scholarly journals Florid Proliferation of Hyalinized Vessels in a Spermatic Cord STAT6 Positive Solitary Fibrous Tumor and Its Potential Clinical Implications

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Christopher P. Marquez ◽  
Haiyan Zhang ◽  
Jason Goodrum ◽  
J. Nicholas Sreshta ◽  
Marjan Afrouzian
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Rare Event ◽  
Stem Cell Differentiation ◽  
Anatomical Site ◽  
Microscopic Appearance ◽  
Mesenchymal Stem Cell Differentiation ◽  
Immunohistochemical Markers ◽  
Molecular Features ◽  
Fibrous Tumor

A solitary fibrous tumor (SFT) arising in the paratesticular region is a rare event. Typically most SFTs present as a lung mass and have a characteristic microscopic appearance. Although uncommon, SFTs may present at just about any anatomical site. Here we present a case of a SFT arising along the right spermatic cord, with histologic features mimicking a cellular angiofibroma. We describe the diagnostic immunohistochemical markers useful for arriving at its diagnosis. We also summarize our current understanding of the structural and molecular features that make up SFTs and discuss how these features may help us better understand the pathophysiology of pluripotent mesenchymal stem cell differentiation.

scholarly journals A Rare Case of a Solitary Fibrous Tumor of the Spermatic Cord

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Moyosore Awobajo ◽  
Stefanie Hettwer ◽  
Sarah Hackman
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Rare Case ◽  
Surgical Excision ◽  
Mesenchymal Tumors ◽  
Solitary Fibrous Tumors ◽  
Important Differential Diagnosis ◽  
History Of ◽  
Scrotal Swelling ◽  
Fibrous Tumor

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, originally identified in the pleura. Even though they have subsequently been described in several extrapleural sites, the incidence of SFTs in the spermatic cord is particularly rare. Here, we report a case of a 27-year-old male that presented with a 3-year history of left scrotal swelling. Computed tomography (CT) and ultrasound demonstrated multiple solid, hypoechoic well-circumscribed masses that were separate from the testis. Surgical excision of the mass led to pathologic diagnosis of a solitary fibrous tumor involving the spermatic cord. Solitary fibrous tumors, although rare, are an important differential diagnosis for urogenital tumors.

Aggressive CD34-positive Fibrous Scalp Lesion of Childhood: Extrapulmonary Solitary Fibrous Tumor

2001 ◽  
Vol 4 (3) ◽  
pp. 267-275 ◽  
Author(s):  
P.K. Ramdial ◽  
A. Madaree
Keyword(s):  
Solitary Fibrous Tumor ◽  
Infratemporal Fossa ◽  
Female Child ◽  
Soft Tissue Tumors ◽  
Cd34 Antigen ◽  
Immunohistochemical Markers ◽  
Cranial Fasciitis ◽  
Scalp Lesion ◽  
Fibrous Tumor

Although solitary fibrous tumor (SFT) was originally described as a pleural tumor, an increasing number of extrapleural sites of SFTs have been documented. This has been attributed not only to the heightened awareness of the spectrum of histopathological features that characterizes SFTs but also to the recognition of the role of CD34 immunostaining in soft tissue tumors in general, and in SFTs in particular. Despite the large number of documented extrapleural SFTs in adults, cranial SFTs are rare, having been documented in the meninges, scalp, and infratemporal fossa. Extrapleural SFTs are, to date, an unrecognized entity in children. We document an aggressive fibrous scalp lesion in a 30-month-old female child that demonstrated features common to benign cranial fasciitis and SFT. However, based on bright, diffuse CD34 antigen immunopositivity, a diagnosis of SFT was made. The need to include the CD34 antigen stain in a panel of immunohistochemical markers used to assess spindle cell lesions of childhood is emphasized.

Solitary fibrous tumor of the orbit: Morphological, cytogenetic and molecular features

2006 ◽  
Vol 26 (6) ◽  
pp. 557-563 ◽  
Author(s):  
Miguel Cerdá-Nicolás ◽  
Concha López-Gines ◽  
Rosario Gil-Benso ◽  
Rafael Benito ◽  
Antonio Pellin ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Molecular Features ◽  
Fibrous Tumor

An uncommon cause of inguinoscrotal swelling: Solitary fibrous tumor of the spermatic cord

2008 ◽  
Vol 67 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Ahmet Turan Ilica ◽  
Fatıh Ors ◽  
Murat Bag ◽  
Inanc Guvenc ◽  
Cihan Duran ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Fibrous Tumor

scholarly journals Solitary fibrous tumor of the spermatic cord: A case report and literature review

