scholarly journals Hidradenitis Suppurativa Recurrence in a Caesarean Scar

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
K. M. Darch ◽  
T. L. Holland ◽  
L. J. Spelman
Keyword(s):  
Case Report ◽  
Patient Group ◽  
Hidradenitis Suppurativa ◽  
Skin Condition ◽  
Psychosocial Impact ◽  
Acne Inversa ◽  
Review Of The Literature ◽  
Caesarean Scar ◽  
Systemic Treatments ◽  
The Cost

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic, relapsing inflammatory skin condition characterised by the presence of painful nodules, abscesses, and sinus tracts or scarring. Affecting up to 4% of the population, it is not uncommon and is seen predominantly in females at a ratio of 3 : 1. HS carries a substantial burden for those who suffer from it, from the significant psychosocial impact, to the cost of the multitude of topical and systemic treatments which often do not successfully control its symptoms. In this case report, we discuss a 33-year-old female known to our clinic, who presented with a recurrence of her HS in a caesarean scar, with otherwise silent disease. From our review of the literature, this appears to be only the second case of recurrence of HS in a caesarean scar reported to date. With a predilection for females of reproductive ages, involvement of sensitive areas, and an average of greater than seven years from onset of symptoms until diagnosis, the ability to recognise HS and ensure referral for specialist management is essential for all who are regularly involved in the management of this patient group.

scholarly journals Utility of Botulinum Injections in Stiff-Person Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
L. M. Conners ◽  
A. Betcher ◽  
A. Shahinian ◽  
P. Janda
Keyword(s):  
Case Report ◽  
Adverse Reactions ◽  
Intravenous Immunoglobulins ◽  
Initial Therapy ◽  
High Dose ◽  
B Cell Depletion ◽  
Stiff Person Syndrome ◽  
Review Of The Literature ◽  
Systemic Treatments ◽  
Muscle Spasms

Stiff-person syndrome (SPS) is an uncommon neurological disorder characterized by significant rigidity and muscle spasms primarily affecting the truncal and proximal musculature. Furthermore, a wide-based gait with functional impairment is generally seen. High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing. Refractory cases may be treated with intravenous immunoglobulins (IVIG), plasma exchange, or B-cell depletion with rituximab, although these are also associated with major, sometimes fatal, adverse reactions. Several reports have validated the safety and utility of botulinum injections in this setting, yet botulinum remains markedly underutilized in this cohort. Below, a case report and review of the literature show botulinum can decrease pain and stiffness, improve gait and balance, and decrease dependence on powerful systemic treatments in this group.

An unusual presentation of hidradenitis suppurativa: case report and review of the literature

Urology ◽  
1994 ◽  
Vol 44 (4) ◽  
pp. 606-608 ◽  
Author(s):  
David C. Chaikin ◽  
Lawrence R. Volz ◽  
Gregory Broderick
Keyword(s):  
Case Report ◽  
Hidradenitis Suppurativa ◽  
Unusual Presentation ◽  
Review Of The Literature

scholarly journals Squamous cell carcinoma complicating a chronic lesion of hidradenitis suppurativa: a case report and review of the literature

2016 ◽  
Vol 14 (2) ◽  
pp. 435-438 ◽  
Author(s):  
Natanel Jourabchi ◽  
Alexander H Fischer ◽  
Ashley Cimino-Mathews ◽  
Kevin M Waters ◽  
Ginette A Okoye
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Review Of The Literature

Novel Therapeutic Approaches and Targets for the Treatment of Hidradenitis Suppurativa

2020 ◽  
Vol 22 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Roberta Giuffrida ◽  
Serafinella Patrizia Cannavò ◽  
Marialorena Coppola ◽  
Claudio Guarneri
Keyword(s):  
Hidradenitis Suppurativa ◽  
Current Knowledge ◽  
Target Therapy ◽  
Skin Condition ◽  
Complex Nature ◽  
Therapeutic Approaches ◽  
Cellular Targets ◽  
Systemic Treatments ◽  
Laser Treatments ◽  
Surgery Research

Background: Hidradenitis Suppurativa (HS) is a chronic, recurrent and disabling inflammatory skin condition, clinically characterized by nodules, bullae, abscesses, fistulae, and draining sinus tracts mainly located in axillae, inguinal folds, inframammary region and buttocks, often leading to pain, scarring, disfigurement and decreased quality of life. Due to its complex nature, with still no completely elucidated etiology and pathogenesis, the management of HS can be challenging. In fact, many patients do not respond to the traditionally available systemic treatments, including antiinflammatories, antibiotics and surgery. Research has provided new insights into the mechanisms of HS, mainly investigating the inflammatory cytokine pathways underlying the disease. Methods: We review the current knowledge on newer therapeutic approaches and targets for the treatment of HS, through a PubMed-based literature search. Results: In this setting, studies on tumor necrosis factor-α, IL-1β, IL-10, and the IL-23/T-helper (Th) 17 and IL12/Th1 axes in immune dysregulation in HS have helped in developing new regimens. Inhibitor of phosphodiesterase 4 and laser treatments have shown clinically meaningful efficacy with good short-term safety and tolerability. Conclusion: Target therapy has revolutionized the treatment of moderate to severe HS, based on the inhibition of specific molecular or cellular targets, directly involved in the pathogenesis of the condition.

Pyoderma Gangrenosum Associated with Hidradenitis Suppurativa: A Case Report and Review of the Literature

2010 ◽  
Vol 101 (8) ◽  
pp. 717-721
Author(s):  
A.E. García-Rabasco ◽  
A. Esteve-Martínez ◽  
V. Zaragoza-Ninet ◽  
J.L. Sánchez-Carazo ◽  
V. Alegre-de-Miquel
Keyword(s):  
Case Report ◽  
Pyoderma Gangrenosum ◽  
Hidradenitis Suppurativa ◽  
Review Of The Literature
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