Effect of vitamin D supplementation on thyroid autoimmunity among subjects of autoimmune thyroid disease in a coastal province of India: A randomized open-label trial

The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. The overall results indicated thatVDRrs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD. However, a stratification analysis based on clinical types showed thatVDRrs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT. A stratification analysis by ethnicity showed thatVDRrs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.VDRrs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.VDRrs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.VDRrs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations. In conclusion, the present study suggested thatVDRrs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results.

Download Full-text

Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802012000500005 ◽

2012 ◽

Vol 130 (5) ◽

pp. 294-298 ◽

Cited By ~ 6

Author(s):

Ruy Felippe Brito Gonçalves Missaka ◽

Henrique Costa Penatti ◽

Maria Regina Cavariani Silvares ◽

Célia Regina Nogueira ◽

Gláucia Maria Ferreira da Silva Mazeto

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Case Control Study ◽

Thyroid Autoimmunity ◽

Case Control ◽

Chronic Idiopathic Urticaria ◽

Public Institution ◽

Autoimmune Thyroid ◽

Allergic Condition ◽

Control Study

CONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND SETTING: Case-control study including 115 patients with CIU at a tertiary public institution. METHODS: The patients were evaluated with regard to occurrence of angioedema and presence of ATD, hypothyroidism or hyperthyroidism. RESULTS: Angioedema was detected in 70 patients (60.9%). There were 22 cases (19.1%) of ATD, 19 (16.5%) of hypothyroidism and nine (7.8%) of hyperthyroidism. The risk among patients with ATD was 16.2 times greater than among those without this thyroid abnormality (confidence interval, CI = 2.07-126.86). The odds ratio for hypothyroidism was 4.6 (CI = 1.00-21.54) and, for hyperthyroidism, 3.3 (CI = 0.38-28.36). CONCLUSIONS: Patients with CIU and ATD presented greater risk of angioedema, which reinforces the idea that a relationship exists between this allergic condition and thyroid autoimmunity. This finding could imply that such patients require specifically directed therapy.

Download Full-text

IS THE QUESTIONNAIRE USEFUL IN ASSESSING SERUM VITAMIN D LEVELS IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE?

7th SWS International Scientific Conference on SOCIAL SCIENCES - ISCSS 2020 Proceedings, ◽

10.5593/sws.iscss.2020.7.1/s13.67 ◽

2020 ◽

Author(s):

Ibadula Seila ◽

Olesea Scrinic ◽

Eduard Circo

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Serum Vitamin ◽

Autoimmune Thyroid ◽

Serum Vitamin D ◽

Vitamin D Levels

Download Full-text

Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Nutrients ◽

10.3390/nu12092791 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2791

Author(s):

Inês Henriques Vieira ◽

Dírcea Rodrigues ◽

Isabel Paiva

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Minor Role ◽

Vicious Cycle ◽

Autoimmune Process ◽

Autoimmune Thyroid ◽

A Minor ◽

Pleiotropic Expression ◽

The Relationship

Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

Download Full-text

SUN-P299: Assessment of Vitamin D Level in Autoimmune Thyroid Disease in Turkish Population

Clinical Nutrition ◽

10.1016/s0261-5614(17)30332-1 ◽

2017 ◽

Vol 36 ◽

pp. S164

Author(s):

B.P. Sarer-Yurekli ◽

E. Bellikci-Koyu ◽

H. Ozisik ◽

D. Ongan ◽

G. Ozgen

Keyword(s):

Vitamin D ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Turkish Population ◽

Autoimmune Thyroid

Download Full-text

CTLA-4 and its role in autoimmune thyroid disease

Journal of Molecular Endocrinology ◽

10.1677/jme.0.0310021 ◽

2003 ◽

Vol 31 (1) ◽

pp. 21-36 ◽

Cited By ~ 90

Author(s):

DA Chistiakov ◽

RI Turakulov

Keyword(s):

T Lymphocyte ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Cytotoxic T Lymphocyte ◽

Thyroid Autoimmunity ◽

Hashimoto Thyroiditis ◽

Gene Encoding ◽

Autoimmune Thyroid ◽

Functional Studies

Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.

Download Full-text