scholarly journals Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil

1998 ◽  
Vol 5 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Udai P. Singh ◽  
Sudha Singh ◽  
Sukh Mahendra Singh
Keyword(s):  
Metal Complexes ◽  
Room Temperature ◽  
Magnetic Measurements ◽  
Antitumour Activity ◽  
Tumour Cells ◽  
Sarcoma 180 ◽  
X Ray Diffraction ◽  
X Ray

Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.

Effects of dietary alteration of bicarbonate and magnesium on rat bone

1986 ◽  
Vol 250 (2) ◽  
pp. F302-F307 ◽  
Author(s):  
J. M. Burnell ◽  
C. Liu ◽  
A. G. Miller ◽  
E. Teubner
Keyword(s):  
Crystal Structure ◽  
Bone Formation ◽  
X Ray Diffraction ◽  
X Ray ◽  
Growing Rats ◽  
Final Composition ◽  
Rat Bone

To study the effects of bicarbonate and magnesium on bone, mild acidosis and/or hypermagnesemia were produced in growing rats by feeding ammonium chloride and/or magnesium sulfate. Bone composition, quantitative histomorphometry, and mineral x-ray diffraction (XRD) characteristics were measured after 6 wk of treatment. The results demonstrated that both acidosis (decreased HCO3) and hypermagnesemia inhibited periosteal bone formation, and, when combined, results were summative; and the previously observed in vitro role of HCO3- and Mg2+ as inhibitors of crystal growth were confirmed in vivo. XRD measurements demonstrated that decreased plasma HCO3 resulted in larger crystals and increased Mg resulted in smaller crystals. However, the combined XRD effects of acidosis and hypermagnesemia resembled acidosis alone. It is postulated that the final composition and crystal structure of bone are strongly influenced by HCO3- and Mg2+, and the effects are mediated by the combined influence on both osteoblastic bone formation and the growth of hydroxyapatite.

Synthesis, Crystal Structure and Magnetic Properties of a Copper(II) p-Formylbenzoate Complex

2012 ◽  
Vol 67 (11) ◽  
pp. 1185-1190 ◽  
Author(s):  
Jin-Li Qi ◽  
Wei Xu ◽  
Yue-Qing Zheng
Keyword(s):  
Room Temperature ◽  
Magnetic Measurements ◽  
X Ray Diffraction ◽  
Complex Molecules ◽  
Triclinic Space Group ◽  
X Ray ◽  
Cell Dimensions ◽  
Ferromagnetic Interactions ◽  
Aqueous Conditions ◽  
Discrete Complex

A new Cu(II) complex was prepared at room temperature from the reaction of p-formylbenzoic acid, phenanthroline, CuCl2⋅2H2O, and NaOH under ethanolic aqueous conditions. The complex has been characterized by X-ray diffraction, IR spectroscopy, TG-DTA analyses, and magnetic measurements. Single-crystal X-ray diffraction analysis indicated that the complex crystallizes in the triclinic space group P1̄ with the cell dimensions a=7.875(2), b=10.724(2), c=15.317(3) Å , α =102.65(3), β =93.71(3), γ =107:64(3)°. The Cu atoms are in the environment of distorted CuN2O3 tetragonal pyramids. These discrete complex molecules are packed through intermolecular π...π-stacking interactions and C-H...O hydrogen bonds forming a supramolecular structure. The title complex obeys the Curie-Weiss law with a Curie constant C=0:53 cm3 K mol-1 and a Weiss constant θ = -0:27 K. The shape of the xmT curve is characteristic of weak ferromagnetic interactions between the Cu(II) centers from 300 to 7 K, while there are weak antiferromagnetic interactions below 7 K.

