scholarly journals Protective Effect of Joa-Gui Em through the Improvement of the NLRP3 and TLR4/NF-κb Signaling by Ischemia/Reperfusion-Induced Acute Renal Failure Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Se Won Na ◽  
Youn Jae Jang ◽  
Mi Hyeon Hong ◽  
Jung Joo Yoon ◽  
Ho Sub Lee ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Kidney Function ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Renal Tissue ◽  
Kidney Size ◽  
Acute Renal Dysfunction

Joa-gui em (左歸飮, JGE) is known to be effective for treating kidney-yin deficient syndrome. However, there is a lack of objective pharmacological research on improving kidney function. This study was designed to evaluate whether JGE improves renal function and related mechanisms in rats with acute renal injury induced by ischemia/reperfusion (I/R). The acute renal failure (ARF) group was subjected to reperfusion after inserting a clip into the renal artery for 45 min. The ARF + JGE (100 or 200 mg/kg/day) groups were orally administered for four days after their I/R surgery, respectively. JGE treatment suppressed the increase in kidney size in the ARF animal model and alleviated the polyuria symptoms. In addition, to confirm the effect of improving the kidney function of JGE, lactate dehydrogenase levels, blood urea nitrogen/creatinine ratio, and creatinine clearance were measured. As a result, it decreased in the ARF group but significantly improved in the JGE group. Also, as a result of examining the morphological aspects of renal tissue, it was shown that JGE improved renal fibrosis caused by ARF. Meanwhile, it was confirmed that JGE reduced inflammation through the nucleotide-binding oligomerization domain-like receptor pyrin domain containing-3 (NLRP3) and toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling pathways, which are the major causes of acute ischemic kidney injury, thereby improving renal function disorder. The JGE has a protective effect by improving the NLRP3 and TLR4/NF-κB signaling pathway in rats with acute renal dysfunction induced by I/R injury.

scholarly journals Effect of Cuscuta chinensis on renal function in ischemia/reperfusion‐induced acute renal failure rats

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Sun Shin ◽  
An Sook Lee ◽  
Eun Ju Kim ◽  
Dae Gill Kang ◽  
Ho Sub Lee
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Ischemia Reperfusion ◽  
Cuscuta Chinensis

Acute kidney injury

2018 ◽  
Author(s):  
Aron Chakera ◽  
William G. Herrington ◽  
Christopher A. O’Callaghan
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Urine Volume ◽  
Kidney Injury ◽  
Rapid Decrease

Acute renal failure (also referred to as acute kidney injury) refers to a rapid decrease in renal function; it is reflected by an increase in blood urea and creatinine and is often associated with oliguria (a urine volume of less than 400 ml/24 hours). It usually develops over days to weeks. Acute kidney injury has been variously classified, but the current classifications are based on the glomerular filtration rate (or creatinine), looking at changes from baseline, and the presence of oliguria or anuria. The potential etiologies of acute kidney injury are usually considered anatomically under the headings prerenal, renal (intrinsic), and postrenal. This chapter looks at the etiology, symptoms, clinical features, demographics, complications, diagnosis, and treatment of acute kidney injury.

scholarly journals Considerações sobre a Função Renal no Período Perioperatório

2013 ◽  
Vol 8 (22) ◽  
pp. 93
Author(s):  
Hellen Tatiane De Pontes ◽  
Jady Elen De Pontes ◽  
Fábio Dos Santos Cosso Martins
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Kidney Injury ◽  
Function Evaluation

A lesão renal aguda é observada especialmente nas cirurgias de grande porte, em especial as cirurgias cardíacas, podendo sua prevalência atingir até 40,2% na população adulta no período pós-operatório imediato. Nesta revisão, buscamos conhecer os aspectos fisiopatológicos envolvidos na lesão renal aguda, os critérios de classificação utilizados atualmente, fatores de risco associados para a disfunção no período pós-cirúrgico imediato e medidas profiláticas. Para tanto, foram pesquisados artigos originais e revisões indexados na base de dados Medline e Pubmed, compreendendo o período de 2002 até Junho de 2012, empregando-se os seguintes termos: acute kidney injury, acute renal failure e renal function evaluation. Verificamos que há necessidade uso de novos biomarcadores associados aos níveis séricos de creatinina e débito urinário atualmente utilizados para o diagnóstico, visto que a detecção precoce da lesão renal aguda por meio da creatinina sérica é difícil de ser estabelecida. Há necessidade de mais estudos que estabeleçam profilaxia farmacológica no tratamento da lesão renal aguda. Medidas como um método padronizado para estratificação de pacientes que apresentam maiores riscos no período pré-operatório, estabelecimento de terapêutica adequada precoce no período perioperatório, introdução nos critérios diagnósticos de novos biomarcadores séricos e urinários, serão úteis utilizados em conjuntos para o manejo clínico adequado nesses pacientes.

scholarly journals Considerações sobre a Função Renal no Período Perioperatório

2013 ◽  
Vol 8 (22) ◽  
pp. 93-79
Author(s):  
Hellen Tatiane De Pontes ◽  
Jady Elen De Pontes ◽  
Fábio dos Santos Cosso Martins
Keyword(s):  
Acute Kidney Injury ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Kidney Injury ◽  
Function Evaluation

