Stromal cell-derived factor-1/CXC chemokine receptor-4 axis and hepatic stem cell transplantation

Stem cell therapy has shown promise in treating a variety of pathologies, such as myocardial infarction, ischaemic stroke and organ transplantation. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) axis plays a key role in stem cell mobilization. This review describes the important role of SDF-1 in tissue injury and how it works in tissue revascularization and regeneration via CXCR4. Furthermore, factors influencing the SDF-1/CXCR4 axis and its clinical potential in ischaemia reperfusion injury, such as renal transplantation, are discussed. Exploring signalling pathways of the SDF-1/CXCR4 axis will contribute to the development of stem cell therapy so that more clinical problems can be solved. Controlling directional homing of stem cells through the SDF-1/CXCR4 axis is key to improving the efficacy of stem cell therapy for tissue injury. CXCR4 antagonists may also be effective in increasing circulating levels of adult stem cells, thereby exerting beneficial effects on damaged or inflamed tissues in diseases that are currently not treated by standard approaches.

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Expression and function of the stromal cell-derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in the swine ovarian follicle

Domestic Animal Endocrinology ◽

10.1016/j.domaniend.2019.106404 ◽

2020 ◽

Vol 71 ◽

pp. 106404 ◽

Cited By ~ 3

Author(s):

G. Basini ◽

L. Ragionieri ◽

S. Bussolati ◽

R. Di Lecce ◽

A. Cacchioli ◽

...

Keyword(s):

Chemokine Receptor ◽

Stromal Cell ◽

Ovarian Follicle ◽

Cxc Chemokine Receptor 4 ◽

Cxc Chemokine ◽

Stromal Cell Derived Factor ◽

And Function ◽

Chemokine Receptor 4

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Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation

General Thoracic and Cardiovascular Surgery ◽

10.1007/s11748-021-01696-0 ◽

2021 ◽

Author(s):

Qin Jiang ◽

Keli Huang ◽

Fang Lu ◽

Shaoping Deng ◽

Zhenglin Yang ◽

...

Keyword(s):

Stem Cell ◽

Mesenchymal Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Chemokine Receptor ◽

Gene Engineering ◽

Promising Candidate ◽

Mesenchymal Stem Cell Transplantation ◽

Stromal Cell Derived Factor ◽

Chemokine Receptor 4

AbstractMesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for successful clinical translation of MSC therapy are poor survival, retention, and engraftment in the infarcted heart. Stromal cell-derived factor-1/chemokine receptor 4 (SDF-1/CXCR4) constitutes one of the most efficient chemokine/chemokine receptor pairs regarding cell homing. In this review, we mainly focused on previous studies on how to regulate the SDF-1/CXCR4 interaction through various priming strategies to maximize the efficacy of mesenchymal stem cell transplantation on ischaemic hearts or to facilitate the required effects. The strengthened measures for enhancing the therapeutic efficacy of the SDF-1/CXCR4 interaction for mesenchymal stem cell transplantation included the combination of chemokines and cytokines, hormones and drugs, biomaterials, gene engineering, and hypoxia. The priming strategies on recipients for stem cell transplantation included ischaemic conditioning and device techniques.

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