scholarly journals Comparison of Different Types of Corneal Foreign Bodies Using Anterior Segment Optical Coherence Tomography: A Prospective Observational Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Tao Wang ◽  
Lei Zhong ◽  
Shiyi Yin ◽  
Tiancheng Bao ◽  
Jiezheng Yang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Foreign Body ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Foreign Bodies ◽  
Anterior Segment ◽  
Different Types ◽  
Shadowing Effect ◽  
Group A ◽  
Group B

Purpose. The present study highlighted the value of anterior segment optical coherence tomography (AS-OCT) for different types of corneal foreign bodies in humans. Methods. This study was a prospective observational study. The patients included were divided into two groups. If the patients were directly diagnosed based on eye injury history and slit-lamp examination, then they were assigned to Group A. Otherwise, the patients were assigned to Group B. We compared and described the characteristics of the corneal foreign body in both groups using AS-OCT. Results. From October 2017 to January 2020, 36 eyes of 36 patients (9 females and 27 males) with a mean age of 37.8 ± 11.7 years were included in the study. Patients in Group A were the majority and accounted for 72.2% (26/36). High signals on AS-OCT images were the main constituent and accounted for 92.3% (24/26) in Group A and 70.0% (7/10) in Group B. Most of the patients in Group A, 96.2% (25/26), had clear boundaries. A blurred boundary was observed in 70.0% (7/10) of the patients in Group B. The foreign bodies on AS-OCT images had key characteristics of a high signal followed by a central zone shadowing effect and a low signal followed by a marginal zone shadowing effect. Further, all of the lesions could be directly located in Group B, and 92.3% (24/26) of the patients in Group A did not have directly located lesions. Six representative cases are described in detail. Conclusions. AS-OCT is a valuable tool in the diagnosis and management of corneal foreign bodies, especially for unusual corneal foreign body.

SPOSAB ABP 501 - A SICILIAN PROSPECTIVE OBSERVATIONAL STUDY OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED WITH ADALIMUMAB BIOSIMILAR ABP 501

2021 ◽  
Vol 27 (Supplement_1) ◽  
pp. S59-S59
Author(s):  
Fabio Salvatore Macaluso ◽  
Maria Cappello ◽  
Anita Busacca ◽  
Walter Fries ◽  
Anna Viola ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Observational Study ◽  
Bowel Disease ◽  
Prospective Observational Study ◽  
Treatment Persistence ◽  
Group A ◽  
Inflammatory Bowel ◽  
Abp 501 ◽  
Group B

Abstract Background and Aims There are few clinical data on Adalimumab (ADA) biosimilars in inflammatory bowel disease. Methods SPOSAB ABP 501 is a multicenter, observational, prospective study performed among the cohort of the Sicilian Network for Inflammatory Bowel Disease. All consecutive patients treated with ADA biosimilar ABP 501 from the introduction of the drug in Sicily (February 2019) to February 2020 (12 months) were enrolled to assess its safety and effectiveness. Patients were divided into 3 groups: group A, naïve to ADA and naïve to anti-TNFs; group B, naïve to ADA, previously exposed to anti-TNFs; group C: switched from ADA originator to ABP 501. Results 559 patients (median age 39 years; CD 88.0%, UC 12.0%) were included, with a follow-up time of 403.4 patient-years. Thirty-six SAEs occurred in 36 patients [(6.4% - incidence rate (IR): 8.9 per 100 person-years (PY)]. The IR of SAEs was higher among patients in group A compared with group C (17.4 vs. 4.8 per 100 PY; IR ratio=3.61; p<0.001) and among patients in group B compared with group C (16.4 vs. 4.8 per 100 PY; IR ratio=3.42; p=0.041). Among ADA-naïve patients (group A+B), 188 (85.8%) had a clinical response after 12 weeks, including 165 (75.3%) who achieved steroid-free remission. Higher treatment persistence estimates were reported for patients in group C compared with group A and B (log-rank p<0.001). Conclusions Safety and effectiveness of ABP 501 seem to be overall similar to those reported for ADA originator. Switching from originator to ABP 501 was safe and effective.

scholarly journals Repeatability of corneal and epithelial thickness measurements with anterior segment optical coherence tomography in keratoconus

