scholarly journals Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ahmed Hassan ◽  
Enji Ahmed ◽  
Dalia Ghalwash ◽  
Azza Ezz Elarab
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Postoperative Pain ◽  
Color Match ◽  
Free Gingival Graft ◽  
Analgesic Consumption ◽  
Vas Score ◽  
Acid Gel ◽  
Gingival Graft ◽  
Hyaluronic Acid Gel

Aim. This study aimed to compare the effect of MEBO versus 0.2% hyaluronic acid gel (Gengigel®) applied to the palatal donor site on postoperative pain reduction and wound healing after free gingival graft harvesting. Methodology. Thirty-nine patients with different mucogingival defects were included in this study for harvesting a free gingival graft (FGG) for soft tissue augmentation. Patients were randomly assigned into three equal groups: group I (MEBO), group II (0.2% HA Gengigel®), and group III (control). Postoperative pain was recorded by using the Visual Analogue Scale (VAS). Analgesic consumption was recorded for 7 days postoperatively. Wound size was measured at baseline and on days 3, 7, 14, and 21. Postoperative healing of the palatal wound was assessed by the VAS score for color match on days 3, 7, 14, 21, and 42. Results. Results of this study showed significant postoperative pain reduction for the three groups; MEBO showed statistically significant less VAS score compared to the other two groups, while HA showed statistically significant less VAS score compared to the control group. Both MEBO and HA showed statistically significant less total analgesic consumption. No statistically significant difference was observed between groups for wound size. MEBO showed statistically significant higher VAS for color match. Conclusions. Both treatment modalities could reduce postoperative pain following harvesting of FGG and improve the palatal wound healing. However, MEBO showed better outcomes in terms of postoperative pain and color match.

scholarly journals Effects of Vitamin and Amino Acid-Enriched Hyaluronic Acid Gel on the Healing of Oral Mucosa: In Vivo and In Vitro Study

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 285
Author(s):  
Elena Canciani ◽  
Riccardo Sirello ◽  
Gaia Pellegrini ◽  
Dolaji Henin ◽  
Mariachiara Perrotta ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Healing Process ◽  
Third Molar ◽  
In Vitro Study ◽  
Vitro Study ◽  
Acid Gel ◽  
Hyaluronic Acid Gel

Background and Objectives: Wound healing is a dynamic process that can be compromised in patients with chronic and metabolic conditions or unhealthy lifestyles. Numerous medical substances designed for topical use, charged with compounds that promote the healing process, have been developed to improve wound healing, especially in compromised subjects. The present study aimed to extend our understanding of the in vivo effects of a hyaluronic acid gel charged with amino acids (HAplus gel, Aminogam gel® Errekappa Euroterapici spa, Milan, Italy) and study the in vitro effects of the same gel charged with additional substances in an attempt to optimize its formulation. Materials and Methods: In a randomized controlled split-mouth clinical and histological trial, HAplus gel was tested on the gingival tissue of the lower third molar post-extraction socket. The gingiva was collected at the time of extraction (T0) and ten days after the extraction (T1) to be histologically analyzed. During the second stage of the study, culture media with HAplus gel and vitamin C and E at different concentrations (TEST) were tested on human gingival fibroblasts and compared to the HAplus-enriched medium (HA-Control). Results: Histological and immunohistochemical analysis of collected gingiva showed higher microvascular density and collagen fibers organized in closely packed and well-oriented bundles in sites treated with HAplus gel. In the in vitro study, all TEST groups showed an increased viability from 24 h to 48 h. After 24 h, the viability percentage in all experimental groups was below 100% of the HA-Control, demonstrating a mild toxicity. After 48 h from seeding, the TEST groups’ viability grew significantly compared to HA-Control. Conclusions: These encouraging preliminary results suggest that the use of HAplus gel enriched with vitamins C and E may be beneficial in patients with conditions that impair soft tissue healing.

Does Adjunctive Use of Hyaluronic Acid Improve Clinical Outcome of Mechanical Therapy for Cases of Mild Aggressive Periodontitis

2017 ◽  
Vol 68 (3) ◽  
pp. 612-614
Author(s):  
Andreea A. Pogan ◽  
Roxana Buzatu ◽  
Dan Onisei ◽  
Doina Onisei
Keyword(s):  
Hyaluronic Acid ◽  
Antimicrobial Effect ◽  
Aggressive Periodontitis ◽  
Gingival Tissue ◽  
Potential Benefits ◽  
Therapeutic Properties ◽  
Acid Gel ◽  
Mechanical Therapy ◽  
Improve Clinical Outcome ◽  
Hyaluronic Acid Gel

Hyaluronic acid is an essential component of the periodontal ligament matrix and it has shown a number of clinical therapeutic properties, especially an anti-inflammatory effect on the gingival tissue. The aim of this study is to evaluate the potential benefits of using hyaluronic acid gel in topical application as an adjunct to mechanical therapy in the management of aggressive periodontitis. Results show an obvious improvement of clinical parameters, especially regarding the evolution of healing of the gingival tissue after periodontal therapy. Nevertheless, the antimicrobial effect needs to be proven in further studies.

scholarly journals Adolescents and primary herpetic gingivostomatitis: an Italian overview

2021 ◽  
Author(s):  
Elena Bardellini ◽  
Francesca Amadori ◽  
Federica Veneri ◽  
Giulio Conti ◽  
Alberto Paderno ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Antibiotic Therapy ◽  
Medical Records ◽  
Bacterial Infections ◽  
Group A ◽  
Acid Gel ◽  
Herpetic Gingivostomatitis ◽  
Group B ◽  
Italian Adolescents ◽  
Hyaluronic Acid Gel

Abstract Aim The aim of this study was to investigate the therapies administered to Italian adolescents with primary herpetic gingivostomatitis (PHGS) Methods The medical records of 74 adolescents with PHSG were reviewed. The following data were recorded: age, gender, day of onset, type of treatment, lesions’ severity, pain scoring, eating, and drinking ability. The oral examination was performed at the first evaluation (T0) and after one week (T1). Results All patients showed up at the first visit at least 48 h after the onset of symptoms. No patient was prescribed an antiviral therapy. An antibiotic therapy was prescribed in order to prevent secondary bacterial infections. Fifteen patients had been treated with non alcoholic chlorhexidine rinses (group A), 29 patients with non alcoholic chlorhexidine rinses plus hyaluronic acid gel (group B); 30 patients with non alcoholic chlorhexidine rinses plus Mucosyte® (group C). A significant improvement of the pain scoring and lesions’ severity was noted in group C. Conclusion In Italian adolescents, PHGS is diagnosed at least 48 h after onset and the antibiotic therapy is widely prescribed in order to prevent overinfections. Among topical therapies, an association of verbascoside and sodium hyaluronhate seems to favour a faster healing.

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