A lesão renal aguda é observada especialmente nas cirurgias de grande porte, em especial as cirurgias cardíacas, podendo sua prevalência atingir até 40,2% na população adulta no período pós-operatório imediato. Nesta revisão, buscamos conhecer os aspectos fisiopatológicos envolvidos na lesão renal aguda, os critérios de classificação utilizados atualmente, fatores de risco associados para a disfunção no período pós-cirúrgico imediato e medidas profiláticas. Para tanto, foram pesquisados artigos originais e revisões indexados na base de dados Medline e Pubmed, compreendendo o período de 2002 até Junho de 2012, empregando-se os seguintes termos: acute kidney injury, acute renal failure e renal function evaluation. Verificamos que há necessidade uso de novos biomarcadores associados aos níveis séricos de creatinina e débito urinário atualmente utilizados para o diagnóstico, visto que a detecção precoce da lesão renal aguda por meio da creatinina sérica é difícil de ser estabelecida. Há necessidade de mais estudos que estabeleçam profilaxia farmacológica no tratamento da lesão renal aguda. Medidas como um método padronizado para estratificação de pacientes que apresentam maiores riscos no período pré-operatório, estabelecimento de terapêutica adequada precoce no período perioperatório, introdução nos critérios diagnósticos de novos biomarcadores séricos e urinários, serão úteis utilizados em conjuntos para o manejo clínico adequado nesses pacientes.

Effect of Cuscuta chinensis on Renal Function in Ischemia/Reperfusion-Induced Acute Renal Failure Rats

2011 ◽  
Vol 39 (05) ◽  
pp. 889-902 ◽  
Author(s):  
Sun Shin ◽  
Yun Jung Lee ◽  
Eun Ju Kim ◽  
An Sook Lee ◽  
Dae Gill Kang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Ischemia Reperfusion ◽  
Periodic Acid ◽  
Water Channel ◽  
Free Water ◽  
Tubular Damage ◽  
Waste Products ◽  
Cuscuta Chinensis

The kidneys play a central role in regulating water, ion composition and excretion of metabolic waste products in the urine. Cuscuta chinensis has been known as an important traditional Oriental medicine for the treatment of liver and kidney disorders. Thus, we studied whether an aqueous extract of Cuscuta chinensis (ACC) seeds has an effect on renal function parameters in ischemia/reperfusion-induced acute renal failure (ARF) rats. Administration of 250 mg/kg/day ACC showed that renal functional parameters including urinary excretion rate, osmolality, Na +, K +, Cl -, creatinine clearance, solute-free water reabsorption were significantly recovered in ischemia/reperfusion-induced ARF. Periodic acid Schiff staining showed that administration of ACC improved tubular damage in ischemia/reperfusion-induced ARF. In immunoblot and immunohistological examinations, ischemia/reperfusion-induced ARF decreased the expressions of water channel AQP 2, 3 and sodium potassium pump Na , K -ATPase in the renal medulla. However, administration of ACC markedly incremented AQP 2, 3 and Na , K -ATPase expressions. Therefore, these data indicate that administration of ACC ameliorates regulation of the urine concentration and renal functions in rats with ischemia/reperfusion-induced ARF.

scholarly journals Protective effect of a specific proteasome inhibitor, lactacystin, against acute renal failure induced by ischemia-reperfusion in rats.

2000 ◽  
Vol 82 ◽  
pp. 249
Author(s):  
Makoto Itoh ◽  
Masanori Takaoka ◽  
Akihide Shibata ◽  
Yasuo Matsumura
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Proteasome Inhibitor ◽  
Ischemia Reperfusion

Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms

2005 ◽  
Vol 289 (1) ◽  
pp. F31-F42 ◽  
Author(s):  
Florian Tögel ◽  
Zhuma Hu ◽  
Kathleen Weiss ◽  
Jorge Isaac ◽  
Claudia Lange ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Clinical Problem ◽  
Cell Phenotype ◽  
Target Cells

Severe acute renal failure (ARF) remains a common, largely treatment-resistant clinical problem with disturbingly high mortality rates. Therefore, we tested whether administration of multipotent mesenchymal stem cells (MSC) to anesthetized rats with ischemia-reperfusion-induced ARF (40-min bilateral renal pedicle clamping) could improve the outcome through amelioration of inflammatory, vascular, and apoptotic/necrotic manifestations of ischemic kidney injury. Accordingly, intracarotid administration of MSC (∼ 106/animal) either immediately or 24 h after renal ischemia resulted in significantly improved renal function, higher proliferative and lower apoptotic indexes, as well as lower renal injury and unchanged leukocyte infiltration scores. Such renoprotection was not obtained with syngeneic fibroblasts. Using in vivo two-photon laser confocal microscopy, fluorescence-labeled MSC were detected early after injection in glomeruli, and low numbers attached at microvasculature sites. However, within 3 days of administration, none of the administered MSC had differentiated into a tubular or endothelial cell phenotype. At 24 h after injury, expression of proinflammatory cytokines IL-1β, TNF-α, IFN-γ, and inducible nitric oxide synthase was significantly reduced and that of anti-inflammatory IL-10 and bFGF, TGF-α, and Bcl-2 was highly upregulated in treated kidneys. We conclude that the early, highly significant renoprotection obtained with MSC is of considerable therapeutic promise for the cell-based management of clinical ARF. The beneficial effects of MSC are primarily mediated via complex paracrine actions and not by their differentiation into target cells, which, as such, appears to be a more protracted response that may become important in late-stage organ repair.

