scholarly journals Triphenyltin Ortho-Aminophenyl- and 2-Pyridyl-Thiolates: Synthesis and In Vitro Antitumour Activity

1996 ◽  
Vol 3 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Marcel Gielen ◽  
Abdeslam Bouhdid ◽  
Edward R. T. Tiekink ◽  
Dick de Vos ◽  
Rudolph Willem
Keyword(s):  
Cell Lines ◽  
Antitumour Activity ◽  
Spectroscopic Characterization ◽  
X Ray Diffraction ◽  
Tetrahedral Geometry ◽  
X Ray ◽  
Distorted Tetrahedral Geometry ◽  
Monodentate Coordination

The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) Å), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.

Effect of Hydrated Metal Salts on the Coordination Product of Cobalt(II) halide and PNP Type Ligand, 2,6-bis(di-tertbutylphosphinomethyl) pyridine

2018 ◽  
Author(s):  
Tasneem Siddiquee ◽  
Abdul Goni
Keyword(s):  
Metal Salts ◽  
Molar Ratio ◽  
Pincer Complexes ◽  
Asymmetric Unit ◽  
X Ray Diffraction ◽  
Pincer Ligand ◽  
Tetrahedral Geometry ◽  
X Ray ◽  
Distorted Tetrahedral Geometry ◽  
Cobalt Center

Chemical treatment of CoX<sub>2</sub><b><sup>. </sup></b>6H<sub>2</sub>O (X = Cl, Br, I) with the potentially tridentate PNP pincer ligand 2,6-bis(di-<i>tert</i>-butylphosphinomethyl)pyridine in 1:1 molar ratio results in cobalt(II) halide-PNP pincer complexes. The effect of the hydrated metal source on molecular structure and geometry of the complexes was studied by single crystal X-ray diffraction analysis. The complexes are neutral and the cobalt center adopts a penta-coordinate system with potential atropisomerization. Within the unit cell there are two distinct molecules per asymmetric unit. One of the two phosphorus atoms in the PNP ligand was observed to be partially oxidized to phosphinoxide. Disorder in the structure reflects a mixture of square pyramidal and distorted tetrahedral geometry.

Diorganotin difluorobenzoates: synthesis, spectroscopic characterization and in vitro antitumour activity. X-Ray structure determination of bis[di-n-butyl(2,6-difluorobenzoato)tin] oxide

1993 ◽  
Vol 64 (3) ◽  
pp. 279-291 ◽  
Author(s):  
Marcel Gielen ◽  
Monique Biesemans ◽  
Abdelaziz El Khloufi ◽  
Jacqueline Meunier-Piret ◽  
François Kayser ◽  
...  
Keyword(s):  
Tin Oxide ◽  
Structure Determination ◽  
Antitumour Activity ◽  
Spectroscopic Characterization ◽  
X Ray

Lewis acidity of group 14 elements toward intramolecular sulfur in ortho-aryl-thioanisoles

2003 ◽  
Vol 81 (11) ◽  
pp. 1388-1397 ◽  
Author(s):  
Teresita Munguia ◽  
Ioana S Pavel ◽  
Ramesh N Kapoor ◽  
Francisco Cervantes-Lee ◽  
László Párkányi ◽  
...  
Keyword(s):  
Self Assembly ◽  
Silicon Germanium ◽  
Lewis Acidity ◽  
X Ray Diffraction ◽  
Group 14 ◽  
Tetrahedral Geometry ◽  
Triclinic Crystal System ◽  
X Ray ◽  
Distorted Tetrahedral Geometry ◽  
Group 14 Elements

The series of compounds (o-CH3SC6H4)CH2EPh3 (E = Si (1), Ge (2), Sn (3), and Pb (4)) have been synthesized and characterized by NMR spectroscopy and by single crystal X-ray diffraction. Compounds 1 and 2 are isostructural with a triclinic crystal system and P-1 space group; however, morphotropic steps occur between Ge and Sn, and Sn and Pb. While the E-S distances in 1 and 2 are 3.985 and 3.974 Å, respectively, ~100% of the sum of the respective van der Waals (vdW) radii, there is a notable distortion from tetrahedral geometry about E. Compound 3 is also triclinic with P-1 symmetry, but has two molecules in the unit cell that demonstrate a distorted tetrahedral geometry and intramolecular Sn-S distances of 3.699 and 3.829 Å, 88% and 91% of the sum of the vdW radii. Compound 4 has a Pb-S distance of 3.953 Å (91% of Σ vdW radii). The structure of the Grignard coupling product [o-(SCH3)C6H4CH2]2 is also reported.Key words: intramolecular self-assembly, silicon, germanium, tin, lead, sulfur.

A Spectral and Structural Study of the New Cadmium Salt [(H2L)2][Cd2I6][(NO3)2]

2013 ◽  
Vol 68 (3) ◽  
pp. 272-276 ◽  
Author(s):  
Mohammad Hakimi ◽  
Zahra Mardani ◽  
Keyvan Moeini ◽  
Esther Schuh ◽  
Fabian Mohr
Keyword(s):  
Chair Conformation ◽  
Cyclohexene Oxide ◽  
X Ray Diffraction ◽  
Intermolecular Hydrogen Bonds ◽  
Tetrahedral Geometry ◽  
X Ray ◽  
Distorted Tetrahedral Geometry ◽  
Ft Ir ◽  
Ir And Raman ◽  
Cadmium Salt

