scholarly journals A Case Report of Steroid-Resistant Cryptogenic Organizing Pneumonia Managed with Intravenous Immunoglobulins

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Christian Akem Dimala ◽  
Urvi Patel ◽  
Benjamin Lloyd ◽  
Anthony Donato ◽  
William B. Kimmel ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Case Report ◽  
Lung Biopsy ◽  
Intravenous Immunoglobulins ◽  
High Dose ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Steroid Resistant ◽  
Steroid Sparing ◽  
Satisfactory Recovery

Fewer than ten reported cases of cryptogenic organizing pneumonia (COP) have been managed with intravenous immunoglobulins (IVIg). We report a case of a 72-year-old man who presented with a worsening cough and diffuse opacities on chest radiograph. Following no improvement with antibiotics and negative complementary investigations for infectious, malignant, and autoimmune etiologies, COP was confirmed on lung biopsy. Due to continued clinical deterioration despite high-dose steroids and new severe steroid-induced hallucinations, the patient was placed on intravenous immunoglobulins (IVIg) and mycophenolate mofetil and made a satisfactory recovery. IVIg should be considered as an important steroid-sparing alternative in patients with COP.

scholarly journals Cryptogenic organizing pneumonia: Case report

2009 ◽  
Vol 137 (11-12) ◽  
pp. 681-683
Author(s):  
Natasa Miladinovic-Djukanovic ◽  
Jelena Djokovic ◽  
Nikola Torbica ◽  
Martin Popevic
Keyword(s):  
Lung Biopsy ◽  
Disease Onset ◽  
Work Capacity ◽  
Open Lung Biopsy ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Methyl Prednisolone ◽  
Histological Criteria ◽  
Erroneous Diagnosis

Introduction. Cryptogenic organizing pneumonia is a particular form of inflammatory and fibroproliferative lung disease. The disease onset is subacute with cough, dyspnoea, fever, weight loss, and elevation of biological inflammatory markers. Chest imaging usually shows multifocal alveolar opacities predominating in the subpleural regions. Lung biopsy reveals budding connective tissue filling the distal airspaces. Case outline. A 57-year-old electrician complaining of cough, dyspnoea, and fatigue was diagnosed with pneumonia and treated with antibiotics and antihistaminics. After clinical and radiographic progression of the disease, open lung biopsy was performed, some 15 months after the disease onset. The diagnosis of cryptogenic organising pneumonia was made. The patient was treated with oral and inhalatory corticosteroids and finally with cytostatics, which led to a partial improvement of his condition. However, work capacity was lost and the quality of life seriously deteriorated. Conclusion. The diagnosis is established by combining clinical, radiological and histological criteria. Similarities with other disease processes can lead to a delayed or erroneous diagnosis. Most patients respond well to corticosteroid therapy (prednisone or methyl-prednisolone). Relapses are frequent but can generally be controlled.

scholarly journals Effectiveness of steroid treatment for SARS-CoV-2 pneumonia with COP-like reaction: a case report

2020 ◽  
pp. 1-13
Author(s):  
Taehwa Kim ◽  
Eunjeong Son ◽  
Doosoo Jeon ◽  
Su Jin Lee ◽  
Seungjin Lim ◽  
...  
Keyword(s):  
Case Report ◽  
Severe Acute Respiratory Syndrome ◽  
Inflammatory Responses ◽  
Clinical Course ◽  
Steroid Treatment ◽  
Lung Damage ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Steroid Administration ◽  
Anti Inflammatory

Abstract Several studies on the treatment of coronavirus disease (COVID-19) are being conducted, and various drugs are being tried; however, the results have not been uniform. Steroids have been widely used in the treatment of COVID-19, but their effects are controversial. As immunosuppressive and anti-inflammatory agents, steroids are considered to reduce lung damage by regulating various inflammatory responses. We report a case of severe acute respiratory syndrome coronavirus-2 pneumonia manifesting as a cryptogenic organizing pneumonia-like reaction and discuss its treatment, clinical course, and favorable outcomes after steroid administration.

