Atraumatic Splenic Rupture Associated with Influenza A (H1N1) Pneumonia: Case Report and Review of the Literature

Influenza virus infection may present with fever, chills, headache, myalgia, malaise, and respiratory symptoms, with a few cases developing into pneumonia, respiratory failure, and other organ damage. Very few cases of atraumatic splenic rupture associated with influenza infection have been reported. Atraumatic splenic rupture, while rare, is associated with high mortality. Here, we report the first case of atraumatic splenic rupture associated with influenza infection in the English literature and review the prior reported literature. The patient was diagnosed with influenza A (H1N1) pneumonia and subsequently developed hemorrhagic shock requiring emergency laparotomy and removal of the ruptured spleen.

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Progression and Trends in Virus from Influenza A to COVID-19: An Overview of Recent Studies

Viruses ◽

10.3390/v13061145 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1145

Author(s):

Hakimeh Baghaei Daemi ◽

Muhammad Fakhar-e-Alam Kulyar ◽

Xinlin He ◽

Chengfei Li ◽

Morteza Karimpour ◽

...

Keyword(s):

Influenza A ◽

H1n1 Virus ◽

World Health ◽

H1n1 Pandemic ◽

Global Pandemic ◽

First Case ◽

Influenza A H1n1 ◽

The World ◽

Novel Coronavirus ◽

Health Organization

Influenza is a highly known contagious viral infection that has been responsible for the death of many people in history with pandemics. These pandemics have been occurring every 10 to 30 years in the last century. The most recent global pandemic prior to COVID-19 was the 2009 influenza A (H1N1) pandemic. A decade ago, the H1N1 virus caused 12,500 deaths in just 19 months globally. Now, again, the world has been challenged with another pandemic. Since December 2019, the first case of a novel coronavirus (COVID-19) infection was detected in Wuhan. This infection has risen rapidly throughout the world; even the World Health Organization (WHO) announced COVID-19 as a worldwide emergency to ensure human health and public safety. This review article aims to discuss important issues relating to COVID-19, including clinical, epidemiological, and pathological features of COVID-19 and recent progress in diagnosis and treatment approaches for the COVID-19 infection. We also highlight key similarities and differences between COVID-19 and influenza A to ensure the theoretical and practical details of COVID-19.

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Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1997.272.2.r621 ◽

1997 ◽

Vol 272 (2) ◽

pp. R621-R630 ◽

Cited By ~ 17

Author(s):

W. Kozak ◽

V. Poli ◽

D. Soszynski ◽

C. A. Conn ◽

L. R. Leon ◽

...

Keyword(s):

Interleukin 6 ◽

Influenza A ◽

Influenza Infection ◽

Influenza Virus Infection ◽

Sickness Behavior ◽

Tissue Necrosis ◽

Control Groups ◽

Dark Cycle ◽

Viral Origin ◽

And Control

Interleukin-6 (IL-6), among other cytokines, is thought to be involved in the regulation of sickness behavior (e.g., anorexia, cachexia, fever, and lethargy) induced by infections bacterial and viral origin) and sterile tissue necrosis (burns and surgical traumas). Mice deficient in IL-6 (IL-6 KO) were generated by gene targeting. Homozygous IL-6 KO male and female mice and their appropriate controls were implanted with biotelemeters to monitor body temperature (Tb) and motor activity (Act). Normal circadian rhythms in Tb and Act as well as rates of food intake and weight gain did not differ significantly between sex-matched IL-6 KO and control groups at 30 degrees C in a 12:12-h light-dark cycle. Sterile tissue damage was induced in mice by subcutaneous injection of turpentine (0.1 ml, left hindlimb). Influenza pneumonitis was induced by intranasal inoculation of mouse-adapted influenza A virus (17.5 plaque-forming units). Lack of IL-6 completely prevented fever, anorexia, and cachexia because of turpentine abscess in both sexes. It did not prevent lethargy, although IL-6 KO mice recovered to normal Act significantly sooner than wild-type mice. Symptoms of sickness were only slightly modified during influenza virus infection in IL-6 KO mice. Attenuation of sickness behavior was more pronounced in IL-6 KO female than in male mice. We conclude that, although IL-6 is induced during both turpentine abscess and influenza infection, this cytokine appears to be more critical in induction of the symptoms of sickness behavior during sterile tissue abscess than during influenza infection.

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Radiologic Findings of Influenza A (H1N1) Pneumonia: Report of Two Cases

Journal of the Korean Society of Radiology ◽

10.3348/jksr.2010.62.4.361 ◽

2010 ◽

Vol 62 (4) ◽

pp. 361

Author(s):

Jin Kyoung Oh ◽

Myeong Im Ahn ◽

Jung Im Jung ◽

Dae Hee Han ◽

Seog Hee Park ◽

...

Keyword(s):

Influenza A ◽

Radiologic Findings ◽

Influenza A H1n1 ◽

H1n1 Pneumonia

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Effectiveness of Influenza Vaccines in the HIVE household cohort over 8 years: is there evidence of indirect protection?

