scholarly journals Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Eun Jung Kyung ◽  
Hyun Bum Kim ◽  
Eun Sang Hwang ◽  
Seok Lee ◽  
Bup Kyung Choi ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Liver Cirrhosis ◽  
Magnetic Resonance ◽  
Biochemical Analysis ◽  
Normal Liver ◽  
Hepatoprotective Effect ◽  
Curcumin Treatment ◽  
Conductivity Imaging ◽  
Inflammatory Effect ◽  
Liver Tissues

In oriental medicine, curcumin is used to treat inflammatory diseases, and its anti-inflammatory effect has been reported in recent research. In this feasibility study, the hepatoprotective effect of curcumin was investigated using a rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Together with biochemical analysis, we used a magnetic resonance-based electrical conductivity imaging method to evaluate tissue conditions associated with a protective effect. The effects of curcumin treatment and lactulose treatment on liver cirrhosis were compared. Electrical conductivity images indicated that liver tissues damaged by DMN showed decreased conductivity compared with normal liver tissues. In contrast, cirrhotic liver tissues treated with curcumin or lactulose showed increased conductivity than tissues in the DMN-only group. Specifically, conductivity of cirrhotic liver after curcumin treatment was similar to that of normal liver tissues. Histological staining and immunohistochemical examination showed significant levels of attenuated fibrosis and decreased inflammatory response after both curcumin and lactulose treatments compared with damaged liver tissues by DMN. The conductivity imaging and biochemical examination results indicate that curcumin’s anti-inflammatory effect can prevent the progression of irreversible liver dysfunction.

Electrical conductivity imaging by magnetic resonance electrical impedance tomography (MREIT)

2003 ◽  
Vol 50 (4) ◽  
pp. 875-878 ◽  
Author(s):  
Suk H. Oh ◽  
Jae Y. Han ◽  
Soo Y. Lee ◽  
Min H. Cho ◽  
Byung I. Lee ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Magnetic Resonance ◽  
Electrical Impedance Tomography ◽  
Electrical Impedance ◽  
Impedance Tomography ◽  
Conductivity Imaging

scholarly journals Gene expression profiles in liver cirrhosis and normal liver tissues

2004 ◽  
Vol 12 (2) ◽  
pp. 339
Author(s):  
Lian-Xin Liu ◽  
Zhi-Hong Chen ◽  
Lin-Feng Wu ◽  
Hong-Wei Li ◽  
Zhi-Hua Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Cirrhosis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Normal Liver ◽  
Liver Tissues

scholarly journals Identification of Brain Damage after Seizures Using an MR-Based Electrical Conductivity Imaging Method

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 569
Author(s):  
Sanga Kim ◽  
Bup Kyung Choi ◽  
Ji Ae Park ◽  
Hyung Joong Kim ◽  
Tong In Oh ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Magnetic Resonance ◽  
Electrical Properties ◽  
Brain Damage ◽  
High Frequency ◽  
Neuronal Cell ◽  
Imaging Method ◽  
Nissl Staining ◽  
Functional Changes ◽  
Conductivity Imaging

Previous imaging studies have shown the morphological malformation and the alterations of ionic mobility, water contents, electrical properties, or metabolites in seizure brains. Magnetic resonance electrical properties tomography (MREPT) is a recently developed technique for the measurement of electrical tissue properties with a high frequency that provides cellular information regardless of the cell membrane. In this study, we examined the possibility of MREPT as an applicable technique to detect seizure-induced functional changes in the brain of rats. Ultra-high field (9.4 T) magnetic resonance imaging (MRI) was performed, 2 h, 2 days, and 1 week after the injection of N-methyl-D-aspartate (NMDA; 75 mg/kg). The conductivity images were reconstructed from B1 phase images using a magnetic resonance conductivity imaging (MRCI) toolbox. The high-frequency conductivity was significantly decreased in the hippocampus among various brain regions of NMDA-treated rats. Nissl staining showed shrunken cell bodies and condensed cytoplasm potently at 2 h after NMDA treatment, and neuronal cell loss at all time points in the hippocampus. These results suggest that the reduced electrical conductivity may be associated with seizure-induced neuronal loss in the hippocampus. Magnetic resonance (MR)-based electrical conductivity imaging may be an applicable technique to non-invasively identify brain damage after a seizure.

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