2014 ◽  
Vol 9 (1) ◽  
pp. 55-58 ◽  
Author(s):  
SHANBIAO HU ◽  
LU YI ◽  
LUOYAN YANG ◽  
YINHUAI WANG
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Fibrous Tumor

Histological and molecular features of solitary fibrous tumor of the extremities: clinical correlation

2019 ◽  
Vol 476 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Giuseppe Bianchi ◽  
Andrea Sambri ◽  
Elena Pedrini ◽  
Laura Pazzaglia ◽  
Luca Sangiorgi ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Clinical Correlation ◽  
Molecular Features ◽  
Fibrous Tumor

scholarly journals Orbital Solitary Fibrous Tumor: Four Case Reports—Clinical and Histopathological Features

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Carmen Navarro-Perea ◽  
Cristina Calleja-García ◽  
Álvaro Bengoa-González ◽  
María-C. Garrido ◽  
Enrique Mencía-Gutiérrez ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Case Reports ◽  
Surgical Removal ◽  
Movement Restriction ◽  
Ultrasonic Aspirator ◽  
Immunohistochemical Markers ◽  
History Of ◽  
Fibrous Tumor ◽  
Multiple Recurrences ◽  
Orbital Invasion

Purpose. To retrospectively describe the clinical characteristics, management, and outcomes of four cases of orbital solitary fibrous tumor (SFT). In one patient, we present an ultrasonic aspirator system for tumor removal. Methods. Four patients with orbital SFT were selected: one patient with orbital SFT, another patient with frontal and ethmoidal SFT and orbital affectation with high rates of recurrence, the third patient with frontal lobe SFT and orbital invasion with multiple recurrences, and the fourth case with a history of craniopharyngioma surgery and SFT located on the orbital apex. Results. All cases showed proptosis, eye movement restriction, and, in three cases, visual acuity alteration. Different treatments were applied: in three cases, excision was performed, one of them with an ultrasonic aspirator system, and in the remaining case, an exenteration was done (in two cases, radiosurgery treatment was also applied). The immunohistochemical study revealed SFT, similar to hemangiopericytomas (HPCs). No recurrence has been observed after surgical treatment. Conclusion. The SFT is a spectrum of different tumors with similar histopathological characteristics. The use of immunohistochemical markers is very helpful in the diagnosis. The main problem of orbital involvement is the risk of damaging important structures adjacent to the tumor during the surgical removal. The ultrasonic aspirator system allows elimination of the tumor without damaging other orbital structures.

scholarly journals Clinical, Histological, and Molecular Features of Solitary Fibrous Tumor of Bone: A Single Institution Retrospective Review

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2470
Author(s):  
Giuseppe Bianchi ◽  
Debora Lana ◽  
Marco Gambarotti ◽  
Cristina Ferrari ◽  
Marta Sbaraglia ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Soft Tissues ◽  
Immunohistochemical Analysis ◽  
Pcr Analysis ◽  
Molecular Features ◽  
Chimeric Transcripts ◽  
High Cellularity ◽  
Mitotic Figures ◽  
Fibrous Tumor ◽  
Promoter Mutations

Primary solitary fibrous tumor (SFT) of the bone is extremely rare, with only few cases reported in the literature. We retrieved all cases of primary SFT of the bone treated at our institution and we assessed the morphology and the immunohistochemical and molecular features to investigate the clinical outcome of primary SFT of the bone and any clinical relevance of clinical and histological criteria of aggressiveness currently adopted for the soft tissues counterpart. Morphologically, 15 cases evidenced high cellularity, cytologic atypia, and foci of necrosis and were associated with more than 4 mitotic figures/10 HPF. Immunohistochemical analysis showed an expression of CD34 and of STAT6 immunopositivity in 95% and in 100% of cases, respectively. The presence of NAB2-STAT6 chimeric transcripts was found in 10 out of 12 cases in which RT-PCR analysis was feasible, whereas TERT promoter mutations analysis was feasible in 16 cases and only a C-to-T substitution in a heterozygous state was found in one DNA sample for the C228T genetic variant. P53 variants were assessed in 12 cases: 11 (91.6%) cases showed a variation, while in one case, no alteration was found. Disease-specific survival was 64% at 5 years and 49% at 10 years. Statistical analysis showed no correlation between survival and all the clinicopathological and molecular parameters evaluated. In conclusion, at difference to SFT of soft tissues, aggressive behavior of primary SFT of the bone seems to be independent from mitotic count or any other clinicopathological and molecular features.

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