Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. The overall results indicated thatVDRrs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD. However, a stratification analysis based on clinical types showed thatVDRrs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT. A stratification analysis by ethnicity showed thatVDRrs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.VDRrs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.VDRrs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.VDRrs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations. In conclusion, the present study suggested thatVDRrs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results.

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Vitamin D Receptor Gene (VDR) Polymorphisms Are Not Associated with Autoimmune Thyroid Disease Risk in Turner Syndrome Patients

10.1210/endo-meetings.2011.part4.p8.p3-594 ◽

2011 ◽

pp. P3-594-P3-594

Author(s):

Bianca Bianco ◽

Ieda Therezinha do Nascimento Verreschi ◽

Kelly Cristina Oliveira ◽

Alexis Dourado Guedes ◽

Caio Parente Barbosa ◽

...

Keyword(s):

Vitamin D ◽

Turner Syndrome ◽

Vitamin D Receptor ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Disease Risk ◽

Receptor Gene ◽

Vitamin D Receptor Gene ◽

Autoimmune Thyroid ◽

Vdr Polymorphisms

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Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease

Nutrients ◽

10.3390/nu7042485 ◽

2015 ◽

Vol 7 (4) ◽

pp. 2485-2498 ◽

Cited By ~ 70

Author(s):

Jiying Wang ◽

Shishi Lv ◽

Guo Chen ◽

Chenlin Gao ◽

Jianhua He ◽

...

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Meta Analysis ◽

Autoimmune Thyroid

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Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial

Nigerian Medical Journal ◽

10.4103/nmj.nmj_200_20 ◽

2020 ◽

Vol 61 (5) ◽

pp. 237

Author(s):

KishoreKumar Behera ◽

GautomKumar Saharia ◽

Debasish Hota ◽

DurgeshPrasad Sahoo ◽

Madhusmita Sethy ◽

...

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Thyroid Autoimmunity ◽

Vitamin D Supplementation ◽

Open Label ◽

Autoimmune Thyroid ◽

Coastal Province ◽

Open Label Trial

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Association of serum IL-21 and vitamin D concentrations in Chinese children with autoimmune thyroid disease

Clinica Chimica Acta ◽

10.1016/j.cca.2020.04.030 ◽

2020 ◽

Vol 507 ◽

pp. 194-198

Author(s):

Yaling Feng ◽

Ting Qiu ◽

Huijuan Chen ◽

Yarong Wei ◽

Xinye Jiang ◽

...

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Chinese Children ◽

Autoimmune Thyroid

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The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

Endocrine Journal ◽

10.1507/endocrj.ej19-0307 ◽

2020 ◽

Vol 67 (3) ◽

pp. 317-326 ◽

Cited By ~ 2

Author(s):

Ziyi Chen ◽

Yue Wang ◽

Xi Ding ◽

Meng Zhang ◽

Mingqian He ◽

...

Keyword(s):

T Cells ◽

Peripheral Blood ◽

Thyroid Disease ◽

Cd4 T Cells ◽

Autoimmune Thyroid Disease ◽

Meta Analysis ◽

Autoimmune Thyroid

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Association between vitamin D receptor (VDR) polymorphisms and the risk of multiple sclerosis (MS): an updated meta-analysis

BMC Neurology ◽

10.1186/s12883-019-1577-y ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 7

Author(s):

Danyal Imani ◽

Bahman Razi ◽

Morteza Motallebnezhad ◽

Ramazan Rezaei

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Asian Populations ◽

Increased Risk ◽

Apai Polymorphism

Abstract Background The association between the Vitamin D Receptor (VDR) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several researches. However, the findings were inconsistent and inconclusive. Therefore, we set out a meta-analysis of all eligible published case-control studies to obtain an exact evaluation of the association between VDR gene polymorphisms and MS. Method All relevant studies reporting the association between the VDR gene FokI (rs2228570), or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms and susceptibility to MS published up to May, 2019 were identified by comprehensive systematic search in the electronic database of web of science, Scopus, and PubMed. After that, the strength of association between VDR gene polymorphisms and susceptibility to MS was evaluated by odds ratio (OR) and 95% confidence interval (CI). Results A total of 30 case–control studies were included in the meta-analysis. The overall results suggested a significant association between TaqI polymorphism and MS risk under heterozygote genetic model (OR = 1.27, 95%CI = 1.01–1.59, random effect). Moreover, the pooled results of subgroup analysis declined presence of significant association under all defined genetic model. In subgroup analysis, BsmI polymorphisms was associated with increased risk of MS under recessive model in Asian populations. On the other hand, ApaI polymorphism was associated with decreased risk of MS under recessive and aa vs. AA model in Asian populations. Conclusion This meta-analysis suggested a significant association between TaqI polymorphism and MS susceptibility. Furthermore, BsmI polymorphism was associated with increased risk of MS in Asian populations. In contrast, ApaI polymorphism was associated with decreased risk of MS in Asian populations. Future large-scale studies on gene–environment and gene–gene interactions are required to estimate risk factors and assist early diagnosis of patients at high risk for MS.

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Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis

Endocrine Connections ◽

10.1530/ec-16-0110 ◽

2017 ◽

Vol 6 (3) ◽

pp. 159-171 ◽

Cited By ~ 22

Author(s):

Ozlem Atan Sahin ◽

Damla Goksen ◽

Aysel Ozpinar ◽

Muhittin Serdar ◽

Huseyin Onay

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Receptor ◽

Meta Analysis ◽

Vdr Gene ◽

Increased Risk ◽

Funnel Plots ◽

Type 1 Dm ◽

Study Inclusion

Background There have been studies focused on FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results. Methods This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age. Results A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB (P < 0.05), BsmIBb, (P < 0.05), BsmIbb (P < 0.05), TaqITT (P < 0.05) and TaqItt (P < 0.05) in children. Conclusion The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of type 1 DM, whereas BsmIbb and TaqITT had protective effect for type 1 DM in children.

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IS THE QUESTIONNAIRE USEFUL IN ASSESSING SERUM VITAMIN D LEVELS IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE?

7th SWS International Scientific Conference on SOCIAL SCIENCES - ISCSS 2020 Proceedings, ◽

10.5593/sws.iscss.2020.7.1/s13.67 ◽

2020 ◽

Author(s):

Ibadula Seila ◽

Olesea Scrinic ◽

Eduard Circo

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Serum Vitamin ◽

Autoimmune Thyroid ◽

Serum Vitamin D ◽

Vitamin D Levels

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Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Nutrients ◽

10.3390/nu12092791 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2791

Author(s):

Inês Henriques Vieira ◽

Dírcea Rodrigues ◽

Isabel Paiva

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Minor Role ◽

Vicious Cycle ◽

Autoimmune Process ◽

Autoimmune Thyroid ◽

A Minor ◽

Pleiotropic Expression ◽

The Relationship

Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

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