scholarly journals Correlation Analysis between Macular Choroidal Thickness and Visual Field Mean Defect in Primary Open-Angle Glaucoma

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Fan Li ◽  
Yiming Huo ◽  
Lihua Ma ◽  
Guangxian Tang
Keyword(s):  
Visual Field ◽  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Open Angle ◽  
Imaging Optical Coherence Tomography ◽  
The Mean

Purpose. To evaluate the differences in macular choroidal thickness and volume between patients with primary open-angle glaucoma (POAG) and healthy controls to assess the correlation between macular choroidal thickness and visual field mean defect (MD). Methods. Case-control study. A total of 101 patients (101 eyes) with POAG who were hospitalized in our hospital and 102 healthy subjects (102 eyes) matched by age, sex, and axial length were consecutively selected as the POAG group and the control group, respectively. The macular choroidal thickness and volume in nine regions were measured in all subjects by enhanced-depth imaging optical coherence tomography (EDI-OCT). Results. The mean thicknesses of the choroid in the macular area in the POAG group and healthy group were 207.97 ± 62.83 µm and 208.24 ± 47.97 µm, and the mean volumes were 0.63 ± 0.19 µm3 and 0.64 ± 0.14 µm3. There were no significant differences in macular choroidal thickness, volumes of various macular regions, or mean choroidal thickness or volume between the POAG and healthy groups (all p > 0.05 ). The macular choroidal thickness of various macular regions was not correlated with visual field MD in the POAG group (all p > 0.05 ). Conclusion. The macular choroidal thicknesses and volumes in POAG patients were not significantly different from those in healthy individuals. The macular choroidal thickness was not correlated with MD in POAG patients. Therefore, macular choroidal thickness is not an appropriate parameter to evaluate damage caused by POAG, and the role of the macular choroid thickness in POAG needs to be further investigated.

scholarly journals Clinical Analysis of Macular Choroidal Thickness in Pseudoexfoliative Glaucoma and Primary Open-Angle Glaucoma

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Fan Li ◽  
Yiming Huo ◽  
Lihua Ma ◽  
Qing Zhang ◽  
Hengli Zhang ◽  
...  
Keyword(s):  
Axial Length ◽  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Healthy Individuals ◽  
Pseudoexfoliative Glaucoma ◽  
The Mean ◽  
Choroidal Volume

Purpose. To evaluate the differences in macular choroidal thickness and volume among patients with pseudoexfoliative glaucoma (PXG), patients with primary open-angle glaucoma (POAG), and controls. Methods. A total of 50 PXG patients (50 eyes) and 56 POAG patients (56 eyes) were selected as the PXG group and the POAG group, respectively, in this case-control study. A total of 54 age-, gender-, IOP-, and axial length-matched healthy individuals (54 eyes) were selected as the control group. Enhanced-depth imaging-optical coherence tomography (EDI-OCT) was used to measure and analyze the choroidal thicknesses and volumes in 9 macular regions of all subjects. Results. The choroidal thicknesses in the central subfield (CSM), temporal inner macula (TIM), inferior inner macula (IIM), and temporal outer macula (TOM) and the mean macular choroidal thickness were significantly thinner in the PXG group than in the control group (all P < 0.05 ). The choroidal volumes in the TIM, IIM, and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the control group (all P < 0.05 ). The choroidal thicknesses in the CSM and IIM and the mean macular choroidal thickness were significantly thinner in the PXG group than in the POAG group (all P < 0.05 ). The choroidal volumes in the IIM and TOM and the mean macular choroidal volume were significantly smaller in the PXG group than in the POAG group (all P < 0.05 ). Multivariable linear regression analysis showed that the mean macular choroidal thickness was significantly thinner in association with older subjects and longer axial length eyes. There was no association between the macular choroidal thickness of various macular regions and visual field mean defect (MD) in groups PXG and POAG (all P > 0.05 ). Conclusions. The macular choroidal thicknesses and volumes (inferior and temporal) in PXG patients were thinner and smaller than those in POAG patients and healthy individuals. The role of choroidal thickness changes in the course of PXG remains unclear. A future prospective study is needed to better define these changes in PXG patients.

Topographic correlation between juxtapapillary choroidal thickness and parapapillary deep-layer microvasculature dropout in primary open-angle glaucoma

2017 ◽  
Vol 102 (8) ◽  
pp. 1134-1140 ◽  
Author(s):  
Seung Hyen Lee ◽  
Eun Ji Lee ◽  
Tae-Woo Kim
Keyword(s):  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Deep Layer ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Swept Source ◽  
En Face ◽  
Swept Source Oct ◽  
The Mean

