scholarly journals Clinical, Histological, and Molecular Features of Solitary Fibrous Tumor of Bone: A Single Institution Retrospective Review

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2470
Author(s):  
Giuseppe Bianchi ◽  
Debora Lana ◽  
Marco Gambarotti ◽  
Cristina Ferrari ◽  
Marta Sbaraglia ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Soft Tissues ◽  
Immunohistochemical Analysis ◽  
Pcr Analysis ◽  
Molecular Features ◽  
Chimeric Transcripts ◽  
High Cellularity ◽  
Mitotic Figures ◽  
Fibrous Tumor ◽  
Promoter Mutations

Primary solitary fibrous tumor (SFT) of the bone is extremely rare, with only few cases reported in the literature. We retrieved all cases of primary SFT of the bone treated at our institution and we assessed the morphology and the immunohistochemical and molecular features to investigate the clinical outcome of primary SFT of the bone and any clinical relevance of clinical and histological criteria of aggressiveness currently adopted for the soft tissues counterpart. Morphologically, 15 cases evidenced high cellularity, cytologic atypia, and foci of necrosis and were associated with more than 4 mitotic figures/10 HPF. Immunohistochemical analysis showed an expression of CD34 and of STAT6 immunopositivity in 95% and in 100% of cases, respectively. The presence of NAB2-STAT6 chimeric transcripts was found in 10 out of 12 cases in which RT-PCR analysis was feasible, whereas TERT promoter mutations analysis was feasible in 16 cases and only a C-to-T substitution in a heterozygous state was found in one DNA sample for the C228T genetic variant. P53 variants were assessed in 12 cases: 11 (91.6%) cases showed a variation, while in one case, no alteration was found. Disease-specific survival was 64% at 5 years and 49% at 10 years. Statistical analysis showed no correlation between survival and all the clinicopathological and molecular parameters evaluated. In conclusion, at difference to SFT of soft tissues, aggressive behavior of primary SFT of the bone seems to be independent from mitotic count or any other clinicopathological and molecular features.

scholarly journals Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

2016 ◽  
Vol 19 (1) ◽  
pp. 113
Author(s):  
Antonione Santos Bezerra Pinto ◽  
Vera Cavalcanti De Araújo ◽  
Fabrício Passador Santos ◽  
José Ferreira de Menezes Filho ◽  
Viviane Siqueira ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Hard Palate ◽  
Salivary Gland Tumor ◽  
Immunohistochemical Analysis ◽  
Soft Tissue Tumors ◽  
Rare Entity ◽  
Gland Tumor ◽  
Clinical Imaging ◽  
Fibrous Tumor

<p align="justify"><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US">A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least </span></span></span></span><span style="font-family: Arial, serif;"><span><span lang="en-US">2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. </span></span></span><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US">Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. </span></span></span></span></p><p lang="en-US" align="justify"> </p><p align="justify"><span style="color: #000000;"><span style="font-family: Arial, serif;"><span><span lang="en-US"><strong><span>Keywords</span></strong></span></span></span></span></p><p align="justify"><span style="font-family: Arial, serif;"><span><span lang="en-US">Solitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.</span></span></span></p><p lang="en-US" align="justify"> </p>

scholarly journals TERT promoter mutations and prognosis in solitary fibrous tumor

2016 ◽  
Vol 29 (12) ◽  
pp. 1511-1522 ◽  
Author(s):  
Armita Bahrami ◽  
Seungjae Lee ◽  
Inga-Marie Schaefer ◽  
Jennifer M Boland ◽  
Kurt T Patton ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Fibrous Tumor ◽  
Promoter Mutations

scholarly journals Histopathological and Immunohistochemical Analysis of 6 Cases of Solitary Fibrous Tumor of the Pleura.

