Expression of lncRNA-ANRIL before and after Treatment and Its Predictive Value for Short-Term Survival in Patients with Coronary Heart Disease

This study aimed at observing the expression of lncRNA-ANRIL (ANRIL) before and after treatment and its predictive value for short-term survival in patients with coronary heart disease (CHD). Altogether, 112 patients with CHD admitted to the hospital were enrolled as a study group (SG), which was divided into a pretreatment study group (preSG) and a posttreatment study group (postSG). Further 72 healthy people undergoing physical examinations during the same period were enrolled as a control group (CG). Peripheral blood was collected from the subjects in the three groups, to detect the expression level of serum ANRIL using quantitative reverse transcription PCR (qRT-PCR). A receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic value of ANRIL for CHD. Kaplan-Meier survival curves were plotted to analyze 3-year survival rates in high- and low-ANRIL expression groups. Cox regression was conducted to analyze independent risk factors affecting the patients. The expression level of serum ANRIL in preSG was significantly lower than those in CG and postSG ( P < 0.05 ). According to the ROC curve, the area under the curve (AUC) of serum ANRIL for diagnosing CHD in CG was 0.894 and the optimal cutoff value was 0.639, with the sensitivity of 86.61% and the specificity of 93.67%. According to the survival curves, the 3-year overall survival rate in the high-ANRIL expression group was significantly lower than that in the low-expression group ( P < 0.05 ). History of smoking, high total cholesterol (TC), high triglyceride (TG), high homocysteine (Hcy), and ANRIL expression were independent prognostic factors affecting the overall survival time of the patients ( P < 0.05 ). ANRIL is poorly expressed in the peripheral blood of patients with CHD. Its detection has good sensitivity and specificity for diagnosing the disease, and its expression may be related to the poor prognosis of the patients.

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Bioinformatics Analysis of The Expression of ATP Binding Cassette Transporters and The Screening of Regulatory Genes in PTEN/PI3K/Akt/mTOR Signaling Pathway in The Hepatocellular Carcinoma

10.21203/rs.3.rs-674099/v1 ◽

2021 ◽

Author(s):

Tingdan Zheng ◽

Wuqi Song ◽

Aiying Yang

Keyword(s):

Gene Expression ◽

Hepatocellular Carcinoma ◽

Overall Survival ◽

Bioinformatics Analysis ◽

Wilcoxon Test ◽

Rank Test ◽

Short Term ◽

Term Survival ◽

Log Rank Test ◽

Short Term Survival

Abstract Objective Here we performed the Bioinformatics analysis on the data from The Cancer Genome Atlas (TCGA), in order to find the correlation between the expression of ATP Binding Cassette (ABC) Transporters’ genes and hepatocellular carcinoma (HCC) prognosis; Methods Transcriptome profiles and clinical data of HCC were obtained from TCGA database. Package edgeR was used to analyze differential gene expression. Patients were divided into low-ABC expression and high-ABC expression groups based on the median expression level of ABC genes in cancer. The overall survival and short-term survival (n= 341) of the two groups was analyzed using the log-rank test and Wilcoxon test; Results We found that ABC gene expression was correlated with the expression of PIK3C2B (p<0.001, ABCC1: r=0.27; ABCC10: r=0.57; ABCC4: r=0.20; ABCC5: r=0.28; ABCB9: r=0.17; ABCD1: r=0.21). All patients with low-ABC expression showed significantly increased overall survival. Significantly decreased overall survival (Log-rank test: p<0.05, Wilcoxon test: p<0.05) was found in patients with high expression of ABCC1 (HR=1.58), ABCD1 (HR=1.45), ABCC4 (HR=1.56), and ABCC5 (HR=1.64), while decreased short-term survival (Log-rank test: p>0.05, Wilcoxon test: p<0.05) was correlated with the increased expression of ABCC10 (HR=1.29), PIK3C2B (HR=1.29) and ABCB9 (HR=1.23); Conclusions Our findings indicate that the specific ABC gene expression correlates with the prognosis of HCC. Therefore, ABC expression profile could be a potential indicator for HCC patients.

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Factors affecting short-term survival in patients older than 85 treated with resection for stage II and III colon cancer

Surgery ◽

10.1016/j.surg.2021.10.020 ◽

2021 ◽

Author(s):

Gabriela Poles ◽

Roma Kaur ◽

Erika Ramsdale ◽

Maria J. Schymura ◽

Larissa K. Temple ◽

...