10.1101/2021.02.16.21251827 ◽

2021 ◽

Author(s):

Ryan E. Malosh ◽

Joshua G. Petrie ◽

Amy Callear ◽

Rachel Truscon ◽

Emileigh Johnson ◽

...

Keyword(s):

Influenza Vaccine ◽

Influenza A ◽

Vaccine Coverage ◽

Influenza Virus Infection ◽

Influenza Vaccines ◽

Mixed Effect ◽

Vaccination Programs ◽

Vaccine Recommendations ◽

Influenza A H1n1 ◽

Low Coverage

AbstractBackgroundThe evidence that influenza vaccination programs regularly provide protection to unvaccinated individuals (i.e. indirect effects) of a community is lacking. We sought to determine the direct, indirect, and total effects of influenza vaccine in the Household Influenza Vaccine Evaluation (HIVE) cohort.MethodsUsing longitudinal data from the HIVE cohort from 2010-11 through 2017-18, we estimated direct, indirect, and total influenza vaccine effectiveness (VE) and the incidence rate ratio of influenza virus infection using adjusted mixed-effect Poisson regression models. Total effectiveness was determined through comparison of vaccinated members of full or partially vaccinated households to unvaccinated individuals in completely unvaccinated households.ResultsThe pooled, direct VE against any influenza was 30.2% (14.0-43.4). Direct VE was higher for influenza A/H1N1 43.9% (3.9 to 63.5) and B 46.7% (17.2 to 57.5) than A/H3N2 31.7% (10.5 to 47.8); and was higher for young children 42.4% (10.1 to 63.0) than adults 18.6% (−6.3 to 37.7). Influenza incidence was highest in completely unvaccinated households (10.6 per 100 person-seasons) and lower at all other levels of household vaccine coverage. We found little evidence of indirect VE after adjusting for potential confounders. Total VET was 56.4% (30.1-72.9) in low coverage, 43.2% (19.5-59.9) in moderate coverage, and 33.0% (12.1 to 49.0) in fully vaccinated households.ConclusionInfluenza vaccines may have a benefit above and beyond the direct effect but that effect in this study was small. While there may be exceptions, the goal of global vaccine recommendations should remain focused on provision of documented, direct protection to those vaccinated.

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Routine blood parameters are helpful for early identification of influenza infection in children

10.21203/rs.3.rs-54705/v2 ◽

2020 ◽

Author(s):

Ronghe Zhu ◽

Cuie Chen ◽

Qiu Wang ◽

Xixi Zhang ◽

Chaosheng Lu ◽

...

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Influenza A Virus ◽

Early Identification ◽

Influenza A ◽

Influenza Infection ◽

Influenza Virus Infection ◽

Cutoff Value ◽

Routine Blood ◽

Influenza A Virus Infection

Abstract Purpose Routine blood parameters, such as the lymphocyte (LYM) count, platelet (PLT) count, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), LYM*PLT and mean platelet volume-to-platelet ratio (MPV/PLT), are widely used to predict the prognosis of infectious diseases. We aimed to explore the value of these parameters in the early identification of influenza virus infection in children.Methods We conducted a single-center, retrospective, observational study of fever with influenza-like symptoms in pediatric outpatients from different age groups and evaluated the predictive value of various routine blood parameters measured within 48 hours of the onset of fever for influenza virus infection.Results The LYM count, PLT count, LMR and LYM*PLT were lower, and the NLR and MPV/PLT were higher in children with an influenza infection (PCR-confirmed and symptomatic). The LYM count, LMR and LYM*PLT in the influenza infection group were lower in the 1- to 6-year-old subgroup, and the LMR and LYM*PLT in the influenza infection group were lower in the >6-year-old subgroup. In the 1- to 6-year-old subgroup, the cutoff value of the LMR for predicting influenza A virus infection was 3.75, the sensitivity was 81.87%, the specificity was 84.31%, and the area under the curve (AUC) was 0.886; the cutoff value of the LMR for predicting influenza B virus infection was 3.71, the sensitivity was 73.58%, the specificity was 84.31%, and the AUC was 0.843. In the >6-year-old subgroup, the cutoff value of the LMR for predicting influenza A virus infection was 3.05, the sensitivity was 89.27%, the specificity was 89.61%, and the AUC was 0.949; the cutoff value of the LMR for predicting influenza B virus infection was 2.88, the sensitivity was 83.19%, the specificity was 92.21%, and the AUC was 0.924.Conclusions Routine blood tests are simple, inexpensive and easy to perform, and they are useful for the early identification of influenza virus infection in children. The LMR had the strongest predictive value for influenza virus infection in children older than 1 year, particularly influenza A virus infection.

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Simultaneous Cytomegalovirus Disease and Novel Influenza A (H1N1) Pneumonia in a Renal Transplant Recipient

Surgical Infections Case Reports ◽

10.1089/crsi.2016.0024 ◽

2016 ◽

Vol 1 (1) ◽

pp. 108-111 ◽

Cited By ~ 1

Author(s):

Hugo Bonatti ◽

Rajeev Sharma ◽

Cynthia Snider ◽

Klaus D. Hagspiel ◽

Kenneth Brayman ◽

...