Granular Structure and Magnetic Properties of FePt/C Films

2005 ◽  
Vol 475-479 ◽  
pp. 3729-3732
Author(s):  
Cong Mian Zhen ◽  
Xiao Xia Zhai ◽  
Chengfu Pan ◽  
Xiangfu Nie
Keyword(s):  
Room Temperature ◽  
Magnetic Measurements ◽  
Carbon Layer ◽  
Fept Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
L10 Structure ◽  
Probe Microscope ◽  
Higher Temperature ◽  
20 Nm

FePt/C mutilayer films were successfully prepared by using RF and DC magnetron sputtering system. FePt nanoparticles embedded in a C matrix were formed by consequently annealing. X-ray diffraction (XRD) results show the degree of atomic ordering of the L10 structure increases with higher temperature annealing. Room temperature magnetic measurements reveal that in-plane coercivity HC, and squareness Mr/MS depend on the thickness of carbon layer. Relatively High HC (3245.1Oe) and squareness (0.67) were obtained when the thickness of C layer is 2.0 nm. The carbon layer not only isolates the FePt grain, but also suppresses the growth of fct FePt grains. When the thickness of carbon layer is 2.0 nm, the FePt grain size decreases down to ~20 nm measured by Scan Probe Microscope (SPM). Interactions between particles can be tuned to near zero when we select the proper thickness of C layer.

Structural, Magnetic, and Electrical Properties of BiFe1-xMnxO3 Thin Films

2009 ◽  
Vol 1199 ◽  
Author(s):  
Danilo G Barrionuevo ◽  
Surinder P Singh ◽  
Maharaj S. Tomar
Keyword(s):  
Thin Films ◽  
Room Temperature ◽  
Magnetic Measurements ◽  
Sol Gel ◽  
Ion Concentration ◽  
Ferromagnetic Phase ◽  
X Ray Diffraction ◽  
X Ray ◽  
Si Substrates ◽  
Sol Gel Process

AbstractWe synthesized BiFe1-xMnxO3 (BFMO) for various compositions by sol gel process and thin films were deposited by spin coating on platinum Pt/Ti/SiO2/Si substrates. X-ray diffraction shows all the diffraction planes corresponding to rhombohedrally distorted perovskite BiFeO3 structure. The absence of any impurity phase in the films suggests the incorporation Mn ion preferentially to Fe site in the structure for low concentration. Magnetic measurements reveal the formation of ferromagnetic phase at room temperature with increased Mn substitution. On the other hand, ferroelectric polarization decreases with increasing Mn ion concentration. Raman studies suggest the dopant induced structural distortion.

Preparation of N, O-Carboxymethyl Chitosan with Different Substitutional Degree and its Application for Hemostasis

2013 ◽  
Vol 798-799 ◽  
pp. 1061-1066 ◽  
Author(s):  
Yan Wei Zhao ◽  
Lu Liu ◽  
Xiang Han ◽  
Jing Guan
Keyword(s):  
Carboxymethyl Chitosan ◽  
X Ray Diffraction ◽  
Clotting Time ◽  
X Ray ◽  
Angle Measurements ◽  
Contact Angle Measurements ◽  
Ft Ir ◽  
Ubbelohde Viscometer

We prepared N, O-carboxymethyl chitosans (CMCSs) with different substitutional degrees (SDs) to evaluate their effects of hemostasis, and provided experimental basis on biomedical materials. Chloroethanoic acid was used to synthesize CMCSs. The structure were characterized by Fourier transform infrared (FT-IR) and wide-angle X-ray diffraction (WXRD). Potentiometric titration and Ubbelohde viscometer were adopted to determine the SD and intrinsic viscosity of CMCSs. Contact angle measurements were investigated to determine surface wettability. Method of dynamic clotting time and coagulation test in vivo were used to evaluate their effects of hemostasis. SDs of CMCSs were from 50% to 110%. As the SD increased, molecular weight decreased. CMCS powder with SD 63% possessed excellent hemostasis both in vitro and in vivo. CMCS powder owned hemostatic capability prior to CS. CMCS powder with SD 63% (neither too high, nor too low) possessed excellent hemostasis both in vitro and in vivo.

scholarly journals Hydrophilic Sugars for Enhancing Dissolution Rate of Cilostazol: Effect of Wet Co-Processing

2020 ◽  
Vol 27 (1) ◽  
pp. 111-120
Author(s):  
Alaa Yosf Bazeed ◽  
Ahmed Nouh ◽  
Ebtessam Ahmed Essa ◽  
Gamal El Maghraby
Keyword(s):  
Aqueous Solubility ◽  
Submicron Particles ◽  
Drug Dissolution ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Swallowing Difficulties ◽  
Fast Disintegrating Tablets

