Serum uric acid level as a cardio-cerebrovascular event risk factor in middle-aged and non-obese Chinese men

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

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STUDY OF SERUM URIC ACID LEVEL AS A RISK FACTOR AND FOR EVALUATING THE SEVERITY OF CORONARY ARTERY DISEASE

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/1281 ◽

2016 ◽

Vol 5 (77) ◽

pp. 5678-5683

Author(s):

Shruthi S ◽

Ramchandra Prabhu H D ◽

Tirthankar Mukherjee

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Risk Factor ◽

Coronary Artery ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Artery Disease

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Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men

Journal of Clinical Medicine ◽

10.3390/jcm9030773 ◽

2020 ◽

Vol 9 (3) ◽

pp. 773 ◽

Cited By ~ 1

Author(s):

Tae Ryom Oh ◽

Hong Sang Choi ◽

Chang Seong Kim ◽

Dong-Ryeol Ryu ◽

Sun-Hee Park ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Lupus Nephritis ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Lupus Erythematosus ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level ◽

Cox Proportional Hazards

Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan–Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018–1.317; p = 0.028) but not in men (HR, 1.499; CI, 0.964–2.331; p = 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.

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Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology ◽

10.5152/akd.2013.039 ◽

2012 ◽

Cited By ~ 1

Author(s):

Asli Inci Atar ◽

Omer Caglar Yilmaz ◽

Kayihan Akin ◽

Yusuf Selcoki ◽

Okan Er ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Coronary Arteries ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level ◽

Controlled Study

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Study of Serum Uric Acid Level as an Independent Risk Factor in Acute Ischemic Stroke

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2020/95 ◽

2020 ◽

Vol 7 (9) ◽

pp. 442-445

Author(s):

Chandrashekhar K ◽

Mohammed Anwar Hussain ◽

Ishwar S. Hasabi ◽

Suryakanth Suryakanth ◽

Chethan K. Ganteppanavar

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Independent Risk Factor ◽

Serum Uric Acid Level

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NO CORRELATION BETWEEN METABOLIC SYNDROME AND SERUM URIC ACID IN THE OFFICE WORKERS OF BUMN COMPANY IN SURABAYA

Majalah Biomorfologi ◽

10.20473/mbiom.v31i1.2021.13-20 ◽

2021 ◽

Vol 31 (1) ◽

pp. 13

Author(s):

Jihan Jauza Fairuz ◽

Dewi Ratna Sari ◽

Soebagijo Adi Soelistijo

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Office Workers ◽

Abdominal Circumference

Background: Metabolic syndrome is a cluster of risk factor which consists of central obesity, hypertriglyceride, low High Density Lipoprotein (HDL) level, hypertension, and hyperglycemia where the incidence increases among the office workers. Uric acid is often associated with cardiovascular disease while risk factor of cardiovascular disease is associated with metabolic syndrome. Objective: To analyze the correlation between metabolic syndrome and serum uric acid level in office workers. Method: This study used medical record of health examination of PT Wijaya Karya Divisi IV male office workers aged of 20 – 60 years. The data taken consisted of abdominal circumference, triglyceride level, HDL level, fasting blood glucose level, blood pressure, and serum uric acid levels. The diagnostic criterion of metabolic syndrome which was used in this study was National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) that had been modified for Asian. The correlation of metabolic syndrome and serum uric acid level was analyzed by chi-square test with IBM SPSS Statistic 20 application. Results: There was no significant correlation between metabolic syndrome and serum uric acid leves in male office workers of PT Wijaya Karya Divisi IV (p=0.598). Conclusion: Among the male office workers of PT Wijaya Karya Division IV, it had no significant correlation between metabolic syndrome and serum uric acid level.

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CORRELATION BETWEEN METABOLIC SYNDROME AND SERUM URIC ACID IN THE OFFICE WORKERS OF A BUMN COMPANY IN SURABAYA, INDONESIA

Majalah Biomorfologi ◽

10.20473/mbiom.v31i1.2021.11-17 ◽

2021 ◽

Vol 31 (1) ◽

pp. 11

Author(s):

Jihan Jauza Fairuz ◽

Dewi Ratna Sari ◽

Soebagijo Adi Soelistijo

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Office Workers ◽

Abdominal Circumference

Background: Metabolic syndrome is a cluster of risk factor which consists of central obesity, hypertriglyceride, low High Density Lipoprotein (HDL) level, hypertension, and hyperglycemia. Its incidence among the office workers is increasing. Uric acid is often associated with cardiovascular disease while risk factor of cardiovascular disease is associated with metabolic syndrome. Objective: To analyze correlation between metabolic syndrome and serum uric acid level in office workers. Materials and Methods: This study used medical record of health examination of PT Wijaya Karya Divisi IV male office workers aged of 20 – 60 years. The data taken consisted of abdominal circumference, triglyceride level, HDL level, fasting blood glucose level, blood pressure, and serum uric acid levels. The diagnostic criterion of metabolic syndrome used in this study was National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) that had been modified for Asians. The correlation of metabolic syndrome and serum uric acid level was analyzed with chi-square test with IBM SPSS Statistic 20 application. Results: There was no significant correlation (p=0.598) between metabolic syndrome and serum uric acid leves in male office workers of PT Wijaya Karya Divisi IV. Conclusion: Metabolic syndrome and serum uric acid level among male office workers of PT Wijaya Karya Division IV had no correlation.

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