Endoscopic ultrasound in combination with pathological examination for diagnosis of duodenal Brunner's gland hyperplasia and selection of appropriate endoscopic treatment

Abstract Brunner’s gland hamartomas (BGHs) are rare, benign, primary duodenal tumors. The clinical presentations can vary, and confirming a diagnosis can be challenging because of the submucosal nature of the lesions. We report two cases of BGHs with different clinical presentations. The diagnoses were not determined initially, despite utilizing endoscopy, mucosal biopsies, endoscopic ultrasound, and, in one case, fine-needle aspiration. Confirmation of BGHs was subsequently made following endoscopic or surgical resection.

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Adenocarcinoma of the duodenum arising from Brunner’s gland resected by partial duodenectomy: a case report

Surgical Case Reports ◽

10.1186/s40792-019-0732-4 ◽

2019 ◽

Vol 5 (1) ◽

Cited By ~ 2

Author(s):

Tetsuya Mochizuki ◽

Nobuaki Fujikuni ◽

Koichi Nakadoi ◽

Masahiro Nakahara ◽

Kazuaki Tanabe ◽

...

Keyword(s):

Invasive Carcinoma ◽

Carcinoma Cells ◽

Pathological Examination ◽

Case Presentation ◽

Non Invasive ◽

Uncontrolled Diabetes ◽

Epithelial Marker ◽

Duodenal Carcinoma ◽

Brunner’S Gland ◽

Brunner's Gland

Abstract Background Duodenal carcinoma originating in Brunner’s gland is rare. Herein, we report a case of duodenal carcinoma arising from Brunner’s gland in a 63-year-old man. Case presentation On diagnostic imaging, the lesion presented as a non-invasive carcinoma; the patient also had uncontrolled diabetes and liver cirrhosis. Hence, we decided to perform partial duodenectomy to reduce operative stress. Pathological examination revealed that the tumor consisted of tissue from Brunner’s gland. Additionally, the carcinoma cells were strongly positive for Mucin-6 protein, which is an epithelial marker of Brunner’s gland. The patient’s post-operative course was uneventful, and he has been well for 2 years after the surgery. Conclusions This a rare case of an adenocarcinoma arising from Brunner’s gland of the duodenum that was resected by duodenectomy.

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Brunner’s Gland Hamartoma: A Rare Cause of Gastrointestinal Bleeding – Case Report and Review of the Literature

Canadian Journal of Gastroenterology ◽

10.1155/2002/797934 ◽

2002 ◽

Vol 16 (5) ◽

pp. 309-313 ◽

Cited By ~ 16

Author(s):

David R Stolpman ◽

Gordon C Hunt ◽

Brett Sheppard ◽

Hahn Huang ◽

Deepak V Gopal

Keyword(s):

Gastrointestinal Bleeding ◽

Endoscopic Ultrasound ◽

Deficiency Anemia ◽

Normal Range ◽

Ferritin Concentration ◽

The Third ◽

Brunner’S Gland ◽

Brunner's Gland ◽

Brunner’S Gland Hamartoma ◽

Upper Gastrointestinal

An unusual cause of upper gastrointestinal bleeding is described in a previously healthy 45-year-old man who was admitted to hospital with weakness and fatigue, and had experienced an episode of melena two days before admission. His medical and surgical history was unremarkable. Upon admission to hospital, he showed evidence of iron-deficiency anemia, with a hemoglobin concentration of 61 g/L (normal range 135 to 175 g/L), a mean corpuscular volume of 73 fL (normal range 85.0 to 95.0 fL) and a ferritin concentration of 1.0 µg/L (normal range in males 15 to 400 µg/L). Upper gastrointestinal endoscopy revealed a 3.5 cm ulcerated submucosal mass in the third portion of the duodenum, for which mucosal biopsies were nondiagnostic. A subsequent endoscopic ultrasound revealed a 2.7×4.0 cm hyperechoic, cystic, submucosal tumour in the third portion of the duodenum. Endoscopic ultrasound-guided fine needle aspiration revealed no malignant cells. The patient eventually underwent a resection of the third portion of his duodenum. Surgical pathology revealed that this tumour was a Brunner’s gland hamartoma, 4.5 cm in its greatest dimension.

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