PurposeTo investigate the topographic relationship between parapapillary deep-layer microvasculature dropout (MvD) as assessed by optical coherence tomography (OCT) angiography (OCTA) and the juxtapapillary choroidal thickness (JPCT) in primary open-angle glaucoma (POAG).MethodsA total of 194 eyes (138 POAG and 56 control eyes) having parapapillary atrophy (PPA) were imaged using the swept-source OCT and OCTA to examine the microstructure of PPA and measure the JPCT, and to determine the presence of the MvD. MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in the parapapillary deep-layer in the en face OCTA images.ResultsJPCT was smaller in the POAG group than control group at 6-, 6.5-, 7- and 7.5-o’clock meridians (all p≤0.002). When POAG eyes were classified into those with parapapillary γ-zone and those with only β-zone without γ-zone, the mean JPCT was significantly smaller in the latter (p=0.027). The JPCT differed between with and without MvD only in eyes with a γ-zone: the JPCT was smaller in the eyes having MvD at 7- and 7.5-o’clock meridians (both p=0.001), where MvD was detected most frequently. However, such a difference was not observed in the eyes with only β-zone without the γ-zone at any of the meridians.ConclusionsLocalised reductions in JPCT were observed at the location of MvD in POAG eyes with parapapillary γ-zone. Such a correlation was not observed in the POAG eyes with only β-zone, but the mean JPCT was significantly smaller in this group.

scholarly journals Effect of mean ocular perfusion pressure on primary open angle glaucoma

2018 ◽  
Vol 11 (4) ◽  
pp. 286-290
Author(s):  
Pallab Kumar Sen ◽  
Nazneen Khan ◽  
Md. Shafiqul Islam
Keyword(s):  
Odds Ratio ◽  
Primary Open Angle Glaucoma ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Ocular Perfusion Pressure ◽  
Ocular Perfusion ◽  
The Mean ◽  
The Right

Primary open angle glaucoma is the most common form of glaucoma and it remains asymptomatic until the late stage of the disease. The purpose of this study is to compare the mean ocular perfusion pressure with the primary open angle glaucoma. A total of 60 study subjects were divided into two following groups: a) newly diagnosed patients with primary open angle glaucoma (case) and b) age and sex-matched healthy volunteers (control). The intraocular pressure and blood pressure were measured 3 hourly from 8:00 am to 11:00 pm. The mean ocular perfusion pressure of the right eyes in untreated primary open angle glaucoma was 39.9 ± 7.5 mm Hg whereas it was 47.7 ± 7.7 mm Hg in the control. The odds ratio was 6.6 (95% CI, 2.1-20.5; p=0.002). The right eyes of untreated primary open angle glaucoma had 6.6 times more risk compared to the control group. The mean ocular perfusion pressure of left eyes in untreated primary open angle glaucoma was 39.9 ± 7.5 mm Hg and 48.6 ± 4.0 mm Hg in the control group. The odds ratio was 5.7 (95% CI, 1.8-17.5; p=0.004). The left eyes of untreated primary open angle glaucoma had 5.7 times more risk compared to control group. The findings revealed the evidence of vascular mechanism in glaucoma pathogenesis: Reduction of mean ocular perfusion pressure ≤48 mm Hg, may lead to daily repetitive ischemic insult to the optic nerve.

scholarly journals Assessment of primary open-angle glaucoma peripapillary and macular choroidal area using enhanced depth imaging optical coherence tomography

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0231214
Author(s):  
Hirokazu Kojima ◽  
Kazuyuki Hirooka ◽  
Eri Nitta ◽  
Shozo Sonoda ◽  
Taiji Sakamoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Open Angle ◽  
Depth Imaging ◽  
Imaging Optical Coherence Tomography

scholarly journals The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome

2015 ◽  
Vol 9 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Seyed Ahmad Rasoulinejad ◽  
Ali Kasiri ◽  
Mahdi Montazeri ◽  
Negin Rashidi ◽  
Maryam Montazeri ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Mean Values ◽  
Conflicting Evidence ◽  
The Mean ◽  
Spss Software ◽  
Glaucoma Group

Purpose : There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma. Methods : A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed. Results : The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018). Conclusion : Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

scholarly journals Choroidal Thickness in Lipoid Proteinosis

2021 ◽  
Author(s):  
Armağan Özgür ◽  
Isa An
Keyword(s):  
Choroidal Thickness ◽  
Disease Process ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Depth Imaging ◽  
Lipoid Proteinosis ◽  
Corrected Visual Acuity ◽  
Imaging Optical Coherence Tomography ◽  
The Mean ◽  
Thickness Measurements

Abstract Purpose: To assess choroidal thickness in patients with lipoid proteinosis versus healthy subjects using enhanced depth imaging optical coherence tomography. Methods: 40 eyes of 20 patients and the same number of age and sex-matched healthy individuals were enrolled. Comprehensive ocular examinations including measurement of best-corrected visual acuity, spherical equivalent values of refractive errors, and axial length were performed. Choroidal thickness at three points (subfoveal, 500 µm nasal and temporal regions) were measured. Results: The mean age was 15,68 ± 5,98 years in the patient group and 16,48 ± 5,69 years in the control group. Mean choroidal thickness was statistically significantly thicker at each point in patients with lipoid proteinosis compared to the healthy controls: subfoveal, temporal and nasal choroidal thickness measurements were 414,13 ± 53.88, 359.97 ± 64.75, 322.10 ± 56.74 in the study group; 341.60 ± 42.01, 329.55 ± 41.30, 295.44 ± 43.07 in the control group, respectively ( P < 0.05). Conclusion: Patients with lipoid proteinosis have thicker choroid compared to control eyes. Hyalin deposition and ensuing potential inflammation in the disease process may explain this finding.

