospitalized patients submitted to computed tomography at a teaching hospital in the South of Brazil. During the study period, all adverse reactions showed mild intensity, at a frequency of 12.5% with ionic iodinated contrast media, and 1% with non-ionic contrast agent. The extravasation of contrast occurred in 2.2% of the injections in a peripheral vein without complications in any of the cases. The results are within the limits cited in international literature and suggest that tomography service professionals should know their own rates of adverse reactions to iodinated contrast agent, as well as the conditions in which they occur, in order to obtain evidence to evaluate the respective care delivery processes.

Dose optimization of nonionic contrast agent in dynamic computed tomography scanning of the abdomen and pelvis

1994 ◽  
Vol 18 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Deborah A. Allen ◽  
Christophoros Stoupis ◽  
Gladys M. Torres ◽  
Glenn A. Call ◽  
Tony L. Litwiller ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Dose Optimization ◽  
Dynamic Computed Tomography ◽  
Computed Tomography Scanning ◽  
Tomography Scanning ◽  
Nonionic Contrast Agent
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