The reaction between 2-(piperazin-1-yl)ethanol and cyclohexene oxide under microwave irradiation gave 2-(4-(2-hydroxyethyl)piperazin-1-yl)cyclohexanol (L). The new cadmium salt [(H2L)2][Cd2I6][(NO3)2] (1) was prepared from the reaction of cadmium iodide with L and identified by elemental analysis, FT-IR and Raman spectroscopy, and single-crystal X-ray diffraction. In the crystal structure of 1, there is a [Cd2I6]2- dianion with distorted tetrahedral geometry for each cadmium atom. The piperazine and cyclohexane rings in 1 have a chair conformation. In the crystal there are several intermolecular hydrogen bonds including N-H···O, O-H···O, O-H···I, C-H···O, and C-H···I interactions.

scholarly journals Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil

1998 ◽  
Vol 5 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Udai P. Singh ◽  
Sudha Singh ◽  
Sukh Mahendra Singh
Keyword(s):  
Metal Complexes ◽  
Room Temperature ◽  
Magnetic Measurements ◽  
Antitumour Activity ◽  
Tumour Cells ◽  
Sarcoma 180 ◽  
X Ray Diffraction ◽  
X Ray

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.

scholarly journals X-Ray Structure and In Vitro Anti-Tumoural Activity of the Dimeric Bis[(2-Phenyl-1,2-Dicarba-Closo-Dodecaborane-1-Carboxylato)-Di-n-Butyltin] Oxide

1997 ◽  
Vol 4 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Edward R. T. Tiekink ◽  
Marcel Gielen ◽  
Abdeslam Bouhdid ◽  
Rudolph Willem ◽  
Vladimir I. Bregadze ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carboxylate Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Anti Tumour Activity ◽  
Common Motif ◽  
The Common ◽  
Tumour Activity ◽  
Oxygen Atoms

X-ray diffraction studies reveal the structure of {[(2-C6H5-1,2-C2B10H10-1-COO)Bu2Sn]2O}2, 1, to conform to the common motif found for {[(R′COO)R2Sn]2O}2 compounds. The dimer features a central Bu4Sn2O2 unit (two-fold symmetry) with the two Bu2Sn groups being linked via bridging oxygen atoms, each of which also carries an exocyclic Bu2Sn moiety. The two pairs of exo- and endo-cyclic tin atoms are each linked via an almost symmetrically bridging carboxylate ligand and the two remaining ligands coordinate an exocyclic tin atom only, in the monodentate mode. The in vitro anti-tumour activity of 1, determined against a variety of cell lines, is compared with those of the corresponding 2-methylcarboranylacetate, derivative 2, and with clinically used compounds.

scholarly journals Synthesis and spectroscopic characterization of new solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediaminen, N,N’,N’-tetraacetate (1,3-pdta) ligand: In vitro antifungal activity of 1,3-pdta-Cu(II) complexes

2020 ◽  
Vol 18 (1) ◽  
pp. 47-56
Author(s):  
Ivana Stanojevic ◽  
Jelena Gitaric ◽  
Darko Asanin ◽  
Biljana Glisic ◽  
Nenad Draskovic ◽  
...  
Keyword(s):  
Solid Solution ◽  
Biological Activities ◽  
Spectroscopic Characterization ◽  
Colletotrichum Acutatum ◽  
X Ray Diffraction ◽  
Mycelium Growth ◽  
X Ray ◽  
In Vitro Antifungal Activity

New solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediamine-N,N,N?,N?-tetraacetate ligand (1,3-pdta), [Mg(H2O)6] [Mg0.5Cu0.5(1,3-pdta)].2H2O was synthesized and structurally characterized by elemental microanalyses, molar conductivity, and spectroscopic (IR and UV-Vis) measurements. The spectroscopic data of [Mg(H2O)6][Mg0.5Cu0.5(1,3-pdta)].2H2O were compared with those for [Mg(H2O)6][Cu(1,3-pdta)].2H2O complex of the known molecular structure determined by single-crystal X-ray diffraction analysis. In vitro growth inhibition activity of [Mg(H2O)6][Mg0.5Cu0.5(1,3-pdta)].2H2O and [Mg(H2O)6][Cu(1,3-pdta)].2H2O against Colletotrichum acutatum and their effects on this fungus sporulation level are investigated. The obtained results showed that the highest percentage of inhibition for mycelium growth was achieved at a concentration of 500 ?g/mL for the investigated complexes. The biological activities of the investigated complexes were compared with those for the commercial formulation of fungicide captan (Method 480 SC).

Effect of Hydrated Metal Salts on the Coordination Product of Cobalt(II) halide and PNP Type Ligand, 2,6-bis(di-tertbutylphosphinomethyl) pyridine

2018 ◽  
Author(s):  
Tasneem Siddiquee ◽  
Abdul Goni
Keyword(s):  
Metal Salts ◽  
Molar Ratio ◽  
Pincer Complexes ◽  
Asymmetric Unit ◽  
X Ray Diffraction ◽  
Pincer Ligand ◽  
Tetrahedral Geometry ◽  
X Ray ◽  
Distorted Tetrahedral Geometry ◽  
Cobalt Center

Chemical treatment of CoX<sub>2</sub><b><sup>. </sup></b>6H<sub>2</sub>O (X = Cl, Br, I) with the potentially tridentate PNP pincer ligand 2,6-bis(di-<i>tert</i>-butylphosphinomethyl)pyridine in 1:1 molar ratio results in cobalt(II) halide-PNP pincer complexes. The effect of the hydrated metal source on molecular structure and geometry of the complexes was studied by single crystal X-ray diffraction analysis. The complexes are neutral and the cobalt center adopts a penta-coordinate system with potential atropisomerization. Within the unit cell there are two distinct molecules per asymmetric unit. One of the two phosphorus atoms in the PNP ligand was observed to be partially oxidized to phosphinoxide. Disorder in the structure reflects a mixture of square pyramidal and distorted tetrahedral geometry.

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