scholarly journals Pulmonary tuberculosis presenting secondary organizing pneumonia with organized polypoid granulation tissue: case series and review of the literature

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Eun Jin Kim ◽  
Kyung Chan Kim
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Lung Biopsy ◽  
Miliary Tuberculosis ◽  
Case Series ◽  
Acid Fast Bacillus ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia ◽  
Polymerase Chain ◽  
Tuberculosis Therapy

Abstract Background Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it has not been reported as a sequela of disseminated tuberculosis. Methods From January 2016 to December 2018, we identified six cases of tuberculosis-associated SOP in which Mycobacterium tuberculosis was revealed by microbiological examination; one of the cases was miliary tuberculosis. Results Of the six cases, 17% were positive for acid fast bacillus (AFB) stain, but 100% were positive for M. tuberculosis polymerase chain reaction (MTB PCR) and AFB culture. In all cases, transbronchial lung biopsy was performed and organizing pneumonia was confirmed pathologically. All survived after treatment with anti-tuberculosis therapy. Conclusions Pulmonary tuberculosis, which shows OP in lung biopsy, is diagnosed through MTB PCR and AFB culture, and the prognosis is thought to be good.

scholarly journals Utility of Botulinum Injections in Stiff-Person Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
L. M. Conners ◽  
A. Betcher ◽  
A. Shahinian ◽  
P. Janda
Keyword(s):  
Case Report ◽  
Adverse Reactions ◽  
Intravenous Immunoglobulins ◽  
Initial Therapy ◽  
High Dose ◽  
B Cell Depletion ◽  
Stiff Person Syndrome ◽  
Review Of The Literature ◽  
Systemic Treatments ◽  
Muscle Spasms

Stiff-person syndrome (SPS) is an uncommon neurological disorder characterized by significant rigidity and muscle spasms primarily affecting the truncal and proximal musculature. Furthermore, a wide-based gait with functional impairment is generally seen. High-dose benzodiazepines or baclofen are widely considered the optimal initial therapy; however, major adverse effects often preclude adequate dosing. Refractory cases may be treated with intravenous immunoglobulins (IVIG), plasma exchange, or B-cell depletion with rituximab, although these are also associated with major, sometimes fatal, adverse reactions. Several reports have validated the safety and utility of botulinum injections in this setting, yet botulinum remains markedly underutilized in this cohort. Below, a case report and review of the literature show botulinum can decrease pain and stiffness, improve gait and balance, and decrease dependence on powerful systemic treatments in this group.

Nodular Cryptogenic Organizing Pneumonia: A Case Report

CHEST Journal ◽  
2016 ◽  
Vol 149 (4) ◽  
pp. A192
Author(s):  
Xiao-yan Zhang ◽  
Bei Wang ◽  
Li-Yuan Zheng ◽  
Qian-Qian Feng ◽  
Qianli Ma ◽  
...  
Keyword(s):  
Case Report ◽  
Organizing Pneumonia ◽  
Cryptogenic Organizing Pneumonia

scholarly journals Idiopatic Systemic Capillary Leak Syndrome Treated Successfully with High-Dose Intravenous Immunoglobulins

2015 ◽  
Vol 13 (2) ◽  
pp. 87-89
Author(s):  
Ferhat Ekinci ◽  
Utku Erdem Soyaltın ◽  
Harun Akar ◽  
Mehmet Can Ugur ◽  
Ercan Ersoy ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Clinical Management ◽  
Relevant Literature ◽  
Intravenous Immunoglobulins ◽  
Capillary Leak Syndrome ◽  
High Dose ◽  
Capillary Leak ◽  
Systemic Capillary Leak Syndrome

AbstractIdiopathic systemic capillary leak syndrome (ISCLS) is characterized by a triad of hypotension, hemoconcentration and hypoalbuminemia due to a shift of intravascular fluid and albumin to the extravascular area. We describe a hypovolemic patient with hemoconcentration and hypoalbuminemia who was successfully treated with high-dose intravenous immunoglobulins (IVIG). The purpose of this case report is to discuss the clinical management of idiopathic systemic capillary leak syndrome on the background of relevant literature review.

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