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0248350
Author(s):  
Ye Li ◽  
Akilesh Gokul ◽  
Charles McGhee ◽  
Mohammed Ziaei
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Thickness ◽  
Intraclass Correlation ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Epithelial Thickness ◽  
History Of ◽  
Group A ◽  
Temporal Aspect ◽  
Group B

Purpose To investigate the repeatability in corneal thickness (CT) and epithelial thickness (ET) measurements using spectral domain anterior segment optical coherence tomography (AS-OCT, REVO NX, Optopol) in keratoconus, and examine the effect of corneal crosslinking (CXL) on repeatability. Methods A cross-sectional study of 259 eyes of 212 patients with keratoconus attending the corneal disease clinic at a university hospital tertiary referral center were enrolled. Two groups were analysed: eyes with no prior history of CXL (Group A) and eyes with prior CXL (Group B). Repeatability of measurements was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CV). Results In Group A, central corneal thickness (CCT) was 472.18 ± 45.41μm, and the ET was found to be the thinnest in the inferior-temporal aspect at 51.79 ± 5.97μm and thickest at the superior-nasal aspect at 56.07 ± 5.70μm. In Group B, CCT was 465.11± 42.28μm, and the ET was the thinnest at the inferior-temporal aspect at 50.63 ± 5.52μm and thickest at the superior aspect at 56.80 ± 6.39μm. When evaluating CT measurements, ICC was above 0.86 and 0.83 for Group A and Group B respectively. When evaluating ET measurements, ICC was above 0.82 for both groups. CXL had no statistically significant impact on the repeatability of measurements. Conclusions AS-OCT provides repeatable CT and ET measurements in the central and peripheral cornea in patients with keratoconus. Repeatability is not affected by a history of CXL.

Central Corneal Thickness: Ultrasound Pachymetry Verus Anterior Segment Optical Coherence Tomography

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Waqas Ali ◽  
Munira Shakir ◽  
Sahira Wasim ◽  
Ronak Afza
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Mean Difference ◽  
P Value ◽  
Optical Coherence ◽  
Ultrasound Pachymetry ◽  
Group A ◽  
Group B

Purpose: To determine the mean difference in central corneal thickness between ultrasound pachymetry and anterior segment optical coherence tomography in patients visiting tertiary care hospital of Karachi Study design: Cross sectional study Place and Duration of Study: Department of Ophthalmology, Liaquat National Hospital, Karachi from 27th December 2018 to 26th June 2019. Methods: Total 216 eyes of 108 patients were divided into two groups. Central corneal thickness was measured using ultrasound pachymeters in group A and with anterior segment optical coherence tomography in group B. Data was collected and analyzed using SPSS version 21. Mean central corneal thickness was compared between the two methods. Stratification was done on gender, age and post-stratification independent sample t-test was applied for mean difference CCT and P-value ? 0.05 was taken as significant. Results: Total 108 patients were equally divided into two groups. Mean age was 48.70±7.82 years in group A and 50.66±6.88 years in group B. In group A, there were 74.1% males and 25.9% females while in group B, there were 75.9% males and 24.1% females. There was statistically significant difference between the mean central corneal thickness of group A and group B for right and left eyes (p<0.001). Mean difference was also compared for gender and age groups. We found statistically significant differences in central corneal thickness in between the two methods in both age groups (?45 years and > 45 years). Conclusion: Central corneal thickness was more with pachymeters as compared to the AS-OCT (p value < 0.05) Key Words: Central Corneal Thickness, Anterior Segment Optical Coherence Tomography, Ultrasound Pachymetry.

scholarly journals Comparison of cryotherapy versus intralesional measles, mumps, rubella vaccine versus their combination therapy in Indian patients with cutaneous wart: a single centre prospective observational study

2019 ◽  
Vol 5 (4) ◽  
pp. 715
Author(s):  
Mithila Uday Vanarase
Keyword(s):  
Observational Study ◽  
Group Treatment ◽  
Prospective Observational Study ◽  
Intralesional Injection ◽  
Mmr Vaccine ◽  
Indian Patients ◽  
Cutaneous Wart ◽  
Group A ◽  
Group B ◽  
Cutaneous Warts

