Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration

Obesity is a civilization disease representing a global health problem. Excessive body weight significantly reduces the quality of life. It is also associated with the leading causes of death, including type 2 diabetes mellitus, cardiovascular diseases, and numerous types of cancer. The mainstay of therapy is a dietary treatment. However, in morbidly obese patients, dietary treatment is often insufficient. In these patients, the most effective procedure is bariatric surgery, but it is still difficult to predict its outcome and metabolic changes. Hepatokines are proteins secreted by hepatocytes. Many of them, including fetuin-A, selenoprotein P, angiopoietin-like protein 6, and fibroblast growth factor 21, have been linked to metabolic dysfunctions. In this context, hepatokines may prove helpful. This review investigates the possible changes in hepatokine profiles after selected bariatric surgery protocols. In this regard, Roux-en-Y gastric bypass is the most studied type of surgery. The overall analysis of published research identified fetuin-A as a potential marker of metabolic alternations in patients after bariatric surgery.

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Effects of a three‐month combined exercise programme on fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women

Clinical Endocrinology ◽

10.1111/j.1365-2265.2011.04078.x ◽

2011 ◽

Vol 75 (4) ◽

pp. 464-469 ◽

Cited By ~ 78

Author(s):

Sae Jeong Yang ◽

Ho Cheol Hong ◽

Hae Yoon Choi ◽

Hye Jin Yoo ◽

Geum Ju Cho ◽

...

Keyword(s):

Growth Factor ◽

Arterial Stiffness ◽

Fibroblast Growth Factor ◽

Exercise Programme ◽

Fibroblast Growth Factor 21 ◽

Fibroblast Growth ◽

Obese Women ◽

Fetuin A ◽

Combined Exercise

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Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2015-2192 ◽

2015 ◽

Vol 100 (8) ◽

pp. 3004-3010 ◽

Cited By ~ 21

Author(s):

Thomas Reinehr ◽

Beate Karges ◽

Thomas Meissner ◽

Susanna Wiegand ◽

Maria Fritsch ◽

...

Keyword(s):

Type 2 Diabetes ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 21 ◽

Fibroblast Growth ◽

Fetuin A ◽

Obese Adolescents

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P0025BARIATRIC SURGERY MAY REDUCE UPREGULATED EXPRESSION OF FIBROBLAST GROWTH FACTOR 21 AND ANGIOTENSIN-CONVERTING ENZYME 2 IN OBESE PATIENTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0025 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Byung Chul Yu ◽

Hyoungnae Kim ◽

Mooyong Park ◽

Soon hyo Kwon

Keyword(s):

Bariatric Surgery ◽

Growth Factor ◽

Angiotensin Converting Enzyme ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 21 ◽

Obese Patients ◽

Fibroblast Growth ◽

Ang Ii ◽

Converting Enzyme ◽

Angiotensin Converting Enzyme 2

Abstract Background and Aims Recent studies showed that the fibroblast growth factor 21 (FGF21) and angiotensin-converting enzyme 2 (ACE2)/Angiotensin 1-7 (Ang (1-7))/MAS axis of the renin-angiotensin system counteract to the negative role of Ang II in various disease. In this study, we examed FGF21 and ACE2/Ang (1-7) in obesity and its change after bariatric surgery. Method We prospectively enrolled obese patient who performed bariatric surgery and age-sex matched healthy volunteers (HV) (n=12 each). We obtained their clinical information and serum samples. Serum FGF-21, Ang II, ACE2, and Ang (1-7) levels were measured by enzyme-linked immunosorbent assay kits. We measured also FGF-21, Ang II, ACE2, and Ang (1-7) 6 months after bariatric surgery in obese patients (n=12). Results FGF21, Ang II, and ACE2 levels were significantly higher in obese patients compared with HV (p= 0.045, < 0.001, and 0.020, respectively). FGF21, Ang II, and ACE2 levels were significantly decreased after bariatric surgery (p = 0.002, 0.005, and 0.023, respectively). There was no significant difference in Ang (1-7) levels between obese patients and HV (p = 0.887) (Figure 1). Although Ang (1-7) levels did not change after bariatric surgery (p = 0.480), changes in Ang (1-7) levels were positively correlated with changes in body mass index (BMI) (R2 = 0.580, p = 0.048) (Figure 2). Conclusion FGF21 and ACE2 were upregulated in obese patients and they are reduced after bariatric surgery. A decrease in BMI after bariatric surgery could lead to decrease in Ang (1-7).

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