scholarly journals Secondary Syphilis with Eosinophilia Complicated by Severe Jarisch–Herxheimer Reaction

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Anthony Elias ◽  
Kirsty Wark ◽  
Dana Slape ◽  
David Cook ◽  
Kenneth Lee ◽  
...  

It has long been acknowledged that syphilis is a disease with a diverse range of presentations. We herein describe a case of a young man who presented with fever, rash, and eosinophilia following the commencement of allopurinol, only to be diagnosed with secondary syphilis on histopathology. His treatment was complicated by a severe exacerbation of his cutaneous eruption following the commencement of penicillin, likely secondary to a Jarisch–Herxheimer reaction, an entity often overlooked by clinicians managing syphilis.

Author(s):  
Majid Darraj ◽  
Andrew Walkty ◽  
John Toole ◽  
Thomas Marrie ◽  
Leah Huzel ◽  
...  

Nodular skin lesions are infrequently reported among patients with syphilis. We describe a 42-year-old man with secondary syphilis who presented with a nodular cutaneous eruption involving his neck, upper chest, back, arms, and legs. Because there was uncertainty regarding the diagnosis at presentation, the patient underwent a punch biopsy of one of the lesions. Spirochetes were not seen with a Steiner silver stain, but they were visualized on subsequent immunohistochemical staining. The diagnosis was confirmed with serology, and the patient responded well to treatment with benzathine penicillin G. Given the current increase in syphilis cases across North America, it is critical that clinicians become familiar with some of the less common dermatologic manifestations of this infection so that the diagnosis is entertained and appropriate serologic testing is ordered in a timely fashion.


2014 ◽  
Vol 56 ◽  
pp. 207-219 ◽  
Author(s):  
Chi L.L. Pham ◽  
Ann H. Kwan ◽  
Margaret Sunde

Amyloids are insoluble fibrillar protein deposits with an underlying cross-β structure initially discovered in the context of human diseases. However, it is now clear that the same fibrillar structure is used by many organisms, from bacteria to humans, in order to achieve a diverse range of biological functions. These functions include structure and protection (e.g. curli and chorion proteins, and insect and spider silk proteins), aiding interface transitions and cell–cell recognition (e.g. chaplins, rodlins and hydrophobins), protein control and storage (e.g. Microcin E492, modulins and PMEL), and epigenetic inheritance and memory [e.g. Sup35, Ure2p, HET-s and CPEB (cytoplasmic polyadenylation element-binding protein)]. As more examples of functional amyloid come to light, the list of roles associated with functional amyloids has continued to expand. More recently, amyloids have also been implicated in signal transduction [e.g. RIP1/RIP3 (receptor-interacting protein)] and perhaps in host defence [e.g. aDrs (anionic dermaseptin) peptide]. The present chapter discusses in detail functional amyloids that are used in Nature by micro-organisms, non-mammalian animals and mammals, including the biological roles that they play, their molecular composition and how they assemble, as well as the coping strategies that organisms have evolved to avoid the potential toxicity of functional amyloid.


1980 ◽  
Vol 116 (10) ◽  
pp. 1103a-1104 ◽  
Author(s):  
D. Kahn
Keyword(s):  

1972 ◽  
Vol 17 (4) ◽  
pp. 213-214
Author(s):  
WILLIAM F. BATTIG
Keyword(s):  

2014 ◽  
Vol 11 (3) ◽  
pp. 387-390
Author(s):  
Antonina Levatino

Martin Geiger & Antoine Pécoud (eds.), Disciplining the Transnational Mobility of People, Palgrave Macmillan, 2013, 271 pp., (ISBN 978-1-137-26306-3).In the last decades a very diverse range of initiatives have been undertaken in order to intensify and diversify the ways human mobility is managed and restricted. This trend towards a ‘diversification’ of the migration control strategies stems from the increased awareness by the nation-states of the profoundly controversial nature of the migration management enterprise because of its political, economic, social and moral implications.


What did it mean to be a man in Scotland over the past nine centuries? Scotland, with its stereotypes of the kilted warrior and the industrial ‘hard man’, has long been characterised in masculine terms, but there has been little historical exploration of masculinity in a wider context. This interdisciplinary collection examines a diverse range of the multiple and changing forms of masculinities from the late eleventh to the late twentieth century, exploring the ways in which Scottish society through the ages defined expectations for men and their behaviour. How men reacted to those expectations is examined through sources such as documentary materials, medieval seals, romances, poetry, begging letters, police reports and court records, charity records, oral histories and personal correspondence. Focusing upon the wide range of activities and roles undertaken by men – work, fatherhood and play, violence and war, sex and commerce – the book also illustrates the range of masculinities that affected or were internalised by men. Together, the chapters illustrate some of the ways Scotland’s gender expectations have changed over the centuries and how, more generally, masculinities have informed the path of Scottish history


This book opens a cross-regional dialogue and shifts the Eurocentric discussion on diversity and integration to a more inclusive engagement with South America in private international law issues. It promotes a contemporary vision of private international law as a discipline enabling legal interconnectivity, with the potential to transcend its disciplinary boundaries to further promote the reality of cross-border integration, with its focus on the ever-increasing cross-border mobility of individuals. Private international law embraces legal diversity and pluralism. Different legal traditions continue to meet, interact and integrate in different forms, at the national, regional and international levels. Different systems of substantive law couple with divergent systems of private international law (designed to accommodate the former in cross-border situations). This complex legal landscape impacts individuals and families in cross-border scenarios, and international commerce broadly conceived. Private international law methodologies and techniques offer means for the coordination of this constellation of legal orders and value systems in cross-border situations. Bringing together world-renowned academics and experienced private international lawyers from a wide range of jurisdictions in Europe and South America, this edited collection focuses on the connective capabilities of private international law in bridging and balancing legal diversity as a corollary for the development of integration. The book provides in-depth analysis of the role of private international law in dealing with legal diversity across a diverse range of topics and jurisdictions.


2010 ◽  
Vol 4 (1-2) ◽  
pp. 75-96
Author(s):  
Mohammed Rustom

This article offers the first comprehensive survey of scholarly literature devoted to the Qur??nic works of the famous Muslim philosopher, Mull? ?adr? (d. 1050/1640). While taking account of the merits and shortcomings of studies on ?adr?’s Qur??nic writings, we will also be concerned with highlighting some of the methodological problems raised by the diverse range of approaches adopted in these studies. Chief amongst them is the tendency to pit ?adr? the philosopher against ?adr? the scriptural exegete. Such a dichotomy is not entirely helpful, both with respect to painting a clearer picture of ?adr?’s religious worldview, and to addressing broader questions pertaining to the intimate relationship shared between the “act” of philosophy and the “act” of reading scripture.


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