Haigan ◽  
1998 ◽  
Vol 38 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Futoshi Tsubokawa ◽  
Yukio Takeshima ◽  
Taijirou Sueda ◽  
Hiroo Shikata ◽  
Shinkichiro Yoshioka ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Immunohistochemical Analysis ◽  
Fibrous Tumor

scholarly journals Primary endodermal hemangiopericytoma/solitary fibrous tumor of the cervical spine: a case report and literature review

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liyun Wang ◽  
Jianbo Yu ◽  
Dongping Shu ◽  
Bin Huang ◽  
Yumin Wang ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Magnetic Resonance ◽  
Solitary Fibrous Tumor ◽  
Postoperative Radiotherapy ◽  
Immunohistochemical Analysis ◽  
Resonance Spectroscopy ◽  
Common Location ◽  
Imaging Characteristics ◽  
Fibrous Tumor

Abstract Background Hemangiopericytoma (HPC), also known as solitary fibrous tumor (SFT), is a type of soft tissue sarcoma with a special aggressive behavior. The HPC/SFT is locally aggressive with possibility of late recurrence locally or distant extraneural metastasis. The most common location of this HPC/SFT is the lower extremities. The HPC/SFT in the central nervous system (CNS) is very rare, and compared with the brain, it is rarer in the spinal region. However, clinicians also lack an overall understanding of the diagnosis of HPC/SFT in the spinal cord. Case presentation In this study, we report a rare case of primary cervical spine HPC/SFT in a 53-year-old woman. Two to three weeks before admission, she experienced pain and numbness in her left upper extremity. After computerized tomography (CT) and magnetic resonance imaging (MRI), a gross total resection was performed. Obvious neurological improvement was observed postoperatively. The pain and numbness in the patient's left upper limb were relieved subsequently. We then reviewed the literature on HPC/SFT, such as its clinical presentation, imaging characteristics, treatment, and follow-up. Conclusions Diagnosis of HPC/SFT relies on magnetic resonance spectroscopy, enhanced CT, and MRI. Postoperative radiotherapy is strongly recommended to reduce the HPC/SFT recurrence. Immunohistochemical analysis can also help in the differential diagnosis. However; early and long-term follow-up is necessary for patients.

scholarly journals Florid Proliferation of Hyalinized Vessels in a Spermatic Cord STAT6 Positive Solitary Fibrous Tumor and Its Potential Clinical Implications

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Christopher P. Marquez ◽  
Haiyan Zhang ◽  
Jason Goodrum ◽  
J. Nicholas Sreshta ◽  
Marjan Afrouzian
Keyword(s):  
Solitary Fibrous Tumor ◽  
Spermatic Cord ◽  
Rare Event ◽  
Stem Cell Differentiation ◽  
Anatomical Site ◽  
Microscopic Appearance ◽  
Mesenchymal Stem Cell Differentiation ◽  
Immunohistochemical Markers ◽  
Molecular Features ◽  
Fibrous Tumor

A solitary fibrous tumor (SFT) arising in the paratesticular region is a rare event. Typically most SFTs present as a lung mass and have a characteristic microscopic appearance. Although uncommon, SFTs may present at just about any anatomical site. Here we present a case of a SFT arising along the right spermatic cord, with histologic features mimicking a cellular angiofibroma. We describe the diagnostic immunohistochemical markers useful for arriving at its diagnosis. We also summarize our current understanding of the structural and molecular features that make up SFTs and discuss how these features may help us better understand the pathophysiology of pluripotent mesenchymal stem cell differentiation.

scholarly journals Solitary Fibrous Tumor of the Sigmoid Colon Masquerading as an Adnexal Neoplasm

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Laura Bratton ◽  
Rabih Salloum ◽  
Wenqing Cao ◽  
Aaron R. Huber
Keyword(s):  
Sigmoid Colon ◽  
Solitary Fibrous Tumor ◽  
High Power ◽  
Spindle Cell ◽  
Cytologic Atypia ◽  
Spindle Cell Neoplasm ◽  
Solitary Fibrous Tumors ◽  
Cell Neoplasm ◽  
Mitotic Figures ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare, benign spindle cell neoplasm that was first described in the thoracic pleura. This tumor is now known to occur at many extrapleural sites. There are established criteria for the diagnosis of malignant solitary fibrous tumor including ≥4 mitotic figures per 10 high-power fields, increased cellularity, cytologic atypia, infiltrative margins, and/or necrosis. Although all solitary fibrous tumors have the potential to recur or metastasize, those with malignant histologic features tend to behave more aggressively. We report a case of solitary fibrous tumor, with malignant histologic features, in a 21-year-old woman which arose from the serosal surface of the sigmoid colon.

