scholarly journals Prolonged Hypercupremia after Laparoscopic Vertical Sleeve Gastrectomy Successfully Treated with Oral Zinc

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Timothy R. Koch ◽  
Elizabeth A. Zubowicz ◽  
John B. Gross
Keyword(s):  
Sleeve Gastrectomy ◽  
Blood Levels ◽  
Slit Lamp ◽  
Vertical Sleeve Gastrectomy ◽  
Significant Weight Loss ◽  
Urinary Copper ◽  
Plasma Copper ◽  
M Spike ◽  
Hepatic Synthesis ◽  
Urinary Copper Excretion

A 30-year-old female underwent vertical sleeve gastrectomy. Postoperatively, hypercupremia and elevated ceruloplasmin were identified. Further testing revealed normal blood levels of transaminases, alkaline phosphatase, and albumin. She stopped ingestion of multivitamins, began a copper-free multivitamin, and then began a low copper diet, but with no improvement in hypercupremia. Protein electrophoresis was normal with no M-spike. Urinary copper excretion was normal at 0.24 micromol/24 hours (normal: < 0.55), and there were no Kayser-Fleischer rings on slit lamp examination. Two years postoperatively, she lost 44% of excess preoperative weight and she began zinc sulfate before meals twice daily (115 mg elemental Zinc/day). At 2 months and 8 months later, plasma copper and ceruloplasmin had essentially normalized. Increased production of ceruloplasmin could have been a response to significant weight loss or the presence of nonalcoholic steatohepatitis. The mechanism of zinc’s beneficial effect is uncertain but may be related to suppressing hepatic synthesis of or secretion of ceruloplasmin.

scholarly journals Evaluation of a commercially available molybdate formulation and zinc oxide boluses in preventing hepatic copper accumulation and thus enzootic icterus in sheep

2001 ◽  
Vol 72 (4) ◽  
Author(s):  
C.J. Botha ◽  
A.S. Shakespeare ◽  
R. Gehring ◽  
D. Van der Merwe
Keyword(s):  
Zinc Oxide ◽  
Copper Concentration ◽  
Histopathological Examination ◽  
Copper Accumulation ◽  
Copper Excretion ◽  
Hepatic Copper ◽  
Liver Copper ◽  
Urinary Copper ◽  
Plasma Copper ◽  
Urinary Copper Excretion

The efficacy of a molybdate formulation and a zinc oxide bolus as prophylactic agents for enzootic icterus was evaluated in sheep. Before copper loading, liver biopsies were performed on 12 male, 6-month-old, Mutton Merino sheep to determine hepatic copper (Cu) and zinc (Zn) concentrations. The animals were restrictively randomised according to liver copper concentrations to 3 treatment groups (n = 4) to achieve similar mean liver copper concentrations per group. All sheep received 4 m /kg of a 0.5 %aqueous solution of CuSO4·5H2O intraruminally 7 days per week for 10 weeks. On Day 0 the sheep in the Mo-group were injected subcutaneously with 42 mg molybdenum (Mo) contained in a commercial molybdate formulation. The animals in the Zn-group each received a zinc oxide bolus, containing 43 g zinc oxide, via a rumen cannula. Treatment was repeated on Day 42. Four animals served as untreated controls. Urinary copper excretion, plasma copper concentration, haematocrit and glutamate dehydrogenase (GLDH) activity were determined throughout the trial. The animals were sacrificed after 10 weeks and liver samples were submitted for histopathological examination. Liver and kidney copper and zinc concentrations were determined. Neither the molybdate treatment nor the zinc oxide boluses prevented hepatic copper accumulation. The urinary copper excretion, plasma copper concentration, haematocrit and GLDH activity were not significantly different (P > 0.05) from the controls.

Impact of vertical sleeve gastrectomy on patients with preoperative gastroesophageal reflux disease

2016 ◽  
Vol 12 (7) ◽  
pp. S212-S213
Author(s):  
Jacqueline Paolino ◽  
Sajani Shah ◽  
Wesley Vosburg ◽  
Julie Kim ◽  
Adam Blau ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Vertical Sleeve Gastrectomy

scholarly journals Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development

2018 ◽  
Vol 132 (2) ◽  
pp. 295-312 ◽  
Author(s):  
Redin A. Spann ◽  
William J. Lawson ◽  
Gene L. Bidwell ◽  
C. Austin Zamarripa ◽  
Rodrigo O. Maranon ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Gestational Hypertension ◽  
The Body ◽  
Obese Women ◽  
Vertical Sleeve Gastrectomy ◽  
Fetal Demise ◽  
Maternal Immune System ◽  
Structural Abnormalities ◽  
Immune Health ◽  
Metalloproteinase 9

Bariatric surgery is increasingly employed to improve fertility and reduce obesity-related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism, and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnormalities that may be responsible for fetal demise during pregnancy. VSG dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3+ and CD8+) populations compared with lean or obese controls. Further, local interleukin (IL) 1β and IL 1 receptor antagonist (il1rn) cmRNA were increased in placenta of VSG dams. Placental barrier function was also affected, with increased transplacental permeability to small molecules, increased matrix metalloproteinase 9 expression, and increased apoptosis in VSG. Furthermore, we identified increased placental mTOR signaling that may contribute to preserving the body weight of the fetuses during gestation. These changes occurred in the absence of a macronutrient deficit or gestational hypertension in the VSG dams. In summary, previous VSG in dams may contribute to fetal demise by affecting maternal immune system activity and compromise placental integrity.

scholarly journals Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats

2011 ◽  
Vol 141 (3) ◽  
pp. 950-958 ◽  
Author(s):  
Adam P. Chambers ◽  
Lene Jessen ◽  
Karen K. Ryan ◽  
Stephanie Sisley ◽  
Hilary E. Wilson–Pérez ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Glucose Homeostasis ◽  
Vertical Sleeve Gastrectomy ◽  
Blood Glucose Homeostasis
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