scholarly journals The Association between the Serum Uric Acid Level and Hypertension in Middle-Aged and Elderly Adults

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Xianpeng Xu ◽  
Jinke Huang ◽  
Simin Wu ◽  
Qingjie Ji ◽  
Xuguang Guo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Turning Point ◽  
Serum Uric Acid Level ◽  
Recursive Algorithm ◽  
Multiple Logistic Regression Analysis ◽  
Elderly Adults ◽  
Middle Aged ◽  
Health And Nutrition ◽  
The Relationship

Background. Studies on serum uric acid (sUA) levels and hypertension (HTN) are controversial. To investigate the association between the sUA level and the incident of HTN in middle-aged and elderly adults, we performed this study. Methods. 6399 participants aged ≥40 years from the National Health and Nutrition Examination Survey (NHANES) were included. Weighted multiple logistic regression analysis was carried out to evaluate the relationship between the sUA level and the incident of HTN, exploring the potential nonlinear relationship using the fitted smoothing curves. If nonlinearity was observed, the inflection point was further calculated by a recursive algorithm. Results. A positive relationship between the sUA level and the incident of HTN was found. However, it may differ in different race groups, nor between male and female. Moreover, the association between the sUA level and the incident of HTN followed a U-shaped curve in male (turning point: sUA 4.1 mg/dL) and Whites (turning point: sUA 7.9 mg/dL). Conclusions. The results revealed that the sUA level is positively correlated with the incident of HTN, in middle-aged and elderly adults. However, it followed a U-shaped curve in males and Whites.

Prognostic Nomogram on Clinicopathologic Features and Serum Uric Acid for Precancerous Lesions and Gastric Cancer

2021 ◽  
Author(s):  
Shanshan Tang ◽  
Ying Chen ◽  
Chenhong Fu ◽  
Xin Xie ◽  
Ziyu Song ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Precancerous Lesions ◽  
Multiple Logistic Regression Analysis ◽  
Precancerous Lesion ◽  
Multiple Logistic Regression ◽  
Diagnosis Rate ◽  
H Pylori ◽  
The Relationship

Abstract The relationship between Uric acid (UA) and malignant tumor are still confusing. Gastric cancer(GC) is recognized to be closely related to Helicobacter pylori (H. pylori) infection, early diagnosis rate is very low. In this study, we aimed to investigate the relationship between H. pylori and hyperuricemia (HUA), and evaluate the predictive value of serum uric acid (SUA) in gastric precancerous lesion (GPL) and gastric cancer (GC). This retrospective study included 486 patients who underwent gastroscopy (155 controls, 272 GPL, 59 GC patients). The risk factors for GPL and GC were identified by multiple logistic regression analysis and nomogram was constructed to evaluate the ability of SUA to predict the risk of these diseases based on SUA score. We found that in healthy controls, HUA is positively correlated with H. Pylori (+). SUA was an independent risk factor for GPL and GC. Verification shows that the nomogram was better fitted for GC than for GPL. In conclusion, our study established nomogram based on SUA to predict the risk of GPL and GC, suggested that the incidence of GPL and GC is higher in H. pylori (+) HUA patients, so early intervention and vigilance should be raised.

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