<p class="abstract"><strong>Background:</strong> Need for more effective and less time consuming therapeutic method is current necessity for treatment of cutaneous warts. The objective of the study was to evaluate and compare the efficacy, safety of cryotherapy versus intralesional measles, mumps, rubella (MMR) vaccine versus combination of cryotherapy and intralesional MMR vaccine in Indian patients with cutaneous wart.</p><p class="abstract"><strong>Methods:</strong> This prospective observational study was conducted in 60 patients of cutaneous warts. Patients were divided into three groups viz., group A, group B and group C. Group A was treated with cryotherapy alone, Group B received intralesional injection 0.1 to 0.3 ml of MMR vaccine alone and Group C received combination of group A and group B therapy. In each group treatment was repeated at 3 week interval for a maximum of 4 sittings. Percentage of improvement was evaluated using visual analogue scale (VAS) for local as well as distant (non-inoculated) warts. Follow-up was made every 2 months till 4 months to detect any recurrence.<strong></strong></p><p class="abstract"><strong>Results:</strong> For local warts in second half of treatment (12<sup>th</sup> week) patients of Group B and Group C showed significantly better response than patients in Group A. For distant warts in first half of treatment session patients showed significantly better response to Group C than as compared to Group B therapy (p&lt;0.039).</p><p class="abstract"><strong>Conclusions:</strong> Immunotherapy with MMR is superior treatment than cryotherapy for cutaneous warts with minimum side effects but the combination of cryotherapy with intralesional MMR has shown to have complementary effect in treatment response.</p>

scholarly journals Effect of BMI on Postoperative Outcome, after Off-Pump CABG, A Prospective Observational Study

2021 ◽  
Vol 6 (1) ◽  
pp. 1-6
Author(s):  
Musfeq-Us-Saleheen Khan ◽  
Saikat Das Gupta ◽  
Ambia Afza ◽  
Bappy Basak ◽  
MD Kamrul Hasan ◽  
...  
Keyword(s):  
Observational Study ◽  
Wound Infection ◽  
Prospective Observational Study ◽  
Artery Bypass ◽  
Obese Patients ◽  
Off Pump ◽  
Opcab Surgery ◽  
Group A ◽  
Group B ◽  
Harvest Site

Background: Obesity and its complications are global health concerns with rising interests, and in Bangladesh, the scenario is not different. This study was designed to analyze the effect of BMI on postoperative outcomes in patients who underwent Off-Pump Coronary Artery Bypass (OPCAB)graft surgery. Methods: This prospective observational study was conducted from September 2017 to August 2018 in the department of cardiac surgery, NICVD & 90 patients were divided into two groups. 43 patients in group A, with BMI ≥ 25 kg/m2 and 47 patients in group B, with BMI<25 kg/m2. Results: In between groups, homogenous distribution was noted in terms of age and sex. Pre-operative risk factors, such as hypertension, dyslipidemia, and sternal wound infection, harvest site infection along with post-operative AF, were significantly higher in group A in comparison to group B. Conclusion: Obese patients undergoing OPCAB surgery should undergo maximum care. Meticulous tissue handling during OPCAB surgery in obese patients is needed to avoid or minimize sternal, and harvest site wound infection.

Negative effect of hypopituitarism following brain trauma in patients with diffuse axonal injury

2010 ◽  
Vol 113 (3) ◽  
pp. 532-538 ◽  
Author(s):  
Jae Hyun Jeong ◽  
Young Zoon Kim ◽  
Yong Woon Cho ◽  
Joon Soo Kim
Keyword(s):  
Observational Study ◽  
Functional Outcomes ◽  
Prospective Observational Study ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Abnormal Signal ◽  
Group A ◽  
Group B ◽  
The Brain

