Abstract B261: A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growthin vivo

2009 ◽  
Author(s):  
Christopher R. Ireson ◽  
Stephen Jamieson ◽  
Stephen Stribbling ◽  
Rachel Sutherland ◽  
Tony Raynham ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Protein Kinase D ◽  
Molecule Inhibitor

scholarly journals A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

2010 ◽  
Vol 9 (5) ◽  
pp. 1136-1146 ◽  
Author(s):  
Kuzhuvelil B. Harikumar ◽  
Ajaikumar B. Kunnumakkara ◽  
Nobuo Ochi ◽  
Zhimin Tong ◽  
Amit Deorukhkar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Protein Kinase D ◽  
Molecule Inhibitor

414 A Novel Small Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth Both In Vitro and In Vivo

2010 ◽  
Vol 138 (5) ◽  
pp. S-62 ◽  
Author(s):  
Christopher R. Ireson ◽  
Kuzhuvelil B. Harikumar ◽  
Ajaykumar B. Kunnumakkara ◽  
Amit Deorukhkar ◽  
Zhimin Tong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Protein Kinase ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Protein Kinase D ◽  
Molecule Inhibitor

scholarly journals A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth

2020 ◽  
Vol 522 (3) ◽  
pp. 633-638 ◽  
Author(s):  
Tomohiro Yoshida ◽  
Shingo Yamasaki ◽  
Osamu Kaneko ◽  
Naofumi Taoka ◽  
Yusuke Tomimoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Cancer Growth ◽  
Glutamate Oxaloacetate Transaminase ◽  
Molecule Inhibitor

TW-37, A NONPEPTIDIC SMALL-MOLECULE INHIBITOR OF BCL-2, INHIBITS INVASION AND ANGIOGENESIS IN PANCREATIC CANCER

Pancreas ◽  
2007 ◽  
Vol 35 (4) ◽  
pp. 434-435
Author(s):  
Z. Wang ◽  
W. Song ◽  
A. Aboukameel ◽  
G. Wang ◽  
S. Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor

scholarly journals MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

2015 ◽  
Vol 35 (6) ◽  
Author(s):  
Lijs Beke ◽  
Cenk Kig ◽  
Joannes T. M. Linders ◽  
Shannah Boens ◽  
An Boeckx ◽  
...  
Keyword(s):  
Dna Damage ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Small Molecule ◽  
Damage Tolerance ◽  
Replication Stress ◽  
Small Molecule Inhibitor ◽  
Dna Damage Tolerance ◽  
Molecule Inhibitor ◽  
Senescence Phenotype

Protein kinase MELK has oncogenic properties and is highly overexpressed in some tumors. In the present study, we show that a novel MELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence phenotype.

scholarly journals A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

Cell Cycle ◽  
2009 ◽  
Vol 8 (15) ◽  
pp. 2435-2443 ◽  
Author(s):  
Steven N. Hochwald ◽  
Carl Nyberg ◽  
Min Zheng ◽  
Donghang Zheng ◽  
Cheng Wood ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Human Pancreatic Cancer ◽  
Molecule Inhibitor
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