Background: Cilostazol is an anti-platelets drug with considerable antithrombotic effects in vivo. Therefore, it is widely used by elderly patients. However, it suffers from poor bioavailability due to its low aqueous solubility. The objective of this work was to enhance the dissolution of cilostazol with the aim of formulating fast dissolving tablets for geriatrics and those of swallowing difficulties. Methods: Ethanol-assisted co-grinding of cilostazol with sugar-based excipients was adopted. Sucralose and mannitol were used for this purpose as hydrophilic excipient as well as taste improving agents. The obtained products were investigated regarding differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction, scanning electron microscope (SEM) and in vitro drug dissolution. Fast disintegrating tablets were prepared and evaluated. Results: Thermal behavior of the developed products reflected reduced crystallinity, it also suggested possible existence of new crystalline species with sucralose. Eutexia was also suggested for mannitol mixtures, that was supported by X-ray diffraction data. SEM indicated size reduction with the deposition of the drug as submicron particles over the excipient surface. Co-processing markedly improved cilostazol dissolution compared to unprocessed drug. The optimized formulations were successively formulated into fast disintegrating tablets. Conclusion: This investigation introduced the wet grinding strategy with sugar excipients as a platform for the formulation of easy to use tablets with optimum drug release.

scholarly journals Chemical, Microstructural and Morphological Characterisation of Dentine Caries Simulation by pH-Cycling

Minerals ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 5
Author(s):  
Juan Sebastián Zuluaga-Morales ◽  
María Victoria Bolaños-Carmona ◽  
Carolina Cecilia Cifuentes-Jiménez ◽  
Pedro Álvarez-Lloret
Keyword(s):  
Microstructural Properties ◽  
Third Molars ◽  
X Ray Diffraction ◽  
X Ray ◽  
In Vitro Simulation ◽  
Ph Cycling ◽  
Residual Caries ◽  
Microscopy Techniques

In vitro simulation of natural caries is of great importance in dental research for the development of more effective clinical treatments. The pH-cycling (pHc) procedure consists of a dynamic caries process with alternating de-remineralisation periods. The current research aims to evaluate the effects of the pHc procedure on mineral dentine properties in comparison with sound dentine and natural residual caries. For this purpose, dentine slices from human third molars were submitted to cycling periods of 14 and 28 days. The chemical composition, morphological and microstructural properties of the dentine samples were examined by infrared and Raman spectroscopies, X-ray diffraction, and scanning electron microscopy techniques. In addition, the depth of the demineralisation front was evaluated by Masson’s trichrome (MT) staining. The results showed that the pHc procedure led to notable changes in the mineral composition and the crystalline characteristics with respect to sound dentine and some extent to natural caries. The MT results revealed that pHc 28 yields a deeper lesion than pHc 14, simulating potential progression of natural caries. The results of this study provide a better understanding of the mechanisms of demineralisation that could occur in an in vivo environment and provide a standardised substrate similar to natural residual caries.

Two Metal–Organic Coordination Polymers Based on Polypyridyl Ligands: Crystal Structures and Inhibition of Human Spinal Tumour Cells

2018 ◽  
Vol 71 (11) ◽  
pp. 902
Author(s):  
Hua-Jie Mao ◽  
Qi-Xin Chen ◽  
Bin Han
Keyword(s):  
Coordination Polymers ◽  
Tumour Cells ◽  
Spinal Tumour ◽  
X Ray Diffraction ◽  
Polypyridyl Ligands ◽  
X Ray ◽  
Metal Organic ◽  
Diphenyl Tetrazolium Bromide ◽  
Rpmi 8226

In this work, two new metal–organic coordination polymers [Co2.5(dtp)2(H2O)5](NO3)(H2O)2 (1, H2dtp = 4′-(3,5-dicarboxyphenyl)-2,2′:6′,2″-terpyridine) [Ni(dpt)](H2O)3 (2, H2dpt = 4′-(3,5-dicarboxyphenyl)-4,2′:6′,4″- terpyridine) have been successfully prepared by reaction of metal ions with two similar carboxylic-pyridinyl ligands with different arrangement of N atoms of terpyridines under solvothermal conditions. Powder X-ray diffraction, elemental analysis, and single-crystal X-ray diffraction techniques were used to probe the structures of the as-prepared complexes. The CoII-based complex 1 exhibits a finite molecular structure and 2 displays a 3D porous framework with a 1D channel. Furthermore, the in vitro anticancer activity of complexes 1 and 2 was evaluated via the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay against U-266, MM1S, and RPMI-8226 human spinal tumour cells.