Keyword(s):

Renal Transplant ◽

Transplant Recipient ◽

Renal Transplant Recipient ◽

Influenza A ◽

Cytomegalovirus Disease ◽

Influenza A H1n1 ◽

H1n1 Pneumonia ◽

Novel Influenza A

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Extracorporeal membrane oxygenation in Jehovah’s Witness patients: Case report, literature review, and summary of recommendations

Perfusion ◽

10.1177/02676591211047774 ◽

2021 ◽

pp. 026765912110477

Author(s):

Abrahán Mera ◽

Eduard Argudo ◽

María Martínez-Martínez ◽

Clara Palmada ◽

Camilo Bonilla ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Influenza A ◽

Jehovah’S Witness ◽

Jehovah's Witness ◽

Membrane Oxygenation ◽

Influenza A H1n1 ◽

Refractory Hypoxemia ◽

Venovenous Ecmo ◽

H1n1 Pneumonia ◽

Witness Patient

Extracorporeal Membrane Oxygenation (ECMO) is commonly associated with a high blood transfusion requirement. Jehovah’s Witness patients present a particular challenge. The impossibility of transfusing blood cells and starting anticoagulation treatment are common contraindications for this supportive measure. Here we report the case of a Jehovah’s Witness patient with refractory hypoxemia due to influenza A H1N1 pneumonia who required venovenous ECMO for 11 days. We describe the use of a bloodless approach to reduce the waste of blood, avoiding anticoagulation, and improving red blood cell production. We then summarize the current literature on the use of ECMO in Jehovah’s Witness patients and, finally, we propose some recommendations for their management.

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HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus in Mice

Journal of Molecular Microbiology and Biotechnology ◽

10.1159/000448895 ◽

2016 ◽

Vol 26 (6) ◽

pp. 422-432 ◽

Cited By ~ 2

Author(s):

Xilong Kang ◽

Yun Yang ◽

Yang Jiao ◽

Hongqin Song ◽

Li Song ◽

...

Keyword(s):

Influenza Virus ◽

Influenza A ◽

H1n1 Virus ◽

Influenza Virus Infection ◽

Candidate Vaccine ◽

Major Barrier ◽

Excellent Starting Point ◽

Starting Point ◽

Influenza A H1n1 ◽

N Terminus

In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a recombinant candidate vaccine, HA1-2-fljB, in which the globular head of the hemagglutinin (HA) antigen (residues 62-284) from H1N1 virus was fused genetically to the N-terminus of <i>Salmonella typhimurium</i> ﬂjB. The recombinant HA1-2-fljB protein was expressed efficiently in<i> Escherichia coli</i>, and the immunogenicity and protective efficacy of recombinant HA1-2-fljB were evaluated in a mouse model. Immunization with HA1-2-fljB elicited robust IgG antibodies and neutralizing antibodies and completely protected the mice against infection by swine-origin influenza A/swine/Jangsu/38/2010 (H1N1). These results suggest that HA antigen placed at the N-terminus of flagellin is also an excellent starting point for creating a fusion HA1-2-fljB protein as a candidate vaccine, and the recombinant HA1-2-fljB protein will contribute to the development of a more effective vaccine against swine-origin influenza virus infection.

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Dual and Triple Infections With Influenza A and B Viruses: A Case-Control Study in Southern Brazil

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz221 ◽

2019 ◽

Vol 220 (6) ◽

pp. 961-968 ◽

Cited By ~ 6

Author(s):

Tatiana Schäffer Gregianini ◽

Ivana R Santos Varella ◽

Patricia Fisch ◽

Letícia Garay Martins ◽

Ana B G Veiga

Keyword(s):

Influenza Virus ◽

Influenza A ◽

Clinical Symptoms ◽

Antiviral Treatment ◽

Influenza Virus Infection ◽

H3n2 Virus ◽

Influenza Surveillance ◽

Influenza B Virus ◽

Influenza B ◽

Influenza A H1n1

Abstract Influenza surveillance is important for disease control and should consider possible coinfection with different viruses, which can be associated with disease severity. This study analyzed 34 459 patients with respiratory infection from 2009 to 2018, of whom 8011 were positive for influenza A virus (IAV) or influenza B virus (IBV). We found 18 cases of dual influenza virus infection, including coinfection with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) and influenza A(H3N2) virus (1 case), A(H1N1)pdm09 and IBV (6 cases), A(H3N2) and IBV (8 cases), and nonsubtyped IAV and IBV (3 cases); and 1 case of triple infection with A(H3N2), A(H1N1)pdm09, and IBV. Compared with 76 monoinfected patients, coinfection was significantly associated with cardiopathy and death. Besides demographic characteristics and clinical symptoms, we assessed vaccination status, antiviral treatment, timeliness of antiviral use, hospitalization, and intensive care unit admission, but no significant differences were found between coinfected and monoinfected cases. Our findings indicate that influenza virus coinfection occurs more often than previously reported and that it can lead to a worse disease outcome.

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