Keyword(s):

Colon Cancer ◽

Stage Ii ◽

Short Term ◽

Term Survival ◽

Factors Affecting ◽

Short Term Survival

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Evaluating the Association between Insulin-Like Growth Factor-1 Values and Short-Term Survival Rates following Acute Myocardial Infarction

Clinical Medicine Insights Cardiology ◽

10.4137/cmc.s6629 ◽

2011 ◽

Vol 5 ◽

pp. CMC.S6629 ◽

Cited By ~ 2

Author(s):

Shokoufeh Hajsadeghi ◽

Hamed Mohseni ◽

Masoud Moradi ◽

Elham Rahmani ◽

Kiarash Kordshakeri ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Growth Factor ◽

Survival Rates ◽

P Value ◽

Survival Curves ◽

Short Term ◽

Term Survival ◽

The Difference ◽

Short Term Survival

Backgrounds In recent years, low levels of Insulin-like Growth Factor-1 (IGF-1) have been suggested to be associated with higher risks of developing heart failure and higher long-term mortality rates following Acute Myocardial Infarction (AMI). However, the effect of IGF-1 levels on short-term survival has been rarely studied. In this study we aimed to assess any possible association between serum IGF-1 concentration following AMI and short-term survival rates. Methods In this study, serum total IGF-1 levels were measured in 56 patients within 24 hours following AMI and were compared to 56 individuals with no cardiovascular disease. Patients were followed up to death or discharge from hospital (median = 6 days) and survival curves were compared based on median IGF-1 value. Results Mean (±SD) of serum IGF-1 levels were 232.73 ng/ml (±81.74) and 211.00 ng/ml (±58.22) in survived and expired patients respectively and the difference was not statistically significant ( P value = 0.501). The difference between survival curves was also not statistically significant ( P value = 0.246). Conclusion According to findings of this study, serum total IGF-1 concentration does not seem to be associated with short-term survival rates.

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Evaluation of prognostic factors affecting long and short term survival rates of Hodgkin's lymphoma patients using the cure fraction models

Scientific Journal of Kurdistan University of Medical Sciences ◽

10.29252/sjku.24.1.66 ◽

2019 ◽

Vol 24 (1) ◽

pp. 66-77

Author(s):

Amir Elhaei ◽

Amal Saki Malehi ◽

Mohammad Seghatoleslami ◽

◽

...

Keyword(s):

Prognostic Factors ◽

Hodgkin’S Lymphoma ◽

Survival Rates ◽

Hodgkin's Lymphoma ◽

Short Term ◽

Term Survival ◽

Factors Affecting ◽

Cure Fraction ◽

Short Term Survival ◽

Fraction Models

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Movement, fishery sector impact, and factors affecting the recapture rate of tagged sand crabs, Portunus pelagicus (L.), in Moreton Bay, Queensland

Marine and Freshwater Research ◽

10.1071/mf9910751 ◽

1991 ◽

Vol 42 (6) ◽

pp. 751 ◽

Cited By ~ 17

Author(s):

MA Potter ◽

WD Sumpton ◽

GS Smith

Keyword(s):

Bacterial Infection ◽

Spatial Heterogeneity ◽

Fishing Effort ◽

Mature Male ◽

Short Term ◽

Portunus Pelagicus ◽

Term Survival ◽

Factors Affecting ◽

Moreton Bay ◽

Short Term Survival

Selected mature male sand crabs (Portunus pelagicus) (6827 individuals with carapace widths of 120-192 mm) were tagged with Floy ED-68BA anchor tags and released in 14 areas of Moreton Bay and adjacent oceanic waters. In all, 1003 tagged crabs (14.7%) were recaptured, with 79% of these recaptured less than 2 km from their release points and 4% recaptured more than 10 km from their release points. Of the total recaptures, 63% were made within 14 days of crabs being released. Commercial pot fishers recaptured the largest proportion (70%) of crabs, whereas recreational fishers and commercial trawl fishers recaptured only 18 and 12% of tagged crabs, respectively. Recapture rates varied from 2 to 59%, depending on location, reflecting a massive spatial heterogeneity of fishing effort. Only 2.6% of recaptured crabs moulted between release and recapture. Crabs that were undamaged at release had twice the recapture rate of damaged crabs (i.e. crabs that had missing appendages), and the probability of recapture increased with crab size. Under laboratory conditions, unmodified Floy FD-68BA tags reduced the short-term survival of male P. pelagicus, possibly because of bacterial infection, and it was concluded that Floy anchor tags were not suitable for field growth studies of P. pelagicus.

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