scholarly journals DNA Damage Response and Growth Factor Signaling Pathways in Gliomagenesis and Therapeutic Resistance: Figure 1.

2011 ◽  
Vol 71 (18) ◽  
pp. 5945-5949 ◽  
Author(s):  
Massimo Squatrito ◽  
Eric C. Holland
Keyword(s):  
Dna Damage ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Therapeutic Resistance ◽  
Growth Factor Signaling ◽  
Damage Response

scholarly journals Bisphenol A exposure triggers apoptosis via three signaling pathways in Caenorhabditis elegans

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32624-32631 ◽  
Author(s):  
Yun Wang ◽  
Lianfeng Zhang ◽  
Xun Luo ◽  
Shunchang Wang ◽  
Yuanyuan Wang
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Bisphenol A ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Mitogen Activated Protein Kinase ◽  
Mapk Cascades ◽  
Damage Response ◽  
Mitogen Activated Protein

Bisphenol A can trigger germline apoptosis via three signaling pathways including DNA damage response (DDR) pathway, mitogen-activated protein kinase (MAPK) cascades and insulin-like growth factor-1 (IGF-1) network in Caenorhabditis elegans.

scholarly journals Avian Sarcoma and Leukosis Virus Cytopathic Effect in the Absence of TVB Death Domain Signaling

2005 ◽  
Vol 79 (13) ◽  
pp. 8243-8248 ◽  
Author(s):  
Sara Klucking ◽  
Asha S. Collins ◽  
John A. T. Young
Keyword(s):  
Dna Damage ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Cytopathic Effect ◽  
Tumor Necrosis Factor Receptor ◽  
Death Domain ◽  
Trail Receptors ◽  
Damage Response ◽  
Cellular Dna ◽  
Avian Sarcoma

ABSTRACT The cytopathic effect (CPE) seen with some subgroups of avian sarcoma and leukosis virus (ASLV) is associated with viral Env activation of the death-promoting activity of TVB (a tumor necrosis factor receptor-related receptor that is most closely related to mammalian TNF-related apoptosis-inducing ligand [TRAIL] receptors) and with viral superinfection leading to unintegrated viral DNA (UVD) accumulation, which is presumed to activate a cellular DNA damage response. In this study, we employed cells that express signaling-deficient ASLV receptors to demonstrate that an ASLV CPE can be uncoupled from the death-promoting functions of the TVB receptor. However, these cell-killing events were associated with much higher levels of viral superinfection and DNA accumulation than those seen when the virus used signaling-competent TVB receptors. These findings suggest that a putative cellular DNA damage response that is activated by UVD accumulation might act in concert with the death-signaling pathways activated by Env-TVB interactions to trigger cell death. Such a model is consistent with the well-established synergy that exists between TRAIL-signaling pathways and DNA damage responses which is currently being exploited in cancer therapy regimens.

scholarly journals Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways

2010 ◽  
Vol 8 (10) ◽  
pp. 1388-1398 ◽  
Author(s):  
Maureen Gilmore-Hebert ◽  
Rajani Ramabhadran ◽  
David F. Stern
Keyword(s):  
Dna Damage ◽  
Growth Factor ◽  
Dna Damage Response ◽  
Damage Response

Abstract 44: Leukemia-associated DNMT3A R882 mutations and their role in anthracycline-induced DNA damage response and therapeutic resistance

2014 ◽  
Author(s):  
Olga A. Guryanova ◽  
Kaitlyn Shank ◽  
Luisa Luciani ◽  
Evangelia Loizou ◽  
Matthew D. Keller ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Therapeutic Resistance ◽  
Damage Response

scholarly journals ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 845
Author(s):  
Liem Minh Phan ◽  
Abdol-Hossein Rezaeian
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Cancer Development ◽  
Cellular Processes ◽  
Cycle Arrest ◽  
Damage Response ◽  
Cancer Cell Survival

ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, proliferation, oxidative sensing, among others. Of note, ATM is often considered a major tumor suppressor because of its ability to induce apoptosis and cell cycle arrest. However, in some advanced stage tumor cells, ATM signaling is increased and confers remarkable advantages for cancer cell survival, resistance to radiation and chemotherapy, biosynthesis, proliferation, and metastasis. This review focuses on addressing major characteristics, signaling pathways and especially the diverse roles of ATM in cellular homeostasis and cancer development.

scholarly journals Crosstalk between signaling pathways and DNA damage response

2019 ◽  
Vol 1 (2) ◽  
pp. 81-91 ◽  
Author(s):  
Kangjunjie Wang ◽  
Long Li ◽  
Yuxue Zhang ◽  
Daming Gao
Keyword(s):  
Dna Damage ◽  
Signaling Pathways ◽  
Dna Damage Response ◽  
Damage Response
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