No Relationship between Visual Field Damage and Choroidal Thickness in Eyes with Primary Open-Angle Glaucoma

2020 ◽  
Vol 63 (5) ◽  
pp. 491-496
Author(s):  
Umut Karaca ◽  
Gokhan Ozge ◽  
Tarkan Mumcuoglu ◽  
Gulsah Usta
Keyword(s):  
Visual Field ◽  
Choroidal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Visual Field Damage

scholarly journals Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma

2021 ◽  
Vol 84 (1) ◽  
pp. 2486-2494
Author(s):  
Moustafa Kamal Nassar ◽  
Hany Ahmed Khairy ◽  
Sameh Mohamed El Gohary ◽  
Ahmed Mohamed Fawzy Deif
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Open Angle ◽  
Visual Field Testing

The role of rs2075575 polymorphism of the aquaporin 4 gene in the development of primary open-angle glaucoma

2019 ◽  
pp. 16-20
Author(s):  
Е.В. Собанчеев ◽  
Ю.А. Витковский ◽  
А.С. Емельянов ◽  
А.Н. Емельянова ◽  
Е.А. Жаринова ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Protective Role ◽  
Aquaporin 4 ◽  
Control Group ◽  
Open Angle ◽  
Aquaporin Gene ◽  
Significant Difference

Актуальность. Несмотря на всестороннее изучение патогенеза первичной открытоугольной глаукомы (ПОУГ), механизмы возникновения заболевания до конца не изучены. В настоящее время определена роль аквапоринов в регуляции внутриглазного давления. Были обнаружены мутации, усиливающие и снижающие функции аквапорина 4, описано влияние различных генетических вариантов аквапоринов на величину внутриглазного давления. Цель исследования. Исследовать частоту встречаемости вариантов полиморфизма rs2075575 (C/Т) гена аквапорина 4 у больных ПОУГ. Материалы и методы. В исследовании приняли участие 101 пациент с ПОУГ и 80 здоровых людей (контрольная группа). Возраст исследуемых колебался от 45 до 87 лет. Средний возраст составил 66 лет. Критерием включения в основную группу служил диагноз ПОУГ развитой, далеко зашедшей и терминальной стадий. Критериями включения в контрольную группу служили возраст старше 60 лет, отсутствие глаукомы и выраженной соматической патологии. ДНК выделяли из буккального эпителия. Полиморфизм гена аквапорина 4 rs2075575 определяли методом полимеразной цепной реакции. Результаты. Установлено, что распределение генотипов у пациентов с ПОУГ отличается от группы здоровых лиц. Обнаружено, что генотип СС среди больных глаукомой встречается в 1,8 раза чаще, чем в контрольной группе. Наоборот, генотип СТ выявляется в 1,5 раза чаще в контрольной группе. Отношение шансов (OR) для генотипа СС равно 2,48 (95% CI 1,30-4,74). У генотипа СТ выявляется протекторная роль, OR =0,52 (95% CI 0,28-0,97). Частота встречаемости генотипа ТТ в исследуемых группах не различается. Выводы. Полиморфный вариант rs2075575 (C/Т) гена аквапорина 4 вносит вклад в риск развития ПОУГ в исследованной выборке. Background. Despite a comprehensive study of the pathogenesis of the disease, the mechanisms of primary open-angle glaucoma are not completely clear. Currently, the role of aquaporins in the regulation of intraocular pressure has been determined. Mutations were discovered that enhance and decrease the functions of aquaporin 4. The effect of various genetic variants of aquaporins on the value of intraocular pressure is described. The aim of research. To investigate the variability of the polymorphism of aquaporin 4 rs2075575 (C / T) in patients with glaucoma. Materials and methods. 101 persons with primary open-angle glaucoma and 80 persons without glaucoma (the control group) were examined. The age of the subjects ranged from 45 to 87 years. The average age was 66 years. The criterion for inclusion in the main group was the diagnosis of primary open-angle glaucoma of a developed, distant and terminal stage. The criteria for inclusion in the control group were age over 60 years, the absence of glaucoma, the absence of pronounced somatic pathology. DNAs were extracted from buccal epithelium. The polymerase chain reaction (PCR) method was used to determine the polymorphism of the aquaporin gene 4 rs2075575. Results. There was a significant difference in the distribution of genotypes in the study and control groups. СС genotype among patients with glaucoma occurs 1.8 times more often than in the control group. CT genotype, on the contrary, is 1.5 times more often in the control group. The odds ratio (OR) for this genotype is 2.48 (95% CI 1.30 - 4.74). The CT genotype reveals a protective role, OR = 0.52 (95% CI 0.28 - 0.97). The genotype of TT in the studied groups is slightly different in frequency of occurrence. Conclusion. The frequencies of gene polymorphisms of aquaporin 4 rs2075575 (C/Т) in patients with primary open-angle glaucoma and healthy were diverse. The likelihood of developing primary open-angle glaucoma is increased in carriers of the СС genotype. Genotype CT play a protective role for primary open-angle glaucoma.

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