Object The aim of this prospective observational study was to assess the incidence and pattern of hypopituitarism after diffuse axonal injury (DAI) and to identify its effect on these patients in terms of functional outcome. Methods Of 1307 patients with traumatic brain injury treated at the authors' institution between March 2005 and June 2008, 65 patients with DAI were enrolled in the present study. The authors determined basal hormone levels, initial Glasgow Coma Scale scores, the Marshall CT grades, the presence of abnormal signal intensity indicating lesions on MR images, and duration of unconsciousness. At the 6-month follow-up visits, functional outcomes were estimated using the Modified Barthel Index. Univariate and multivariate analyses were performed to identify factors that influenced functional outcomes. Results Twenty-one patients with hypopituitarism (Group A) had more lesions in the body of the corpus callosum, basal ganglia, thalamus, and the gray–white matter junction than those without hypopituitarism (Group B). In Group A, growth hormone deficiency (17 patients, 80.9%) was the most common, and multiple pituitary hormone deficiencies were found in 12 patients (57.1%). The mean Modified Barthel Index score at the 6-month follow-up was 64.7 in Group A and 88.5 in Group B (p = 0.027). Duration of unconsciousness (p = 0.035), the Marshall CT grade (p = 0.021), hypopituitarism (p = 0.044), and abnormal signal intensities on MR imaging in midline or deep structures of the brain (p = 0.001) were found to be associated with functional outcome. Conclusions The findings in this prospective observational study suggest that hypopituitarism in patients with DAI has a relationship not only with injuries in the midline or deep structures of the brain, but also with a poor outcome.

Acute calcium deposits in the hand and wrist; comparison of acute calcium peritendinitis and acute calcium periarthritis

2013 ◽  
Vol 39 (4) ◽  
pp. 436-439 ◽  
Author(s):  
J. K. Kim ◽  
E. S. Park
Keyword(s):  
Conservative Treatment ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Age At Onset ◽  
Radiographic Finding ◽  
The Other ◽  
Group A ◽  
Calcium Deposits ◽  
Group B ◽  
Calcific Periarthritis

Acute calcium deposits are characterized by acute pain and a radiographic finding of amorphous calcification. A prospective, observational study was carried out on 30 consecutive patients undergoing conservative treatment for acute calcium deposits of the hand and wrist. Thirteen patients presented with acute calcific peritendinitis (Group A), and the other 17 with acute calcific periarthritis (Group B). All patients were followed for more than 12 months (mean 29 months). The average age at onset and recurrence rate of acute calcific peritendinitis were both significantly greater than for acute calcific periarthritis.

scholarly journals Single Dose Prophylactic Antibiotic in Caesarean Delivery and its Effect on Maternal Infectious Morbidity: A Prospective Observational Study

2020 ◽  
Author(s):  
Shreedevi Somashekhar Kori ◽  
Aruna Mallangouda Biradar ◽  
Dayanand Biradar ◽  
Subhash Mudanur ◽  
Neelamma Patil ◽  
...  
Keyword(s):  
Single Dose ◽  
Observational Study ◽  
Caesarean Delivery ◽  
Prospective Observational Study ◽  
Skin Incision ◽  
Research Centre ◽  
Wound Infections ◽  
Cord Clamping ◽  
Group A ◽  
Group B

Introduction: Caesarean delivery is the most common surgery performed in obstetrics. Antibiotics have revolutionised the surgical practise in this era. But multidrug resistance is a challenging issue in day to day practise. So, antibiotics have to be administered judiciously at the appropriate time with respect to surgery. Aim: To determine whether the administration of single dose injection ceftriaxone 1 gm intravenously prior to skin incision was superior to administration at the time of cord clamping for prevention of post-caesarean maternal infection. Materials and Methods: A prospective observational study was conducted in BLDE (DU) Shri BM Patil Medical College and Research Centre, Vijayapura, Karnataka, India. Patients undergoing caesarean sections for singleton term pregnancies both elective and emergency with intact membranes were included in study during one-year period. Alternatively, group A received 1 gm injection ceftriaxone intravenously 60 minutes before skin incision and group B received at the time of cord clamping during surgery. Chi-square (χ2) test was used for association between two categorical variables. Results: Incidence of obstetric complications such as nausea (0.5% vs 0.0%) and wound infections (6.6% vs 4.1%) were more in patients who received a single dose of ceftriaxone at cord clamping than patients receiving the same antibiotic, preoperatively whereas, incidence of postoperative fever was more in group A (4.1%) than group B (3.3%) which was although not significant but is an important finding in this study. Conclusion: Administration of single dose antibiotic either preoperatively or at the time of cord clamping was not statistically significant in reducing the incidence of wound infections.

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