Subclinical Left Ventricular Systolic Dysfunction in Patients with Septic Shock Based on Sepsis-3 Definition: A Speckle-Tracking Echocardiography Study

Introduction. Left ventricular dysfunction is quite common in septic shock. Speckle-tracking echocardiography (STE) is a novel, highly sensitive method for assessing left ventricular function, capable of detecting subclinical myocardial dysfunction, which is not identified with conventional echocardiography. We sought to evaluate subclinical left ventricular systolic function in patients with septic shock using speckle-tracking echocardiography. Methods. From May 2017 to December 2018, patients aged ≥18 years admitted to the intensive care unit with the diagnosis of sepsis and septic shock based on the sepsis-3 definition were included. Patients with other causes of cardiac dysfunction were excluded. Transthoracic echocardiography was performed for all the patients within 24 hours of diagnosis. Left ventricular systolic function was assessed using conventional echocardiography and speckle-tracking echocardiography. Results. Patients with septic shock (n = 90) (study group) and 37 matched patients with sepsis but no septic shock (control group) were included. Left ventricular ejection fraction (LVEF) by conventional echocardiography showed no significant difference between two groups (58.2 ± 9.9 vs. 58.6 ± 8.3, p=0.804). The global longitudinal strain (GLS) by STE was significantly reduced in patients with septic shock compared with that in the control (−14.6 ± 3.3 vs. −17.1 ± 3.3, p<0.001). Based on the cutoff value of GLS ≥ −15% for the definition of subclinical left ventricular systolic dysfunction, this dysfunction was detected in 50 patients with septic shock (55.6%) and in 6 patients in the control group (16.2%) (p<0.05). Conclusions. Speckle-tracking echocardiography can detect early subclinical left ventricular systolic dysfunction via the left ventricular global longitudinal strain compared with conventional echocardiographic parameters in patients with septic shock.

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Left ventricular systolic dysfunction in patients with ankylosing spondylitis without clinically overt cardiovascular disease by speckle tracking echocardiography

Rheumatology International ◽

10.1007/s00296-014-3130-z ◽

2014 ◽

Vol 35 (4) ◽

pp. 607-611 ◽

Cited By ~ 7

Author(s):

Nilgun Ustun ◽

Mustafa Kurt ◽

Alper Bugra Nacar ◽

Hacer Paksoy Karateke ◽

Hayal Guler ◽

...

Keyword(s):

Cardiovascular Disease ◽

Ankylosing Spondylitis ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Systolic Dysfunction

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Subclinical left ventricular systolic dysfunction by two-dimensional speckle-tracking echocardiography and its relation to ambulatory arterial stiffness index in hypertensive patients

Journal of Hypertension ◽

10.1097/hjh.0000000000002330 ◽

2020 ◽

Vol 38 (5) ◽

pp. 864-873 ◽

Cited By ~ 1

Author(s):

Tarek A.N. Ahmed ◽

Hamdy Shams-Eddin ◽

Marwa A. Fathy ◽

Heba M. El-Naggar ◽

Yehia T. Kishk

Keyword(s):

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Stiffness Index ◽

Two Dimensional ◽

Ventricular Systolic Dysfunction ◽

Hypertensive Patients ◽

Arterial Stiffness Index

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Two dimensional speckle tracking echocardiography in detection of subclinical left ventricular systolic dysfunction in patients with severe aortic stenosis

Indian Heart Journal ◽

10.1016/j.ihj.2014.10.400 ◽

2014 ◽

Vol 66 (6) ◽

pp. 602-606 ◽

Cited By ~ 1

Author(s):

Hany Younan

Keyword(s):

Aortic Stenosis ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Left Ventricular Systolic Dysfunction ◽

Severe Aortic Stenosis ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Two Dimensional ◽

Ventricular Systolic Dysfunction

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Subclinical left ventricular systolic dysfunction in patients with severe aortic stenosis: A speckle tracking echocardiography study

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology ◽

10.5543/tkda.2017.43037 ◽

2017 ◽

Author(s):

Betul Cengiz

Keyword(s):

Aortic Stenosis ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Left Ventricular Systolic Dysfunction ◽

Severe Aortic Stenosis ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Ventricular Systolic Dysfunction

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Fragmented QRS as an early predictor of left ventricular systolic dysfunction in healthy individuals: A nested case-control study in the era of speckle tracking echocardiography

10.21203/rs.2.20205/v1 ◽

2020 ◽

Author(s):

Mohammad Hossein Nikoo ◽

Zahra Jamali ◽

Iman Razeghian-Jahromi ◽

Mehrab Sayadi ◽

Firoozeh Abtahi

Keyword(s):

Ejection Fraction ◽

Speckle Tracking ◽

Speckle Tracking Echocardiography ◽

Left Ventricular Systolic Dysfunction ◽

Systolic Dysfunction ◽

Left Ventricular ◽

Diagnostic Methods ◽

Ventricular Systolic Dysfunction ◽

Control Groups ◽

Fragmented Qrs

Abstract Background: The burden of cardiovascular diseases have been become a concerning health challenge throughout the world. Stopping this condition needs applying early, yet inexpensive diagnostic methods. The aim of this study is to evaluate the capacity of fragmented QRS (fQRS) on 12-lead EKG for detecting left ventricular dysfunction in healthy individuals.Methods: Out of 500 healthy participants without detected cardiovascular disorders from Shiraz Heart Study cohort, 20 subjects diagnosed with fQRS (case) and 20 peers without fQRS (control) were participated. Global longitudinal strain was measured by speckle tracking echocardiography for two groups. Comparison was made between case and control groups by using chi-square or independent sample t-test or ANOVA. P value of less than 5% considered statistical significance. Results: There was no difference between the case and the control groups in terms of age, gender, ejection fraction, left ventricular volume and dimensions. Out of 40 subjects, 14 had reduced GLS (≤20%) with 10 of them had fQRS. GLS in the case group was significantly lower than in the control group.Conclusions: Apparent healthy subjects with fQRS diagnosed with left ventricular systolic dysfunction with respect to GLS despite normal ejection fraction. It seems that EKG, as one of the simplest way toward assessing heart function, could be a prominent informative clue to detect high-risk individuals among healthy population in advance.

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