scholarly journals Volume Replacement in Critically Ill Patients with Acute Renal Failure

2001 ◽  
Vol 12 (suppl 1) ◽  
pp. S33-S39
Author(s):  
MAXIMILIAN J. R. RAGALLER ◽  
HERMANN THEILEN ◽  
THEA KOCH
Keyword(s):  
Molecular Weight ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Intravascular Volume ◽  
Acute Renal Dysfunction ◽  
Crystalloid Solutions

Abstract. Maintenance and restoration of intravascular volume are essential tasks of critical care management to achieve sufficient organ function and to avoid multiple organ failure in critically ill patients. Inadequate intravascular volume followed by impaired renal perfusion is the predominate cause of acute renal failure. Crystalloid solutions are the first choice to correct fluid and electrolyte deficits in these patients. However, in case of major hypovolemia, particularly in situations of increased capillary permeability, colloid solutions are indicated to achieve sufficient tissue perfusion. Whereas albumin should be avoided for correction of intravascular hypovolemia, synthetic colloids can restore intravascular volume and stabilize hemodynamic conditions. In addition to a faster, more effective and prolonged restoration of intravascular volume, colloid solutions are able to improve microcirculation. Of the synthetic colloids, hydroxyethyl starch (HES) solutions with a low in vivo molecular weight, such as HES 200/0.5, offer the best risk/benefit ratio. These solutions are safe with respect to effects on coagulation, platelets, reticuloendothelial system, and renal function, if used below their upper dosage limits. For patients with acute renal dysfunction, daily monitoring of renal function is necessary if colloids are required to stabilize hemodynamic conditions. In these patients, measurement of the colloidal osmotic pressure and adequate amounts of crystalloid solutions will reduce the risk of hyperoncotic renal failure. Of all colloids, gelatin and HES solutions with low in vivo molecular weight are preferred in these cases. In the very specific situation of kidney transplantation, colloid solutions should be administered in a restricted manner to organ donors and kidney recipients.

scholarly journals Interaction among nitric oxide, reactive oxygen species, and antioxidants during endotoxemia-related acute renal failure

2003 ◽  
Vol 284 (3) ◽  
pp. F532-F537 ◽  
Author(s):  
Wei Wang ◽  
Suparoek Jittikanont ◽  
Sandor A. Falk ◽  
Ping Li ◽  
Lili Feng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Renal Vasoconstriction ◽  
Mrna And Protein Expression ◽  
No Bioavailability ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Acute renal failure (ARF) during sepsis is associated with increased nitric oxide (NO) and oxygen radicals, including superoxide (O[Formula: see text]). Because O[Formula: see text] reacts with NO in a rapid manner, it plays an important role in modulating NO levels. Therefore, scavenging of O[Formula: see text] by superoxide dismutase (SOD) may be critical for preserving NO bioavailability. In mice, substantial renal extracellular SOD (EC-SOD) expression implies its important role in scavenging O[Formula: see text] in the kidney. We hypothesized that during endotoxemic ARF, EC-SOD is decreased in the kidney, resulting in increased O[Formula: see text] and thus decreased vascular NO bioavailability with resultant renal vasoconstriction and ARF. In the present study, normotensive endotoxemic ARF was induced in mice using lipopolysaccharide (LPS; 5 mg/kg ip). Sixteen hours after LPS, glomerular filtration rate (GFR; 50 ± 16 vs. 229 ± 21 μl/min, n = 8, P < 0.01) and renal blood flow (RBF; 0.61 ± 0.10 vs. 0.86 ± 0.05 ml/min, n = 8, P < 0.05) were subsequently decreased. EC-SOD mRNA and protein expression in endotoxemic kidneys were decreased at 16 h compared with controls. A catalytic antioxidant, metalloporphyrin, reversed the deleterious effects of endotoxemia on renal function as GFR (182 ± 40 vs. 50 ± 16 μl/min, n = 6, P < 0.01) and RBF (1.08 ± 0.10 vs. 0.61 ± 0.10 ml/min, n = 6, P < 0.05) were preserved. Similar results were obtained with tempol, a chemically dissimilar antioxidant. Specific inhibition of inducible nitric oxide synthase (iNOS),l- N 6-(1-iminoethyl)-lysine, reversed the renal protective effect on GFR and RBF observed with antioxidant treatment during endotoxemia. In summary, renal EC-SOD expression is decreased during endotoxemia. Antioxidant therapy preserved GFR and RBF during endotoxemia. The reversal of this protective effect by inhibition of iNOS suggests the importance of the bioavailability of NO for preservation of renal function during early endotoxemia.

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