scholarly journals Role of 24-Hour Intraocular Pressure Monitoring in Glaucoma Management

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Chun Hing Ho ◽  
Jasper K. W. Wong
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Clinical Relevance ◽  
Current Practice ◽  
Normal Tension Glaucoma ◽  
Treatment Modalities ◽  
Pressure Monitoring ◽  
Optic Nerve Damage ◽  
Glaucoma Treatment

Glaucoma is the leading cause of irreversible blindness worldwide and the prevalence is on the rising trend. Intraocular pressure (IOP) reduction is the mainstay of treatment. The current practice of IOP monitoring is based on spot measurements during clinic visits during office hours. However, there are up to 50% of glaucoma patients who had normal initial IOP, while some treated patients continued to have progressive glaucomatous optic nerve damage even with a low IOP. Recent studies have shown that the IOP of glaucoma patients fluctuated during the day with different patterns, and some of them had peak IOP outside office hours. These findings provided us with new insights on the role of 24-hour IOP monitoring in managing normal tension glaucoma and patients with progressive deterioration despite apparently well-controlled IOP. Nevertheless, results to date are rather inconsistent, and there is no consensus yet. In this review, we briefly highlighted the current modalities of 24-hour IOP monitoring and summarized the characteristic 24-hour IOP pattern and the clinical relevance of IOP parameters in predicting glaucomatous progression in different glaucoma subtypes. We also discussed the therapeutic efficacy of current glaucoma treatment modalities with respect to the mentioned 24-hour IOP profiles, so as to strengthen the role of 24-hour IOP monitoring in identifying and stratifying the risks of progression in glaucoma patients, as well as optimizing treatments according to their IOP profiles.

Letter to the Editor. Low ICP and normal tension glaucoma: optic nerve damage due to barotraumatic factors, failure of CSF dynamics, or both?

2018 ◽  
Vol 129 (4) ◽  
pp. 1100-1103
Author(s):  
Peter Wostyn ◽  
Veva De Groot ◽  
Debby Van Dam ◽  
Kurt Audenaert ◽  
Peter Paul De Deyn ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Nerve Damage ◽  
Csf Dynamics ◽  
Optic Nerve Damage ◽  
Letter To The Editor

scholarly journals An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models

2021 ◽  
Author(s):  
Sophie Pilkinton ◽  
T.J. Hollingsworth ◽  
Brian Jerkins ◽  
Monica M. Jablonski
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Animal Models ◽  
Retinal Ganglion Cells ◽  
Optic Nerve Head ◽  
Ganglion Cells ◽  
Treatment Modalities ◽  
Retinal Ganglion ◽  
Glaucomatous Damage

Glaucoma is a multifactorial, polygenetic disease with a shared outcome of loss of retinal ganglion cells and their axons, which ultimately results in blindness. The most common risk factor of this disease is elevated intraocular pressure (IOP), although many glaucoma patients have IOPs within the normal physiological range. Throughout disease progression, glial cells in the optic nerve head respond to glaucomatous changes, resulting in glial scar formation as a reaction to injury. This chapter overviews glaucoma as it affects humans and the quest to generate animal models of glaucoma so that we can better understand the pathophysiology of this disease and develop targeted therapies to slow or reverse glaucomatous damage. This chapter then reviews treatment modalities of glaucoma. Revealed herein is the lack of non-IOP-related modalities in the treatment of glaucoma. This finding supports the use of animal models in understanding the development of glaucoma pathophysiology and treatments.

Treatment with Bifemelane for Optic Nerve Damage following High Intraocular Pressure in Rat Eyes

1996 ◽  
Vol 6 (4) ◽  
pp. 415-420
Author(s):  
M. Adachi ◽  
K. Takahashi ◽  
K. Yuge ◽  
M. Nishikawa ◽  
H. Miki ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Nerve Damage ◽  
Optic Nerve Damage

Aqueous misdirection syndrome masking as myopic surprise following phacoemulsification surgery

2021 ◽  
Vol 14 (12) ◽  
pp. e242777
Author(s):  
Chung Shen Chean ◽  
Duminda Gabadage ◽  
Subhanjan Mukherji
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Early Diagnosis ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Surgical Management ◽  
Clinical Presentation ◽  
Optic Nerve Damage ◽  
Shallow Anterior Chamber ◽  
Aqueous Misdirection

