Long-Term Medical Follow-Up (for More than 15 Years) of a Patient with Stage IA Mycosis Fungoides Originally Presenting in Childhood: Remission for >15 Years with Localised Electron Beam Therapy

A man now aged 80 years has received specialist care for stage 1A mycosis fungoides for 58 years. The disease developed in childhood. Long-term follow-up (>30 years) of patients with mycosis fungoides is infrequently described in the world literature. The disease in this patient was limited to 5 areas, but these were large (up to 25 cm in diameter). The rest of the skin was normal clinically. All 5 areas were treated separately with electron beam therapy (3–4 MeV) to a dose of 30 Gy in 15 fractions over 3 weeks between 2000 and 2005. Complete regression was obtained in all 5 areas, and the patient has been in complete remission for 15 years after living with the disease previously for over 40 years.

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Efficacy of total skin electron beam therapy in early stages t1-2 mycosis fungoides : results of a long-term follow-up

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(02)03576-9 ◽

2002 ◽

Vol 54 (2) ◽

pp. 300

Author(s):

T Gilles ◽

Y Loı̈c ◽

D Sophie ◽

L Daniel ◽

P Tony ◽

...

Keyword(s):

Electron Beam ◽

Mycosis Fungoides ◽

Electron Beam Therapy ◽

Early Stages ◽

Long Term Follow Up

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58 Oral Efficacy of total skin electron beam therapy in early stages T1–2 Mycosis Fungoides : results of a long-term follow-up

Radiotherapy and Oncology ◽

10.1016/s0167-8140(02)82377-5 ◽

2002 ◽

Vol 64 ◽

pp. S18

Keyword(s):

Electron Beam ◽

Mycosis Fungoides ◽

Electron Beam Therapy ◽

Early Stages ◽

Long Term Follow Up

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Long-term follow-up and secondary malignancy in mycosis fungoides patients treated by electron beam irradiation.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e18511 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e18511-e18511

Author(s):

Miroslav Lutsyk ◽

Orit Kaidar-Person ◽

Micha Bar-Hanna ◽

Yoram Cohen ◽

Abraham Kuten

Keyword(s):

Electron Beam ◽

Mycosis Fungoides ◽

Electron Beam Irradiation ◽

Secondary Malignancy ◽

Secondary Malignancies ◽

Beam Irradiation ◽

Photon Irradiation ◽

Long Term Follow Up

e18511 Background: Mycosis fungoides (MF) and Sezary's syndrome are the most common subgroup of cutaneous T-cell lymphoma. Total or partial skin electron beam irradiation (TSEI, PSEI) is an accepted treatment option in cases of disease that is limited to the skin and as palliative treatment in advanced disease. Consequently, long term follow-up of these patients and detection of secondary malignancies after TSEI/PSEI is crucial. The aim of this study was to summarize long term follow-up of MF patients treated by TSEI or PSEI and to evaluate the rates of secondary malignancies. Methods: A retrospective review of the medical charts of all consecutive patients diagnosed with MF who was treated from January 1960 to June 2010 at our hospital was conducted. Data collected included demographics, date of diagnosis, staging, treatment, and secondary malignancies. Results: One hundred ninety six patients were included (132 M, 64 F). The median age at diagnosis was 67.3 years. The mean follow-up was 109.4±89.4 months (range 1-566). One hundred patients received TSEI, 45 patients received PSEI, and one patient was treated by low dose total body photon irradiation combined with TSEI. Fifty patients (50/196, 25.5%) developed a second malignancy, 16 patients (16/196, 8%) had a third malignancy, and 4 (2%) patients developed a fourth malignancy. Conclusions: MF is associated with development of sequential malignancies. The contribution of TSEI or PSEI to the development of secondary malignancies is yet to be determined. Long term follow-up in this group of patients is essential.

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Extramedullary Nasal Plasmacytoma — An Unusual Clinical Entity

Ear Nose & Throat Journal ◽

10.1177/014556139607500314 ◽

1996 ◽

Vol 75 (3) ◽

pp. 171-173 ◽

Cited By ~ 8

Author(s):

Gordon Soo ◽

Anthony Chan ◽

Dennis Lam ◽

Victor Abdullah ◽

C. Andrew van Hasselt

Keyword(s):

World Literature ◽

Residual Disease ◽

Disease Recurrence ◽

Extramedullary Plasmacytoma ◽

Intracranial Extension ◽

Long Term Follow Up ◽

Unusual Appearance

A case of extramedullary plasmacytoma with its unusual appearance is reported. This is the second reported case in world literature affecting the paranasal sinuses with intracranial extension. The role of surgery is to obtain tissue for diagnosis and to excise residual disease. Radiotherapy is the treatment of choice and long-term follow-up is necessary for monitoring disease recurrence. The overall 10-year survival is about 50%. The case is discussed with a general review of the management of this pathology.

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Dermatofibrosarcoma Protuberans Metastatic to the Lung. A Case Report

Tumori Journal ◽

10.1177/030089169207800112 ◽

1992 ◽

Vol 78 (1) ◽

pp. 49-51 ◽

Cited By ~ 2

Author(s):

Prakash K. Patil ◽

Snehal G. Patel ◽

S. Krishnamurthy ◽

Rajesh C. Mistry ◽

Raman K. Deshpande ◽

...

Keyword(s):

Case Report ◽

World Literature ◽

Dermatofibrosarcoma Protuberans ◽

Primary Lesion ◽

Wide Excision ◽

Pathologic Features ◽

The World ◽

Long Term Follow Up

A case is presented of dermatofibrosarcoma protuberans of the gluteal region with metastasis to the lung appearing 7 years after wide excision of the primary lesion. The world literature is reviewed. The clinical and pathologic features of dermatofibrosarcoma are reviewed and treatment is discussed, with the aim of emphasizing the need for long-term follow-up examination of lymph nodes and for metastases following wide excision of these lesions.

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