scholarly journals Quanzhenyiqitang Reverses LPS-Induced Inflammation via Inhibiting PYK2/p38MAPK/HDAC2/CK2 Signaling Pathway in Rat Alveolar Macrophage

2022 ◽  
Vol 2022 ◽  
pp. 1-11
Author(s):  
Ke-Qiang Chen ◽  
Da-zhi Li ◽  
Zhi-bin Chen ◽  
Chuan-lin Zhang ◽  
Bin-can Wang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Pulmonary Disease ◽  
Lung Inflammation ◽  
Therapeutic Drug ◽  
Chronic Obstructive ◽  
Chronic Pulmonary Disease ◽  
Pathological Changes ◽  
Obstructive Pulmonary Disease ◽  
Qrt Pcr ◽  
Underlying Mechanisms

Chronic obstructive pulmonary disease (COPD) is a common chronic pulmonary disease with multiple etiologies and pathological changes. PYK2 expression is significantly increased in lipopolysaccharide-induced lung injury, but it mediates chronic lung inflammation. The mechanism of its occurrence remains unclear. Quanzhenyiqitang is often used in clinical treatment of COPD, so this study explored the mechanism of its treatment of lipopolysaccharide-induced lung injury. In this study, transfection, flow cytometry, QRT-PCR, and Western blotting methods were used to study the mechanism of Quanzhenyiqitang lipopolysaccharide-induced lung injury. The results showed that the mechanism of occurrence remains unclear. Our novel observations imply that the PYK2/p38MAPK/HDAC2/CK2 pathway is one of the fundamental underlying mechanisms that mediate the pathogenic progression of COPD, and Quanzhenyiqitang may be the therapeutic drug to prevent chronic inflammation and delay the progression of COPD by inhibiting PYK2 signaling pathways.

Novosphingobiumspp. in Chronic Obstructive Pulmonary Disease in Humans and Subacute Lung Inflammation in Mice

2014 ◽  
Vol 11 (Supplement 1) ◽  
pp. S76-S77 ◽  
Author(s):  
Alleluiah Rutebemberwa ◽  
Mark Stevens ◽  
Mario Perez ◽  
Lynelle Smith ◽  
Linda Sanders ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Inflammation ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hyojung Lee ◽  
Youngeun Kim ◽  
Hye Jin Kim ◽  
Soojin Park ◽  
Young Pyo Jang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Murine Model ◽  
Lung Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Chronic Obstructive ◽  
Herbal Formula ◽  
Obstructive Pulmonary Disease ◽  
Beneficial Effects

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-αand IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.

scholarly journals Genetic and epigenetic heterogeneity of chronic obstructive pulmonary disease

2020 ◽  
Vol 131 (2) ◽  
pp. 15-22
Author(s):  
M.A. Sadvokasova ◽  
◽  
B.A. Azimkhanova ◽  
А.А. Аripova ◽  
A.Yu. Akparova ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Dna Methylation ◽  
Chronic Disease ◽  
Pulmonary Disease ◽  
Tobacco Smoke ◽  
Chronic Obstructive ◽  
Pathological Changes ◽  
Genetic Determinants ◽  
Obstructive Pulmonary Disease ◽  
The Impact

Chronic obstructive pulmonary disease (COPD) is a global chronic disease of the respiratory system. The formation of pathological changes in the lungs is primarily associated with the impact of harmful chemicals of the tobacco smoke on the epithelium of the respiratory tract. In addition to the activation of key COPD processes, an important role in the development of the disease played by genetic determinants and disruption of epigenetic regulation, including changes in DNA methylation, histone modification, and microRNA expression. The article discusses the genetic and epigenetic aspects of COPD as a heterogeneous disease with a complex pathogenesis.

scholarly journals Urinary protein changes in the early phase of smoking-induced Chronic Obstructive Pulmonary Disease in a rat model

2018 ◽  
Author(s):  
He Huang ◽  
Ting Wang ◽  
Youhe Gao
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Rat Model ◽  
Chronic Obstructive ◽  
Pathological Changes ◽  
Obstructive Pulmonary Disease ◽  
Human Orthologs ◽  
Proteomics Technology ◽  
Differential Proteins

AbstractChronic obstructive pulmonary disease (COPD) is a group of severe respiratory diseases. Identifying COPD through early urinary biomarkers by proteomics technology may help to reduce the mortality rate of the disease, improve the quality of life of patients and reduce the burden on society. Urine samples from a COPD rat model induced by smoking were taken at week 2, week 4 and week 8. By LC-MS/MS, 15 differential proteins with human orthologs were identified. After smoking for 2 weeks when there were no significant pathological changes, 8 differential proteins were identified: 2 proteins had been reported to be markers of COPD, while 4 proteins were associated with COPD. After smoking for 4 weeks, which is when slight pathological changes were observed, 7 differential proteins were identified: 3 of them were reported to be associated with COPD, while 1 protein had been reported to be a marker of COPD. After smoking for 8 weeks, there were significant pathological changes: 5 differential proteins were identified, 3 of which were reported to be associated with COPD. The results of this study suggest that differential urinary proteins may provide important clues for the early diagnosis of COPD.

Sign in / Sign up

Export Citation Format

Share Document