Aqueous misdirection syndrome is a rare but serious condition that can present after routine phacoemulsification surgery. This report examines a case of myopic surprise following an uncomplicated left eye (LE) phacoemulsification surgery. The patient had previous bilateral peripheral iridotomies for narrow anterior chamber angles. Repeat biometry measurement of the pseudophakic LE did not show shallow anterior chamber, and intraocular pressure (IOP) was normal at initial presentation. However, approximately 3 years postoperatively, LE IOP was raised. Surgical management was considered as medical and laser procedures did not stop deterioration. Clinical presentation of aqueous misdirection syndrome may be subtle and can occur weeks to years after routine uncomplicated phacoemulsification surgery. Myopic surprise may be the only initial presenting sign. Patients who are at risk of aqueous misdirection syndrome should be followed up closely after cataract surgery with accurate gonioscopic assessments for early diagnosis and treatment to prevent optic nerve damage.

scholarly journals Role of nitric oxide in optic nerve head blood flow regulation during an experimental increase in intraocular pressure in healthy humans

2013 ◽  
Vol 116 ◽  
pp. 247-253 ◽  
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
Stefan Palkovits ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Flow Regulation ◽  
Healthy Humans ◽  
Blood Flow Regulation

A Prospective Study of Patients with Pseudoexfoliation Glaucoma and Its Management in a Tertiary Care Centre in South India

2021 ◽  
Vol 8 (31) ◽  
pp. 2848-2854
Author(s):  
Nishat Sultana ◽  
Priyam Gupta
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Medical Therapy ◽  
Tertiary Care ◽  
Pseudoexfoliation Syndrome ◽  
Age Group ◽  
Care Centre ◽  
Pseudoexfoliation Glaucoma ◽  
Tertiary Care Centre ◽  
Optic Nerve Damage

BACKGROUND Pseudoexfoliation syndrome is the most common identifiable cause of open angle glaucoma worldwide. Pseudoexfoliation glaucoma develops in 50 % of patients with pseudoexfoliation syndrome. The purpose of this study was to assess the clinical profile, intraocular pressure (IOP), gonioscopic findings, disc changes and need for medical or surgical line of management for the control of pseudoexfoliation glaucoma. METHODS It was a prospective hospital based interventional study of 68 consecutive patients diagnosed with pseudoexfoliation glaucoma, who presented to the glaucoma clinic at a tertiary care centre from Nov 2017 to Mar 2019. RESULTS 68 patients diagnosed with pseudoexfoliation glaucoma were evaluated during the study period from November 2017 to March 2019. Male predominance of 43 (63 %) was noticed. Mean age group of study population was 68 years with 44 (65 %) of patients in age group of 61 – 75 years. 55 cases had bilateral pseudoexfoliation. 85 (69 %) eyes had a pressure of > 21 mm of Hg. 97 (79 %) eyes had open angles, 4 (3 %) occludable angles, 22 (18 %) had closed angles. 4 (3 %) of eyes had cup disc ratio < 0.5, 49 (40 %) eyes had cup disc ratio of 0.5 - 0.7, 64 (52 %) had > 0.7 cupping. 38 (31 %) eyes were controlled on medical therapy with topical antiglaucoma medications. In 14 (11 %), eyes were treated with Nd: YAG PI (neodymium-doped yttrium aluminium garnet peripheral laser iridotomy) with medical treatment, 59 (48 %) eyes were taken up for triple procedure. 10 (8 %) eyes could not be controlled using medical therapy and had to be taken for surgical treatment. CONCLUSIONS Pseudoexfoliation glaucoma leads to irreversible visual loss if high IOP is not treated leading to glaucomatous optic nerve damage and visual field loss. The response to medical therapy is poor and needs surgical intervention. KEYWORDS Pseudoexfoliation Glaucoma, Intraocular Pressure, Optic Nerve Damage, Dandruff Like Material

scholarly journals Recovery of canine retina and optic nerve function after acute elevation of intraocular pressure: implications for canine glaucoma treatment

2007 ◽  
Vol 10 (s1) ◽  
pp. 101-107 ◽  
Author(s):  
Sinisa D. Grozdanic ◽  
Milan Matic ◽  
Daniel M. Betts ◽  
Donald S. Sakaguchi ◽  
Randy H. Kardon
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Nerve Function ◽  
Acute Elevation ◽  
Glaucoma Treatment

Critical Role of Monocyte Recruitment in Optic Nerve Damage Induced by Experimental Optic Neuritis

2019 ◽  
Vol 56 (11) ◽  
pp. 7458-7472 ◽  
Author(s):  
Marcos L. Aranda ◽  
Diego Guerrieri ◽  
Gonzalo Piñero ◽  
María F. González Fleitas ◽  
Florencia Altschuler ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Critical Role ◽  
Nerve Damage ◽  
Optic Nerve Damage ◽  
Monocyte Recruitment
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