scholarly journals Synthesis, characterization, electrochemical studies and X-ray structures of mixed-ligand polypyridyl copper(II) complexes with the acetate

2016 ◽  
Vol 81 (11) ◽  
pp. 1251-1262 ◽  
Author(s):  
Oluwafunmilayo Adekunle ◽  
Ray Butcher ◽  
Oladapo Bakare ◽  
Olusegun Odunola
Keyword(s):  
Room Temperature ◽  
Magnetic Measurements ◽  
Magnetic Moments ◽  
Copper Ion ◽  
X Ray Diffraction ◽  
Visible Spectroscopy ◽  
X Ray ◽  
Elemental Analyses ◽  
Structural Details ◽  
Uv Visible

[Cu(phen)2(CH3COO)](ClO4).2H2O (1) and [Cu(bipy)2(CH3COO)]-(ClO4).H2O (2) {phen = 1,10-phenanthroline, bipy = 2,2?-bipyridine}were synthesized and characterized. The complexes were characterized by employying elemental analyses, infrared and UV-Visible spectroscopy, room temperature magnetic measurements and the crystal structures elucidated using X-ray diffraction experiment. The redox properties of the complexes were also investigated. Both structures have a square pyramidal CuN4O chromophore which exhibit significant distortions due to long Cu-O [2.217(3) ? for (1) and 2.179 (1) for (2)] and Cu-N [2.631(2) ? for (1) and 2.714(1) ? for (2)] bonds. This distortion if further shown by the O-Cu-N bond angles [147.71(8) o for (1) and 153.40(5) o for (2)]. The elemental analyses further support the structural details unveiled by the single crystal X-ray diffraction analysis. The infrared spectra shows the acetate vibrational frequencies at 1587 cm-1,1428 cm-1, 1314 cm-1 for (1) and 1571 cm-1, 1441 cm-1, 1319c m-1 for (2) and the perchlo-rate bands at 1059 cm-1, 720 cm-1 (1) and 1080 cm-1,768 cm-1 (2). The broad d-d bands for the copper ion at 14,514 cm-1(1) and 14,535 cm-1(2) support the adoption of square pyramid geometries. The magnetic moments for the two complexes are 1.83 B.M for (1) and 1.72 B.M for (2). The peak to peak values of the two complexes show that the electrode reactions are quasi-reversibile with ?Ep = 0.023V (1) and 0.025V for (2). In both structures, there are ?-? intermolecular interactions in addition to hydrogen bonding between the units.

scholarly journals Synthesis, Characterization, and Biological Activity ofN′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Jonnie N. Asegbeloyin ◽  
Oguejiofo T. Ujam ◽  
Emmanuel C. Okafor ◽  
Ilknur Babahan ◽  
Esin Poyrazoglu Coban ◽  
...  
Keyword(s):  
Magnetic Measurements ◽  
Structure Study ◽  
Molar Conductance ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Spectral Studies ◽  
X Ray Diffraction ◽  
X Ray ◽  
Gram Positive Bacteria

Reaction of 1-phenyl-3-methyl-4-benzoyl-pyrazol-5-one and benzoyl hydrazide in refluxing ethanol gaveN′-[(Z)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide (HL1), which was characterized by NMR spectroscopy and single-crystal X-ray structure study. X-ray diffraction analyses of the crystals revealed a nonplanar molecule, existing in the keto-amine form, with intermolecular hydrogen bonding forming a seven-membered ring system. The reaction of HL1with Co(II), Ni(II), and Cu(II) halides gave the corresponding complexes, which were characterized by elemental analysis, molar conductance, magnetic measurements, and infrared and electronic spectral studies. The compounds were screened for theirin vitrocytotoxic activity against HL-60 human promyelocytic leukemia cells and antimicrobial activity against some bacteria and yeasts. Results showed that the compounds are potent against HL-60 cells with the IC50value ≤5 μM, while some of the compounds were active against few studied Gram-positive bacteria.

Sign in / Sign up

Export Citation Format

Share Document