scholarly journals Imaging of benign solitary fibrous tumor of the pleura: a pictorial essay

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Luciano Cardinale ◽  
Francesco Ardissone ◽  
Irene Garetto ◽  
Valerio Marci ◽  
Giovanni Volpicelli ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Immunohistochemical Analysis ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Radiographic Appearance ◽  
Positron Emission ◽  
Pleural Surface ◽  
Pictorial Essay ◽  
Fibrous Tumor ◽  
Cutting Needle

Solitary fibrous tumor of the pleura (SFTP) is a mesenchymal tumor that tends to involve the pleura, and is also described in other thoracic and extrathoracic sites. SFTP usually presents as a peripheral mass abutting the pleural surface, to which it is attached by a broad base or by a pedicle that allows it to be mobile. SFTPs exist in benign and malignant forms. A precise pre-operative diagnosis can be arrived at with a cutting-needle biopsy, although most cases are diagnosed with postoperative histology and immunohistochemical analysis. In this pictorial essay, we review a large series of cases, with emphasis on the radiographic appearance of these lesions and their findings from computed tomography, magnetic resonance imaging, ultrasonography and positron emission tomography.

scholarly journals Solitary Fibrous Tumor of the Auditory Canal

2004 ◽  
Vol 128 (12) ◽  
pp. e169-e171 ◽  
Author(s):  
Sherif Rezk ◽  
Mohammad Yousef ◽  
Marshall Zamansky ◽  
Ashraf Khan
Keyword(s):  
Salivary Glands ◽  
Solitary Fibrous Tumor ◽  
Paranasal Sinuses ◽  
Spindle Cell ◽  
Immunohistochemical Analysis ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor

Abstract Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of increasing incidence that was originally described to be of pleural origin; however, more recently, SFT has been reported in extrapleural sites, including the orbit, liver, salivary glands, tongue, nose, paranasal sinuses, larynx, retroperitoneum, meninges, and thyroid. The increase in the number of SFTs does not necessarily mean increased incidence of this tumor but rather an increased understanding of this tumor, especially recognition of this tumor in extrapleural locations, which has been aided by immunohistochemical analysis. We report a case of SFT in the auditory canal, which to our knowledge has not been previously reported, as evident by morphologic findings and immunophenotype.

Solitary Fibrous Tumor of Nasal Cavity in Patient With Long-Standing History of Cocaine Inhalation

2004 ◽  
Vol 128 (1) ◽  
pp. e1-e4 ◽  
Author(s):  
Suman S. Chauhan ◽  
Jayshree Krishnan ◽  
Denis K. Heffner
Keyword(s):  
Nasal Cavity ◽  
Solitary Fibrous Tumor ◽  
Soft Tissues ◽  
S100 Protein ◽  
Large Mass ◽  
Left Nasal Cavity ◽  
Posterior Aspect ◽  
History Of ◽  
Fibrous Tumor ◽  
The Right

Abstract We report a solitary fibrous tumor in the nasal cavity of a 48-year-old woman who presented with a history of bilateral nasal obstruction and long-standing cocaine inhalation. Physical examination revealed a large mass involving the right nasal cavity and extending into the posterior aspect of the left nasal cavity. The computed tomography scan showed opacification of airways. During surgery, the mass was found to involve the entire nasal cavity, with extension to the right maxillary sinus, posterior nasal airways, and left nasal cavity. The mass was completely excised. Pathologic examination revealed a polypoid mass 3.7 × 3.0 × 1.2 cm. This tumor was composed of spindle cells that were cytologically bland in a background of ropey and nodular collagen, giving a “patternless” pattern. Immunohistochemically, the neoplastic cells stained for CD34 and vimentin but not for S100 protein, keratin, desmin, HMB-45, and c-Kit. This immunohistochemical pattern confirmed the diagnosis of solitary fibrous tumor. Although solitary fibrous tumors are usually found in the pleura, they can occur in various other locations, such as the orbit, nasal cavity, paranasal sinuses, mediastinum, breast, vagina, meninges, and soft tissues. This case is of interest because the tumor occurred in a patient with prolonged cocaine inhalation. Such an association has not been previously described. The exact causal relationship between cocaine inhalation and the tumor is not known.

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